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4 43 @ @ <>?>> > >>? > >?>?> >> > > >> @ @??@?> > <?@?> > > > > >> >?> @ 3/5 < >?> >?? > > >? >? < > > >? > >>? >? > > E @ > >. > @ @ > (%56/4) > >?>?> @ @ >? >?> 44 >>? <>>> @?> @ >?> 42/5 >>? >.(5) > > >? >@ >??> >@ @> (Grad @ @?> >. > >> @ > > >>??> @ > >.(7) @>>> REFERENCES. Aaltonen LA, Salovaara R, Kristo P. Incidence of hereditary nonpolyposis colorectal cancer and the feasibility of molecular screening for the disease. N Engl J Med 998; 338:

5 4 > > /44 2. Islamic Republic of Iran, Ministry of Health and Medical Education, Office of Deputy Minister for Health Center for Disease Control, Cancer Office. Iranian annual national cancer registration report, Tehran: Iranian Center for Disease Control; Cancer Office of Deputy Minister for Health Center for disease control, Ministry of Health and Medical Education, Islamic Republic of Iran. Iranian annual national cancer registration report, 2005: Tehran: Iranian Center for Disease Control; Naccarati A, Pardini B, Hemminki K, Vodicka P. Sporadic colorectal cancer and individual susceptibility: a review of the association studies investigating the role of DNA repair genetic polymorphisms. Mutat Res 2007; 635: Boyle P, Langman JS. ABC of colorectal cancer. Epidemiology. BMJ 2000; 32: Roncucci L, Fante R, Losi L, Di Gregorio C, Micheli A, Benatti P, et al. Survival for colon and rectal cancer in a population based cancer registry. Eur J Cancer 995; 32A: Marie RG, Erik JB, Robert JC, Robert WB, Josep LM. Predictors of survival after curative resection of carcinoma of the colon and rectum. Cancer 987; 60: Nishisho I, Nakamura Y, Miyosshi Y. Mutation of chromosome 5q2 genes in FAP and colorectal cancer patients. Science 99; 253: Lynch HT, Smyrk TC, Watson P. Genetics, natural history, tumor spectrum, and pathology of hereditary nonpolyposiscolorectal cancer: an updated review. Gastroenterology 993; 04: Lynch HT, Smirk TC. Hereditary nonpolyposis colorectal cancer (Lynch syndrome): updated review. Cancer 996; 78: Piñol V, Castells A, Andreu M, Castellví-Bel S, Alenda C, Llor X, et al. Accuracy of revised Bethesda guidelines, microsatellite instability, and immunohistochemistry for the identification of patients with hereditary nonpolyposis colorectal cancer. JAMA 2005; 293: Kleinbaum D, Kupper L, eds. Applied regression analysis another multivariable methods. st edition. Boston: Duxburg; 978. p Sankila R, Aaltonen LA, Jarvinen HJ. Better survival rates in patients with MLH-associated hereditary colorectal cancer. Gastroenterology 996; 0: Elsakov P, K Urtinaitis J. Survival from colorectal carcinoma in families as compared to the general population in Lithuania-initial results. Fam Cancer 2006; 5: Percesepe A, Benatti P, Roncucci L. Survival analysis in families affected by hereditary non polyposis colorectal cancer. Int J Cancer 997; 7: Chapuis PH, Dent OF, Fisher R, Newland RC, Pheils MT, Smyth E, et al. A multivariate analysis of clinical and pathological variables in prognosis after resection of large bowel cancer. Br J Surg 985; 72: Moghimi-Dehkordi B, Safaee A, Zali MR. Prognostic factors in,38 Iranian colorectal cancer patients. Int J Colorectal Dis 2008 ; 7: Aarnio M, Mecklin JP, Aaltonen LA. Life-time risk of different cancers in hereditary non-polyposis colorectal cancer () syndrome. Int J Cancer 995; 64: Hosseninasab AR, Modir Abbas, Shir yazdi SM. Survival analysis of colorectal cancers, Yazd, Journal of Shahid Sadoughi University of Medical Science 2002; 9: [In Persian]

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