CellaVision. Ola Andersson Peter Wilson. Siemens Belgium

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1 CellaVision Ola Andersson Peter Wilson Siemens Belgium

2 CellaVision in short Headquarters in Lund, Sweden Around 80 employees globally Market support offices in the Nordic countries, the US, Canada, Japan, China, UAE and Korea 2 6/10/2016

3 Our unique product concept Digital Cell Morphology by CellaVision Digital Cell Morphology by CellaVision CellaVision Peripheral Blood Application CellaVision Remote Review Software CellaVision DM1200 CellaVision Proficiency Software CellaVision Advanced RBC Application CellaVision Server Software CellaVision DM9600 CellaVision Body Fluid Application CellaVision Image Capture System CellaVision CellAtlas

4 Our unique product concept Digital Cell Morphology by CellaVision CellaVision DM1200 Loading capacity: 12 slides Throughput: 20 slides / hour CellaVision DM1200 CellaVision DM9600 CellaVision Peripheral Blood Application CellaVision Advanced RBC Application CellaVision Body Fluid Application CellaVision DM9600 Loading capacity: 96 slides CellaVision Remote Review Software CellaVision Server Software CellaVision Image Capture System Throughput: 30 slides / hour CellaVision Proficiency Software CellaVision CellAtlas

5 Body Fluid Application

6 Body Fluid application is available on all models of CellaVision The Body Fluid application is built into the software but a license key is necessary to unlock it.

7 Cytocentrifuged Preparations are needed for application Designed to utilize existing Cytocentrifuged slide preparations Default settings for Shandon/Wescor/Statspin Custom settings of sample area Accepts all Romanovsky staining protocols (MGG/Wright/WG) Still requires a clipped cornered slide

8 Body Fluid Differential Artificial neural network pre-classifies: Neutrophils, Lymphocytes, Eosinophils, Macrophages (incl. monocytes) Other cells (e.g. blasts, tumor cells) Smudge cells Artefacts Ability for user to add user defined cell categories

9 Body Fluid Diff Screen Example Same user interface, for the verification of cells, as for peripheral blood

10 Image collection of whole cytospin area A digital scan of the entire sample area is available in 10x- and 50x- magnifications. Sample Area Ø = 6-7 mm

11 Digitizing area 10 x

12 Area Selection 50 x

13 The Mini Map Entire sample area digitized Navigate using the keyboard arrows or mouse or buttons Select magnification 10x or 50x

14 The Mini Map The selected image area (red box) is displayed in 10X magnification

15 Regions of Interest Interesting areas, so-called»regions of interest«(roi), can be tagged and stored for pathological review, educational purposes, comments added, stored and shared anywhere on the laboratory network

16 Advanced RBC Application

17 Advanced RBC application is available on all models of CellaVision The Advanced RBC Application is avialable for all CellaVision analyzers running version 5 or higher The Advanced RBC application is built into the software but a license key is necessary to unlock it.

18 The Advanced RBC analysis Precharacterization of 21 different morphologies Example cells included RBC monolayer is defined by using the 50x oil objective Separate RBC monofinder Same area as for Standard RBC but new segmentation. 35 images are captured for analysis of RBC cell morphology

19 Advanced RBC GUI

20 Highlight

21 Individual View

22 Example Cells

23 Individual View with highlight

24 Show Excluded

25 CellaVision Proficiency Software

26 CellaVision Proficiency Software Competency & Educational tool for: Peripheral Blood differentials Body Fluid differentials Compatible with CellaVision DM Software version 3.1 and higher 26 6/10/2016

27 Key Features Web-based program that can be accessed from any computer with internet access Upload your own cell images from your CellaVision instrument Supports any size organization Allows you to assess your group down to the individual cell level Automated result analysis and report generation ready for instant viewing and exporting 27 6/10/2016

28 Licenses Free Trial 10 participants Any organization Valid for 90 days Professional 10, 30, 70-participants Suitable for: Laboratories, Integrated health networks, Universities Enterprise Participants Suitable for: External quality assurance (EQA) and Proficiency testing organizations 28 6/10/2016

29 Transfer Tool Application to transfer interesting slides Transfer slides using the Remote Review Upload to the CellaVision Proficiency Software No patient information transfered 29 6/10/2016

30 Work Flow Examiner Easy work flow Create tests Select slides Select participants Review the result Participant Takes the test Compare result to Examiner or Majority of test group. 30 6/10/2016

31 Languages English German French Spanish Japanese Simplified Chinese 31 6/10/2016

32 Free Trial Try out the product, go to and get your free trial account! 32 6/10/2016

33 SmearChecker

34 SmearChecker Optimal monolayer area Optimal stain intensity Optimal smear color

35 SmearChecker No good monolayer Smear is too dark (low stain intensity) Color is OK

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