Detection of skin cancer
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1 Detection of skin cancer Jan Larsen Section for Cognitive Systems DTU Informatics isp.imm.dtu.dk 1 Digital economy Systems neuroscience Multimedia Mobile services Machine learning Signal processing Cognitive modeling Biomedical Monitor systems HCI Demining and tools for EOD extraction of meaningful and actionable information by ubiquitous learning from data 2 DTU Informatics, Technical University of Denmark 1
2 Biomedical Neuroimaging (PET,EEG,fMRI) EEG EEG sensor for early warning of low blood suguar Mobile services Improved SP in hearing aids Cognitive modeling Digital economy Monitor systems Systems neuroscience Multimedia Machine learning Signal processing Cognitive modeling hendrix.imm.dtu.dk HCI Biomedical isp.imm.dtu.dk Demining and tools for EOD extraction of meaningful and actionable information by ubiquitous learning from data 3 DTU Informatics, Technical University of Denmark Skin cancer More than 800 cases in Denmark yearly Benign nevi Atypical nevi Malignant melanoma Inexperienced doctors detect 31% Annual increase 5-10% Experienced doctors detect 63-75% 4 DTU Informatics, Technical University of Denmark 2
3 Skin cancer More than 800 cases in Denmark yearly Benign nevi Atypical nevi Malignant melanoma Inexperienced doctors detect 31% Annual increase 5-10% Experienced doctors detect 63-75% 5 DTU Informatics, Technical University of Denmark Objectives Develop a cost-effective and practical tool for diagnosis support Gain more insight into the understanding of factors in the development of skin cancer 6 DTU Informatics, Technical University of Denmark 3
4 Cross-disciplinary research Signal and Image processing Domain knowledge Machine learning Statistics 7 DTU Informatics, Technical University of Denmark Outline Machine learning framework for skin cancer detection Involves all issues of machine learning An image processing system for skin cancer detection Involves feature selection, projection and integration Involves linear and nonlinear classifiers Other approaches Summary 8 DTU Informatics, Technical University of Denmark 4
5 The potential of learning machines Most real world problems are too complex to be handled by classical physical models In most real world situations there is access to data describing properties of the problem Learning machines can offer Learning of optimal prediction/decision/action Adaptation to the usage environment New insights into the problem and suggestions for improvement 9 DTU Informatics, Technical University of Denmark A short history of learning machines classical ADALINE Neural nets Mixture of experts Kernel machines Gaussian processes modern 10 DTU Informatics, Technical University of Denmark 5
6 Issues in machine learning Data quantity stationarity quality structure Features representation selection extraction integration Models structure type learning selection and integration Evaluation performance robustness complexity interpretation and visualization HCI 11 DTU Informatics, Technical University of Denmark Issues in machine learning Data quantity stationarity quality structure Features Models unsupervised representation structure parametric: linear, nonlinear, mixture models non- Evaluation parametric: kernel, Gaussian performance processes, robustness clustering complexity noise models interpretation integration of and prior visualization and domain HCI knowledge semisupervised extraction selection supervised integration type learning selection and integration cost function maximum likelihood Bayesian online vs. off-line 12 DTU Informatics, Technical University of Denmark 6
7 Dermatoscopy imaging technique 13 DTU Informatics, Technical University of Denmark Domain knowledge dematoscopic features 14 DTU Informatics, Technical University of Denmark 7
8 Feature extraction 15 DTU Informatics, Technical University of Denmark Median filtering Removal of impulsive noise 16 DTU Informatics, Technical University of Denmark 8
9 Feature extraction 17 DTU Informatics, Technical University of Denmark Segmentation 18 DTU Informatics, Technical University of Denmark 9
10 Feature extraction 19 DTU Informatics, Technical University of Denmark Assymetry 20 DTU Informatics, Technical University of Denmark 10
11 Feature extraction 21 DTU Informatics, Technical University of Denmark Edge abruptness 22 DTU Informatics, Technical University of Denmark 11
12 Edge abruptness 23 DTU Informatics, Technical University of Denmark Feature extraction 24 DTU Informatics, Technical University of Denmark 12
13 Color prototypes 25 DTU Informatics, Technical University of Denmark Segmentation into color prototypes 26 DTU Informatics, Technical University of Denmark 13
14 Bayes classifier 27 DTU Informatics, Technical University of Denmark Bayes classifier 28 DTU Informatics, Technical University of Denmark 14
15 Neural network classifier 29 DTU Informatics, Technical University of Denmark Likelihood learning Training set: N samples of related x(k) and classes y(k) 30 DTU Informatics, Technical University of Denmark 15
16 Generalization How well are we doing on future data from the same problem? 31 DTU Informatics, Technical University of Denmark Bias Variance dilemma 32 DTU Informatics, Technical University of Denmark 16
17 33 DTU Informatics, Technical University of Denmark Confusion matrix 34 DTU Informatics, Technical University of Denmark 17
18 Other techniques Raman spectroscopy A NIR laser beam excites molecules in the skin The Raman scattering is a frequency shift in the reflected light which is related to the molecule structure 35 DTU Informatics, Technical University of Denmark Raman spectrum MM: malignant melanoma NV: pigmented navi BCC: basal cell carcinoma SK: seborrhoeic keratosis NOR: normal 36 DTU Informatics, Technical University of Denmark 18
19 Raman classification results Ref: Sigurdur Sigurdsson * s are predicted values using a NN 37 DTU Informatics, Technical University of Denmark Further reading Hintz-Madsen, M., A probabilistic framework for classification of dermatoscopic images, pp. 156, Informatics and Mathematical ti Modelling, Technical University of Denmark, DTU, 1998 Sigurdsson, S., A Probabilistic Framework for Detection of Skin Cancer by Raman Spectra, pp. 202, Informatics and Mathematical Modelling, Technical University of Denmark, DTU, 2003 Have, A. S., Datamining on distributed medical databases, Informatics and Mathematical ti Modelling, Technical University of Denmark, DTU, 2003 Papers accessible via 38 DTU Informatics, Technical University of Denmark 19
20 Related courses Introduction to Machine Learning and Data Modeling Digital Signal Processing Nonlinear Signal Processing Machine Learning for Signal Processing Digital image analysis, vision and computer graphics Medical Image Analysis Advanced topics in Biomedical Signal Processing 39 DTU Informatics, Technical University of Denmark Summary Machine learning is, and will become, an important component in most real world applications Designing a system involves cross-disciplinary competence domain knowledge, features, classifiers etc. Automatic detection of skin cancer for diagnosis support is possible 40 DTU Informatics, Technical University of Denmark 20
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