Advanced Packaging for Wearables (Vital Signs Monitoring) Vikram Venkatadri IMAPS New England 5/1/2018

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Advanced Packaging for Wearables (Vital Signs Monitoring) Vikram Venkatadri IMAPS New England 5/1/2018

Healthcare at ADI Improving Quality of Life Through Better Care Technology Diagnostics & therapy Imaging subsystems for ultrasound, digital X-ray, and CT detectors Miniaturized sensing for point of care diagnostics and minimally invasive procedures (catheters, surgical robots, and implantables) Diagnostic Imaging Subsystem Wellness & disease management Mobile solutions for digital health Long battery life Clinical grade performance Vital Signs Monitoring/Wellness Platform Prevention and Wellness Diagnosis Treatment and Therapy Disease Managemen t

Wearables for Remote Monitoring Outside the Hospital Chronic Disease Management Medication adherence and titration State of wellness or decline, trends Remote patient management and telemedicine Prevention Lifestyle Habits: Behavior Change Stress, Sleep, Nutrition, Activity Point of Care Diagnostics and Genomics Chronic Disease Management Big Themes in Healthcare Prevention (Behavior) Aging in Place Emergency Detection (ex: Falls) Lifestyle Analytics (activity, mental state, motor skills) Big Data and Analytics Doctor Shortage in Emerging Markets Aging Populations 3

Body Worn Sensing Head Wearables (headphones), gas sensing Core Body Breathing, core temp, stress markers, heart rate, EEG Wrist Heart rate, EEG, exercise monitoring Extremity Muscle firing, limb motion, stress markers Shoe Sensing Location based services, gait / movement analysis 4

How Electronics Can Make a Difference Small Clinical Accuracy Long Battery Life 5

A Typical System Level Solution Optical Sensor Motion Sensor Microprocessor Communications LAN/WAN/BAN Electrodes Etc.. Temp Sensor Memory User Interface Connectors Antennas ECG Passives Other Sensors Battery Energy Harvesting Power Management Co-Packaged! 6

Vital Signs Monitoring Flex Package Examples at ADI 7

Disposable Vital Signs Monitoring Patch Supports short/medium term wear on the skin Technology Dual sided, plated flex (60um pitch min.) ECG electrodes + AFE Skin temperature sensing Micro-processor RF communication w/patterned or discrete antenna Power management based on coin cell or flat battery Buttons for user interface Challenges Low cost flex technology Printed at equivalent geometries in 2 layers (vias) Solder mask or equivalent High temperature capable for assembly (solder or equivalent) Robust, bio-compatible materials and processes for adhesion to the skin

Rechargeable Vital Signs Monitoring Patch Supports longer term wear or integration in textiles Technology Dual sided, plated flex (60um pitch min.) ECG electrodes + AFE Micro-processor RF communication w/patterned or discrete antenna Power management w/inductive, wireless charging Buttons for user interface Challenges Low cost flex technology Printed at equivalent geometries in 2 layers (vias) Solder mask or equivalent High temperature capable for assembly (solder or equivalent) Robust materials and processes for textile integration

High Density Integration and Miniaturization Supports sensor integration in extreme, space-constrained applications (hearing aids, jewelry, pills, etc.) PPG / SP02 (optical) ECG w/filtering on IPD Activity (XL-based) Cap Touch w/electrodes 3D Gesture BTLE w/antenna and matching circuit on IPD Antenna Microprocessor Technology Dual sided plated flex (30um pitch min.) Silicon IPDs Flip chip, wirebond, passive reflow Flat or folded (4.0 x 5.0 x 2.5mm) Challenges Performance of sensors and electronics in tight spaces Battery technologies

Optical Sensing for SPO2 at the Finger Supports integration into patches and clips bending around the finger Technology Dual sided plated flex (40um pitch min.) Optical AFE + PDA + LED Accelerometer Micro-processor LEBT + matching circuit + patterned antenna NFC + coil Power management and two zinc air batteries Passive components Challenges Robust materials and processes for patch integration Battery technology LEBT Radio SPO2 Front End PMU

Flex Density vs. Cost The challenge Plated flex = capable of density, but costly Low cost printed flex and assembly = not mature Requirements 2 routing layers (vias) 30um line and space Solder mask (or equivalent) at 30um registration Support temperatures required at assembly High temperature solder, or Low cost, lower temperature epoxy 0.35 10 s of millimeters 5-10 interconnects 2.80 0.40 2.80 Micro (64p) 2.40 Power 2.80 10 s of centimeters 5-20 interconnects 0.40 2.60 AFE (36p) 2.60 RF (42p) Ground

Extending Battery Life Batteries don t follow Moore s Law Strategies for longer battery life Improve efficiency of electronics (100X in last few years) Clever algorithms Where and how often to measure Curate data quality Manage the power hogs Radio is 20mW vs. processor and sensor/afe at 1mW each Processing at the node is more efficient that transmitting to the Cloud Energy harvesting 13

Advanced Packaging for Wearables Fashionable Small Size Communication Low Power/ Re-chargeable Comfortable Affordable Purposeful Safe Robustness Ecosystem 14

Conclusions and Needs Ultra low power electronics and sensors Novel radio schemes Higher density and flexible batteries Low cost flexible substrates and interconnects Bio-compatible, robust and reliable integration into textiles 15

Contact Details Vikram Venkatadri Staff Package Development Engineer Analog Devices Inc. 804 Woburn Street Wilmington, MA 01887 Email: vikram.venkatadri@analog.com Ph: 339-645-3157 16