Agilent 7890 GC Instrument Control Software Version 2.5

R E L E A S E N O T E S Agilent 7890 GC Instrument Control Software Version 2.5 The Agilent 7890 GC Instrument Control Software version 2.5 enables dual-tower injection capability and provides support for the following GC detectors: Nitrogen-Phosphorous Detector (NPD) Enhanced Flame Photometric Detector (Dual FPD; includes support for FPD) Sulfur Chemiluminescence Detector (SCD, model 355) Nitrogen Chemiluminescence Detector (NCD, model 255) Important: Dual-tower injection capability requires upgrading Empower Software. Empower 2 software must be upgraded to Empower 2 Service Pack H Hotfix 1. Empower 3 software must be upgraded to Empower 3 Feature Release 1. These release notes explain how to install Agilent 7890 GC ICS v2.5 for Empower 2 software and Empower 3 software. This v2.5 release of the ICS supports Agilent 7890 GC firmware version A.01.10.3, A.01.11.1, A.01.12, A.01.12.1, and A.01.13. Note: Firmware version A.01.11 is not supported. Tested firmware and software The versions of 7890 GC firmware tested in this release are A.01.10.3, A.01.11.1, A.01.12, A.01.12.1, and A.01.13. This version of the ICS supports Empower 2 and Empower 3 software in English, Japanese, Chinese, and Korean. The following table lists the software configurations, feature releases, service packs, and operating systems that were tested with the 7890 GC ICS v2.5. In this table, Windows XP means Microsoft Windows XP Professional, 32-bit and Windows 7 means Microsoft Windows 7 Professional, 64-bit. Waters is a registered trademark and THE SCIENCE OF WHAT S POSSIBLE. is a trademark of Waters Corporation. All other trademarks are the sole property of their respective owners. Copyright 2012 Waters Corporation *716003636* *Rev.B* Page 1 of 10

Application Software Empower Personal Minimum Feature Release/ Service Pack Operating system Empower 2 FR3 Windows XP SP3 Empower 3 SR1 Empower Workgroup and Enterprise Empower 2 Client FR5 Windows XP SP3 Windows Vista SP2 Windows 2003 Server SP2 Empower 3 Client FR1 Windows Server 2008 R2 SP1 Enterprise (64-bit) Citrix Application Server Empower 2 Citrix Server Empower 3 Citrix Server Windows Server 2003, SP2 (32-bit) Windows 2000 Server, SP4 Windows Server 2008 R2 SP1 Enterprise (64-bit) MassLynx SCN 723 for Xevo QTof SCN 781 for Synapt G2 ETD SCN 802 for Xevo G2 QTof SCN 805 for Quattro Micro GC SCN 815 for Autospec SCN 816 for GCT Premier SCN 843 for Xevo TQ-S/XEVO TQ MS SCN 851 for Synapt G2-S APGC Windows XP SP3 Windows XP SP3 Windows XP SP3 Requirements: For Windows 2000, Windows XP, Windows Vista and Windows 7 systems, Microsoft.NET Framework 3.5 is required and will be installed automatically. For Windows 2000, Windows XP, Windows Vista and Windows 7 systems, Microsoft Visual C++ 2008 redistributable are required and will be installed automatically. If you have a previous version of the Agilent 7890 GC ICS installed, remove it using Add/Remove Programs and then reboot the computer. Page 2 of 10

Minimum requirements for Empower 2 and Empower 3 Software: - Empower 2 FR3 - Empower 3 SR1 The computer configurations, operating systems and hotfixes that the Waters Instrument Control Software (ICS) supports for the 7890 GC are the same as those tested with Empower 3 Software and Empower 2 Software, FR3 and FR5. For details on supported service packs and incremental operating system and hotfix support, see the Empower 2 and Empower 3 installation and configuration guides, software release notes as well as the Waters Web site (www.waters.com). Installing the Agilent 7890 GC ICS Recommendation: Back up all Empower projects, library information, and databases before installing this software. The Agilent 7890 GC ICS v2.5 consists of these components: Driver Needed for Empower software to communicate with the module. User interface Includes the instrument method editor and control panels in Empower Quick Start and Run Samples utility. Online Help for the 7890 GC Access Help when working with an Agilent instrument method by clicking the question mark button while using the instrument method editor. As the software included in this release is installed, only the files required by the software are installed. No Oracle or system files are affected. Requirement: Install Empower software or MassLynx software before installing the 7890 driver. To use the ICS software on an Empower Enterprise (client/server) system, you must install it on every computer, LAC/E 32 module, client, and Citrix application server that interacts with the 7890 GC, its methods, or results. For consistency, install the ICS on all clients, LAC/E 32 modules, and Citrix application servers. You need not install the ICS software on the database server unless the server hosts client software and interacts with the GC instrument, its methods, or results. General installation instructions using ICS media (not for a Citrix application server): 1. Power-off the 7890 GC, and reboot the computer. 2. Log in to the computer using an account with local administrator privilege. 3. If you have a previous version of the Agilent 7890 GC ICS installed, use the Windows Add/Remove Programs function to remove it, and then reboot the computer. 4. Log in to the computer using an account with local administrator privileges. 5. Insert the Agilent 7890 GC ICS media in the media drive. 6. Browse to the root of the media, and double-click the setup.exe file. 7. Follow all prompts to finish the installation. 8. Reboot the computer to correctly establish communication with the instruments. Requirement: Use Configuration Manager to verify Waters DHCP Server Service is running on the computer before you power-on the 7890 GC. 9. Power-on the 7890 GC. Page 3 of 10

General installation instructions using a downloaded executable file: 1. Power-off the 7890 GC, and reboot the computer. 2. Log in to the computer using an account with local administrator privileges. 3. If you have a previous version of the Agilent 7890 GC ICS installed, remove it using the Windows Add/Remove Programs function, and then reboot the computer. 4. Log in to the computer using an account with local administrator privileges. 5. Browse to the A7890v2.5.12.0210.exe file (downloaded from Waters.com) on your local hard drive, and then double-click it 6. Click Unzip to extract the installation files, browse to the extracted file location, and then double-click the setup.exe file. 7. Follow all prompts to finish the installation. 8. Reboot the computer to correctly establish communication with the instruments. Requirement: Use Configuration Manager to verify Waters DHCP Server Service is running on the computer before you power-on the Agilent GC. 9. Power-on the 7890 GC. To install the Agilent 7890 GC ICS on a Citrix server: 1. If you have a previous version of the Agilent 7890 GC ICS installed, remove it using the Windows Add/Remove Programs function. 2. Insert the Agilent 7890 GC ICS media in the media drive. 3. Open the Control Panel and double-click Add/Remove Programs. 4. Click Add New Programs. 5. In the Run Installation Program dialog box, click Browse. 6. Browse to root of the media. 7. Select the setup.exe file and then click Open. Tip: To view the file, you sometimes must select All Files from the Files of type list. 8. Follow all prompts to finish the installation. Validation Information After you install or uninstall the Agilent 7890 GC ICS on a qualified system, Waters recommends determining your requalification needs based on your laboratory s standard operating procedures. If this is an initial installation in a GxP-regulated environment, perform a full qualification of Empower Software. Waters recommends that you run the Verify Files utility or the ConnectionsAQT for Empower IQ and review the resulting file for an entry that states No installation changes were detected. Note: The date displayed when running Verify Files (IQ) always reflects the last installation. See the Empower.log file for the complete history. Page 4 of 10

Verifying the Installation To verify the installation, select Start > All Programs > Empower > Empower Installation Log. Search for lines similar to this: ***************************************************************** Installed Waters 7890 Software 2.5.12.0210 on 1-15-2012 14:00:28 ***************************************************************** The installation of any option or service pack is documented in the checksum.txt file on your Empower computer. This file indicates the installation of any option(s) or service pack(s) and verifies the integrity of disk files by comparing their current CRC and sizes with original values recorded during installation of the base software and any installed option or service pack. This file is created when you run the Verify Files utility by selecting Start > Programs > Empower > Verify Files. To display the checksum.txt file, navigate to the \Empower\Script directory, and then double-click the checksum.txt file. Uninstalling the ICS for the Agilent 7890 module To ensure successful file verification following the removal of the ICS, you must reboot the computer before you uninstall the ICS. To remove any version of the Agilent 7890 GC ICS from your system: 1. Reboot the computer. 2. Log in to the computer using an account with local administrator privilege. 3. Open the Control Panel and double-click Add/Remove Programs. 4. At the Add/Remove Programs dialog box, click the Change or Remove Programs icon. 5. Click the version of Agilent 7890 GC ICS that is on your system, and then click the Change/Remove button. 6. Follow the prompts to remove the control software from your system. The registry and new CRC checksums are updated for the Empower installation. No Oracle or system files are affected. Resolved issues Note: Waters uses Product Change System (PCS) numbers to track the status of issues. PCS Number Description 43981 Search capability of online Help is now supported in Asian languages. 44385 The 7890 GC would run full oven method during baseline monitoring instead of maintaining initial conditions, until the user stopped monitoring. This has been corrected. The GC will now maintain its initial settings during baseline monitor. Page 5 of 10

PCS Number Description 44584 Two possible file verification issues would occur if the 7890 GC ICS was installed on the same Empower node as Agilent LC ICS version 1.06: If the 7890 GC ICS was installed after Agilent LC ICS v1.06, then the 7890 binary files in Empower\instruments\bin were not correctly verified after running Empower Verify Files. If Agilent LC ICS v1.06 was installed after the 7890 GC ICS, then the file InstrIDL.dll showed up as changed in the Empower file verification results. These issues have been corrected. 45045 Concerning dual-tower capability: There was no option to select both front and back injectors at the same time in the 7890 GC instrument method. This has been corrected. 45311 An existing instrument method would become corrupted after adding 7890 GC instrument. 45354 Support for Nitrogen Phosphorus Detector (NPD) 45399 Previous versions of the 7890 GC ICS allowed selection of the Gas Sampling (GS) Valve only if the valve was installed in position 1. Because the GS valve can now be installed in position 2, version 2.5 of the 7890 GC ICS has been modified to accommodate this enhancement 45737 Agilent 7890 GC would not regain communication after an instrument failure. 45738 The Agilent 7693A Tray chiller status information was not visible in the 7890 GC Run Sample control panel. 46456 Support for Enhanced Flame Photometric Detector: (Dual FPD) 47736 The random loss of 7890 GC column parameters in MassLynx Software no longer occurs. 48059 The CTC PAL-MS-analog signal defect with 7890 GC ICS in MassLynx software has been corrected. 48274 When previous versions of the 7890 GC ICS were configured to use the Volatiles Interface, the Split Ratio was limited to the range of 0.1 to 100.0. With version 2.5 of the 7890 GC ICS, the range is now 0.1 to 7500.0. 48277 7890 GC ICS v2.5 dual tower Ch1 Ch3, index 0 2 resolution. In order to support dual-tower operation, the existing data channels now require a hierarchy. Data Channel 1 must be enabled before Data Channel 2 may be enabled and Data Channel 2 must be enabled before Data Channel 3 may be enabled. This is a requirement for all 7890 GC instrument methods, not just those used for dualtower operation. 48452 The default sampling offset on an Agilent 7890 GC ALS was downloaded from MassLynx software even when sampling offset was not enabled; this has been corrected. 48486 7890 GC Instrument Method was not updating Split Flow/Split Ratio changes when Column Flow was changed. 48599 The allowable pressure range for the Split/Splitless inlet is now 0 to 150 psi; inlet hardware capable of 150 psi is required in order to take advantage of pressure settings above 100 psi. Page 6 of 10

Known issues Note: Waters uses Product Change System (PCS) numbers to track the status of issues. PCS Number Description 44323 The signal zero event of the analog signal does not function as expected. 47710 If you use the Inject Ahead feature on a sample with a run time greater than 10 minutes, you may receive an error that results in instrument failure. The Inject Ahead feature is not compatible with dual-tower injection capability in Empower Software and has been discontinued. 47858 If you do not enter the serial number in the Empower node properties on the DHCP tab, the instrument will scan as No instead of Yes. To prevent this, during installation, you must complete all the fields in the table in order for Yes to display when you scan the instrument. 48391 If you create a back injector instrument method and set Empower to dual tower mode, then you must also enable the second channel in the instrument method. 48600 Even if the dual-tower check box is enabled, the dual-tower option might not appear in the tool bar as expected. Disabling and then re-enabling dual-tower mode (by deselecting and then re-selecting it using View > Toolbars > Dual Tower Mode) should cause the option to appear in the tool bar. 48682 The Help description of the tray chiller is inaccurate. The tray chiller interface does not control heating or cooling of the vial tray. The tray chiller interface only checks if the set temperature has been achieved or if the temperature is out of range. 48685 If you set up a run, then disconnect the Ethernet cable while the system is running, you will see error 39 (Client is not GC owner). If this happens, you must reboot the 7890 GC and the Empower node in order to reestablish the connection. 48724 An error message (1905) is displayed when you uninstall the 7890 GC ICS from a MassLynx workstation or Empower Server and it is the last (or only) ICS to be uninstalled from the target machine. This does not affect the functionality of MassLynx or Empower software. 48741 Following the upload of new parameters for temperature settings for the valve box are not displayed on the front panel of the GC. 48769 For data acquired prior to Empower 3, use the Comprehensive Status report group to report the post run information that was stored with the channel. For data acquired in Empower 3, use the Post Run report group to report the post run information that was stored with the injection. 48773 48774 If you try to report pre-empower 3 data using the Post Run report group, or you try to report Empower 3 or later data using the Comprehensive Status report group, you will receive an error message. Within the architecture of Empower Software, it is not technically possible to support both dual-tower GC injections and the "Inject Ahead" capability of the Agilent 7890 GC at this time. With the support of dual-tower injection capability in Empower 2 SP H Hotfix 1 and Empower 3 FR1, support for the "Inject Ahead" capability of the 7890 GC autosampler has been discontinued. 48802 When the 7890 GC ICS v2.5 is installed with MassLynx SCN851, the 7890 Additional Status is not updated in the MassLynx Inlet Editor. This appears to be an issue with the display in MassLynx SCN851. Page 7 of 10

Installation Files The following files are installed in the Empower\Instruments directory. DiscoverInstruments.dll Waters DHCP Server Configuration WDHCPServerSvc WDHCPServerSvcResCHI.dll WDHCPServerSvcResENU.dll WDHCPServerSvcResJPN.dll WDHCPServerSvcResKOR.dll The following files are installed in the Empower\Instruments\Bin directory. A7890Common.dll A7890EditMgr.ocx A7890Instr.dll A7890Xml.dll InstrIDL.dll WS7890.dll WS7890Comms.dll The following files are installed in the Empower\Instruments\Bin\En directory. A7890ResENU.dll The following files are installed in the Empower\Instruments\Bin\ja directory. A7890ResJPN.dll The following files are installed in the Empower\Instruments\Bin\ko directory. A7890ResKOR.dll The following files are installed in the Empower\Instruments\Bin\ zh-chs directory. A7890ResCHI.dll The following files are installed in the Empower\Instruments\ HTML\A7890 directory. A7890-Config-Current.xml A7890-Config-R100.xsd A7890-Config-r100.xsl A7890-Method-Default.xml A7890-Method-R100.xsd A7890-PrintMethod-r100.xsl A7890-PrintMethodNoALS-r100.xsl A7890-Report-Current.xml Page 8 of 10

A7890-Report-r100.xsl A7890-Report-r100.xsd A7890-ResourceCHI-r100.xml A7890-ResourceENU-r100.xml A7890-ResourceJPN-r100.xml A7890-ResourceKOR-r100.xml A7890-StatusDetail-Current.xml A7890-StatusDetail-R100.xsd A7890.js A7890Button.bmp A7890ControlPanel.htm DefaultPrint-r102.xsl FieldDefToHTML.xsl FieldDefToText.xsl FieldDefToTextNoTabs.xsl ICSResources-r100.xsd Locale.xsl overlib_mini.js Syringe.JPG The following file is installed in the Empower\Instruments\HTML\A7890\en directory, and is replicated for all localized languages (ja, ko, zh-chs). A7890.chm The following file is installed in the Empower\Instruments\HTML\A7890\LVI directory. Useful GC calculations.xlsx This file contains calculations for Large Volume Injections for the Multimode inlet. It is included for convenience. Test Configurations The following test configurations were used during the development and evaluation of A7890 ICS v2.5. Personal workstation test configuration Operating system and service pack: Microsoft Windows XP Professional SP3, 32 Bit Microsoft Windows Hotfixes: Q147222, Q282784, Q954430, Q973688, KB2378111_WM9, KB952069_WM9, KB954155_WM9, KB973540_WM9, KB975558_WM8, KB978695_WM9, KB2447568- IE8, KB2482017-IE8, KB2510531-IE8 KB2544521-IE8, KB2618444-IE8, KB982381-IE8, Q282784, KB2564958, KB93692, KB2079403, KB2115168 KB2121546, KB2229593, KB2259922, KB2296011, KB2345886, KB2347290, KB2360937, KB2387149, KB2393802, KB2412687, KB2419632, KB2423089, KB2440591, KB2443105, KB2443685, KB2467659 KB2476490, KB2476687, KB2478960, KB2478971, KB2479628, KB2479943, KB2481109, KB2482017, KB2483185, KB2485376, KB2485663, KB2506212, KB2507618, KB2507938, KB2508429, KB2509553, KB2535512, KB2536276-v2, KB2541763, KB2544893-v2, KB2566454, KB2567680, KB2570222, KB2570947, KB2584146, KB2592799, KB2598479, KB2603381, KB2618451, KB2619339, KB2620712, KB2624667, KB2631813, KB2633171, KB2633952, KB2639417, KB2641690, KB2646524, KB923561, KB946648, KB950762, KB950974, KB951376-v2, KB951748, KB951978, KB952004, KB952287, KB952954, KB954459, KB954550-v5, KB955759, KB956572, KB956744, KB956802, KB956803, KB956844, KB958644, KB958869, KB959426, KB960803, KB960859, KB961118, KB961501, KB967715, KB968389, KB969059, KB970430, KB971029, KB971657, KB971737, KB971961, KB972270, KB973507, KB973687, KB973815, KB973869, KB973904, KB974112, KB974318, KB974392, KB974571, KB975025, KB975467, KB975560, KB975562, KB975713, Page 9 of 10

KB977816, KB977914, KB978338, KB978542, KB978601, KB978706, KB979309 KB979482, KB979687, KB980195, KB980232, KB980436, KB981322, KB981349, KB981997, KB982132, KB982214, KB982665 Operating system and service pack: Windows 7 Professional SP1 64 Bit Microsoft Windows Hotfixes: KB2425227, KB2479943, KB2484033, KB2488113, KB2491683, KB2503665, KB2506014, KB2506212, KB2507618, KB2509553, KB2510531, KB2511250, KB2511455, KB2515325, KB2518869, KB2522422, KB2533552, KB2536275, KB2536276, KB2539635, KB2541014, KB2544521, KB2544893, KB2545698, KB2547666, KB2552343, KB2556532, KB2560656, KB2563227, KB2564958, KB2567680, KB2570947, KB2572077, KB2579686, KB2588516, KB2598845, KB2603229, KB2618444, KB2618451, KB2619339, KB2620704, KB2620712, KB2633952, KB2639417, KB2641690, KB976902 Database Server test configuration Operating system and service pack: Windows Server 2008 R2 Enterprise, SP1 Microsoft Windows Hotfixes: 982861, KB2425227, KB2484033, KB2488113, KB2492386, KB2503665, KB2505438, KB2506014, KB2506212, KB2506928, KB2507618, KB2509553, KB2510531, KB2511250, KB2511455, KB2515325, KB2518869, KB2522422, KB2529073, KB2530548, KB2533552, KB2536275, KB2536276, KB2539635, KB2541014, KB2544893, KB2545698, KB2547666, KB2552343, KB2556532, KB2560656, KB2563227, KB2564958, KB2567680, KB2570947, KB2572077, KB2584146, KB2585542, KB2588516, KB2603229, KB2607047, KB2618444, KB2618451, KB2620704, KB2620712, KB2631813, KB2633952, KB2639417, KB2641690, KB2644615, KB2656356, KB976902, KB976932, KB982018 Client test configurations Operating system and service pack: Windows 7 Professional SP1 64 Bit Microsoft Windows Hotfixes: 982861, KB971033, KB2425227, KB2479943, KB2484033, KB2488113, KB2491683, KB2492386, KB2503665, KB2505438, KB2506014, KB2506212, KB2506928, KB2507618, KB2509553, KB2510531, KB2511250, KB2511455, KB2515325, KB2518869, KB2522422, KB2532531, KB2533552, KB2536275, KB2536276, KB2539635, KB2541014, KB2544893, KB2545698, KB2547666, KB2552343, KB2556532, KB2560656, KB2563227, KB2564958, KB2567680, KB2570947, KB2572077, KB2579686, KB2584146, KB2585542, KB2588516, KB2603229, KB2618444, KB2618451, KB2619339, KB2620704, KB2620712, KB2631813, KB2633952, KB2639417, KB2641690, KB2644615, KB2656356, KB976902, KB976932 LAC/E32 Acquisition Server test configuration Operating system and service pack: Windows 7 Professional SP1 64 Bit Microsoft Windows Hotfixes: 982861, KB971033, KB2425227, KB2479943, KB2484033, KB2488113, KB2491683, KB2492386, KB2503665, KB2506014, KB2506212, KB2506928, KB2507618, KB2509553, KB2510531, KB2511250, KB2511455, KB2515325, KB2518869, KB2522422, KB2529073, KB2532531, KB2533552, KB2536275, KB2536276, KB2539635, KB2541014, KB2544893, KB2545698, KB2547666, KB2552343, KB2556532, KB2560656, KB2563227, KB2564958, KB2567680, KB2570947, KB2572077, KB2579686, KB2584146, KB2585542, KB2588516, KB2603229, KB2618444, KB2618451, KB2619339, KB2620704, KB2620712, KB2631813, KB2633952, KB2639417, KB2641690, KB2644615, KB2656356, KB976902, KB976932, KB982018 Page 10 of 10