HEALTH is the inestimable value to which Pharmaceutical Industry is committed.

OPHTHALMIC & NASAL

HEALTH is the inestimable value to which Pharmaceutical Industry is committed. BORMIOLI PHARMA contributes to this mission by following the same values that guide this industry: quality, precision, safety, innovation. Our packaging solutions are developed to guarantee absolute integrity of the contained drugs, to allow them expressing their full healing potential and ensure patients a secure treatment. Our products are innovatively designed to satisfy patients functional needs and improve the quality of their life. We are conscious and proud to carry HEALTH INSIDE.

SUMMARY INTRODUCTION 04 OPHTHALMIC 07 Dropper S1 10 Dropper S2 14 NASAL 23 Glass bottles 26 Plastic bottles 29 Dropper S3 16 Dispenser S4 18 Dispenser S5 20 The information contained in this catalogue may be subject to change. For confirmation concerning the relevant information, please contact the sales team. NASAL SPRAY 31 Plastic coated bottles 34 OPHTHALMIC & NASAL 3

COMMITTED TO OPHTHALMIC & NASAL Technologies Bormioli Pharma is an highly specialized glass and plastic primary packaging supplier to the world s leading Pharma companies. We apply the most rigorous quality and hygienic standards to offer the highest level of protection to the patient. Specialization in injection and injectionblow-moulding technologies for the production of high-end plastic packaging Controlled productive environment for the highest level of protection against contamination In-line controls through automated vision systems 4

OPHTHALMIC AND NASAL DRUGS SAFETY Quality Our manufacturing processes and quality standards are aligned with the pharmaceutical requirements and contribute to the integrity of the world`s leading drugs. Manufacturing practices - ISO7 clean rooms dedicated to the production of ophthalmic packaging and equipped with electric machines to ensure the highest hygienic standards - ISO 15378 and ISO 9001 production environment - Full product traceability and inspection - Continuous Quality improvement approach Quality management system - GMP training of personnel - ISO 9001 and ISO 15378 certifications Regulatory support - Compliance with European, United States and Japanese Pharmacopeia and international product guidelines - DMF available upon request for US and Canada - International product registrations Pharma grade for plastic materials Product Our products range is built around the patients and designed to deliver best-in-class packaging for ophthalmic and nasal applications. We provide an integrated packaging offer, including different types of bottles in glass and plastic, eye droppers and closures as well as tailor made solutions. Long-term experience in design and manufacturing of plastic packaging for nasal and ophthalmic applications Wide range of bottles and vials for nasal applications, designed to guarantee a perfect match with dispensing systems Consulting and support for sterilization processes OPHTHALMIC & NASAL 5

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When it comes to eye care, we offer you the safest possible packaging Our complete range of bottles, closures and nozzles are the result of our strong commitment in providing the highest level of quality and safety for ophthalmic applications. Manufactured in cleanrooms compliant to ISO Class 7, our packaging can be sterilized by irradiation or ethylene oxide. OPHTHALMIC Dispenser ophthalmic packaging Size: from 30ml to 150ml Dispensers complementary with screw caps and tamper evident closures 8

Standard ophthalmic packaging Size: from 5ml to 40ml Droppers complementary with screw caps. child resistant or tamper evident closures Different drops sizes available Special materials and additives to enhance barrier performances or squeezability Dispenser ophthalmic packaging Standard ophthalmic packaging OPHTHALMIC 9

BOTTLES Dropper S1 Reference Brimful Weight Height Diameter Material Screw Cap Tamper Evident Child Proof Droppers FI 9164 8,0 3,0 47,1 20,0 LDPE AF 1170 AF 4045 AF 4059* CS 4043 CS 4109 FI 9139 10,0 3,2 47,1 22,2 LDPE AF 1170 AF 4045 AF 4059* CS 4043 CS 4109 FI 9132 13,0 3,7 50,5 24,8 LDPE AF 1170 AF 4045 AF 4059* CS 4043 CS 4109 Combinations for every bottle See all Droppers at page 13 *This Tamper evident cap is not compatible with droppers 10 FI 9164 8 ml FI 9139 10 ml FI 9132 13 ml

Dropper S1 BOTTLES Reference Brimful Weight Height Diameter Material Screw Cap Tamper Evident Child Proof Droppers FI 9172 18,0 5,0 64,3 24,6 LDPE AF 1170 AF 4045 AF 4059* CS 4043 CS 4109 FI 9153 24,0 4,3 60,5 28,2 HDPE or LDPE AF 1170 AF 4045 AF 4059* CS 4043 CS 4109 FI 9204 35,0 5,8 74,0 31,0 LDPE AF 1170 AF 4045 AF 4059* CS 4043 CS 4109 Combinations for every bottle See all Droppers at page 13 *This Tamper evident cap is not compatible with droppers FI 9172 18 ml FI 9153 24 ml FI 9204 35 ml 11

BOTTLES Dropper S1 Reference Brimful Weight Height Diameter Material Screw Cap Tamper Evident Child Proof Droppers FI 9154 43,0 6,0 78,2 32,3 HDPE AF 1170 AF 4045 AF 4059* CS 4043 CS 4109 FI 9203 FI 9208 60,0 40,0 11,0 7,9 80,5 83,0 39,0 43X27,5 LDPE HDPE or LDPE AF 1170 AF 1170 AF 4045 AF 4059* AF 4045 AF 4059* CS 4043 CS 4109 CS 4043 CS 4109 Combinations for every bottle See all Droppers at page 13 *This Tamper evident cap is not compatible with droppers 12 FI 9154 43 ml FI 9203 60 ml FI 9208 40 ml

Dropper S1 CAPS & ACCESSORIES BOTTLES Reference Screw Cap Tamper Evident Child Proof Droppers AF 1170 Standard AF 970-AF 984-AF 1006-AF 1382-AF 1452-AF 1554 AF 4045 Standard AF 970-AF 984-AF 1006-AF 1382-AF 1452-AF 1554 AF 4059 Standard CS 4043 Standard AF 970-AF 984-AF 1006-AF 1382-AF 1574 CS 4109* Standard AF 970-AF 984-AF 1006-AF 1382-AF 1452 *Child proof cap with tamper evident ring AF 1170 AF 4045 AF 4059 CS 4043 CS 4109 AF 970 AF 984 AF 1006 AF 1382 AF 1452 AF 1554 AF 1574 13

BOTTLES Dropper S2 Reference Brimful Weight Height Diameter Material Screw Cap Child Proof Droppers FI 9100 18,5 3,0 55,5 25,5 HDPE AF 2096 AF 2142 CS 4042 FI 9144 24,0 4,5 67,0 25,0 HDPE AF 2096 AF 2142 CS 4042 FI 9115 33,0 4,6 69,5 29,5 HDPE AF 2096 AF 2142 CS 4042 Combinations for every bottle See all Droppers at page 15 14 FI 9100 18,5 ml FI 9144 24 ml FI 9115 33 ml

Dropper S2 CAPS & ACCESSORIES BOTTLES Reference Screw Cap Child Proof Droppers AF 2096 Standard AF 838 AF 2142 Standard AF 1008 CS 4042 Standard AF 838 AF 2096 AF 2142 CS 4042 AF 838 AF 1008 15

BOTTLES Dropper S3 Reference Brimful Weight Height Diameter Material Screw Cap Droppers FI 9180 7,6 2,5 44,7 20,0 LDPE AF 1447 Combinations for every bottle See all Droppers at page 17 16 FI 9180 7,6 ml

Dropper S3 CAPS & ACCESSORIES BOTTLES Reference Screw Cap Droppers AF 1447 Standard AF 1328 AF 1447 AF 1328 17

BOTTLES Dispenser S4 Reference Brimful Weight Height Diameter Material Screw Cap Dispensers FI 9106 38,0 6,8 77,5 29,3 PE AF 1013 Combinations for every bottle See all Dispensers at page 19 18 FI 9106 38 ml

Dispenser S4 CAPS & ACCESSORIES BOTTLES Reference Screw Cap Dispensers AF 1013 Standard AF 1014 AF 1013 AF 1014 19

BOTTLES Dispenser S5 Reference Brimful Weight Height Diameter Oval base Material Tamper Evident Dispensers FI 9181 37,0 7,0 71,7 31,8 LDPE AF 1241 FI 9151 45,0 7,0 81,8 44,5x22,2 HDPE AF 1241 FI 9161 72,0 12,0 99,0 51,3x26,3 HDPE AF 1241 FI 9155 140,0 17,6 121,0 64,3x32,4 HDPE AF 1241 Combinations for every bottle See all Dispensers at page 21 20 FI 9181 37 ml FI 9151 45 ml FI 9161 72 ml FI 9155 140 ml

Dispenser S5 CAPS & ACCESSORIES BOTTLES Reference Tamper Evident Dispensers AF 1241 Standard AF 1242-AF 1261 AF 1241 AF 1242 AF 1261 21

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The nasal drugs packaging shaped around your needs Our bottles are specifically designed to ensure a perfect integration with the most used dispensing systems and can be customized. We are strongly committed to make the delivery safer and easier for patients. Glass bottles Size: from 4ml to 100ml U-save vials shaped to guarantee the perfect restitution of the product Amber type I glass available for the highest level of protection NASAL 24

Plastic bottles Glass bottles Plastic bottles Size: from 4ml to 100ml Customized solution available Can be sterilized by irradiation NASAL 25

BOTTLES Shaped well 19 mm - 20 mm Reference Nominal Brimful Weight Neck Neck Height Diameter finish finish Glass type clear Glass type amber H 477/4 Bis 4,0 5,8 23,0 19 mm 44,6 24,0 H 621/7 4,0 7,0 30,0 19 mm 44,4 28,0 H 527/7 5,0 7,0 30,0 19 mm 45,5 28,0 H 518/5 Bis 5,0 7,5 20,5 20 mm 40,0 25,0 Availability subject to minimum order quantities, please contact our commercial team GLASS 26 H 477/4 Bis 4 ml H 621/7 4 ml H 527/7 5 ml H 518/5 Bis 5 ml

BOTTLES ISO 20 - FEA 20 Reference Nominal Brimful Weight Neck Height Diameter finish Glass type clear Glass type amber H 1/10 10,0 15,0 23,0 ISO 20 53,5 25,4 H 392/15 15,0 17,0 24,5 ISO 20 59,8 28,5 H 655/22 15,0 22,0 39,0 FEA 20 58,9 31,8 H 512/20 20,0 26,0 29,0 ISO 20 58,0 32,0 Availability subject to minimum order quantities, please contact our commercial team H 1/10 10 ml H 392/15 15 ml H 655/22 15 ml H 512/20 20 ml GLASS 27

BOTTLES ISO 20 Reference Nominal Brimful Weight Neck Height Diameter finish Glass type clear Glass type amber H 513/30 30,0 38,0 35,0 ISO 20 62,8 36,0 H 496/50 50,0 60,0 50,0 ISO 20 73,0 42,5 H 507/100 100,0 119,0 89,0 ISO 20 94,5 51,6 Availability subject to minimum order quantities, please contact our commercial team GLASS 28 H 513/30 30 ml H 496/50 50 ml H 507/100 100 ml

No gas BOTTLES SNAP ON SPECIAL - SNAP ON 20 Reference Nominal Brimful Weight Neck Height Diameter finish Material FI 9138 20,0 24,5 5,5 19,2 51,5 31,5 HDPE FI 9158 30,0 34,0 6,0 19,2 56,0 34,5 HDPE FI 9230 10,0 17,0 4,6 20,0 48,7 25,4 HDPE FI 9120 40,0 54,0 9,2 20,0 71,3 37,5 HDPE FI 9138 20 ml FI 9158 30 ml FI 9230 10 ml FI 9120 40 ml 29

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A unique supplier for your product We support our pharmaceutical customers offering a unique product platform to deliver aerosol and spray bottles. You can rely on a large spectrum of glass bottles as well as on plastic coating and printing options to differentiate your brand. NASAL SPRAY 32

Nasal Spray Nasal Spray Compliant with European Directive 75/324/EEC Large options of finishing available NASAL SPRAY 33

BOTTLES Plastic coated bottles PFP 18-20 mm Reference plastic Reference glass Nominal Brimful Neck finish Neck finish Height Diameter Material Glass type clear Glass type amber PQ 0092 PQ 0392 PQ 0512 PQ 0481 PQ 0302 H 92/35 H 392/15 H 512/20 H 481/25 H 302/30 30,0 15,0 20,0 20,0 25,0 35,5 17,7 26,0 25,5 30,0 PFP 18 74,4 35,8 20 mm 20 mm 20 mm 20 mm 59,8 58,0 59,0 67,0 28,5 33,8 34,1 35,7 COATED GLASS COATED GLASS COATED GLASS COATED GLASS COATED GLASS Availability subject to minimum order quantities, please contact our commercial team COATED BOTTLES 34 PQ 0092 30 ml PQ 0392 15 ml PQ 0512 20 ml PQ 0481 20 ml PQ 0302 25 ml

Plastic coated bottles BOTTLES 20 mm Reference plastic Reference glass Nominal Brimful Neck finish Height Diameter Material Glass type clear Glass type amber PQ 0513 PQ 1544 PQ 0488 PQ 0304 H 513/30 H 1544/40 H 488/60 H 304/75 30,0 35,0 50,0 60,0 38,0 40,0 64,0 72,5 20 mm 20 mm 20 mm 20 mm 63,8 74,2 89,0 103,4 37,8 38,1 43,6 43,2 COATED GLASS COATED GLASS COATED GLASS COATED GLASS Availability subject to minimum order quantities, please contact our commercial team PQ 0513 30 ml PQ 1544 35 ml PQ 0488 50 ml PQ 0304 60 ml COATED BOTTLES 35

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