NovAseptic Valve, DIAPHRAGM, EPDM

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Specification Sheet NovAseptic Valve, DIAPHRAGM, EPDM Catalogue Number: NA#/22 Product Description Ø A The NovAseptic Valve is specifically designed for aseptic applications and complies with the most stringent cleanability and sterilization requirements. The focus on aseptic design is a significant feature for all valves. The NovAseptic Valve is designed for minimum dead leg, complete drainability and high chemical resistance. B Ø C Catalogue Number Structure NA# / 22 Diaphragm Model 22 = EPDM Diaphragm Nominal Dimensions in mm (in.) Catalogue Number Ø A B Ø C NA12/22 NA18/22 NA25/22 NA38/22 NA51/22 NA76/22 34.0 (1.339) 46.5 (1.831) 62.0 (2.441) 75.0 (2.953) 97.0 (3.819) 121.4 (4.779) 16.0 (0.630) 23.0 (0.906) 29.3 (1.154) 42.4 (1.669) 52.4 (2.063) 78.2 (3.079) * Note: Non-standard thread, special to fit NovAseptic Actuators 18.0 (0.709) 25.0 (0.984) 34.0 (1.339) 48.3 (1.902) 64.0 (2.520) 88.0 (3.465) Compatible Valve NA# NA12 NA18 NA25 NA38 NA51 NA76 Compatible Valve NU# NU050 NU075 NU100 NU150 NU200 NU300

Specifications Net Weight (approximate) Diaphragm NA12 NA18 NA25 NA38 NA51 NA76 Weight kg (lb) 0.01 (0.022) 0.02 (0.044) 0.05 (0.11) 0.10 (0.220) 0.16 (0.353) 0.44 (0.970) Design Temperature Short Term Use* Max (Dry Heat) 140 C (284 F) except for NA76, 128 C (262 F) Max (Steam) 140 C (284 F) except for NA76, 128 C (262 F) Min -30 C (-22 F) * Note: <1h continuously. Additional Information Material Surface Roughness Design Pressure Labeling Packaging Quality Control Technical Rating EPDM, ethylene propylene diene monomer rubber. The Diaphragm is manufactured from 100% EPDM Smooth (hydrophobic) -1 to 6 bar(g) (-14.5 to 87.0 psi(g)) Each Diaphragm is labeled for full LOT traceability according to our QA routines The Diaphragm is packaged in a closed box Our Quality Assurance System guarantees the control and traceability of the product All Diaphragms are manufactured with materials in compliance with FDA regulations 177.2600 and supplied with statement. The Diaphragm meets USP Biological Tests for Plastics, Class VI www.merckmillipore.com To place an order or receive technical assistance In Europe, please call Customer Service: France: 0825.045.645 Spain: 901.516.645 Option 1 Germany: 069.86798021 Italy: 848.845.645 United Kingdom: 0870.900.46.45 For other countries across Europe, please call: +44 (0) 115 943 0840 Or visit www.merckmillipore.com/offices For Technical Service visit: www.merckmillipore.com/techservice Merck Millipore and the M mark are registered trademarks of Merck KGaA, Darmstadt, Germany. NovAseptic is a registered trademark of Millipore AB. Specifications subject to change without notice. Lit. No. SP1122EN00 Version 2.0 08/2015 PS-15-11275 2015 EMD Millipore Corporation, Billerica, MA, USA. All rights reserved.

Specification Sheet NovAseptic Valve, Diaphragm, Fluoroelastomer Catalogue Number: Product Description NA#/24 The NovAseptic Valve is specifically designed for aseptic applications and complies with the most stringent cleanability and sterilization requirements. The focus on aseptic design is a significant feature for all valves. The NovAseptic Valve is designed for minimum dead leg, complete drain ability, and high chemical resistance. ØA B Catalogue No. Structure ØA NA# Diaphragm Model / 24 24 = Fluoroelastomer Diaphragm Nominal Dimensions in mm (in.) A B ØC Compatible Valve NA# Compatible Valve NU# NA12/24 34.0 (1.339) 16.0 (0.63) 18.0 (0.709) NA12 NU050 NA18/24 46.5 (1.831) 23.0 (0.906) 25.0 (0.984) NA18 NU075 NA25/24 62.0 (2.441) 29.3 (1.154) 34.0 (1.339) NA25 NU100 NA38/24 75.0 (2.953) 42.4 (1.669) 48.3 (1.902) NA38 NU150 NA51/24 97.0 (3.819) 52.4 (2.063) 64.0 (2.520) NA51 NU200 *Note: Non-standard thread, special to fit NovAseptic Actuators

Specifications Net Weight (approximate) Diaphragm NA12 NA18 NA25 NA38 NA51 Weight kg (lb) 0.01 (0.022) 0.02 (0.044) 0.05 (0.11) 0.10 (0.220) 0.16 (0.353) Design Temperature Max (Dry Heat) Max (Steam) Min Short Term Use* 200 C (392 F) 150 C (302 F) (-)20 C ((-)4 F) Additional Information Material Surface Roughness Design Pressure Labeling Packaging Quality Control In Compliance with The Diaphragm is manufactured from 100% Fluorocarbon rubber. Smooth (hydrophobic) (-) 1 to 6 bar (g) (- 14.5 to 87.0 psi (g)) Each Diaphragm is labeled for full LOT traceability according to QA routines. The Diaphragm is packaged in a closed box. Our Quality Assurance System guarantees the control and traceability of the product. All Diaphragms are manufactured with materials in compliance with FDA regulations 177.2600 and supplied with statement. The Diaphragm meets USP Biological Tests for Plastics, Class VI *Note: The applied valve body and actuator may have different design temperature and/or pressure limits. The weakest component in the assembled product determines the maximum design temperature and pressure limits. www.merckmillipore.com Merck Millipore and the M mark are trademarks of Merck KGaA, Darmstadt, Germany. NovAseptic is a registered trademark of Merck KGaA, Darmstadt, Germany. Specifications subject to change without notice. Lit. No. SP1021EN00 Rev. C 03/2012 DP SBU-11-05530 Printed in the USA. 2012 Merck Millipore Corporation, Billerica, MA 01821 USA. All rights reserved. To Place an Order or Receive Technical Assistance In Europe, please call Customer Service: France: 0825 045 645 Germany: 01805 045 645 Italy: 848 845 645 Spain: 901 516 645 Option 1 Switzerland: 0848 645 645 United Kingdom: 0870 900 4645 For other countries across Europe, please call: +44 (0) 115 943 0840 Or visit www.merckmillipore.com/offices For Technical Service visit: www.merckmillipore.com/techservice

Specification Sheet NovAseptic Valve, DIAPHRAGM, PTFE Product Description The NovAseptic Valve is specifically designed for aseptic applications and complies with the most stringent cleanability and sterilization requirements. The focus on aseptic design is a significant feature for all valves. The NovAseptic Valve is designed for minimum dead leg, complete drainability and high chemical resistance. Catalogue Numbers: NA#/25 D A C Catalogue Number Structure NA# / 25 Diaphragm Model 25 = PTFE Diaphragm * Note: Non-standard thread, special to fit NovAseptic Actuators Nominal Dimensions in mm (in.) Catalogue Number A B C Compatible Valve NA# Compatible Valve NU# NA12/25 NA18/25 NA25/25 NA38/25 NA51/25 NA76/25 35.2 (1.386) 47.6 (1.874) 63.3 (2.492) 76.5 (3.012) 98.0 (3.858) 123.0 (4.843) 18.3 (0.720) 24.6 (0.969) 31.2 (1.228) 45.6 (1.795) 59.3 (2.335) 83.0 (3.268) 15.0 (0.591) 21.0 (0.827) 27.0 (1.063) 41.0 (1.614) 54.0 (2.126) 84.0 (3.307) NA12 NA18 NA25 NA38 NA51 NA76 NU050 NU075 NU100 NU150 NU200 NU300

Specifications Net Weight (approximate) Diaphragm NA12 NA18 NA25 NA38 NA51 NA76 Weight kg (lb) 0.01 (0.022) 0.02 (0.044) 0.04 (0.088) 0.09 (0.20) 0.18 (0.397) 0.44 (0.970) Design Temperature Short Term Use* Continous Use Max (Dry Heat) 250 C (482 F) 170 C (338 F) Max (Steam) 250 C (482 F) 170 C (338 F) Min -40 C (-40 F) -40 C (-40 F) * Note: <1h continuously. PTFE Diaphragm Parts (included) Diaphragm - Catalogue No. NA12/25 NA18/25 NA25/25 NA38/25 NA51/25 NA76/25 Support Ring - Catalogue No. N17-12R N17-18R N17-25R N17-38R N17-51R N17-76R PTFE Diaphragm Accessory (not included) Diaphragm - Catalogue No. Spring Closed Valve Seal - Catalogue No.** Specification Sheet - Lit. No. NA12/25 NA12/84 SP1009EN00 NA18/25 NA18/84 SP1009EN00 NA25/25 NA25/84 SP1009EN00 NA38/25 NA38/84 SP1009EN00 NA51/25 NA51/84 SP1009EN00 NA76/25 NA76/84 SP1009EN00 ** Note: Use Spring Closed Valve Seal when using PTFE Diaphragm with NovAsepitc Valves.

Additional Information Material Surface Roughness Labeling Packaging Quality Control In Compliance with Specifications PTFE, polytetrafluoroethylene. The Diaphragm is manufactured from 100% solid PTFE bar Smooth (hydrophobic) Each box is labeled for full traceability according to Millipore QA routines The Diaphragm is packaged in a closed box Millipore Quality Assurance System guarantees the control and traceability of the product All Diaphragms are manufactured with materials in compliance with FDA regulations 177.1550 and supplied with statement. The Diaphragm meets USP Biological Tests for Plastics, Class VI *Note: The applied valve body and actuator may have different design temperature and/or pressure limits. The weakest component in the assembled product determines the maximum design temperature and pressure limits. www.millipore.com/offices Millipore and NovAseptic are registered trademarks of Millipore Corporation. Advancing Life Science Together and M logo are trademarks of Millipore Corporation. Specifications subject to change without notice. Lit. No. SP1123EN00 Rev. A 10/2007. 2007 Millipore Corporation. All rights reserved. ADVANCING LIFE SCIENCE TOGETHER Research. Development. Production.

Specification Sheet NovAseptic Valve, DIAPHRAGM, Silicone Platinum cured Product Description The NovAseptic Valve is specifically designed for aseptic applications and complies with the most stringent cleanability and sterilization requirements. The focus on aseptic design is a significant feature for all valves. The NovAseptic Valve is designed for minimum dead leg, complete drainability and high chemical resistance. Catalogue Numbers: NA#/26 Ø A B Ø C Catalogue Number Structure NA# / 26 Diaphragm Model 26 = Silicone Platinum Cured Diaphragm * Note: Non-standard thread, special to fit NovAseptic Actuators Nominal Dimensions in mm (in.) Catalogue Number Ø A B Ø C Compatible Valve NA# Compatible Valve NU# NA12/26 NA18/26 NA25/26 NA38/26 NA51/26 34.0 (1.339) 46.5 (1.831) 62.0 (2.441) 75.0 (2.953) 97.0 (3.819) 16.0 (0.630) 22.5 (0.886) 27.8 (1.094) 40.9 (1.610) 51.4 (2.024) 18.0 (0.709) 25.0 (0.984) 33.8 (1.331) 48.0 (1.890) 64.0 (2.520) NA12 NA18 NA25 NA38 NA51 NU050 NU075 NU100 NU150 NU200

Specifications Net Weight (approximate) Diaphragm NA12 NA18 NA25 NA38 NA51 Weight kg (lb) 0.01 (0.022) 0.02 (0.044) 0.05 (0.11) 0.09 (0.20) 0.15 (0.331) Design Temperature Max (Dry Heat) Oxygen Rich Environment Max (Dry Heat) Oxygen Poor Environment Max (Steam) Min * Note: <1h continuously. Short Term Use* 220 C (428 F) 150 C (302 F) 130 C (266 F) -50 C (-58 F) Additional Information Material ELASTOSIL R 4001/70MH Silicone Rubber. The Diaphragm is manufactured from 100% medical grade silicone rubber, platinum cured Surface Roughness Design Pressure Labeling Packaging Quality Control In Compliance with Chemically, for your specific needs, see appropriate guidelines and actual media characteristics Smooth (hydrophobic) -1 to 6 bar(g) (-14.5 to 87.0 psi(g)) Each Diaphragm is labeled for full traceability according to Millipore QA routines The Diaphragm is packaged in a closed box Millipore Quality Assurance System guarantees the control and traceability of the product All Diaphragms are manufactured with materials in compliance with FDA regulations 177.2600 and supplied with statement. The Diaphragm meets USP Biological Tests for Plastics, Class VI *Note: The applied valve body and actuator may have different design temperature and/or pressure limits. The weakest component in the assembled product determines the maximum design temperature and pressure limits. www.millipore.com/offices Millipore and NovAseptic are registered trademarks of Millipore Corporation. Advancing Life Science Together and M logo are trademarks of Millipore Corporation. ELASTOSIL is a registered trademark of Wacker-Chemie GMBH Company Specifications subject to change without notice. Lit. No. SP1198EN00 Rev. A 10/2008. 2008 Millipore Corporation. All rights reserved. ADVANCING LIFE SCIENCE TOGETHER Research. Development. Production.