Targetcontrolled infusion TCI) Table 1. Mobile PkPd. PC PDA Palm Palmacokinetics. docomo Doja3.0 MIDP2.0

Transcription

1 Targetcontrolled infusion TCI) 3 PC PDA Palm Palmacokinetics NTT docomo (Mobile PkPd: (2007 ) docomo au softbank WILLCOM 4 JAVA JAVA JA 1 2 () 3 Runge-Kutta Table 1. Mobile PkPd docomo Doja3.0 (Doja ) 3 MIDP2.0 (MIDP 3 MIDP ) Doja i ppli Development Kit for Doja-3.0 (NTT docomo: MIDP JAVA wireless toolkit 2.2 Sun Microsystems: /ja download-2 2.html Table. 1 Doja3.0 MIDP2.0

2 106 3 Fig Runge-Kutta 2 3 6Doja MIDP 7 docomo SA701i n903i SH903i SO505i Softbank V501SH 904SH 911T 812SH au W51S WILLCOM W ZERO3 Doja i pplidevelopment 1 Kit for Doja-3.0 TivaTrainer ( MIDP SA701i V501SH 24 docomo Softbank

3 Fentanyl 100 mcg bolus (155 cm, 50 kg, 40 y, Male) Cmax 1 min 5 min 15 min Tivatrainer (30 sec step) Mobile PkPd (1 sec step) Remifentanil 1mcg/kg/min infusion (155 cm, 50 kg, 40 y, Male) 10 min 20 min 30 min Tivatrainer (30 sec step) Mobile PkPd (1 sec step) Table 2. Mobile PkPd Tiva Trainer au WILLCOM docomo 240 Softbank au docomo WILLCOM W-ZERO Doja TIVA trainer (Table. 2) 24 Doja 86 MIDP 82 JAVA Micro edition Micro edition Connectedlimited device configuration (CLDC) Connecteddevice configuration (CDC) CLDC UI Doja MIDP CLDC Doja docomo MIDP Sun microsystems 4 MIDP 3 MIDP (Nokia S40 S60 ) Doja MIDP 8 JAVA Cross platform

4 108 Palmacokinetics Palm JAVA KVirtual Machine KVM SA701i 4 5 Doja KVM 2 3 MIDP MIDP Doja 1 Runge-Kutta Runge-Kutta MIDP Doja 4 Doja3.0 CLDC1.0 CLDC JAVA ABSTRACT Development and evaluation of off-line pharmacokinetics simulator on cellular phones Ryuji Nakamura 1 Ikuhiro Hidaka 1

5 Michiyoshi Sanuki 1 Hiroshi Hamada 1 Masakazu Nakao 2 Masashi Kawamoto 1 Background Diprifusor, a Propofol infusion system, is the only commercial available pharmacokinetics simulation system in Japan. Non-commercially based simulation systems are used to simulate the effects of other agents, and are available for both personal computers and personal digital assistants (PDA). However, those devices are inferior to cellular phones in regard to portability and availability. We developed a simulation system previously to function on a cellular phone manufactured by NTT docomo (Mobile PkPd <http: //home.hiroshima-u.ac.jp/rnacamura/>) and reported at the 54th Annual Meeting of the Japan Society of Anesthesiologists. In this study, we have improved the Mobile PkPd application and altered it to function on cellular phones manufactured by other Japanese providers. We reported the results of operation testing and precision of calculation. Methods We altered the application so that it would function on cellular phones produced by 4 different domestic providers; NTT docomo, au, Softbank, and WILLCOM. The language used for development was JAVA; Doja3.0 profile was used for docomo phones and MIDP2.0 profile for those of the other 3 providers. The specifications were set so that the program could be used offline. For calculations, we used the Runge-Kutta method with 1-60 seconds interval. The program was designed to display both predicted plasma and effect-site concentrations. We aimed for electricity consumption to remain at the same level when waiting for a receipt. Operation checks were performed using the respective terminals of each cellular phone provider. We compared the results obtained with a Doja emulator with those from a TivaTrainer ( for evaluation of calculation precision. The powersaving function was estimated using SA701i and V501SH. In addition, we calculated the ratio of common coding in each of the software applications. Results The program functioned using the terminal of each provider and all were able to perform the calculation once at every second. Furthermore, the calculation precision was similar between the Doja emulator and TivaTrainer. As for evaluation of the power-saving function, electric charging was unnecessary with both terminals for more than 24 hours. The ratio of common coding in the applications was 86%. Conclusion Using JAVA computing language, we successfully developed a pharmacokinetics simulator for cellular phones. We confirmed that the program was usable in various clinical settings. Key words Cellular phone, pharmacokinetics simulator 1 Department of Anesthesiology and Critical Care Division of Clinical Medical Science Graduate School of Biomedical Sciences Hiroshima University 2 Division of Anesthesia and Pain Control Hiroshima General Hospital