QuiC 2.1 (Senna) User Manual
|
|
- Bruce Dean
- 5 years ago
- Views:
Transcription
1 QuiC 2.1 (Senna) User Manual
2 1 Contents 2 General Information Computer System Requirements Scope of QuiC Software QuiC Licensing QuiC Release Features QuiC 2 (Senna) Supported Data Acquisition Methods Getting Started Getting QuiC QuiC Activation Calibration Kit Settings QC Global Event Tags QuiC Usage Monitor Perspective QC Perspective History Mass Spectrometer irt Peptides General Discovery DDA Advanced Plots References Page 2 of 20
3 2 General Information 2.1 Computer System Requirements Minimal Operating System: CPU: Hard drive: Memory: Software: Windows 7, x64 Intel Core CPU, 2.7 GHz (quad-core) or similar 200 GB free space 8 GB.NET or higher Recommended Operating System: CPU: Hard drive: Memory: Software: Windows 7 or higher, x64 Intel Core i7 4770, 3.4 GHz (octa-core) or similar 500 GB free space, solid state drive (SSD) 16 GB or more.net or higher Page 3 of 20
4 2.2 Scope of QuiC Software QuiC is a software tool for quality control (QC) analysis and visualization of mass spectrometry-based proteomics data. QuiC is especially useful for unifying performance tracking of multiple instruments in a proteomics lab. It supports the analysis of DDA, DIA, MRM and PRM runs from different vendors (to date, ThermoFisher and Sciex). QuiC can help you spot a decline in instrument performance as illustrated in two realworld cases studies depicted in Figures 1 and 2. In the first case, we noted a decrease in mass accuracy over time which was remedied by a recalibration. In the other case, our decrease in identifications was linked to a decrease in peak capacity, ultimately caused by a pump leak. QuiC plots facilitated an early detection of the problems and an accurate insight into their causes. Figure 1. QuiC can detect a drift in your instrument s MS1 and MS2 mass accuracy. Page 4 of 20
5 Figure 2. On the left, a drop in peptide identifications over time, followed by a restoration to normal that correlates with the peak capacity performance on the right. The drop in peak capacity was attributed to a failing pump. The blue dot indicates the point at which we replaced the pump, returning peak capacity to normal levels QuiC Licensing QuiC is free of charge. A free annual license can be requested at info@biognosys.com. QuiC requires the irt Kit or the HRM Calibration Kit to be spiked into each sample. 2.3 QuiC Release Features QuiC 2 (Senna) QC run analysis pipelines Support for MRM, PRM, DIA and DDA Support for Thermo Fisher and Sciex Automated folder monitoring Various LC and MS proteomics QC readouts based on the irt peptides Support for additional background peptides Event tag handling New plotting framework Peak capacity and MS1/MS2 median intensity plots Export QC report to PDF feature Custom plot sorting 2.4 Supported Data Acquisition Methods QuiC analyzes a large variety of different QC data formats from DDA, DIA, MRM and PRM. Minimal requirements are a reversed phase chromatography with a linear or nonlinear gradient. All samples need to contain the irt calibration mix to perform quality control analysis with QuiC. In case you experience technical problems with the software or if you have feature suggestions please contact support@biognosys.com. Page 5 of 20
6 3 Getting Started 3.1 Getting QuiC Free licenses for QuiC software are available for all users. The software package can be downloaded at After successful registration you will receive a download link together with a license key to activate your software. 3.2 QuiC Activation When you start QuiC for the first time, you will be asked to activate your software. You should have received a license key with the download link for QuiC. If you do not have a license key yet, you can obtain one by registering yourself at If your computer has access to the internet, activation will be automatic once you have pasted your license key into the QuiC activation dialogue. In case your QuiC computer does not have an internet connection or the connection is blocked by a firewall, you can also activate your software using . The respective instructions will appear after a few seconds if online activation was not successful. Save the registration information file on your computer and send this file to support@biognosys.com. You will receive a license file usually within one working day. To activate QuiC using a license file, click on the Browse License File button in the QuiC Activation dialogue. 3.3 Calibration Kit To enable fully automated and sensitive QC with QuiC, we developed the calibration kit (irt kit) that is spiked into each sample before the measurement. The calibration kit contains a mix of non-naturally occurring synthetic peptides. For DDA and DIA a prespecified discovery library is additionally targeted for QC analysis. The default background library bundled with QuiC contains Human (HeLa) peptides. 3.4 Settings It is recommended to pre-configure QuiC after the first start to enable optimal performance. Note: if you ve migrated from version 1.0 to 2.1, you will also need to readjust your settings. Page 6 of 20
7 3.4.1 QC Figure 3. Analysis schemas can be created to be used and re-used in your analysis pipelines. In the QC page of the Settings perspective, you can define analysis schemas that contain the parameters that will be passed to the QC analysis pipeline. These settings can be saved to be re-used across multiple analyses. You can create as many schemas as you want as well as import/export them. There are two categories pertaining to your schema: Analysis and Batch Processing. Analysis settings affect the results of an analysis of a single run, while batch processing settings control things like what files in a folder should be considered for analysis. The criteria currently available for your schemas are as follows Batch Processing Age Filter (Days) Only raw files that have been acquired within the specified number of days will be considered. If all are to be considered, this field should be set to -1. Include Subfolder The batch analysis will recursively walk the entire subdirectory hierarchy of the selected folder and add any runs in the hierarchy. Monitor Folder This places a monitor on the folder. Whenever a new run is added to a monitored folder, it will automatically be added to the task queue for processing. Page 7 of 20
8 Future Runs Only If Monitor Folder is selected, you have the option to analyse all runs retrospectively or analyse future runs only. With this option selected, only runs that have been acquired after the monitor was set up will be analysed. Regex File Filter This allows you to specify a regular expression pattern to consider only files whose names match the pattern to be analyzed. More information regarding regular expressions and their syntax can be found here. Vendor Filter Only runs associated with a particular vendor will be considered Analysis Background Path For DDA and DIA analyses, the runs are targeted using a predefined spectral library. This is used to generate richer statistics in the Mass Spectrometer and Discovery sections of the QC perspective. By default, this library is a standard HeLa library that is bundled with the software. Currently, we only accept libraries that are in the Biognosys.kit format. Contact us at support@biognosys.com if you would like more information about generating your own kits Global Figure 4. The Global page of the Settings perspective allows you to specify options that will apply universally to all QC analyses. Things like analysis task auto-deletion, notification options and storage paths can be set here. Page 8 of 20
9 The Global page of the Settings perspective allows you to specify options that will apply universally to all QC analyses. Things like analysis task auto-deletion, notification options and storage paths can be set here General All miscellaneous settings can be found in General. They are summarized as follows. Check for Updates on Startup Tick this box if you d like QuiC to automatically check our server for newer versions of QuiC. CPU Affinity Here you can control what cores will be used in your analyses. If you are running multiple compute-intensive applications, for example, you may want to reduce the amount of cores used by QuiC. File Name Parsing Schema The file name parsing schema specifies a pattern that will be matched against your raw file names. We use this behaviour to extract information, called tags, from the file name (e.g. event tags such as recalibration, new column, S-lens cleaned, etc.). In this case, it is up to the users of QuiC to establish a rigorous file naming convention that allows to parse out this information. See the Tag Management section for more information about tags. Clicking on the File Name Parsing Schema field will bring up the Parsing Rule Editor which provides the capability to edit the parsing rule and test it on a sample file name. Figure 5 depicts the Parsing Rule Editor. The top bar is the parsing rule itself. Grey items are called tokens. Tokens delimit a region of text that you want to parse out as single or multiple tags. You can use any of the provided tokens or define some yourself. The white sections are constant text values that you expect to find in the raw file name. These can be typed explicitly in the parsing rule text field. In the figure, you can see that the file name must start with the string Inst- followed by an instrument name, followed by _Date-, followed by a date string, etc. Below the parsing rule text field, you find the token area. Here you can double click a token and it will be inserted into the position in the parsing rule field where the cursor is currently positioned. Below the token area, you can define your own custom tokens by providing a token name in the Parsing Token text field and, optionally, a delimiter in the Token Separator field. The delimiter splits up a string into multiple elements as in the case of the [EVENTS][-] token which will split the string up based on the - character. In our example, if a file name contains the string Recal-Equil-Slens between the _Evts- and _Meth- strings, the event tags assigned to that run will be Recal, Equil and Slens. In the Parsing Preview field, you can paste a test raw file name to check that all of the tags are correctly extracted. Below that, you will see what tags are assigned to what categories based on your pattern. We encourage our users to pick a naming convention that is consistent so that the parsing schema always extracts the right tags. Page 9 of 20
10 Figure 5. The Parsing Rule Editor allows you to design your own custom file name parsing rule that will extract tag metadata from the raw file names. Instrument Acquisition Buffer [mins] If you are monitoring a folder into which the mass spectrometer is actively writing files, you may need to tune this parameter. Some instruments will leave a certain amount of time between the writing of the spectral data into the file and the addition of the final footer data at the end of acquisition. This duration is difficult to detect and so we leave it as a parameter for the user to control. NOTE: At the time of writing this manual, QuiC has only been thoroughly tested on a live Thermo setup. It has not been tested in a setting where a monitor is set on a folder having files that are partially written by a Sciex instrument. QC Plot History Length To minimize clutter, you can set the maximum number of runs that will be displayed in the plots, regardless of which runs are selected. The most recent runs (according to the user defined order) will be used. QC Run Storage Path You can select where you d like permanent QC history data to be stored. This can be useful if you d like to store your history on a network so that multiple PCs can view it. Skip Duplicate Runs QuiC allows you to analyse the same run multiple times. However, if you have set up a monitor for a particular folder which contains some runs you ve already analysed, you can skip these runs in the analysis with this option. Also, if your plot contains duplicated runs, use this option to only display the most recently analysed duplicate. Temporary Directory QuiC s internal pipelines write large intermediate files to disk. If disk space is limited, you can set the path to which temporary files are written to a separate drive or partition. Page 10 of 20
11 Messaging You can opt for desktop notifications of important events in the analysis pipeline. Here you can specify whether you want notifications when an error occurs during a task, when a task was successfully completed, or when a task completed successfully but warnings were triggered Task Queue Task Queue options pertain to how individual run processing tasks are automatically handled in the Monitoring perspective. The parameters to be set are described as follows. Automatic Task Removal If you expect the task queue to grow substantially over time, you can opt to have tasks removed automatically. Note that removing a task does not remove your QC run data that is displayed in the QC perspective. Task removal will simply keep your analysis queue cleaner and easier to navigate. It also will keep memory usage to a minimum. Periodic task removal will remove all completed tasks at user-defined time increments. Cleanup can occur every N days, hours, or minutes where N is specified in the Value field. You can specify whether you would like successfully completed tasks, skipped tasks or erroneous tasks to be removed. Tasks can also be removed immediately, meaning as soon as completed. Again, successful, skipped and/or erroneous tasks can be selected from removal. Setting Automatic Task Removal to Never will prevent any tasks from being removed. Select Running Task The currently running task in the queue will be selected automatically, guaranteeing that you will always see the most recent runs in the queue Event Tags Tag Management Before describing the Event Tags page, it makes sense to give an overview of tags in QuiC. Tags were introduced in QuiC 2.1 to serve as metadata that the user can encode via the file name. A tag can belong to any category, including user defined categories. Currently, all tags are simply stored into the processed QC run files and are not used for any purpose, with two major exceptions: event tags and condition tags. Event tags can be used to describe what interventions occurred before or during that run. For example, we can encode calibration and cleaning as event tags. Once your runs are processed and visible in the plots, you will be able to see your event tags as visual indicators. Figure 10 shows some tags visualized in a QC plot. Condition tags can be used to distinguish runs belonging to separate conditions (e.g. healthy and sick ). This is useful if you want to order your runs in a plot based on condition rather than time. QuiC maintains a database of all tags, including event tags. QuiC also maintains a repository of all instruments for which runs have been analysed. Each instrument is associated with zero or more tags. We limit each instrument to have no more than 10 tags. This design was chosen to avoid clutter in the plots. When a run is analysed, QuiC will automatically try to assign its event tags to the appropriate instrument for that run, unless the 10 tag cutoff is reached. Page 11 of 20
12 Figure 6. The Event Tags settings page allows you to edit and add new event tags Event Tags Settings Page Event tags are special tags that can be used to indicate interventions in the plots. Event tags that were automatically extracted from analysed runs using your parsing rule will show up here. You can select event tags you want to customize by browsing the list on the left. File tag string The text displayed here in the selection list on the left is the literal text that was matched as a substring in the file name. You cannot change this value. Instruments Event tags are only displayed in a plot if runs in the plot come from an instrument to which those tags are associated. The instruments field allows you to associate your tag to any number of instruments, unless the instrument is full. To assign an instrument to a tag, click in the instruments field and start typing the name of the instrument. An autocomplete field should be displayed, allowing you to select any instrument detected by QuiC. To remove instruments, click the x in their text area. Plot Annotation This is the actual text that will be displayed in a plot. This can be used in case you use code names or abbreviations for tags in your file name. Description This not only serves as a useful description for the user, but will also appear in the tag s hover dialog in the plots. Page 12 of 20
13 4 QuiC Usage QuiC can perform QC analyses in near real time by monitoring the folder in which mass spectrometric data is stored. Alternatively, files can actively be added to perform QC analysis. 4.1 Monitor Perspective The Monitor perspective in QuiC allows you to manage the QC analysis of different files from DDA, DIA, MRM and PRM from ThermoFisher and Sciex. Figure 7. The monitor perspective allows you to set up a task queue of QC runs. As runs are processed, extracted metadata and visualizations will be made available on-the-fly in QC perspective. You can add individual files or entire folders to the queue. Page 13 of 20
14 Figure 8. One powerful feature of QuiC is the ability to monitor folders. Files that are newly added to a monitored folder will automatically be added to the task queue. 4.2 QC Perspective QuiC stores all of the necessary information of the QC analysis and provides the review of the summarized extracted values. This data review step is done in the QC Perspective in the form of run-based visualizations. We start with a description of the History panel which allows you to select one or multiple runs to be visualized. Then, we describe each plot category. Tables 1 through 5 describe the scope of each of the plots. Specifically, whether the plot is identification-based (computed based on peptide precursor identifications) and, if so, whether peptides from the background library and/or irt kit are included in the numbers. The tables also indicate what methods are supported for each plot History Under History, all of the mass spectrometers from which the data was acquired serve as root elements of the run history hierarchy. Each instrument node can be expanded to reveal the different workflows used. The data is further subdivided into acquisition month, analysis time and, finally, individual run. By modifying your selection in the History tree, the displayed data in the plotting panel on the right changes dynamically. You can select multiple nodes in the tree by control-clicking or shift-clicking. Right-clicking on nodes and selections of nodes brings up a context menu of several options. You can assign custom event tags, comments, create sub-folders, or delete nodes. Page 14 of 20
15 Figure 9 depicts the Tag Editor. This form allows you to assign tags beyond the ones that were extracted from the file name. Double clicking tags on the right will annotate all selected runs with those tags. If you don t see your tag on the right, you may need to associate it with the correct instrument. Double clicking tags on the left will delete all custom occurrences of this tag from the runs. This will only remove the tag from the run if it was added via the Assign Event Tags option. Tags extracted from the run file name will still be associated with that run. Figure 9. The tag editor lets you assign custom event tags to your selected runs. QuiC also provides histograms for individually selected runs or ribbon plots to compare distributions across multiply selected runs. Depending on which method is selected in History, the following plots can be viewed. Figure 10. You can select one or multiple runs in the History tree. Runs are organized by instrument, method, acquisition date, and analysis date. Selecting multiple runs allows you to compare the runs within a single QC plot. For example, here we see the MS2 mass accuracy represented as a single box plot per run. Page 15 of 20
16 4.2.2 Mass Spectrometer Instrument QC is displayed in this category for all peptides in the background library. MS1 (MS2) Mass Accuracy Uncalibrated mass errors that were averaged in the Mass Calibration plot below. QuiC Mass Calibration Absolute MS1 and MS2 mass accuracy (systematic shift) in ppm before QuiC s calibration as compared to the precision (noise) after calibration. The average is computed across identified peptides in the background library. Note that the calibration is used in Biognosys other products and has shown to provide a substantial boost to our identification power. Plot MS1 Mass Accuracy MS2 Mass Accuracy QuiC Mass Calibration Identificationbased Background Peptides irt Peptides DDA DIA SRM/MRM PRM yes yes yes yes yes no no yes yes yes yes yes no no yes yes yes yes yes no no Table 1. Mass Spectrometer irt Peptides Plots in this category only display QC data extracted from the identified irt kit peptides. The plot types are summarized as follows. Delta irt Delta irt as given by the difference between the peptide s theoretical irt and its empirical irt, computed from the linear irt/rt regression function. Delta RT Delta RT as given by difference between the peptide s theoretical RT, computed from the linear irt/rt regression function, and its empirical RT. FWHM The full width at half maximum (FWHM) precursor peak width. Fragment ion intensities are summed up across fragments at every RT increment to create a single peak. FWHM is computed on this peak by taking half of the apex intensity and calculating the difference between two RTs associated with this intensity. irt Empirical irts computed from the irt/rt regression. MS1 Area The sum of all isotopic peak areas. MS2 Area Page 16 of 20
17 The sum of all fragment ion peak areas. RT Measured apex retention times. Plot Identificationbased Background Peptides irt Peptides DDA DIA SRM/MRM PRM Delta irt yes no yes yes yes yes yes Delta RT yes no yes yes yes yes yes FWHM yes no yes yes yes yes yes irt yes no yes yes yes yes yes MS1 Area yes no yes yes yes no no MS1 Mass Accuracy yes no yes yes yes no no MS2 Area yes no yes no yes yes yes MS2 Mass Accuracy yes no yes yes yes no yes RT yes no yes yes yes yes yes Table 2. irt peptides General General QC information. Gradient Length LC gradient lengths estimated from the data. MS1 (MS2) Scan Intensity [Box] Each run is represented as a distribution of total scan intensity values computer per scan. MS1 (MS2) Scan Intensity [Median] The median values depicted in the scan intensity box plot. Peak Capacity LC peak capacity computed by the following formula: g/( FWHM n i i) Where g is the gradient length, n is the number of identified peptide precursors, and FWHM i is the peak width at half-maximum of the i-th precursor. TIC Total Ion Chromatogram (TIC), which provides insight into instrument stability and amount of sample injected. Page 17 of 20
18 Plot Background Peptides irt Peptides DDA DIA SRM/MRM PRM Gradient Length no no no yes yes yes yes MS1 Scan Intensity [Box] MS1 Scan Intensity [Median] MS2 Scan Intensity [Box] MS2 Scan Intensity [Median] no no no yes yes no no no no no yes yes no no no no no yes yes no yes no no no yes yes no yes Peak Capacity yes yes no yes yes yes yes TIC no no no yes yes no no Table 3. General Discovery These plots provide QC for discovery-based acquisitions. Identifications The number of identified background precursors and protein groups per run. NOTE: Because our analysis pipelines evolve over time, we allow the user the ability to normalize identifications across QuiC version updates. This is to attempt to mitigate visible increases or decreases in identifications in the plot due simply just a change in our algorithms. If the user thinks his IDs changed due to a QuiC software update, he can right-click anywhere in the Identifications plot and select Normalize Across QuiC Versions. The formula for the normalized ID is given as follows ID normalized = ID median ID unnormalized ID version_median Where ID unnormalized is the original identifications value, ID version_median is the median ID value among all other ID values computed from the same version of QuiC as ID unnormalized, and ID median is the median ID overall. Note these values are only computed on the selected runs and not the entire set of runs. We suggest to use this option only when you have a sufficient number of IDs per version. Plot Identificationbased Identificationbased Background Peptides irt Peptides DDA DIA SRM/MRM PRM Identifications yes yes no yes yes no no Table 4. Discovery Page 18 of 20
19 4.2.6 DDA Advanced These plots pertain only to DDA data and were first presented in (Ma et al., 2012). Max Scan Frequency The fastest frequency [scans per minute] for MS1 (MS2) collection in any minute. MS1 Density The RT at which each quartile of the MS1 scan peaks have occurred. MS1 Events per RT-duration The RT interval for each quartile of all MS1 events divided by RT-Duration. MS2 Density The RT at which each quartile of the MS2 scan peaks have occurred. MS1 Events per RT-duration The RT interval for each quartile of all MS2 events divided by RT-duration. PSM Charge Profile A breakdown of all of the peptide spectrum matches (PSMs) with a clear feature having charges 1, 2, 3, 4, 5, >5. Also considered are peaks originating from the precursor window that lack known charge but appear to have charge 1 or charge >1. Scans The number of MS1 (MS2) scans that were collected. TIC Change Ratio The TIC Change Ratio is computed as follows: For each consecutive scan pair, the TIC fold change is computed. These fold changes are then sorted in increasing order. The TIC Change Ratio for quartile N is given as the ratio of the N-th quartile fold change to the (N-1)-th quartile fold change. TIC per RT-duration The RT interval for which each quartile of the TIC accumulates divided by RT-duration. TIC Ratio The TIC ratio for the N-th quartile is given as the log ratio of the area under N-th intensitysorted quartile to that of the (N-1)-th quartile. Page 19 of 20
20 4.2.7 Plots QuiC provides custom options for the plots via a right-click context menu. This menu provides options to copy, print, save as, sort by various criteria, normalize, and change various visualization characteristics. Plot Max Scan Frequency MS1 Density MS1 Events per RTduration MS2 Density MS Events per RTduration PSM Charge Profile Identificationbased Background Peptides irt Peptides DDA DIA SRM/MRM PRM no no No yes no no no no no no yes no no no no no no yes no no no no no no yes no no no no no no yes no no no yes yes yes yes no no no Scans no no no yes no no no TIC Change Ratio TIC per RTduration no no no yes no no no no no no yes no no no TIC Ratio no no no yes no no no Table 5. DDA Advanced. 5 References Escher, C., Reiter, L., MacLean, B., Ossola, R., Herzog, F., Chilton, J.,... & Rinner, O. (2012). Using irt, a normalized retention time for more targeted measurement of peptides. Proteomics, 12(8), Ma, Z. Q., Polzin, K. O., Dasari, S., Chambers, M. C., Schilling, B., Gibson, B. W.,... & Tabb, D. L. (2012). QuaMeter: multivendor performance metrics for LC MS/MS proteomics instrumentation. Analytical chemistry, 84(14), Page 20 of 20
QuiC 1.0 (Owens) User Manual
QuiC 1.0 (Owens) User Manual 1 Contents 2 General Information... 2 2.1 Computer System Requirements... 2 2.2 Scope of QuiCSoftware... 3 2.3 QuiC... 3 2.4 QuiC Release Features... 3 2.4.1 QuiC 1.0... 3
More informationTutorial 2: Analysis of DIA/SWATH data in Skyline
Tutorial 2: Analysis of DIA/SWATH data in Skyline In this tutorial we will learn how to use Skyline to perform targeted post-acquisition analysis for peptide and inferred protein detection and quantification.
More informationRetention time prediction with irt for scheduled MRM and SWATH MS
Retention time prediction with irt for scheduled MRM and SWATH MS EuPa course, 28.11.2013 Oliver Rinner, PhD CEO Biognosys Summary Why to schedule MRM acquisition? How to schedule? Prediction of retention
More informationSpectroDive 8 - Coelacanth. User Manual
SpectroDive 8 - Coelacanth User Manual Table of Contents 1 System Requirements... 4 2 General Information... 4 2.1 Supported Instruments... 4 3 Getting Started... 5 3.1 Getting SpectroDive... 5 3.2 SpectroDive
More informationTutorial 7: Automated Peak Picking in Skyline
Tutorial 7: Automated Peak Picking in Skyline Skyline now supports the ability to create custom advanced peak picking and scoring models for both selected reaction monitoring (SRM) and data-independent
More informationSkyline irt Retention Time Prediction
Skyline irt Retention Time Prediction Predicting peptide retention time has long been of interest in targeted proteomics. As early as version 0.2, Skyline integrated the SSRCalc hydrophobicity calculator
More informationSpectronaut Pulsar X
Spectronaut Pulsar X User Manual 1 General Information... 8 1.1 Scope of Spectronaut Pulsar X Software... 8 1.2 Spectronaut Pulsar X Release Features... 8 1.3 Computer System Requirements... 9 1.4 Post
More informationStatistical Process Control in Proteomics SProCoP
Statistical Process Control in Proteomics SProCoP This tutorial will guide you through the installation of SProCoP and using it to perform statistical analysis on a sample Skyline file. Getting Started
More informationSkyline Targeted MS/MS
Skyline Targeted MS/MS Skyline now supports several methods of extracting chromatography-based quantitative measurements from the raw data files of full-scan mass spectrometers, such as ion trap and Q-TOF
More informationProtein Deconvolution Quick Start Guide
Protein Deconvolution Quick Start Guide The electrospray ionization (ESI) of intact peptides and proteins produces mass spectra containing a series of multiply charged ions with associated mass-to-charge
More informationhttps://www.labkey.org/wiki/home/documentation/page.view?name=panoramaqc
Panorama AutoQC The Panorama AutoQC pipeline enables mass spec laboratories to evaluate LC MS/MS performance over time, and quickly identify potential issues. This pipeline comprises three components:
More informationChromQuest 5.0 Quick Reference Guide
ChromQuest 5.0 Quick Reference Guide This guide contains an overview of the ChromQuest chromatography data system, with topics organized by workflow. For more information, refer to the ChromQuest User
More informationTraceFinder Analysis Quick Reference Guide
TraceFinder Analysis Quick Reference Guide This quick reference guide describes the Analysis mode tasks assigned to the Technician role in the Thermo TraceFinder 3.0 analytical software. For detailed descriptions
More informationSkyline MS1 Full Scan Filtering
Skyline MS1 Full Scan Filtering The Skyline Targeted Proteomics Environment provides informative visual displays of the raw mass spectrometer data you import into your Skyline project. These displays allow
More informationProgenesis QI for proteomics User Guide. Analysis workflow guidelines for DDA data
Progenesis QI for proteomics User Guide Analysis workflow guidelines for DDA data Contents Introduction... 3 How to use this document... 3 How can I analyse my own runs using Progenesis QI for proteomics?...
More informationAgilent MassHunter Qualitative Data Analysis
Agilent MassHunter Qualitative Data Analysis Qualitative Navigator B.08.00 Presenters: Kevin Costalunga Stephen Harnos With Matt Leyden & Kevin Costalunga 1 MassHunter Webinar Series MassHunter Qualitative
More informationThermo Xcalibur Getting Started (Quantitative Analysis)
Thermo Xcalibur Getting Started (Quantitative Analysis) XCALI-97207 Revision B September 2010 2010 Thermo Fisher Scientific Inc. All rights reserved. Xcalibur, Surveyor, and Accela are registered trademarks
More informationMSFragger Manual. (build )
MSFragger Manual (build 20170103.0) Introduction MSFragger is an ultrafast database search tool for peptide identifications in mass spectrometry-based proteomics. It differs from conventional search engines
More informationMRMPROBS tutorial. Hiroshi Tsugawa RIKEN Center for Sustainable Resource Science
MRMPROBS tutorial Edited in 2014/10/6 Introduction MRMPROBS is a tool for the analysis of data from multiple reaction monitoring (MRM)- or selected reaction monitoring (SRM)-based metabolomics studies.
More informationGPS Explorer Software For Protein Identification Using the Applied Biosystems 4700 Proteomics Analyzer
GPS Explorer Software For Protein Identification Using the Applied Biosystems 4700 Proteomics Analyzer Getting Started Guide GPS Explorer Software For Protein Identification Using the Applied Biosystems
More informationPanorama Sharing Skyline Documents
Panorama Sharing Skyline Documents Panorama is a freely available, open-source web server database application for targeted proteomics assays that integrates into a Skyline proteomics workflow. It has
More informationMS data processing. Filtering and correcting data. W4M Core Team. 22/09/2015 v 1.0.0
MS data processing Filtering and correcting data W4M Core Team 22/09/2015 v 1.0.0 Presentation map 1) Processing the data W4M table format for Galaxy 2) Filters for mass spectrometry extracted data a)
More informationTraceFinder Analysis Quick Reference Guide
TraceFinder Analysis Quick Reference Guide This quick reference guide describes the Analysis mode tasks assigned to the Technician role in Thermo TraceFinder analytical software. For detailed descriptions
More informationMassHunter File Reader
MassHunter File Reader vers 1.0.0 2015 Quadtech Associates, Inc. All Rights Reserved Release date: November 18, 2015 www.quadtechassociates.com MassHunter File Reader Welcome to MassHunter File Reader.
More informationInstallation Instructions
Analyst QS Service Pack 5 (SP5) Release Notes Final Version Analyst QS Service Pack 5 includes all previous improvements released in Analyst QS SP1 through Analyst QS SP4. It addresses a number of issues
More informationSkyline Collision Energy Optimization
Skyline Collision Energy Optimization As of version 0.6, Skyline now supports a rich user interface and fully automated pipeline for predicting and optimizing SRM instrument parameters like collision energy
More informationAgilent 6400 Series Triple Quadrupole LC/MS System
Agilent 6400 Series Triple Quadrupole LC/MS System Quick Start Guide Where to find information 4 Getting Started 6 Step 1. Start the Data Acquisition software 7 Step 2. Prepare the LC modules 13 Step 3.
More informationSkyline High Resolution Metabolomics (Draft)
Skyline High Resolution Metabolomics (Draft) The Skyline Targeted Proteomics Environment provides informative visual displays of the raw mass spectrometer data you import into your Skyline documents. Originally
More informationQuick Start Guide: Welcome to OceanView
Quick Start Guide: Welcome to OceanView Contents: Ctrl + Click a Topic Below for More Information Introduction to OceanView... 3 Welcome Screen... 3 Data Window... 3 Schematic View... 3 Persistence...
More informationAgilent Triple Quadrupole LC/MS Peptide Quantitation with Skyline
Agilent Triple Quadrupole LC/MS Peptide Quantitation with Skyline Workflow Guide A Peptide Optimization B Review Results in Skyline Create QQQ method in Skyline Edit Skyline settings Import peptides into
More informationTraceFinder Shortcut Menus Quick Reference Guide
TraceFinder Shortcut Menus Quick Reference Guide This quick reference guide describes the right-click shortcut menus available in the Thermo TraceFinder application. Contents Acquisition Mode Analysis
More informationLTQ Velos SP3 Release Notes
LTQ Velos 2.6.0 SP3 Release Notes These release notes briefly list changes in the LTQ Velos 2.6.0 SP3 experiment setup, tuning, and calibration application; fixes to previously reported issues; and known
More informationQ Exactive HF-X Software Manual
Q Exactive HF-X Software Manual Exactive Series 2.9 BRE0012262 Revision A May 2017 Q Exactive HF-X Software Manual Exactive Series 2.9 BRE0012262 Revision A May 2017 Legal Notices 2017 Thermo Fisher Scientific
More informationData processing. Filters and normalisation. Mélanie Pétéra W4M Core Team 31/05/2017 v 1.0.0
Data processing Filters and normalisation Mélanie Pétéra W4M Core Team 31/05/2017 v 1.0.0 Presentation map 1) Processing the data W4M table format for Galaxy 2) A generic tool to filter in Galaxy a) Generic
More informationWhat s New in Empower 3
What s New in Empower 3 Revision A Copyright Waters Corporation 2010 All rights reserved Copyright notice 2010 WATERS CORPORATION. PRINTED IN THE UNITED STATES OF AMERICA AND IN IRELAND. ALL RIGHTS RESERVED.
More informationTutorial for the PNNL Biodiversity Library Skyline Plugin
Tutorial for the PNNL Biodiversity Library Skyline Plugin Developed By: Michael Degan, Grant Fujimoto, Lillian Ryadinskiy, Samuel H Payne Contact Information: Samuel Payne (Samuel.Payne@pnnl.gov) Michael
More informationReal-time Data Compression for Mass Spectrometry Jose de Corral 2015 GPU Technology Conference
Real-time Data Compression for Mass Spectrometry Jose de Corral 2015 GPU Technology Conference 2015 Waters Corporation 1 Introduction to LC/IMS/MS LC/IMS/MS is the combination of three analytical techniques
More informationPRM Method Development and Data Analysis with Skyline. With
Tutorial Webinar #17 PRM Method Development and Data Analysis with Skyline With Brendan MacLean (Principal Developer, Skyline) Eduard Sabidó, Ph.D. (Head of the UPF/CRG Proteomics Unit) Cristina Chiva,
More informationProgenesis CoMet User Guide
Progenesis CoMet User Guide Analysis workflow guidelines for version 2.0 Contents Introduction... 3 How to use this document... 3 How can I analyse my own runs using CoMet?... 3 LC-MS Data used in this
More informationAgilent RapidFire 300 High-throughput Mass Spectrometry System
Agilent RapidFire 300 High-throughput Mass Spectrometry System Data Analysis Guide Installation 2 To install Agilent RapidFire Integrator software 2 Preparing Data Collected in Plates Mode for RapidFire
More informationAgilent G2721AA Spectrum Mill MS Proteomics Workbench Quick Start Guide
Agilent G2721AA Spectrum Mill MS Proteomics Workbench Quick Start Guide A guide to the Spectrum Mill workbench Use this reference for your first steps with the Spectrum Mill workbench. What is the Spectrum
More informationPROTEOMIC COMMAND LINE SOLUTION. Linux User Guide December, B i. Bioinformatics Solutions Inc.
>_ PROTEOMIC COMMAND LINE SOLUTION Linux User Guide December, 2015 B i Bioinformatics Solutions Inc. www.bioinfor.com 1. Introduction Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based proteomics
More informationProMISE 2 user manual
ProMISE 2 user manual Probabilistic model for immiscible separations and extractions (ProMISE) developed by Joost de Folter, is freely available for non-commercial purposes. The model can be downloaded
More informationAgilent MassHunter Workstation Software 7200 Accurate-Mass Quadrupole Time of Flight GC/MS
Agilent MassHunter Workstation Software 7200 Accurate-Mass Quadrupole Time of Flight GC/MS Familiarization Guide Before you begin 3 Prepare your system 3 Prepare the samples required for data acquisition
More information[ WHITE PAPER ] System Policies and Privileges for Processing Data in Empower Software with Data Integrity in Mind INTRODUCTION
System Policies and Privileges for Processing Data in Empower Software with Data Integrity in Mind Explore how Empower Chromatography Data Software System Policies and privileges can be used to control
More informationLarge and Sparse Mass Spectrometry Data Processing in the GPU Jose de Corral 2012 GPU Technology Conference
Large and Sparse Mass Spectrometry Data Processing in the GPU Jose de Corral 2012 GPU Technology Conference 2012 Waters Corporation 1 Agenda Overview of LC/IMS/MS 3D Data Processing 4D Data Processing
More informationUPDATING PESTICIDE RETENTION TIME LIBRARIES FOR THE AGILENT INTUVO 9000 GC
UPDATING PESTICIDE RETENTION TIME LIBRARIES FOR THE AGILENT INTUVO 9000 GC How to Update Retention Time Libraries on Intuvo Introduction When applying methods to a new gas chromatographic (GC) system,
More informationStore and Report Waters Empower Data with OpenLAB ECM and OpenLAB ECM Intelligent Reporter
Store and Report Waters Empower Data with OpenLAB ECM and OpenLAB ECM Intelligent Reporter Matthias Rupp Solution Architect Laboratory Informatics 1 OpenLAB ECM - Content Management Capabilities Centrally
More informationSkyline Targeted Method Editing
Skyline Targeted Method Editing This tutorial will cover many of the features available in the Skyline Targeted Proteomics Environment for creating new instrument methods for Selected Reaction Monitoring
More informationChromatography Software Training Materials. Contents
Chromatography Software Training Materials This document contains information on how to build a method, start the instrument to acquire data, and then process the data using the Galaxie Program. You will
More informationProgenesis LC-MS Tutorial Including Data File Import, Alignment, Filtering, Progenesis Stats and Protein ID
Progenesis LC-MS Tutorial Including Data File Import, Alignment, Filtering, Progenesis Stats and Protein ID 1 Introduction This tutorial takes you through a complete analysis of 9 LC-MS runs (3 replicate
More informationMRMPROBS tutorial. Hiroshi Tsugawa RIKEN Center for Sustainable Resource Science MRMPROBS screenshot
MRMPROBS tutorial Edited in 2016/11/16 Introduction MRMPROBS is launched as a universal program for targeted metabolomics using not only multiple reaction monitoring (MRM)- or selected reaction monitoring
More informationPinpoint Quick Start Guide
Pinpoint Quick Start Guide Thermo Pinpoint, version 1.0 and later 1, targeted protein quantification software simplifies the creation of processing methods and helps you do the following: Select targeted
More informationXcalibur. QuickQuan. User Guide. XCALI Revision C July For Research Use Only Not for use in Diagnostic Procedures
Xcalibur QuickQuan User Guide XCALI-97195 Revision C July 2007 For Research Use Only Not for use in Diagnostic Procedures 2007 Thermo Fisher Scientific Inc. All rights reserved. Microsoft, Access, Excel,
More informationOpenLynx User's Guide
OpenLynx User s Guide OpenLynx User's Guide Version 4.0 Waters part No 715000405 Micromass Part No - 6666670 5 February, 2002 i OpenLynx User s Guide OpenLynx User s Guide The software described in this
More informationSkyline Targeted Method Refinement
Skyline Targeted Method Refinement This tutorial will introduce the features available in the Skyline Targeted Proteomics Environment for refining instrument methods for Selected Reaction Monitoring (SRM,
More informationMascot Insight is a new application designed to help you to organise and manage your Mascot search and quantitation results. Mascot Insight provides
1 Mascot Insight is a new application designed to help you to organise and manage your Mascot search and quantitation results. Mascot Insight provides ways to flexibly merge your Mascot search and quantitation
More informationMassHunter Personal Compound Database and Library Manager for Forensic Toxicology
MassHunter Personal Compound Database and Library Manager for Forensic Toxicology Quick Start Guide What is MassHunter Personal Compound Database and Library Manager? 2 Installation 3 Main Window 4 Getting
More informationAgilent G6854 MassHunter Personal Pesticide Database
Agilent G6854 MassHunter Personal Pesticide Database Quick Start Guide What is MassHunter Personal Pesticide Database? 2 Installation 3 Main Window 4 Getting Started 11 Database operations 12 Searching
More informationReference Manual MarkerView Software Reference Manual Revision: February, 2010
Reference Manual MarkerView 1.2.1 Software Reference Manual - 1 - Revision: February, 2010 This document is provided to customers who have purchased AB SCIEX equipment to use in the operation of such AB
More informationTutorial 1: Library Generation from DDA data
Tutorial 1: Library Generation from DDA data 1. Introduction Before a targeted, peptide-centric DIA analysis can be performed, a spectral library containing peptide-query parameters needs to be generated.
More informationAnalyst QS. Administrator s Guide. Part Number: B July 2004
Analyst QS Administrator s Guide Part Number: 1001930 B July 2004 http://www.appliedbiosystems.com This document is provided to customers who have purchased MDS Sciex equipment to use in the operation
More informationSkyline Targeted Method Refinement
Skyline Targeted Method Refinement This tutorial will introduce the features available in the Skyline Targeted Proteomics Environment for refining instrument methods for Selected Reaction Monitoring (SRM,
More informationData Acquisition with CP-2002/2003 Micro-GC Control
Varian Analytical Instruments 2700 Mitchell Drive Walnut Creek, CA 94598 Star Chromatography Workstation Version 6 Data Acquisition with CP-2002/2003 Micro-GC Control Operation Manual Varian, Inc. 2002
More informationCorra v2.0 User s Guide
Corra v2.0 User s Guide Corra is an open source software Licensed under the Apache License, Version 2.0 and it s source code, demo data and this guide can be downloaded at the http://tools.proteomecenter.org/corra/corra.html.
More informationAll About PlexSet Technology Data Analysis in nsolver Software
All About PlexSet Technology Data Analysis in nsolver Software PlexSet is a multiplexed gene expression technology which allows pooling of up to 8 samples per ncounter cartridge lane, enabling users to
More informationManual. User Reference Guide. Analysis Application (EMG) Electromyography Analysis
Phone: (888) 765-9735 WWW.MINDWARETECH.COM User Reference Guide Manual Analysis Application Electromyography Analysis (EMG) Copyright 2014 by MindWare Technologies LTD. All Rights Reserved. 1 Phone: (614)
More informationOpenManage Power Center Demo Guide for https://demos.dell.com
OpenManage Power Center Demo Guide for https://demos.dell.com Contents Introduction... 3 Lab 1 Demo Environment... 6 Lab 2 Change the default settings... 7 Lab 3 Discover the devices... 8 Lab 4 Group Creation
More informationDe Novo Peptide Identification
De Novo Peptide Identification When a suitable sequence database is not available for your sample of interest, identification of your acquired fragmentation mass spectra becomes quite difficult. Indeed,
More informationDirect Infusion Mass Spectrometry Processing (DIMaSP) Instructions for use
Direct Infusion Mass Spectrometry Processing (DIMaSP) Instructions for use The following instructions assume the user has a batch of paired sample and blank spectra that have been exported to a comma-separated
More informationRetention Time Locking with the MSD Productivity ChemStation. Technical Overview. Introduction. When Should I Lock My Methods?
Retention Time Locking with the MSD Productivity ChemStation Technical Overview Introduction A retention time is the fundamental qualitative measurement of chromatography. Most peak identification is performed
More informationCLC Server. End User USER MANUAL
CLC Server End User USER MANUAL Manual for CLC Server 10.0.1 Windows, macos and Linux March 8, 2018 This software is for research purposes only. QIAGEN Aarhus Silkeborgvej 2 Prismet DK-8000 Aarhus C Denmark
More informationSciex QTrap Operational Steps for Trained Personnel
Sciex 6500+ QTrap Operational Steps for Trained Personnel Last Updated 09172017 1. If any of the following instructions does not make sense to you or was not covered during your hand-on training, stop
More informationAgilent G2721AA/G2733AA Spectrum Mill MS Proteomics Workbench
Agilent G2721AA/G2733AA Spectrum Mill MS Proteomics Workbench Quick Start Guide What is the Spectrum Mill MS Proteomics Workbench? 2 What s New in Version B.06.00? 3 Where to Find More Information 9 Setting
More informationData Handling and Reports
Varian Analytical Instruments 2700 Mitchell Drive Walnut Creek, CA 94598-1675/USA Star Chromatography Workstation Version 6 Data Handling and Reports Tutorials Varian, Inc. 2002 03-914736-00:Rev. 4 Trademark
More informationKAPPA Server Guided Session #1
Kappa Server v5.0.02 Doc v5.0.02 - KAPPA 1988-2013 KAPPA Server Guided Session #1 KSGS01-1/38 KAPPA Server Guided Session #1 A. KAPPA Server overview Before proceeding in the tutorial itself, it is necessary
More informationChromeleon / MSQ Plus Operator s Guide Document No Revision 03 October 2009
MSQ Plus Chromeleon / MSQ Plus Operator s Guide Document No. 065322 Revision 03 October 2009 Chromeleon / MSQ Plus Operator s Guide 2009 by Dionex Corporation All rights reserved worldwide. Printed in
More informationNote: The MS/MSALL with SWATH Acquisition MicroApp version 2.0 supports PeakView software versions 2.1 and later.
MS/MS ALL with SWATH Acquisition MicroApp Add-in for PeakView Software Version 2.0.1 Introduction The MS/MS ALL with SWATH Acquisition MicroApp workflow provides a method for collecting MS/MS of all species
More informationProgenesis CoMet User Guide
Progenesis CoMet User Guide Analysis workflow guidelines for version 1.0 Contents Introduction... 3 How to use this document... 3 How can I analyse my own runs using CoMet?... 3 LC-MS Data used in this
More informationPEAKS Studio 5 User s Manual
BIOINFORMATICS SOLUTIONS INC PEAKS Studio 5 User s Manual Bioinformatics Solutions Inc. 470 Weber St. N. Suite 204 Waterloo, Ontario, Canada N2L 6J2 Phone 519-885-8288 Fax 519-885-9075 Please contact BSI
More informationColorCert Inline API with IntelliTrax
ColorCert Inline API with IntelliTrax Version History October 14 th 2015 - Version 1.0 (IntelliTrax-Colorcert-v1.0.docx based on ColorCert 2.5 and IntelliTrax 1.6) October 12 th 2016 - Version 2.0 March
More informationmotcom loganalyser User Manual
User Manual Part No. 2 900 04 10000 Release 07.03.2016 English revision 160825 Kurt-Schumacher-Str. 28-30 66130 Saarbrücken, Germany e-mail: info@motcomgmbh.com web: www.motcomgmbh.com Contents Introduction...
More informationDiskBoss DATA MANAGEMENT
DiskBoss DATA MANAGEMENT Duplicate Files Search Version 9.1 Apr 2018 www.diskboss.com info@flexense.com 1 1 DiskBoss Overview DiskBoss is an automated, policy-based data management solution allowing one
More informationAgilent MassHunter Metabolite ID Software. Installation and Getting Started Guide
Agilent MassHunter Metabolite ID Software Installation and Getting Started Guide Notices Agilent Technologies, Inc. 2011 No part of this manual may be reproduced in any form or by any means (including
More informationPreprocessing, Management, and Analysis of Mass Spectrometry Proteomics Data
Preprocessing, Management, and Analysis of Mass Spectrometry Proteomics Data * Mario Cannataro University Magna Græcia of Catanzaro, Italy cannataro@unicz.it * Joint work with P. H. Guzzi, T. Mazza, P.
More informationCurrent Perspectives on Clinical Mass Spectrometry Auto-Data Review: An Innovative Solution
Current Perspectives on Clinical Mass Spectrometry Auto-Data Review: An Innovative Solution Alec Saitman, PhD DABCC (CC, TC) Director, Toxicology and Special Chemistry Providence Regional Laboratories
More informationImpact Analysis for Software changes in OpenLAB CDS A.01.04
Impact Analysis for Software changes in OpenLAB CDS A.01.04 Document Information: Filename Product Identifier Product Revision Project Identifier Document Revision Impact_Analysis_OpenLAB_CDS_A0104 OpenLAB
More informationProMISE user manual. System requirements. Installation
ProMISE user manual Probabilistic model for immiscible separations and extractions (ProMISE) developed by Joost de Folter, is freely available for non-commercial purposes (academic e-mail address required
More informationThis manual describes step-by-step instructions to perform basic operations for data analysis.
HDXanalyzer User Manual The program HDXanalyzer is available for the analysis of the deuterium exchange mass spectrometry data obtained on high-resolution mass spectrometers. Currently, the program is
More informationMass Spec Data Post-Processing Software. ClinProTools. Wayne Xu, Ph.D. Supercomputing Institute Phone: Help:
Mass Spec Data Post-Processing Software ClinProTools Presenter: Wayne Xu, Ph.D Supercomputing Institute Email: Phone: Help: wxu@msi.umn.edu (612) 624-1447 help@msi.umn.edu (612) 626-0802 Aug. 24,Thur.
More informationSequencePro Data Analysis Application. User Guide
SequencePro Data Analysis Application User Guide SequencePro Data Analysis Application User Guide DRAFT October 31, 2001 12:52 pm, Title_page.fm Copyright 2001, Applied Biosystems. All rights reserved.
More informationNew features and Workflow Enhancements Empower 3 Software
New features and Workflow Enhancements Empower 3 Software Mogens Hallas Nordic User Training 2011 Långvik, September 6th to 9th, 2011 2011 Waters Corporation 1 Empower 3 Architecture and operating systems
More informationAgilent G6854AA MassHunter Personal Compound Database
Agilent G6854AA MassHunter Personal Compound Database Quick Start Guide This guide describes how to install and use MassHunter Personal Compound Database. Where to find more information What is Personal
More informationAutomated Submission for Analysis Processing (ASAP) Operator s Guide Dionex Corporation
Automated Submission for Analysis Processing (ASAP) Operator s Guide 2002 Dionex Corporation Document No. 031843 Revision 01 May 2002 2002 by Dionex Corporation All rights reserved worldwide. Printed in
More informationWatson TSQ Module Version 1.1
Watson TSQ Module Version 1.1 User Guide XCALI-97304 Revision A March 2010 2010 Thermo Fisher Scientific Inc. All rights reserved. LCquan and TSQ Vantage are trademarks, and Xcalibur, TSQ Quantum, and
More informationPackage specl. November 17, 2017
Type Package Package specl November 17, 2017 Title specl - Prepare Peptide Spectrum Matches for Use in Targeted Proteomics Version 1.13.0 Author Christian Trachsel [aut], Christian Panse [aut, cre], Jonas
More informationAgilent MassHunter Drug Analysis Mode Using Quantitative Analysis Workflow Guide
Agilent MassHunter Drug Analysis Mode Using Quantitative Analysis Workflow Guide Notices Agilent Technologies, Inc. 2013 No part of this manual may be reproduced in any form or by any means (including
More informationTraceFinder Administrator Quick Reference Guide
TraceFinder Administrator Quick Reference Guide This quick reference guide discusses the application configuration tasks assigned to the ITAdmin and LabDirector roles when user security is activated in
More informationFunasset Limited Foundry House Foundry Road Taunton Somerset TA1 1JJ. Tel: +44 (0) Fax: +44 (0) mailmarkup.com funasset.
Funasset Limited Foundry House Foundry Road Taunton Somerset TA1 1JJ Tel: +44 (0)1823 365864 Fax: +44 (0)1823 277266 mailmarkup.com funasset.com Copyright 2012 Funasset Limited. All rights reserved. Products
More informationPEAKS Studio 5.1 User s Manual
BIOINFORMATICS SOLUTIONS INC. PEAKS Studio 5.1 User s Manual Bioinformatics Solutions Inc. 470 Weber St. N. Suite 204 Waterloo, Ontario, Canada N2L 6J2 Phone 519-885-8288 Fax 519-885-9075 Please contact
More information