Life Sciences Opportunity: Preparations for Doing Business in Japan & Overview including Healthcare ICT

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Life Sciences Opportunity: Preparations for Doing Business in Japan & Overview including Healthcare ICT October 2017

Agenda Preparations for Doing Business in Japan (10mins) Overview including Healthcare ICT (15 mins) Q&A Session (10 mins)

Consider the following Using translators cuts the time in half Do you have enough business cards? Paper still widely used (as opposed to digital copies) Use simple language / do not over complicate statements Break the ice (weather is a safe topic) Introduce yourself properly A little effort goes a long way (1-2 words in Japanese will impress) What are the unique selling points of your product / service? Give concrete examples If you have a demo is it working properly? Do not do all the talking If you put people on the spot they will clam up Follow up is key - even if there are no actions send a thank you note

Common issues in doing business with Japan Contact: may be speculative challenges in vetting the opportunity Meetings: be clear on the agenda set expectations Credibility: first impressions are important they will test you Relationships: extremely important Japan is all about face-to-face Process: who are the stakeholders involved consensus Deadlines: extremely important give notice if they will be missed Documentation: different views on NDAs, MOUs etc Pushback: NIH & people staking their reputations on you Budget cycles: Japan FY April through March Patience: everything decided before be ready when the deal is signed Layers: group companies, trading houses, distributors etc Local standards and regulations: how much needs to be done to localize Visibility: often very opaque

Overview of the Japanese Healthcare Market Paul Mori

Japan in Numbers 126.7 million = total population 33 percent = portion of population over the age of 60 83.7 years = life expectancy (longest in the world) 1.44 = birth rate $469 billion = total healthcare expenditures (USD) 11.4 percent = healthcare expenditure share of GDP 8,480 = number of hospitals 13.2 = hospital beds per 1,000 population 1.6 million = number nurses $26 billion = size of medical device market (USD)

Market Drivers Aging population 1.69 million people live in welfare facilities for the elderly Percentage of people over the age of 65 is expected to increase from 26.7% to 38.4% by 2065 40.7% of all private households are elderly households (5.93m one-person elderly households) Shortage of healthcare workers Steadily shrinking population Aging of healthcare workers 36% of doctors will be over the age of 60 by 2035 Increased reliance on foreign workers Ballooning healthcare expenditures Expenditures have increased for 14 fiscal years in a row with no signs of slowing down Government putting stronger pressure on healthcare sector to lower cost of drugs and devices

2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016 Millions of Yen Healthcare Expenditure 60,000,000.0 50,000,000.0 40,000,000.0 30,000,000.0 20,000,000.0 10,000,000.0 0.0 Source: OECD 8

Other trends Focus on self-treatment New incentives for self-medication Consolidations in the industry Hospitals Distribution companies Manufacturers

Healthcare IT Market Total medical solutions market in 2016: USD 11.9 billion (includes surgery equipment, diagnostic equipment, measuring instruments and IT systems) IT systems for healthcare institutions accounted for USD 3.97 billion

Market Trends Digitization of patient records Shift towards the use of cloud Rapid rise of telemedicine Increased use of robotics Strong focus on IoT and AI 11

Domestic IoT-related Devices and Systems Market (Billions JPY) 1800 1600 1400 1200 1000 800 600 400 200 0 (2016: USD 662 million) (2025: USD 1.48 billion) Other IoT-related Systems Medical Treatments/Monitoring Instruments/Systems Mounted Artificial Organs with Communication Functions Source: Fuji Keizai

Domestic AI in Healthcare Market Billions JPY 160 140 120 100 80 60 40 20 0 (2016: USD 325 million) (2025: USD 1.3 billion) Diagnostic Support System AI for Pharmaceutical Company Sales Support AI Drug Development System Source: Fuji Keizai

Examples of ICT in Healthcare: Allm Inc. Offers a smartphone app called Join that allows healthcare professionals to share clinical information with each other Integrated with PACS and also allows in-app sharing of DICOM files Designed to improve diagnostic precision and solve the problem of limited access to specialists First smartphone app to be reimbursed under the Japanese NHI system Credit: Allm Inc. 14

Examples of ICT in Healthcare: KDDI KDDI (the 2 nd largest mobile network operator in Japan) offers blood test services using blood collection kits coupled with a smart phone app Customers receive a blood test kit in the mail, and 1-2 weeks after the blood samples are mailed back, the results are posted on the app Allows users to conduct blood tests from home The service tests for 14 different indicators (e.g. cholesterol, HbA1c, etc) Credit: KDDI 15

Important Considerations in Entering the Market Localization High standards for quality assurance Demands for technical support at local level Concerns about security of data Ambiguity in regulation 16

Q & A 17

Key Operational Sectors Experience Across Multiple Technology and Biotech Fields Automotive and Aerospace Electronics Energy and Environment Healthcare and Medical Industrial and Manufacturing Intellectual Property Network and Telecoms Digital and On-line

About Us Founded in 1990 Headquartered in Oxford, UK Offices across Asia, Europe and the USA Over 70 bilingual staff Global business development for start-ups and enterprise Global technology scouting for enterprise Experience and achievement across multiple industry verticals Deeply networked with startup ecosystems in North America and Europe Worked with over 500 clients over our 26-year history Specialists in Global Business Development