ADVIA 360, ADVIA 560, and ADVIA 560 AL Systems

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Siemens Solutions for Hematology ADVIA 360, ADVIA 560, and ADVIA 560 AL Systems Answers for life.

The ADVIA Hematology Family Siemens can now offer a total solution with the ADVIA 360, ADVIA 560, ADVIA 560 AL and ADVIA 2120i Hematology Systems.* Page 2 2016-06-09 *Product availability varies by country

The ADVIA Hematology Family The ADVIA Hematology Family Solutions for all laboratories of all sizes Safe, reliable, easy to use Accurate, comparable results Siemens service and support Underscores Siemens commitment to hematology Page 3 2016-06-09

ADVIA 360 System Specifications Throughput Up to 60 tests/hr Parameters Technology Samples Reagents 22,* including 3-part WBC differential Impedance for CBC Absorbance for HGB 100 ml sample volume Closed- and open-tube manual modes Three cyanide-free reagents Quality Control Quality-control database Levey-Jennings graphs IT Storage capacity: 10,000 records Easy-to-use multilingual user interface HL7 connectivity *OUS only; 18 parameters in the U.S. Page 4 2016-06-09

ADVIA 360 System Specifications Throughput Up to 60 tests/hr Parameters Technology Samples 22, including 3-part WBC differential Impedance for CBC Absorbance for HGB 100 ml sample volume Closed- and open-tube manual modes 17 kg 36 cm Reagents Three cyanide-free reagents Quality Control Quality-control database Levey-Jennings graphs IT Storage capacity: 10,000 records Easy-to-use multilingual user interface HL7 connectivity 31,6 cm 49,2 cm Page 5 2016-06-09

ADVIA 360 System User Interface Page 6 2016-06-09

ADVIA 560 System Specifications Throughput Parameters Technology Samples Up to 60 tests/hr 26,* including 5-part WBC Differential Laser light scatter for 5-part Differential Impedance for CBC Absorbance for HGB 110 ml sample volume Closed- and open-tube manual modes Reagents Quality Control Three cyanide-free reagents Quality-control database Levey-Jennings graphs IT Storage capacity: 100,000 records Easy-to-use multilingual user interface HL7 connectivity *OUS only; 22 parameters in the U.S. Page 7 2016-06-09

ADVIA 560 System Specifications Throughput Up to 60 tests/hr Parameters Technology Samples 26, including 5-part WBC Differential Laser light scatter for 5-part Differential Impedance for CBC Absorbance for HGB 110 ml sample volume Closed- and open-tube manual modes 52 cm 35 kg Reagents Three cyanide-free reagents Quality Control Quality-control database Levey-Jennings graphs IT Storage capacity: 100,000 records Easy-to-use multilingual user interface HL7 connectivity 41 cm 49 cm Page 8 2016-06-09

ADVIA 560 AL System Specifications Throughput Parameters Technology Samples Up to 60 tests/hr 26, including 5-part WBC Differential Laser light scatter for 5-part Differential Impedance for CBC Absorbance for HGB 110 ml sample volume Closed- and open-tube manual modes Autoloader holds 100 samples (10 racks, 10 samples per rack) Reagents Quality Control IT Three cyanide-free reagents Quality-control database Levey-Jennings graphs Storage capacity: 100,000 records Easy-to-use multilingual user interface HL7 connectivity Page 9 2016-06-09

ADVIA 560 and ADVIA 560AL System User Interface Start-up Screen Reagent Status Autoloader Log Result Screen Page 10 2016-06-09

Quality Control on ADVIA 360 and ADVIA 560 Systems QC Database and 24 QC files Target values can be scanned Levey-Jennings graphs Page 11 2016-06-09

Manual Closed-Vial Sampling Closed- or open-vial sampling Suitable for various cap-pierceable tubes 110 ml sample volume Available on the ADVIA 360,560, and 560 AL Systems Manual bar-code reader for positive sample ID Page 12 2016-06-09

Tube management External Barcode Reader Code 128; Code 39; Interleaved 2 of 5; Codabar; EAN-8; EAN-13 Supported Sample Tube Types K2- or K3-EDTA 13 x 75-mm sample-tubes - Sarstedt Monovette - Becton Dickinson (BD) Vacutainer - Terumo Venosafe Page 13 2016-06-09

Autoloader Upgrade on ADVIA 560 System Page 14 2016-06-09

Reagents Setup 1. ADVIA 360/560 Dil Color Code GREEN Dilution of blood sample Sheat for optical measurement 2. ADVIA 560 Lyse 5P Color code YELLOW Lyses RBCs and PLTs to determine WBC count, 5- diff and HGB concentration Page 15 2016-06-09

Reagents Setup 3. ADVIA 560 Diff-5P Color code ORANGE Stop the lysing process and prevent WBC from lysing Page 16 2016-06-09

Reagents Setup Reagents Lock System/Hardware (HW) Key Each ADVIA 560 Lyse reagent container comes with a reagent HW key that contains 900 measurement credits System count down warns operator when the remaining test is 50 Page 17 2016-06-09

Reagents Setup ADVIA 360 Function Diluent Lyse Cleaner Controls Calibration Product Name ADVIA 360/560 Dil ADVIA 360 Lyse ADVIA 360 Cleaner ADVIA 360 Control Set (L-N-H) ADVIA 360, 560 Calibrator SMN 11170845 11170848 11170849 11170853 11170852 Content 20 Ltr 1 Ltr / 900 tests 1 Ltr 2 x 3 x 3 ml 2 x 3 ml Consumption per measurement 41 ml 1,1 ml 20 ml 110 µl 110 µl Cycle 480 tests 900 tests 50 days 80 tests 80 tests Open vial stability 60 days 90 days 90 days 14 days 7 days Page 18 2016-06-09

Reagents Setup ADVIA 560 Function Diluent Lyse Stopper HypoClean CC Controls Calibration Product Name ADVIA 360/560 Dil ADVIA 560 Lyse ADVIA 560 5P Diff ADVIA 360,560 Hypoclean ADVIA 560 Control Set (L-N-H) ADVIA 360, 560 Calibrator SMN 11170845 11170846 11170847 11170851 11170854 11170852 Content 20 Ltr 5 Ltr / 900 tests 1 Ltr 100 ml 2 x 3 x 3 ml 2 x 3 ml Consumption per measurement 52 ml 5,7 ml 0,7 ml 4mL/jour 110 µl 110 µl Cycles 380 tests 900 tests 1400 tests 25 days 80 tests 80 tests Open vial stability 60 days 60 days 60 days 60 days 8 days 7 days Page 19 2016-06-09

ADVIA 360 and 560 System Methodology Technologies Volumetric Impedance Photometric Measurement Optical Measurement Determine the cellular concentration and volume distribution for WBC, RBC and PLT. The unit is femtoliters (fl). After RBC lysis, HGB concentration is measured based on absorbance variation against blanc.the unit is g/dl. WBC analysis based on a dual-angle measure of light scattering and diffraction. This determines cell volume and granularity for each single cell Page 20 2016-06-09

ADVIA 560 System Result Screen The Diff cytogram has same orientation and color-coding as the ADVIA 2120i System X axis: complexity and granularity Y axis: cell size The baso cytogram X axis: cell complexity Y axis: cell size Red cell and platelet histograms X axis: cell size Y axis: cell number Page 21 2016-06-09

ADVIA 360 and 560 System Methodology PLT RBC PLT, MPV RBC, HGB, HCT, MCV, MCH, MCHC, RDWsd, RDWcv Page 22 2016-06-09

ADVIA 360 and 560 System Methodology DIFF BAS MON NEU EOS BAS LYM Cellular Debris Cellular Debris WBC, NEU, LYM, MON, EOS, NEU%, LYM%, MON%, EOS% Page 23 2016-06-09 BAS, BAS%

ADVIA 560 vs 2120i System Results (USA) Page 24 2016-06-09

ADVIA 560 vs 2120i System Results (USA) PLTS NEUTS LYMPHS WBC HGB MCV Page 25 2016-06-09

Operator Maintenance? Reduced Maintenance Daily: Weekly: Monthly: System Shut Down (automatic) Na* Na* On demand: - Shear valve cleaning 5 min - Cleaning the Wash head 5 min - Measuring chambers 1 min Page 26 2016-06-09

ADVIA 560, ADVIA 560AL, and ADVIA 360 Systems Small footprint with onboard cleaning and zero daily maintenance Good reliability Full support supplied by Siemens Page 27 2016-06-09

Siemens Scalable Hematology Systems to Suit Every laboratory* Siemens Range of Hematology Systems* STAT Labs Satellite Labs Low Workload Page 28 2016-06-09 Medium Workload High Workload Core Automation Lab HemaPrep Device ü ü ü ü ü Diff-Quick Stain Kit ü Hematek 3000 System ü ü ü ü ADVIA 360 System ü ü ü ü ADVIA 560 System ü ü ü ADVIA 560AL System ü ü CellaVision Image Capture System CellaVision DM1200 ü ü CellaVision DM9600 ü ü ADVIA 2120i System ü ü ADVIA Autoslide ü ü Aptio Automation ü ü Backup Systems *Product availability varies by country. Note: CellaVision is a trademark of CellaVision AB.

Meeting Requirements Your Requirements A range of systems to meet future demands Compatible LIS or middleware systems Opportunities for Automation and satellite solutions Protection from exposure to biohazards Potential of digital microscopy Confidence that systems are easy to use Fully supported systems A single supplier providing a total solution ADVIA Hematology Family A range of upgradeable systems HL7 LIS or middleware connectivity Siemens can provide multidisciplinary Automation plus satellite packages All systems provide closed vial sampling All CellaVision systems are available Systems can be used by all skill levels Siemens provides full-service support Siemens can provide a comprehensive solution to meet all your requirements Page 29 2016-06-09

The ADVIA Hematology Family For more information contact: François Richir BM Hematology francois.richir@siemens.com Page 30 2016-06-09