towards a federated infrastructure enabling integrated life science research

Transcription

1 towards a federated infrastructure enabling integrated life science research ELIXIR Innovation & SME forum March Ruben Kok & Jaap Heringa

2 ZOOMING IN AND OUT OF LIFE

3 ALL LEVELS OF (MOLECULAR) ORGANISATION Biomaterial collections All technologies to measure (meta-)genomics, transcriptomics, proteomics, metabolomics, bioimaging, phenotyping,. Model systems Biotech Health Design of Experiment Scientific Project Research Objective Information & Insight Agro Nutrition All technologies to deal with data bioinformatics, informatics, biostatistics, computational (systems) biology & e-science, ICT,

4 INTEGRATED APPROACH TO BIG SCIENCE & BIG DATA DTL mission: establish a federated research infrastructure that enables integrated LS research among sectors in a cost-effective manner and in international collaboration Connect academia & industry around common technology and data challenges Cross-sector: clinical & health, agro- & nutrigenomics & industrial microbiology, ecology & biodiversity Cross-technology: involve technology networks with strong international connection Bundle local efforts in a collective platform set up in three programmes Organised as a formalised PPP

5 BUILDING ON EXISTING NETWORKS ACROSS LIFE SCIENCES e-science omics bioimaging agrogenomics nutrition research BioSB.nl clinical genomics; transl. medicine industrial microbiology

6 BUILDING ON A GROWING PUBLIC-PRIVATE PARTNERSHIP

7 OVER 90 EXPERT GROUPS INVOLVED Technology hotel calls with NWO/ZonMw 2013 & 2014 DTL associated Technology hotels Evaluation of data management approach AMC AMOLF CWI NLeSC NKI SURFSARA University of Amsterdam VU University Amsterdam VUMC Generade LUMC Leiden University Naturalis TUDelft Delft Leiden 15 4 ErasmusMC 3 Rotterdam Amsterdam 18 Utrecht 15 1 TNO Zeist Hubrecht Institute UMCU Utrecht University 10 Wageningen 6 Nijmegen 9 Groningen Enschede Hanze University University Groningen UMCG 1 TU Twente Wageningen UR PRI Radboudumc Radboud University CTMM TUe 4 Eindhoven Technology Hotels 5 Maastricht Maastricht Univ. MUMC+

8 SECTOR EXAMPLE: DTL AGROGENOMICS CLUSTER Connect successful PPP projects VLPB Virtual Lab for Plant Breeding Breed4food CBSG Binding topic: genetic diversity/biodiversity Exchange of expertise on common challenges Link to Horticulture&Starting Materials and Agri&Food Early 2015: DTL-VLPB FAIR data BYODs DNA4Collections Hackaton (genebanks) ELIXIR/ELIXIR-NL Industry event Focus meetings

9 DTL PROGRAMMES STARTING UP 2014 Data: integration & stewardship Link running data (infra) projects Build ELIXIR-NL portfolio Promote FAIR data stewardship Series of focus meetings/hackathons Technologies: facility access & linking Overview and profile of NL-facilities Promote funding for access to DTLassociated technology hotels Learning: training & education Get first course overview Learning Interest Group BioSB collaboration Data Learning Technologies

10 DATA: ENABLING THE RESEARCH DATA LIFECYCLE Big Data, data integration & data stewardship! Coordination: Link data (infra) projects NL node in ELIXIR Promote (FAIR) data stewardship Expert (focus) meetings Involve NL-facilities and collections Data expert training Collaboration with research schools (e.g. BioSB) Data & Design & Planning Data Analysis & Modelling Data & Study Capture data expert network coordination & training standards & infra Data Integration & Preservation Data Processing & Curation

11 SCIENTIFIC DATA (AND TOOLS) MUST BE FAIR Findable Accessible* Interoperable Re-usable for both people and computers *) NB: accessible open! (e.g. proprietary data, privacy-sensitive data)

12 FAIR DATA DTL DTL DataFAIRport Join the DTL FAIR Data IG More info: luiz.bonino@dtls.nl

13 NL-NODE IN ELIXIR ( DATA FOR LIFE ) ELIXIR-NL Data Interoperability e-infrastructure services e.g. SURF for SMEs Training & Education International network EC, NIH/NSF, RDA Cross-RI collaboration ESFRI s, NL-Roadmap EUDAT, DataVerse,.. Collections Industry involvement

14 NL-NODE IN ELIXIR ( DATA FOR LIFE ) ELIXIR links data Expertise Resources (databases) Compute & storage Tools Standards Training

15 DTL FORMAL ORGANISATION & GOVERNANCE DTL Board Domain representatives advise Partner Advisory Committee Executive representatives of DTL Partners Scientific Advisory Committee Academic & Industry PI s advise DTL Team data & technology programmes funding & events partner agreement DTL Partners Universities, UMC s, Institutes, Industry DTL foundation DTL Alliance Formal partnership of universities, UMC s, universities of applied science, institutes & industry with facilitating DTL foundation

16 PARTNERSHIP SET UP AND FEE STRUCTURE Standard DTL Partner Agreement between Stichting DTL and separate university, UMC, institute, company etc. no IP regulation: only entry to DTL Alliance Small companies may enter as collective Organisation annual fee minimal period Academia large small Industry large (>250 empl.) medium (<250) small (<50) micro (<10) 20 k 7.5 k 20 k 5 k 1.5 k yr 2 yr 2 yr 1 yr 1 yr 1 yr Partner Advisory Committee Executive representatives of DTL Partners DTL Partners Universities, UMC s, Institutes, Industry DTL Alliance Partner fees cover costs of the small expert team that helps establish the DTL programmes and supports the DTL Alliance