ECRIN (European Clinical Research Infrastructure Network) the pan-european network for clinical research
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1 ECRIN Meeting in Estonia Tartu, June 15th, 2017 ECRIN (European Clinical Research Infrastructure Network) the pan-european network for clinical research 15 June 2017
2 Need for clinical trials 1 - Development of innovative health products registration trials phase I II III 2 - Repurposing trials exploring new indications for authorised products phase II - III 3 - Comparative effectiveness trials compare efficacy and safety of authorised healthcare strategies phase IV Risk categories C I>A phase I II III IV I>A A>I B I>A A>I A A>I registration New product Modified use Usual care 2 2
3 International cooperation : industry-sponsored vs. academic trials Attal et al. Differential Globalization of Industry- and Non-Industry-Sponsored Clinical Trials PLoS One Dec 14;10(12):e
4 ECRIN model : distributed infrastructure Coordinating services provided by national partners National partner : network of clinical trial units (CTUs) able to manage trials in the country National hub European Correspondent hosted in national hub (ECRIN staff) 4 4
5 EU Commission funding (multi) national funding 2004 ECRIN-RKP 2006 ECRIN-TWG 2008 ECRIN-PPI 2012 ECRIN-IA ECRIN-ERIC PedCRIN
6
7 ECRIN and its national scientific partners Core Team, European Correspondents, national hub, CTU networks Framework contracts with national scientific partners provision of services -> linked third party non-profit cost hosting the European Correspondent
8 ECRIN and its national scientific partners Linked through framework agreements Country National hub National CTU Network Host Institution (linked third party) Czech Republic Brno CZECRIN Masaryk University Germany Cologne KKSN Universität Klinik Köln Spain Barcelona SCReN ISCIII France Toulouse F-CRIN INSERM Hungary Pecs HECRIN HECRIN Italy Rome ItaCRIN ISS Norway Trondheim NORCRIN St Olav s Hospital Portugal Lisbon PtCRIN Nova University Switzerland Basel SCTO SCTO
9 Credits to: Jacques Demotes Distribution of roles in multinational trials : trial management vs. investigation Investigator-initiated or SME-sponsored trial PI Trial management Industry-sponsored trial Sponsor CTU +/- CRO Investigation
10 10
11 ECRIN trial portfolio 11
12 ECRIN trial portfolio average 7 countries per trial 12
13 ECRIN trial portfolio
14
15 11 new clinical trials funded in clinical trials (out of 16) 1 clinical trial 4 clinical trials 15
16 Funding ECRIN services in H2020 trials H2020 clinical trial budget ~6M, 4 years -> beneficiaries ECRIN trial management services ~400k (100k /y) (~7% total budget) ECRIN core team budget ~40k (10k /y) ECRIN partners as subcontractors or third 16 parties, ~360k (90k /y)
17 ECRIN 2017 budget outlines : total 5.515M Contribution of Members and Observers : 1.925M to European Correspondents 0.75M to core team 1.175M Capacity building projects : 0.565M to core team Clinical trials : 3.025M to core team 100k to European Correspondents 200k to national partners 2.722M ~ 40M to countries involved
18 Tools for multinational trials ECRIN tools to facilitate multinational trials ( Quality management Data centre certification Regulatory and ethical database Methodology guidelines Outcome measure database Risk-based monitoring toolbox Mapping of investigation sites Training Communication 18
19 ECRIN Regulatory and Ethical database Central resource covering 22+ European countries and multiple study types. Use to: Locate country-specific competent authorities and ethics committees Consult summary of requirements in each country Browse related documents 19
20 Risk based monitoring toolbox Enables researchers to create appropriate risk-based strategies 20
21 ECRIN data center certification Certification criteria (129 requirements, V 3.1 available on
22 Experience of ECRIN data center certification, and perspectives
23 Capacity projects ECRIN-IA EMTRAIN CORBEL PRO4VIP RI-Train PedCRIN TRANSVAC RISCAPE EOSC pilot MiRoR TESA II CRIGH 23
24 ESFRI-roadmap Biological and Medical Science Research Infrastructures Translational research Clinical research Biomarkers Drug discovery/ development Target identification 24
25 CORBEL cluster project ECRIN o Leader WP3 (health use cases) involved in o Communication o Access Quality management o ELSI o Innovation o Training 25
26 Medical Infrastructures / Users Forum 26
27 Paediatrics Other medical research area Other medical research area PedCRIN consortium and objectives ECRIN and linked third parties: trial management capacity EPCTRI partners: investigation capacity BBMRI and EATRIS as partners Budget 3.3M Duration 36/48 months Pan-European infrastructures providing generic tools and services PedCRIN ECRIN BBMRI EATRIS Pan-European investigation networks developing specific tools and scientific content
28 PedCRIN partners ECRIN & linked third parties ECRIN CH: SCTO CZ : CZECRIN DE : KKSN ES : SCReN FR : F-CRIN HU : HECRIN IT : ISS NO : NorCRIN PT : PtCRIN BBMRI EATRIS EPCTRI partners AT : OKIDS CH : SCTO EE : UTartu ES : FSJD FI : HUS FR : INSERM GR : AUTH IRL : NCRC IT : CVBF NL : RUMC, VSOP NO : HUS SW : KI UK : ULIV
29 PedCRIN activities Project Management & Coordination WP1 ECRIN Ethics Governance-sustainability WP6 WP2 ECRIN,RUMC ULIV Communication WP5 FSJD,VSOP Trial Support WP4 HUS-FI,RUMC ECRIN Tools for neonatal & paediatric clinical trials WP3 CVBF,INSERM
30 International partnerships Bilateral cooperation : Australia, Korea, USA, Brazil, Japan Multilateral cooperation : CRIGH Clinical Research Initiative for Global Health Secretariat NIH + ECRIN (OECD and WHO partners) 6 projects Infrastructure and funding Global core competencies Research ethics Patient involvement Comparative effectiveness research Regulatory awareness 30
31 Clinical Research Initiative for Global Health Nature 545:289 (2017)
32 Added value of ECRIN Membership Scientific impact - structuring effects national standards impact on common tools availability of, and access to common tools quality standards, quality services (ECRIN data centre certification) strengthening of national clinical trial infrastructure, attractiveness for industry and academic trials participation in H2020 structuring projects (CORBEL, etc) training of investigators and support staff / multinational trials 32 32
33 Added value of ECRIN Membership Scientific impact - operational support to clinical trials access to patients and to medical expertise, unlocking the national scientific potential facilitating national participation in H2020 and IMI-funded projects and supporting the applications supporting trial design, methodology, logistics and management facilitating the involvement of national investigators in multinational clinical trials initiated by European investigators 33 33
34 Added value of ECRIN Membership Socio-economic impact on health and on economy health innovation from national SMEs medical device, biotherapy evidence-based medical decision patients and healthcare system fostering H IMI funding 34 34
35 Conditions for ECRIN Membership National network of clinical trial units as Scientific Partner Capacity to manage trials in any disease area Framework contract with ECRIN senior delegate as Member of the Network Committee National hub hosting ECRIN European Correspondent (EuCo), ECRIN employee Commitment of Government : Member, or Observer (3 years max) Contribution stratified / GDP and GDP per capita : Local contribution (in-kind or in-cash, for Members and Observers) : 50k (GDP per capita < 20k) Core contribution (in cash, for Members) : 20k (GDP < 200bn) 35 35
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