1:00 p.m. - 3:00 p.m. Technical Track 2-3 Experience with Implementations. Lee Min Lau, MD, PhD, Lead, Medical Informatics, 3M
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1 1:00 p.m. - 3:00 p.m. Technical Track 2-3 Experience with Implementations Lee Min Lau, MD, PhD, Lead, Medical Informatics, 3M
2 Towards Data Interoperability Lee Min Lau MD PhD 3M Health Information Systems
3 Interoperability The ability of one computer system to exchange data with another computer system U.S. National Committee on Vital and Health Statistics Report on Uniform Data Standards for Patient Medical Record Information July 6, 2000
4 Three Levels of Interoperability Semantic (common): information in the data fields within the message can be used in an intelligent manner by the receiving computer Syntactic (functional): message between computers has a common structural definition (format) Basic: message can be received from another computer, but not interpreted
5 Examples of Syntactic Interoperability: HL7 2.X Hospital A OBX 1 CE ^Potassium Hospital B OBX 1 CE ^K Hospital C OBX 1 CE ^Ser K
6 Towards Semantic Interoperability: Data Standardization Using the same set of codes to encode data throughout a system (a hospital, an organization, a region, a country, a world.) Example: Domain Sex Code Name 1 Male 2 Female 3 Unknown
7 Example of Semantic Interoperability: Exchanging Standard Terminology Codes Hospital A Hospital B Hospital C OBX 1 CE ^Potassium:SCNC:PT:SER/PLAS:QN: Logical Observation Identifier Names and Codes (LOINC)
8 Commitment to Standard Terminologies for Data Exchange Encode Encode data data with with the the identifiers identifiers of of standard standard terminologies terminologies ( standard ( standard codes ) codes ) CDR Patient: John Doe Lab Result: Two Approaches Encode Encode data data with with internal internal identifiers, identifiers, translate translate to to standard standard codes codes for for external external exchange exchange CDR Patient: John Doe HDD Mapping: 1234 Lab Result: LOINC CDR=Clinical Data Repository HDD=Healthcare Data Dictionary
9 Role of the 3M Healthcare Data Dictionary Reg Financials Med. Rec. Order Mgt. Radiology Lab Rx Scheduling Home Health Practice Mgt. Doc. Imaging Transcription LTC PACS Interface Engine Clinical Decision Support Healthcare Data Dictionary (HDD) Mapping EMPI CDR SQL Reporting Case Management Disease Management Protocol Management Single View Clinical Workstation Outcomes Measurement CQI Studies Research Data Mining
10 The 3M Healthcare Data Dictionary Components of the HDD Controlled Medical Vocabulary (CMV) Collection of clinical concepts Knowledge Base (KB) Relationships among concepts Medical Information Model (MIM) Establishes clinical context Alerts Decision Support Medical Information Model Knowledge Base (Ontology) Reports Controlled Medical Vocabulary (Medical Concepts)
11 Controlled Medical Vocabulary A collection of medical concepts, organized to support synonyms and other lexical characteristics A concept is a unique, definable idea or item that has a very specific, known meaning Chloride Glucose Potassium Sodium Lab Test Chem 4 Lab Result
12 Concept Based Vocabulary Concept Representation COLD COLD COLD Concept Domain a sensory perception a pulmonary diagnosis an upper respiratory viral infection Concept Definition I m feeling cold Chronic Obstructive Lung Disease I have a cold Concept ID ID
13 Knowledge Base/Relationships Chem 4 Sodium Potassium Chloride Glucose Lab Result Lab Test is-component-of is-a
14 Medical Information Model Describes the relationships among clinical events and terminologies in a fashion that gives them meaning and context Enforces accepted truths but allow for uncertainty and variation inherent in medical information Clinically correct, complete, flexible and extensible Supported by vocabulary and knowledge base Obeyed by the data gathering software
15 Medical Information Model Information Models Allergy Event Drug Type Allergen Aspirin 3M Database Architecture HDD Allergy Event Allergy Type Allergen Severity Reaction Date Instance Data Mild Severity Reaction Rash CDR Date Patient Allergy Drug (1550) Aspirin ( ) Mild (1554) Rash (82559)
16 Mapping in the HDD Mapping is the process of creating one-way links between concepts and terms in different vocabularies, both standard and legacy Mapping is is accomplished through a variety of of techniques such such as as representation synonymy, term term association, relationship, attribute, granularity, composition/ decomposition, etc. etc. Herpesvirus 3, Human C = UMLS Concept Unique Identifier Herpes-zoster Virus Varicella-zoster Virus = HDD ID HDD Chickenpox Virus VZV 243 = Ft Hood Lab Interface Context
17 HDD Mapping Result A universal cross reference map accounting for all concepts and terms in the HDD The HDD manages ongoing updates from standard terminologies as well as local additions and changes from health care facilities Through mapping in the HDD, the enterprise s s data is now exchangeable and interoperable with the rest of the world via standard codes, e.g. LOINC Fort Sill Interface Code Camp LeJeune Interface Code DoD Short Name PT HDD ID LOINC Code DoD Long Name Protime
18 Commitment to Standard Terminologies for Data Exchange Two Approaches Encode Encode data data with with the the identifiers identifiers of of standard standard terminologies terminologies ( standard ( standard codes ) codes ) CDR Patient: John Doe Lab Result: Encode Encode data data with with internal internal identifiers, identifiers, translate translate to to standard standard codes codes for for external external exchange exchange CDR Patient: John Doe HDD Mapping: 1234 Lab Result: LOINC CDR=Clinical Data Repository HDD=Healthcare Data Dictionary
19 Issue with Encoding Data Using Standard Codes Shift in Meaning of a Standard Code NDC NDC Before Before July July CDR Patient: John Doe Medication: Liposyn (Fat Emulsions), 10%, IV Solution, IV, Abbott Hospital, 200ml Bag After After July July CDR Patient: John Doe Medication: Paclitaxel (Paclitaxel, Semi- Synthetic), 6mg/ml, Vial, Injection, Abbott Hospital, 5ml Vial
20 The HDD Approach to Shift in Meaning of a Standard Code HDD HDD ID ID Before Before July July CDR Patient: John Doe Medication: Active NDC Liposyn (Fat Emulsions), 10%, IV Solution, IV, Abbott Hospital, 200ml Bag After After July July CDR Patient: John Doe Medication: Inactive NDC Liposyn (Fat Emulsions), 10%, IV Solution, IV, Abbott Hospital, 200ml Bag
21 Issue with Encoding Data Using Standard Codes Removal of Standard Codes CPT CPT 0002T 0002T Before Before December December 31, 31, CDR Patient: John Doe Procedure: 0002T Endovascular repair of infrarenal abdominal aortic aneurysm or dissection; aortouni-iliac or aortounifemoral prosthesis After After December December 31, 31, CDR Patient: John Doe Procedure: 0002T?
22 The HDD Approach to Removal of Standard Codes HDD HDD ID ID Before Before December December 31, 31, CDR Patient: John Doe Procedure: Active CPT Code: 0002T Endovascular repair of infrarenal abdominal aortic aneurysm or dissection; aortouni-iliac or aortounifemoral prosthesis After After December December 31, 31, CDR Patient: John Doe Procedure: Inactive CPT Code: 0002T Endovascular repair of infrarenal abdominal aortic aneurysm or dissection; aortouni-iliac or aortounifemoral prosthesis
23 Issue with Encoding Data Using Standard Codes Lack of Comprehensive Standard Codes LOINC LOINC April April December December Database Updates Database 6,500 lab results from the master data files of 7 U.S. labs Updates 2000: 2000: Feb, Feb, June June 2001: 2001: Jan, Jan, Jul Jul 2002: 2002: Jan, Jan, Feb, Feb, Aug, Aug, Sep Sep 2003: 2003: May, May, Oct Oct 28,000 lab results + 14,000 clinical observations
24 Issue with Encoding Data Using Standard Codes Lack of Comprehensive Standard Codes Many lab results will never receive a LOINC code reasons include: Reporting a panel of multiple results through a single result field An interpretive data field containing only theoretical information Lab observations used for internal system processes only, e.g. DNA Samples Attributes that are not compliant with LOINC definitions or rules, e.g., ABO Group, Serum or Plasma, Qualitative HDD Lab Results: ~44,000 At At least least 2,000 2,000 will will never never receive receive a a LOINC LOINC code code
25 The HDD Approach to Lack of Comprehensive Standard Codes Lab Results # of Unique Lab Results # of Unique Lab Results With LOINC Code Proportion of Unique Lab Results With LOINC Code HDD 43,664 27, % Used by U.S. DoD 21,171 9, % Used by Commercial Sites 13,400 6, %
26 Issue with Encoding Data Using Standard Codes Local Extensions Codes added at a health care facility to encode data when the appropriate, equivalent code is not yet found in the standard vocabulary - Many of these may never be added to standard vocabularies
27 Issue with Encoding Data Using Standard Codes Local Extensions An institution may still want additional concepts not provided by standard terminologies: The concepts are of different granularities Terminology A Terminology B Catholic Roman Catholic Catholic Non-Affiliated
28 Issue with Encoding Data Using Standard Codes Local Extensions Vocabulary Atoms (Post Coordination) Additional concepts not provided by standard terminologies: Concepts of different compositional/decompositional structure Vocabulary Molecule (Pre-Coordination) Composition Left Lower Eyelid Laceration Decomposition Left Lower Eyelid Laceration
29 Issue with Encoding Data Using Standard Codes Local Extensions The concepts are strictly local,, e.g. locally made drug compounds The concepts are redundant according to standard terminologies, but are needed to support softwares The concepts are not definable according to standard terminologies, but are needed to support workflows Dr. Dr. X s X s Magic Magic Mouthwash Mouthwash Pregnancy Pregnancy Test Test --Nursing Nursing Pregnancy Pregnancy Test Test -Lab -Lab Specimen Specimen #1 #1 Specimen Specimen #2 #2
30 Issue with Encoding Data Using Standard Codes Potential otential Loss of Historical Data Codes If the legacy data has been encoded with a different or non-standard terminology e.g. lab result: Serum Potassium Hospital A Hospital B Hospital C Hospital A Hospital B Hospital C Paper records or text printouts would be needed for past medical data, e.g., for a follow up visit
31 The HDD Approach to Local Extensions and Backward Compatibility A universal cross reference map accounting for all concepts and terms in the HDD The HDD manages ongoing updates from standard terminologies as well as local additions and changes from health care facilities Through mapping in the HDD, the enterprise s s data is now exchangeable and interoperable with the rest of the world via standard codes, e.g. LOINC Fort Sill Interface Code Camp LeJeune Interface Code DoD Short Name PT HDD ID LOINC Code DoD Long Name Protime
32 Additional Issues with Encoding Data Using Standard Codes Data transformation is needed if data is first stored as a temporary code until the standard code becomes available Additional effort of translation is needed if alternate or additional standards are requested for data communication The standard terminology (and version) needs to be identified and stored together with the code
33 The HDD Approach Incorporate and Map Multiple Terminologies No single medical vocabulary covers all operational needs Different standard terminologies are developed for different domain areas of health care e.g. LOINC for laboratory result names; RxNorm for clinical drugs Different standard terminologies are developed for different purposes in the same domain e.g. ICD9CM in the U.S. for reimbursement; SNOMED CT for clinical documentation
34 The HDD Approach Mapping for Backward Compatibility No single medical vocabulary covers all operational needs Different health care applications developed different data dictionaries Health care facilities have legacy terms in addition to, or instead of, standards: Proprietary terminologies from different commercial applications Self-developed vocabularies/applications Customization/modification of standards or application data dictionaries
35 The HDD Approach Offload Resource and Expertise Burden An institution may not wish to replace legacy systems An institution may not have the manpower or financial resources to convert the local/legacy terms to standard ones, and to maintain currency with reference terminologies (deal with updates)
36 The HDD Approach Adopt/Adapt/Develop Standard terminologies may be difficult for the user to understand, e.g. LOINC lab result name 2823 Standard terminologies may have errors or redundancies e.g. in SNOMED CT, there is aspirin as a substance and a different aspirin as a pharmaceutical/biologic product Standard terminologies may not exist or be in common use for a particular area, e.g. dosage frequencies Potassium:SCNC:PT:SER/PLAS:QN:
37 The HDD Approach Commit to using standard terminologies for data exchange The LOINC committee recommends that LOINC codes should be recorded as attributes of existing test/observation master files for use in the appropriate message segments to communicate among systems Mapping among standard and legacy terminologies for backward compatibility and transparency - minimal change to current operation
38 Clinical Vocabulary Mapping Methods Institute Saturday, October 15, 2005
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