Contents. Making Sense of Statistics 00 Getting Personal: Factors that Modify Your Risk 00 It s a Numbers Game 00
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1 Recto Runninghead v Contents Foreword by Mark H. Greene, M.D. 00 Acknowledgments 00 Introduction 00 Part I. Understanding Cancer, Genetics, and Risk Chapter 1. Breast and Ovarian Cancer Basics 3 Most Cancers Aren t Hereditary 00 An Introduction to Breast Cancer 00 An Introduction to Ovarian Cancer 00 Other Hereditary Cancers 00 Chapter 2. A Peek Inside: Your Genes at Work 00 The Evolution of Genetic Discovery: From Peas to BRCA 00 Your Genetic ABCs... and a D 00 Mutations: Spelling Errors in Your DNA Cookbook 00 How Mutations Lead to Cancer 00 What s So Special about BRCA? 00 Chapter 3. Defining Risk 00 Making Sense of Statistics 00 Getting Personal: Factors that Modify Your Risk 00 It s a Numbers Game Friedman first pages 000i-0xx.indd 5 9/8/11 3:56:57 PM
2 vi verso runninghead contents Chapter 4. Hereditary Cancer: What s Swimming in Your Gene Pool? 00 Hidden Risk in the Family Tree 00 HBOC and Other Hereditary Cancer Syndromes 00 Plotting Your Genetic Pedigree 00 Part Ii. Assessing Your Risk Chapter 5. Genetic Counseling 00 The Value of Counseling 00 What to Expect from the Process 00 Why You Need an Expert to Unravel Your Genetic History 00 Deciding Who Should Test First 00 Chapter 6. Genetic Testing: Facing Your Hereditary Horoscope 00 Which Test Is Right for You? 00 Testing: Powerful, Yet Imperfect 00 Issues for Survivors and Women in Treatment 00 Chapter 7. Decoding Your Test Results 00 Life, Interrupted: It s Positive 00 Good News! You re a True Negative 00 When No Might Mean Maybe 00 Genetic Variants 00 Now What? Implications for You and Your Family 00 Part Iii. Managing Your Risk: Your DNA Doesn t Have to Be Your Destiny Chapter 8. Early Detection Strategies 00 High-Risk Surveillance for Breast Cancer 00 High-Risk Surveillance for Ovarian Cancer 00 Is It Cancer? 00 Screening for Other Hereditary Cancers Friedman first pages 000i-0xx.indd 6 9/8/11 3:56:57 PM
3 Recto Contents Runninghead vii Chapter 9. Chemoprevention 00 Risk-Reducing Medications for Breast Cancer 00 Alternatives under Study 00 Chemoprevention for Ovarian Cancer 00 Chapter 10. Mastectomy for Risk Reduction and Treatment 00 Reducing Cancer Risk by Removing the Breasts 00 Skin-Sparing Procedures 00 Treating Breast Cancer with Mastectomy 00 Who Should Perform Your Surgery? 00 Risks and Recovery 00 Chapter 11. Reconstruction: New Breasts after Mastectomy 00 Delaying Reconstruction to Complete Breast Cancer Treatment 00 Living with a Flat Chest 00 Saline and Silicone Implants 00 Options for Using Your Own Tissue 00 Optional Last Steps: Adding Nipples and Areolas 00 Great Expectations: Surgery and Recovery 00 Choosing the Right Surgeon 00 Chapter 12. Oophorectomy and Other Risk-Reducing Gynecologic Surgeries 00 Oophorectomy Procedures 00 Should You Have a Hysterectomy Too? 00 Oophorectomy, Mastectomy: Either, Neither, or Both? 00 Issues for Breast Cancer Survivors 00 Chapter 13. Dealing with Menopause and Quality-of-Life Issues 00 Symptoms of Surgical Menopause 00 Long-Term Side Effects 00 Should You Take Hormones? 00 Issues for Breast Cancer Survivors Friedman first pages 000i-0xx.indd 7 9/8/11 3:56:57 PM
4 viii verso runninghead contents Part Iv. Living with BRCA: Issues and Answers Chapter 14. Managing Lifestyle Choices 00 The Three-Legged Stool: Nutrition, Weight, and Physical Activity 00 Alcohol: An Unwise Choice 00 Other Lifestyle Risk Factors 00 Chapter 15. Sharing Information with Friends, Family, and Coworkers 00 Sharing Risk and Genetic Testing Information with Family 00 Issues for Spouses, Partners, and People You Date 00 What Should You Tell Employers and Coworkers? 00 Chapter 16. Young and at High Risk 00 Should You Consider Testing Now? 00 Diagnostic Difficulties 00 Dealing with a Diagnosis before Menopause 00 Planning Your Family, Preserving Your Fertility 00 Oophorectomy in Young Women 00 Sorting through Emotions 00 Chapter 17. How BRCA Affects Men 00 Men Get Breast Cancer Too 00 High Risk for Prostate Cancer 00 Other BRCA-Related Cancers 00 Chapter 18. Diagnosis: Hereditary Cancer 00 How Important Is a Second Opinion? 00 Treating Hereditary Cancers 00 Making Breast Cancer Treatment Decisions 00 Ovarian Cancer Issues 00 The Importance of Clinical Trials Friedman first pages 000i-0xx.indd 8 9/8/11 3:56:58 PM
5 Contents Recto Runninghead ix Chapter 19. Putting the Pieces Together to Make Difficult Decisions 00 Start at the Beginning: Should You Be Tested? 00 Making Decisions to Reduce Your Risk 00 Making Decisions about Treatment 00 From Confused to Clear in Fifteen Steps 00 Notes 00 Index Friedman first pages 000i-0xx.indd 9 9/8/11 3:56:58 PM
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