MILESTONE. MacroPATH pro-x Digital Imaging System for the grossing room. Operator Manual MM113

Transcription

1 MILESTONE H E L P I N G P A T I E N T S MacroPATH pro-x Digital Imaging System for the grossing room Operator Manual MM113

2

3 Thank you for having selected our system and welcome to the ever growing world club of users for Milestone laboratory instrumentation. We are sure that you will be completely satisfied with this new tool entering your laboratory. We invite you to read carefully this operator manual and to keep it in reach for convenient and fast consulting. For any possible clarification or any request for assistance please contact either our Representative in your country: Or contact Milestone s.r.l. Via Fatebenefratelli, 1/ Sorisole (BG) Italy Tel Fax web site Please read the user manual before using the device. MM MacroPATH pro-x Operator Manual

4 SUMMARY SUMMARY INTRODUCTION Symbols used Introduction to MacroPATH pro-x Technical Specifications Transport and storage conditions Warning explanation Antivirus Backup MacroPATH pro-x data (IMAGES CASES) Milestone Remote Connection Marking plates for MacroPATH pro-x INSTALLATION Unpacking check list MacroPATH pro-x PC panel connections overview MacroPATH pro-x installation Camera connections Panel connections Camera Lens Setup Camera orientation OPERATING MacroPATH pro-x Start the MacroPATH Log in and Log out How to operate Create a case Enable led light Edit a case Overview of the functions Keyboard hot keys Multifunctional buttons Foot pedal FILE functions LIVE functions Create/retrieve Save Image/Video/Audio Thumbnails Extra camera settings Camera Tab AWB Tab (auto white balance) Areas Camera firmware version EDIT functions Tools Utility display Utility functions SETTINGS General settings User settings Licensing settings Storage settings Camera settings Calibration Third party settings Localization settings Appearance settings Tools settings Preferences settings MacroPATH pro-x AS A MULTISTATION VIEWER How to install the MacroPATH pro-x as viewer

5 4.2. Settings for MacroPATH pro-x Viewer PC Integration of MacroPATH pro-x with LIMS systems How MacroPATH saves the images Taking image Where and how the images are saved: Interface command between LIMS and MacroPATH pro-x MAINTENANCE Cleaning of MacroPATH pro-x Pc Panel and camera Keyboard Foot pedal ACCESSORIES (Optional) Table top camera holder (PN ) Pro-x Camera holder for hood type grossing station (PN ) C bracket for MacroPATH pro-x (PN V) Floor type terminal holder Macrostand WA (REF ) USB Barcode reader (PN ) D USB Barcode reader (PN ) Water proof keyboard and mouse (PN ) TROUBLESHOOTING THE MacroPATH pro-x Camera does not work Foot pedal control does not work Touch screen calibration Return for repair to Manufacturer WASTE DISPOSAL OF MacroPATH pro-x UNIT

6 1. INTRODUCTION 1.1. Symbols used An instruction accompanied by this symbol provides important and requires more attention. An instruction accompanied by this symbol provides a cautionary statement: failure to follow the instruction may endanger the operator or cause damage to the instrument. An instruction accompanied by this symbol provides a caution against electric shock. Be sure to follow the instruction to prevent accidents resulting from electric shock. Biohazard: be careful when you execute the procedure marked with this symbol: danger of biohazard contamination. CE logo: this instrument complies to European Community directives. IVD medical device according to 98/79/EC directive. WEEE European directive symbol (2002/96/EC): Electric/electronic device do not throw out in the environment. Manufacturer Introduction to MacroPATH pro-x MacroPATH pro-x has been designed to carry out complete, safe and reliable image handling of gross histological samples. The system has been conceived for laboratory use and can therefore withstand the harshest laboratory conditions; equipment is intended for laboratory use (indoor use only). Because the MacroPATH pro-x auto-sizing tool is strictly related to the calibration done by the operator and is not controlled by the software of the unit, sample measurements obtained with MacroPATH pro-x are NOT TO BE CONSIDERED AS DIAGNOSTIC values. It is in fact necessary to position a ruler by the sample (see picture below) or to use a caliper to get a diagnostic value of the tumor growth, lesion extension etc It is necessary to calibrate the system (see chapter for calibration procedure) when making a measurement with MacroPATH pro-x. 6

7 1.3. Technical Specifications Hardware (PC PANEL): CPU Intel Core 2 Duo Processor 2.16 GHz RAM: 4 GB Hard disk: 500GB (24 7) CD-Rom: DVD-RW Screen: 17" TFT LCD 1280X M Colors Frontal panel protection: IP 65 (ONLY FRONTAL PANEL), IPX1 complete enclosure I/O ports: 4x Serial ports 2x Gigabit Ethernet LAN ports (RJ-45) 8x USB 2.0 ports, 1x IEEE1394b ports, 1x PS/2 mouse and keyboard interface, 1x DVI-I VGA port 2x SATA port (internal) Mic-in, Line-in, 2x 1W speakers built-in, Dimensions: 437 x 377 x 131 mm (17.20" x 14.84" x 5.15") Power Supply: Input rating: V~ 50/60Hz, 5 3A Camera pro-x: Camera resolution: up to 16Megapixel Focus: Automatic White balancing: Automatic Zoom magnification: 10x optical (Provided with set of three lenses at different close-up) Weight 2.9kg+250g the power supply (6.39Ibs+0.55lbs) Power Supply: Input rating: V~ 50/60Hz, 0.7A Including: Camera holder for photographic stand Software Operating system: MacroPATH 5 software: Installed (complete with license) Capability to manage up to five (5) cameras (same type). Windows 7 Ultimate 32bit Language default English (with MUI) Microsoft Windows 7 and Microsoft Word are Trade Marks of Microsoft Corporation The manufacturer reserves the right to change and/or improve specifications without notice and without incurring in any obligation. Environmental conditions: Operating temperature: Relativity humidity 15 C 30 C from 10% to approx 80%, non-condensation 1.4. Transport and storage conditions Temperature: 20 C to +60 C Humidity: 10 to approx C non-condensation 7

8 1.5. Warning explanation Use of the equipment in ways different than those specified may void the warranty provided by the manufacturer. Do not open the camera box. Infringement voids the warranty. The panel PC shall be connected only to 3-pole earthed main socket outlet (Protective earth must be provided). This note is not valid for the camera power supply. Main plugs are considered as disconnecting device. Disconnect both main plugs from the socket outlet before assembly of the system, before connection of the accessories and before cleaning. Equipment shall be connected to main sockets outlets which is accessible and visible by the operator. Equipment is not provided with replaceable fuses. If the system is still not properly working, please contact your local representative or the manufacturer (always provide the serial number of the unit, see label on the back of the PC panel unit). All parts of the equipment and all accessories shall be supplied only by the manufacturer. In case of malfunction, please shutdown the PC Panel, then restart them again. If the system is still not properly working, please contact local representative or the manufacturer. In case of removal of equipment for repair: 1) Switch the panel PC OFF. Disconnect the main plug of the panel PC from the main socket outlets 2) Disconnect the main plug of the camera power supply from the main socket outlet. 3) Disconnect all accessories (foot pedal, keyboard, bar-code reader, camera). 4) Clean and disinfect all parts of the equipment according to paragraph ) Put all parts of the equipment into the package supplied by the manufacturer (original package). 6) Send device to the manufacturer for repair. It is very important to switch the PC OFF before disconnecting the MacroPATH pro-x Camera and then disconnecting the camera USB/LAN connection and cable in order not to damage the Camera interface board. Besides the CDs of the MacroPATH pro-x software, Milestone will also provide for each unit genuine Microsoft Windows 7 CDs. We strongly recommend that each user makes sure that the original CDs provided with each unit are kept in a safe place, as Milestone is not in a position to supply other CDs or copy of them. The License serial number is on the backside of the PC Panel and reported in the QC Report of the unit Antivirus Milestone suggests to install an antivirus software. Milestone does not install antivirus software so that you can choose your preferred version, according to your needs. Pay attention when setting the Antivirus so that data flow on the USB/LAN protocols and accesses to the Hard Disk are not limited. 8

9 1.7. Backup MacroPATH pro-x data (IMAGES CASES) Milestone strongly suggests storing all cases with relative images on a server with an automated backup procedure. Contact your local Network/IT Manager. The dimension of the images with the suggested settings is around 1.2Mb/image (see Chapter 3.6.4). The unit is provided with a DVD burner to be used for back up of the cases folder using the provided tools. Do not run any burning program during the LIVE mode of MacroPATH pro-x application Milestone Remote Connection MacroPATH pro-x software is provided with Milestone Remote Connection that allows our Customer Support to manage the unit remotely. To be able to obtain support from Milestone, connect the PC to Internet, then contact customer support at customersupport@milestonemedsrl.com and communicate these data: - Serial number of the unit - version of the remote connection software - ID - Password The connection can be established only if the GREEN icon appears: 1.9. Marking plates for MacroPATH pro-x Marking plate of the Panel PC: Marking plate of the camera: For the explanations of the symbols, please refer to the chapter

10 2. INSTALLATION 2.1. Unpacking check list MacroPATH pro-x Installation and preliminary operations are illustrated in this section. Please carefully read the following chapters before operating the MacroPATH pro-x. When unpacking, verify that all parts correspond your product order. MACRO DIGITAL IMAGING SYSTEM REF includes: Description A) POINT-OF-CARE CONTROL TERMINAL (PC Panel) + Pointer Pen B) Camera Pro-x + Set of three lens C) Foot Pedal Control D) CD Software with Product Key E) Table stand microphone F) Sizing Ruler PN A B C E D F For accessories (optional) see Chapter 6. The images shown are only an example. 10

11 2.2. PC panel connections overview D B A C D Description: A. Power cable connection B. PC-Panel power switch C. LAN connections USB Camera connection to the Panel PC USB Foot pedal connection for remote control of Zoom-in/out and save (connect to the BROWN marked) USB available for keyboard and barcode reader DVI-I VGA for external video connection D USB ports Microphone ( MIC-IN connector) and audio line out ( SPEAKER OUT connector) connections MIC-IN 11

12 2.3. MacroPATH pro-x installation The installation of MacroPATH pro-x is a simple process, only taking a few minutes. Make sure that the power is not connected when installing the cables Camera connections Connect the USB extender to the USB port of the PC (picture number 1). Connect the USB converter to the camera pro-x using a Ethernet cable (picture number 2). This is not a standard lan connection. Never connect to the net facility network. 1 2 The camera Pro-x is a USB device of the PC. For that if you have a USB device (for example a USB key) connected to the PC and you want to disconnect it, pay attention to do not disconnect the camera from the PC. If this happens, follow the procedure reported in the chapter 7.1. Insert the proper (115V or 230V) power supply cord in the connector of the camera s power supplier. 12

13 Connect the camera s power supplier to the 12-24V DC camera connector, as shown in the picture below. Then connect the power supply cord to the power. When all connections are done, the led shown in the photo below positioned on the back of the camera lights up Panel connections Connect the power supply cable to the PC panel and then to the socket. Connect the USB foot pedal to the USB port marked with BROWN. Connect the keyboard USB connector (if present) to a USB port. Connect the bar code reader USB connector (if present) to a USB port. Connect microphone to the MIC-IN connector. 13

14 Check that microphone audio switch is ON before using it. All the connections are now set-up Camera Lens Setup MacroPATH pro-x camera kit is supplied with three different lenses: +1 (default), +2 and +4 (close up) having a diameter of 77mm. By using the three lenses, it is possible to modify the maximum and minimum fields of view. To install a lens, simply screw it onto the threaded end of the camera shroud Three different lenses +1, +2 and +4 along with their safety box. By default the lens +1 is mounted on the camera; at the installation time it is possible to change it if required, depending on the information reported in the table below. 14

15 GUIDE FOR DETERMINING THE DISTANCE OF THE CAMERA PRO-X FROM THE SPECIMEN AND TYPE OF LENS USED Lens Functional Distance Minimum Maximum Neutral (none) 72cm More than 3m +1 44cm 102cm +2 31cm 50cm +2 and +1 24cm 35cm +4 19cm 25cm We suggest installing the objective of the camera at about 65cm (25.6inch) from the working surface using a +1 lens. The automatic autofocus capability of the camera depends on environmental conditions. The values reported above are experimental results obtained from Milestone tests captured at 100% of zoom level Camera orientation On the back of the camera there are 2 levers, to adjust the position of the camera. If you open the levers, the camera tilts up and down; when you find the best orientation, fix its position by closing the 2 levers. If you loose the two white knobs, the camera turns on the right or on the left; when you find the best orientation, fix its position tight the 2 knobs. On the back of the camera there is a support for photographic stands, as shown in the square below. 15

16 3. OPERATING MacroPATH pro-x Working with MacroPATH pro-x is a very easy and friendly operation. All functions are described in the following paragraphs Start the MacroPATH Never start the PC if the camera is not connected. Start the MacroPATH pro-x PC Panel by pressing to I on the switch on the back. Let Windows starts up and wait almost 30 seconds. Then double click on the MacroPATH Pro icon on the desktop. Pro It is required to wait almost 30seconds before starting the software; this is a time necessary to the PC to see the camera. 16

17 3.2. Log in and Log out As a default, when the MacroPATH software is switched on, user is logged in as Administrator. To unable the Login function it is necessary to uncheck the auto log-in field (see chapter 3.8.2). You need to be logged in as Administrator to use the main functions. Administrator is allowed to create new users (see chapter 3.8.2). Service Log-in is available for authorized personnel only How to operate Create a case Insert the case name/number into the case number field with keyboard or bar code reader. The case identifier is constrained to a maximum of 40 characters. Special characters such as - or _ can be used for data separation. Go to LIVE selecting Live icon on the right top of the screen. Acquire images, video and audio by using the icons at the left side of the screen or the foot pedal. (See chapter). 17

18 Enable led light It is possible to illuminate the cutting board by led light by pressing the button on the back of the camera, as shown below. The leds are indicated by the arrows in figure below. If you switch off the PC, the light will continue. If you want to switch off it, you need to press again the button Edit a case Double click on a thumbnail or select EDIT icon on the right top of the screen to enter EDIT mode. Edit the images using the tools in this area (see 3.7 chapter). 18

19 3.4. Overview of the functions MacroPATH pro-x functions are grouped in 4 areas: FILE, LIVE, EDIT and SETTINGS. AREA FILE LIVE EDIT SETTINGS FUNCTIONS Browse, delete, tag and present the existing cases Save image, video and audio files Modify acquired images Modify settings of the FILE, LIVE and EDIT The following screen is available only for MacroPATH pro-x complete software (but not for the Viewer). A B E C G D F H I L M A STATUS ICON Shows the status of the software. B LOG IN Shows the current user and allows user to log out by pressing it. C EXIT To exit from MacroPATH pro-x application and go back to the computer operating system. D CASE NAME Shows the name of the current case. E LIVE Allows returning to live camera image of specimen (disabled as default, value set to 0 seconds). F IMAGES, VIDEOS, To filter the thumbnails. AUDIO FILTERS G CAM BUTTON To turn the cam on/off by pressing it and open the camera settings (by holding down the button). H MAIN SCREEN Area in which specimen image is observed during live and then saved. I ZOOM and STATUS BAR By mouse or touching of the button (from 0% to 100% in 7 steps), to zoom in/out as required. This function can also be done with foot pedal control for no-hands operation. L CASE NR. Requires bar code entry or manual entry by operator to create or retrieve a patient session. M ENTER Required in case of operator manual entry of the case name/number. 19

20 Keyboard hot keys Some functions can also be accessed by pressing on the keyboard (see table below): Availablity Press and maintain pressed Hot key Function 1: File 2: Live Always available 3: edit 4: Settings 5: Exit 6: Logout Q: Show case W: Reset search FILE CTRL left + ALT left + E: Print case R: Present case T: Tag case A: Snapshot S: Rec Video LIVE D: Rec Audio F: Autofocus G: Zoom + H: Zoom Q: Select W: Sizing line E: Sizing area R: Sizing free T: Line Y: Circle U: Square I: Arrow O: Compass P: Freehand A: Text S: Sections (1) EDIT mode only Ctrl Left + Left Alt + D: Sections (A) Left Shift + F: Sections (A-1) G: Sections (1-A) H: Quadrant J: Multisection K: Zoom region L: Zoom IN Z: Zoom OUT X: Zoom FIT C: Undo V: Redo B: Print N: Rec Audio M: Save 20

21 Multifunctional buttons There are multifunctional buttons marked with a red triangle on the bottom-right corner of the icon, as shown in the example below. To choose the main function, just press the button-icon. To view multiple functions, press and hold a tool icon for at least 3 seconds. A secondary menu will appear. Salect from the additional choices. Multifunctional buttons: Camera management Measuring tool Line tool Text tool Section marking tool Quadrant Cassette footprint tool Magnification tool (cut area and create new image) 21

22 Foot pedal Foot pedal controls: Zoom in control 2 Zoom out control 3 Save control: allows to acquire images (snapshot) and to save modified images 4 Back to live: allows to go back to LIVE 5 Audio rec: allows to record an audio file in LIVE and or in EDIT 3.5. FILE functions In FILE it is possible to: 1. browse/search or hide on existing case using the relative icon 2. find cases by using the search function 3. delete 4. present 5. print 6. tag cases A case can be retrieved by inserting either the name, creation/last edited date, creator/last editor or tag, and then pressing filter button. 22

23 Reset Search: press this icon to undo all previous modifications and see the case list. Print case: press this icon for a complete or partial printout of the case. Select the template and then the picture to print. 23

24 Present case: press this icon and the whole case (images, video and audio) is displayed Tag case: Press this button to insert a tag in a case. It is possible to tag a case also by the live screen. When a case is opened and you are in live screen, you can add a tag of the current case by pressing the icon Add tag, as shown in the image below. 24

25 Delete case: press this icon to delete a case. Double confirmation is requested to avoid errors. Yes Yes 25

26 3.6. LIVE functions In LIVE it is possible to create/retrieve a case, acquire images, take a video and modify extra camera settings. When the camera has not been used for about 6 hours, it turns off automatically to preserve its life, as explained below. At this time, the procedure of camera wake up starts: the live screen is stopped and the following message appears. The maximum time is 90 seconds, during this period do not press any button, just wait. Then it is possible to use again the camera. During the normal use of the camera, sometimes a fast buffering is automatically executed to extend its life. In this case the following message appears, for a maximum of 20 seconds. During this time do not touch any button. Then it is possible to use again the camera. In particular this procedure may be applied also when the camera is switched off by pressing its icon and then switched on and when entering in edit mode. In these cases the message Buffering showed above may appear for a few seconds, do not touch any button and wait. To extend the life of the camera, by default under Settings screen (see the chapter ), it is set a standby of the camera after 1hour. So when Macropath will not be used for 1hour, the camera turns off and the live screen becomes black. If you want to switch on the camera, press its icon, as shown below. When the camera is switched on, the message Buffering showed above may appear for a few seconds. If you want to unable the standy of the camera, please contact our service department at customersupport@milestonemedsrl.com. 26

27 Create/retrieve Enter case identifier by barcode reader or manually with keyboard to create or retrieve a patient file. When using manual entry, press the return key Save Image/Video/Audio Save an image of the specimen by zooming in/out with the foot pedal control until the desired area of interest is viewed, then press Snapshot button on CPU screen or Save on foot pedal. When you press Save, if the image is not taken ( Image not taken ), please retry again. Import an image from a TWAIN camera (for example a microscope camera): press the TWAIN icon and select the TWAIN source Use the TWAIN camera software to acquire the image (the software is provided by the twain camera supplier). 27

28 To activate the TWAIN function please refer to chapter Check that microphone audio switch is ON before using it. See below. The image of the microphone shown is only an example. Take video by pressing Rec Video button. Press again to stop recording Before taking a video for the first time, when you press the icon Rec video you will be required to choose the correct video Codec. Milestone suggests to use Microsoft video 1 compression. Go to settings screen to change compression type in the settings screen (see chapter ). Press Rec Audio button to record. Press again to stop the recording. 28

29 Thumbnails Saved images, videos and audio appear on the right of the screen (Thumbnails) Extra camera settings Keep pressed the camera icon to open the Camera extra settings window. 29

30 Camera Tab Select Camera to open the page, as shown below. Skip focus before snapshot: enable this option to maintain the showed focus. It allows a faster image acquisition. Snapshot quality: allows to set the acquisition quality. Follow also the chapter settings to decide the best compression quality for images. To set the image quality taken it is required to set properly two parameters as follows: 1. Compression Quality: the amount of compression applied to the image file (see chapter 3.8.4). 2. Snapshot quality: the dimension of the image. From these two parameters depends the size of the image file. The table below lists all possible combinations. Milestone suggests setting cameras to get Snapshot quality 16 Mpx and Compression Quality Standard (see chapter 3.8.4). As this is a good compromise between file size (disk consumption space) and quality of the image to report. Should images be used for publications (articles, papers etc), Milestone suggests to choose quality 16 Mpx and Full Data compression. Compression Quality Standard Full Low Snapshot Quality File dimension 16 Mpx 1.2Mb 7.2Mb 719kb 8 Mpx 516kb 3.6Mb 363kb 3Mpx 204kb 1,4Mb 133kb Note that the space required for each image is the double that which is reported on the table above. In fact, the system automatically saves each image in both JPEG and m5p formats. The changes will be saved in the configuration in use (see chapter 3.8.5) AWB Tab (auto white balance) Select AWB as shown below. White Balance: (Light Source Selection) During the installation it is NOT necessary to perform the white balance camera setting. The digital camera will auto-balance the white according to the light conditions where the MacroPATH PRO-X has been positioned. Therefore user has to select the type of light source in the laboratory among the options reported in the list showed in the image below, in order to perform the best color contrast. 30

31 By default Auto is selected and it is suitable when you are not aware of the type of light source of the grossing room. These modifications take place when the user press yes to the message that asks to confirm the saving of the modifications, and it is not necessary to restart the software. If several cams are present, start each one and modify settings for each cam. The changes will be saved in the configuration in use (see chapter 3.8.1) Areas Select Areas as shown below. By default, the camera applies a focus in the center of the screen; it is done automatically and it is suggested to use it. Anyway if you want to resize the focus area applied into the center, you can check Enable Focus area showed above. If enabled, the Focus area will use the values showed under Focus area that are: 500 as width and 400 as height. It is possible to modify these fields, if required. If you want also to visualize the focus area into the live screen, select also Show Focus Area (a green square will show the focus area before to get the snapshot). As explained above, the Area Focus is automatically centered in the middle of the screen. However it is possible to click on any point of the live window: the area will be automatically re-centered on the selected point and it will be resized to fit to the values indicated under Area Focus Click, showed in figure above. For 31

32 example below the green Area Focus is shown and it is centered on the lower right part of the screen, after a click in that zone. This function can be very useful: in case of big organs with different high levels of field: just select different parts of the live screen to get accurate focus and brightness of the area of interest, when a high level of zoom is used Camera firmware version In this section is shown the camera Firmware version. 32

33 3.7. EDIT functions Single click on the desired picture, video or audio, or click on the EDIT button to enter the Annotation mode. In the Annotation mode, it is possible to add text, measurements, graphic elements and sections to the picture, examine the tissue, record audio or directly print out. Select: click the SELECT button to use the mouse as a pointer, or to select every item to be modified. Once selected the graph annotating draw (follows as item ) it is possible to move the item, or to modify the color line of the item, color background of the item, color text and text size of the item with the Multifunction Keypad. Section letter Section number Text and line color Background color Line thickness Text size Annotation rotation Labels enable/disable Tools Sizing Click and keep the Sizing icon pressed with the mouse or the touch pen. The toolbar circled in red appears. Click on Sizing line icon to draw linear measurement; the system calculates the length of the line. Click on Sizing area icon to draw an area on the specimen; the system calculates the area taken. Click on Sizing free icon to draw freehand lines; the system calculates the length of the line. 33

34 Software needs to be calibrated when unit is installed and every time camera height changes. See chapter for calibration procedures. Because MacroPATH pro-x auto-sizing tool is strictly related to the calibration done by the operator and is not controlled by the software of the unit, sample measurements obtained with MacroPATH pro-x are NOT TO BE CONSIDERED AS DIAGNOSTIC values. It is in fact necessary to position a ruler by the sample (see picture below) to use a caliper to get a diagnostic value of the tumor growth, lesion extension etc Draw Lines Click onto the Lines icon with the mouse or the touch pen. Point and drag the desired line on the picture. Keep holding the button to activate the multiple choice of Lines, Circles, Squares, Arrows, Compass, and freehand drawing tool. 34

35 Add Texts The addition of text can be made by selecting the AbcText icon, then pointing and dragging until the desired text box appears: release and enter desired text by the keyboard or bar code. PRESET CUSTOM TEXT: (see also chapter to see how add preset texts) Once the list has been customized, click on the AbcText icon and keep it pressed until the list is displayed: chose the text required to enter it. Add Sections Click onto the Section icon with the mouse or the touch pen. Point and drag the desired line on the picture Keep holding the button thus activating the multiple choice of labeling styles (either A, 1, A-1 or 1-A). Modify the sequence of the letters and numbers by clicking with the pointer on the section line and then the relatives button on the multifunctional keypad. See the arrow to adjust the sequence of letters and numbers (see Multifunction keypad description in this chapter). Add multisections Click onto the Multi Section icon to display the available tool options (4 or 6 quadrants). Choose a point on the screen and drag the desired sections onto the picture. By press the section button line with the SELECT function, it is possible to deactivate labels and rotate sections. See Edit functions (3.7) Select tool. 35

36 Add footprint of cassettes Click and hold the Cassette Footprint icon to display the available tool options (Standard cassette or Super Mega cassette). Choose a point on the screen and drag the desired sections on the picture. Rotate the Cassettes Footprint using the Multifunction Keypad on the lower left corner of the work area. See Edit functions (3.7) Select tool. Zoom region Click onto the ZOOM icon with the mouse or the touch pen. Point and drag the desired zoom region on the picture: the software automatically creates a new cropped image Keep holding the button thus activating the multiple choice of section styles (zoom in, zoom out and zoom fit). 36

37 Grid Click onto the GRID icon with the mouse or the touch pen to add a grid. In SETTINGS screen it is possible to modify color, thickness and spacing of lines. Camera calibration will have to take place prior to use of the Grid tool. See section Utility display Image, audio and video Library User can easily view case assets in the library by using the following controls. 1. Scroll arrows (up/down) at the top and bottom of the library allow for movement through the case. 2. Images/Audio/Video tabs at the top of the library allow for the filtering of individual file types. (Example: having only the Images tab highlighted causes only the still captured images to be displayed in the library) 37

38 Play the Video Select a video thumbnail on the right of the screen and click on it. Video will automatically start once selected. The Viewer screen appears and the video starts. At the end it is necessary to close the window to go back to the main screen. Play the Audio Click and audio thumbnail in the library to listen: it automatically starts once selected. No windows appear Utility functions Undo & Redo Remove the last edit on the image: press the Undo button and the last entry on the screen disappears (cancellation is done from the last to the first edit). Press Redo button to restore a removed edit. Undo/Redo functions are not operational in case of images with edits already saved. Delete The Delete function allows for the removal of case assets in multiple ways. A deleted image cannot retrieved later. 1. Choose an image, audio or video thumbnail from the Library and press the Delete icon. 2. Selecting and holding down the Delete icon will display and window containing all case assets. You will be able to select multiple files for removal. 38

39 Rec Audio Select the image to be added with an audio to comment. Take an audio file by pressing Rec Audio button and press again to stop the recording The saved audio icon appears on the right of the screen under the related image. Save image When all necessary edits have been made, click or touch on Save icon, as indicated, to save them. Images can also be saved by foot pedal by pressing the Save command. If Exit to Live icon is pressed and edits have not been saved, the system warns if you wish to save them 39

40 3.8. SETTINGS Access and modification of settings is possible according to users access level (see chapter 3.8.2). Press SAVE and it restart the software to enable the changes Click on the Settings icon, MacroPATH Settings appears General settings Click on General tab and follow the instruction how to do a backup of application settings, user settings or full backup are displayed follow them. We recommend to export the backup file to another PC or hard disk User settings Click on the User to create, modify or eliminate a user and/or change users rights. Enable or disable a right by checking or un-checking the related checkbox. At the end press SAVE USER and SAVE. 40

41 Users rights table: Can create new cases Can delete cases Can browse cases Can add elements Can edit elements Can delete elements Autologin Can edit General Can edit Users Can edit app settings Can calibrate Can edit user settings Possibility to create a new case Possibility to delete a whole case Possibility to operate with Show cases icon Possibility to acquire new images, audio or video Possibility to operate in Edit mode Possibility to delete images Possibility to skip the log screen Possibility to operate under General setting; for example full backup function. See the paragraph Possibility to operate in Settings/user screen Possibility to modify settings collected in blue tabs, about storage folders, licensing, camera preferences (calibration) and connections with third programs (see following paragraphs) Possibility to calibrate images Possibility to modify settings collected in green tabs, about languages, display options and general users settings (see following paragraphs) It s possible to set default settings collected under green tabs, as Localization, Appearance, Tool and Preferences, for all existing users by clicking Set for all existing users under the paragraph General Licensing settings DO NOT PERFORM THE PROCEDURE WITHOUT THE SUPPORT NEITHER CHANGE ANY DATA. Click on Licensing button to manage the licensing file or to verify your licensing status. 41

42 To obtain (in case after a problem, you wish to receive a new license file): Insert the Product Key printed on the MacroPATH CD (see the arrow in the previous picture) Press Regenerate (indicated by the circle in the figure above), Press Copy to Clipboard button, to copy the Machine ID (indicated by the circle in the figure above), Paste in a text file or directly in the message, Describe the reason why it is necessary to have a new license, Send to customersupport@milestonemedsrl.com, On receipt the reply mail save the file you received from Milestone customer support, Press Import file (indicated by the circle in left figure below) and select the.lic5 file saved, Press Save button of settings screen (indicated by the arrow below). Restart MACROPATH and verify in Settings that the license level is Unlimited, as shown below. MacroPATH unit is provided with a full License file already installed. 42

43 Storage settings Click on Storage button to either change or add new the storage folders (up to 3). The system automatically saves cases in each selected folder. In order to perform an adequate and proper installation, in particular in case of multistation (more than one MacroPATH unit installed), it is strongly required that the units store the data on to a share folder stored on a server. To correctly perform the installation, as the software allows to store the data to more than one path, the 1st path has to be the shared folder present on the server. The shared folder has to be set with FULL CONTROL for each account and for each PC running the MacroPATH software. So the 2nd path should be the local folder (present on the internal hard disk drive of the PC-panel), then we can suggest the path, for Microsoft Windows 7: C:\Users\Public\Documents\Milestone srl\macropath5\images As shown in the image below (that shows an example for the 1st path): \\SERVER\Pathological Anatomy\Laboratory\MacroPath\IMAGES In the local folder will storage ONLY the cases created and opened by the local MacroPATH that you are using. The shared folder on the server will collect ALL the cases created and managed by all the stations/units. Sql Server icon not enabled. Data compression: it is possible to set three different compression qualities: Full Quality, Standard and Low file size. Refer to chapter to set the best compression according with the snapshot quality. High definition: if selected, a filter is applied on the image to have more constrast. By default it is not checked. When used, more seconds are required to make a picture. This function is not needed for camera pro-x (developed for previus models of camera). 43

44 Enabled shared folder management: The shared folder management is useful when more MacroPATH stations are working on the same cases. In fact, with this function activated, when a case is opened by a station and another MacroPATH tries to open it, a warning message appears, communicating that the case is already opened by another system and displaying its IP address and when the case has been opened. Below an example. Before using this function, please contact our Service Department at: customersupport@milestonemedsrl.com Camera settings Click on Camera button to modify camera settings. Select Cam1 or more such as Cam2, Cam3, Cam4 and Cam5 depending of number of cameras present. Click on Camera short name field to modify the name of the camera. Select: Trust external calibration: MacroPATH pro-x keeps the calibration factor from previous case Force calibration so that MacroPATH pro-x requires to calibrate every image (useful if camera is moved before capturing the image). Auto measure function not available. Vertical Flip Image: vertical mirroring. Horizontal Flip: horizontal mirroring Priority: in case of two or more cameras connected to MacroPATH pro-x, choose the selection sequence. Zoom mode: choose either Extended mode (default and recommended: 100% optical zoom) or standard mode (reduced optical zoom for optimal focus in special cases). 44

45 Foot Pedal: enable foot pedal (if connected) by choosing the serial number in the list shown. Keypad: not enabled Calibration Procedure: by pressing this button it is possible to calibrate the Unit, as explained in the following chapter Calibration Click the Calibration Procedure button and position the ruler on the work surface. Press Focus if the image is not well focused and press Go. Insert the distance (in mm) between the two edges of the image (see picture) Repeat the operation for different zoom levels (7 times). At the end press Save. The calibration procedure is required whenever the position of the camera or the type of the lens are changed. Each camera has its calibration, then each camera must be calibrated independently of each other Third party settings It is possible to create a shortcut icon to recall an external software (up to 3 different external applications, not included): Select the External application checkbox, as show below. In the image is reported an example to recall Notepad. To do that it is required to fill the fields under External application1: - Application : it is the address, in this case C:\Windows\System32\notepad.exe - Process : it is the name of the application, in this case Notepad - Image : it represents the image of the icon that will be visualized to open the application, it is required to browse an image.png, - Label: in this case Notepad. 45

46 By clicking Shutdown MacroPATH after launch, at the starting of the external application, MacroPATH prox closes down. By clicking Disable MacroPATH after launch option, at the starting of the external application, MacroPATH pro-x is disabled. When Disable MacroPATH after launch box is selected, a dedicated program (not included, to be provided by the customer/final user) must also be installed to enable user to return to MacroPATH. On the contrary, return to MacroPATH is not possible and user will have to restart the application MacroPATH trough the red cross CLOSE of windows system. DO NOT thick if not sure. Customization of the Exit button is also possible: add label name and icon path. Use MacroPATH pro-x camera and software as TWAIN devices of an external software (not included) is also possible: enable Install virtual driver and choose: Mode Volatile Shutdown Volatile Minimize Permanent Shutdown Permanent Minimize Description To remove the case data and close the MacroPATH after importing the images To remove the case data and maintain active (reduced to icon) the MacroPATH after importing the images To maintain the case data in the TWAIN folder and close the MacroPATH after importing the images To maintain the case data in the TWAIN folder and maintain active (reduced to icon) the MacroPATH after importing the images 46

47 Tick Enable Twain acquisition to import images from an external imaging acquisition device (such as a microscope, not included). On the main screen a new icon From Twain appears Localization settings From this screen it is possible to modify language (default language English), import new languages; system unit (millimeters and centimeters), time and date format. Select the desired Language from the drop down menu, then press Set Default and reboot the system to enable the modification. Preset custom text allows insertion of up to 100 different preset texts: press Add (see the circle in left figure below) and type the category name (example 1 ), then press the second Add (see the circle in the right image below) icon and type the text (example text1 ) The new added text can now be used in EDIT MODE. 47

48 Appearance settings Open appearance screen and select a theme among those listed. Tick Fullscreen checkbox to disable the preset titlebar and fill with your laboratory name. Tick Virtual Keyboard to enable the keyboard icon. Clicking the icon, the virtual keyboard appears. 48

49 Tick Easy interface to reduce the number of displayed icons. Easy interface Normal interface Thick Fine Tune Mode: it is possible to modify icons, font and thumbs size Tools settings 49

50 Set here your favorite configuration for each tool like font, color etc. and have them as default for each case. Check the field to change the line drawing system (for size line and section line: suggested for touch screen routine operation) It is also possible to change font, color and thickness of text and lines in Edit screen (see picture below), but these changes are valid just for the current case. Disable a single tool by unticking it. 50

51 Preferences settings A. AutoLive. Check the box to return to Live Mode when an image has been acquired and saved. B. Auto Edit Mode. Check to automatically enter in Edit after image acquisition C. Shutdown camera entering Edit mode. Check to shutdown camera during Edit operations. This feature increases camera lifetime. By default it is checked, please do not modify it. D. Force double entry. By checking this box, every time you create a case, you will be required two times to enter the case name, thus avoiding misspelling and/or errors. IT IS NOT POSSIBLE TO CHANGE THE CASE NUMBER AFTER ITS CREATION. E. Live at start. Enable this check to go directly to LIVE when the software starts. F. Audio rec. Maximum audio recording time. G. Video rec. Maximum video recording time. H. Cam standby after. Set the time (in seconds) after which the camera turns in standby mode. This feature increases the camera lifetime. By default it is 1h, as explained in the chapter 3.6. I. Delay for image during Present. Set delay time between each image in a presentation. J. Max case name length. Please do not modify it. K. Reset recording video options. Press this button to cancel video settings. First time a video is taken, user will need to set quality (see chapter). 51

52 Watermark settings can be modified in Preferences tab: select None, Simple or Bordered. None Single: case name only Bordered: full information Bordered mode allows the insertions of information in the watermark. Uncheck data is not required. In Simple mode a watermark is positioned over the image, while in bordered mode is put below it. 52

53 4. MacroPATH pro-x AS A MULTISTATION VIEWER 4.1. How to install the MacroPATH pro-x as viewer MacroPATH pro-x as viewer allows simple retrieval of MacroPATH pro-x images, using either barcode or manual entry of patient identifying number. Images can only be viewed and printed (generating report as explained in the previous chapter), but no modifications i.e. annotations are possible. To carry out any modification on images (such as add notes, section and so on), an extra license of MacroPATH pro-x software must be available. For this, contact your local distributor. MacroPATH pro-x as viewer is the same software installed on the MacroPATH pro-x unit and it does not need a license. Therefore, user is authorized to install MacroPATH pro-x as Viewer software on any PC. For license activation see chapter MacroPATH pro-x Viewer can be installed on any computer: using the MacroPATH pro-x CD and open the MacroPATH pro-x folder. Click on Set Up installer and follow the instructions to proceed with the installation of the MacroPATH pro-x software Settings for MacroPATH pro-x Viewer PC Milestone strongly suggests that the following procedures are carried out by your local Network/IT Manager. Before proceeding with the instructions below, it is necessary to connect the MacroPATH pro-x PC and the MacroPATH pro-x as viewer PC to a local network, setting it with appropriate parameters. Settings the MacroPATH pro-x viewer PC: 1. Turn the MacroPATH pro-x viewer PC on. 2. Open the MacroPATH pro-x software 3. Click on Settings icon on the screen 4. In Storage field click on browse button 5. Select My Network Places folder, 6. Search the MacroPATH pro-x unit (the standard name of the PC is MACROPATH or MILESTONE, 7. Select the shared folder IMAGES then press OK 8. At the end, the full path is displayed (for example \\MACROPATH\images) It is now possible to work from both (or more) working stations. When a new case is added from histological laboratory, every additional station is able to view and print the same images. Milestone strongly suggests storing the cases on a server with an automated backup procedure. Contact your local Network/IT Manager. 53

54 4.3. Integration of MacroPATH pro-x with LIMS systems The images created with Macropath pro-x are 100% compatible (open system). Images are stored in.jpg formats which is universal formats. Any commercial software, pathology reporting, LIMS that are image capable are suitable to retrieve and view images collected by Macropath Pro-x. The system also produces a session file in each specimen directory detailing the Patient file ID, opening and closing time for the specimen gross file How MacroPATH saves the images Through the software interface, for every specimen case it is necessary to insert the ID code, by typing it through the keyboard or using the barcode reading. MacroPATH pro-x doesn t generate automatically any codes, so to start the system the operator is required to enter the specimen identifier file number. The MacroPATH system can also receive the ID number directly by the LIMS system Taking image Take image of specimen by zooming in/out with the foot pedal control until you have the desired area of interest, then press the Save pedal switch. The save feature is also possible by using the icons on the left side of the screen. The image saved will appear on the right of the screen in the film library. (Thumbnails) Where and how the images are saved: With Windows 7 all the specimens directory created by the user by typing the specimens codes are saved (as default) in the directory path C:\Users\Public\Documents\Milestone srl\macropath5\images While Windows XP the images are saved (as default) in the folder path C:\Documents and settings\all Users\ Documents\Milestone srl\macropath5\images. As default this directory is created into the hard-disk C:, but the folder Images can be set on any different location on the local network. The example below shows the way as 5 images taken under the case ABC are saved into the directory C:\Users\Public\Documents\Milestone srl\macropath5\images All the images are saved in.jpg format. The MacropathD/PRO-Xsoftware automatically saves the images with the ID name: ABC_0001.JPG ABC _0002.JPG ABC _0003.JPG ABC _0004.JPG ABC _0005.JPG 54

55 For every specimen case the software generates also an XML file with the information on the saved session. All the images are then available to be retrieved and visualized by any other software Interface command between LIMS and MacroPATH pro-x MacroPATH Pro-x can work as a standalone unit or interfaced to a LIMS system. Trough simple string commands the LIMS system can initialize MacroPATH pro-x with the ID code of the specimen. The command that the LIMS can send to MacroPATH to open the selected case is: macropath abc (name of the case e.g case: ABC) With this command the LIMS can open the selected case directly in the MacroPATH pro-x software 55

56 5. MAINTENANCE 5.1. Cleaning of MacroPATH pro-x Pc Panel and camera DISCONNECT THE PLUGS FROM THE SOCKET BEFORE STARTING THE CLEANING PROCEDURE. During normal use the PC Panel and camera may become soiled and should, therefore, be cleaned regularly. Agents: Green tinctured soap and Enzymatic detergents. Steps: 1. Prepare agent as per the manufacturer s instructions or hospital protocol, 2. Wipe the PC Panel with a clean cloth that has been moistened in the cleaning solution, 3. Wipe thoroughly a clean cloth. Do not immerse or rinse the PC Panel and its peripherals and the camera. Do not use an abrasive cloth to clean the camera s lens. If you accidentally spill liquid on the device, disconnect the unit from the power source. Contact your Biomed regarding the continued safety of the unit before placing it back in operation. Do not spray cleaning agent on the chassis. Do not use disinfectants that contain phenol. Do not autoclave or clean the PC Panel or its peripherals or the camera with strong aromatic, chlorinated, ketone, ether, or Esther solvents, sharp tools or abrasives. Never immerse electrical connectors in water or other liquids Keyboard To clean while the keyboard is plugged in, lock the keyboard by pressing the Locking Key for three seconds. Clean the surface of the product by wiping, brushing, spraying or dipping it. Use only rags, sponges or soft bristle brushes. DO NOT place the USB connector into the fluid. Either wipe with dry cloth or allow to air dry. Unlock the keyboard by pressing the Locking key for three seconds. Disinfectants recommended: Chlorine based (max 10% solution) Chlorox, Novalsan, etc. Formaldehyde based - Formaldehyde Solution 37%, Vinco Formaldegen. Glutaraldehyde based Aldacide 200, Lysofume, Wavicide, etc. Phenol based Lysol I.C., Beaucoup, Magna Clean, Tek-Trol, etc. Alcohol based Cavicide, Isopropyl Alcohol, Medicide, etc. Oxidizing Hydrogen Peroxide 3% Solution, Lifegard Series, etc. Quaternary Ammonium Roccal-D, Bacto-Sep, Parvosol, etc. Soap and water. DO NOT USE: Petroleum based cleaning fluids, such as Gasoline, Acetone, over 10% bleach solutions, temperature or pressure sterilization, buffing pads or scrubbing pads Foot pedal The foot-switches may be cleaned with all common cleaning agents and disinfectants used in hospitals. 56

57 6. ACCESSORIES (Optional) 6.1. Table top camera holder (PN ) Table top camera holder for MacroPATH pro-x camera. Heavy duty stainless steel cabinet. Includes also one Macrostand WA (REF ) showed in the chapter 6.5. Only at the installation time you have to connect the base of the macrostand, as shown below. Use the 6 screws and the allen included. Then you have to connect the camera pro-x to the table top camera holder, below it is shown the final configuration. 57

58 6.2. Pro-x Camera holder for hood type grossing station (PN ) In the following picture it is shown the holder (PN ). Below an example of the camera attached by the camera holder to a fumes hood C bracket for MacroPATH pro-x (PN V) In the picture below it is shown the c braket. 58

59 6.4. Floor type terminal holder Suited for mounting the touch screen terminal where space is restricted inside the grossing area, but with sufficient floor space to mount the terminal on a mobile floor stand, that can be moved between grossing stations, as required. Description: PN PN PN Floor Type Terminal Holder on wheels (Schuko Socket) Floor Type Terminal Holder on wheels (US Socket) Floor Type Terminal Holder on wheels (Without Socket) 6.5. Macrostand WA (REF ) Complete set-up for wet area photography i.e. over the dissection area. REF MACROSTAND WA. 59

60 including. PN High density PE customized board A3 with steel pins and draining channels. Dimensions: 295 mm x 395 mm (11 x 15 ) REF KIT/B Kit of N. 10 Blue plastic cutting sheets A3 with scale (mm) 6.6. USB Barcode reader (PN ) Bar code reader is usefull to automatically enter the patient/specimen number to open a new file or retrieve an existing file. The image shown is only an example D USB Barcode reader (PN ) Bar code reader is usefull to automatically enter the patient/specimen number to open a new file or retrieve an existing file. This model can read 2D barcodes also. The image shown is only an example. 60

61 6.8. Water proof keyboard and mouse (PN ) Water proof (sealed) keyboard with touch-pad built in, with IP68 protection against water and dust. The image shown is only an example. 61

62 7. TROUBLESHOOTING THE MacroPATH pro-x 7.1. Camera does not work If you get the following message The camera is not responding follow the procedure explained below. Press OK, then log out from the software. Switch off the PC. Then disconnect the camera s power supplier, disconnecting the 12-24V DC camera connector shown in the image below. Wait at least 5 seconds and then reconnect the 12-24V DC camera connector. Wait few seconds and restart the PC. Wait at least 30 seconds and then restart the software. If the problem is not solved, contact our Service department at customersupport@milestonemedsrl.com Foot pedal control does not work Open Settings from the relative icon and click the camera button. Select the serial number (each foot pedal has its own serial number) If two or more serial number are displayed, check if any external tool using the same drivers is connected. Select a serial number, save and restart the software. If it still does not work, select the other serial number. If any serial number is displayed: 1) Install the driver included in MacroPATH CD 2) Connect foot pedal control to another USB port. Foot pedal serial number usually begins with ST letters. 62

63 7.3. Touch screen calibration If touching the monitor with the pen the mouse arrow moves to another direction, recalibrate the touch-screen as follows: Select TouchKit icon from the Windows icon or from the Start menu, go to Programs, then TouchKit and select Configure Utility. The following screen appears. Press Setting (see red square above). Press Option button and verify that Enable Auto Right Click is unticked (see the image below). 63

64 Press OK to close the window. Choose the Tools folder (see the circle below). Press 4 Points Calibration (see the arrow above). Now the green target appears: touch on its center with the pen pointer. Repeat for all the green targets that are displayed. At the end, a message appears to advise that the calibration is completed, press OK to continue. The recalibration is now completed. 64

65 7.4. Return for repair to Manufacturer Please, read carefully the following note. This instrument is an in-vitro medical device and it is usually installed in a laboratory where specimens and other biological tissues are present. For your safety, it is therefore required to clean and disinfect before entering in contact with it. Also you must wear gloves when operating with the system. It is required in case of return that the unit is cleaned and disinfected before sending it back to MILESTONE S.R.L. Non-disinfected devices will be no longer accepted and you will be contacted to get the relative disinfection cost. International health rules require that shipments of biohazard materials are not don in standard packages (risk of sanctions). 65

66 8. WASTE DISPOSAL OF MacroPATH pro-x UNIT Removal of equipment from use for disposal: 1) Switch the panel PC OFF. Disconnect the main plugs of the panel PC from the main socket outlets 2) Disconnect the main plug of the camera power supply from the main socket outlet. 3) Disconnect all accessories (foot pedal, keyboard, bar-code reader, camera, camera power supply). 4) Clean and disinfect all parts of the equipment according to the manufacturer specification. 5) Dispose all electric and electronic parts of the equipment according to the manufacturer: Complying with directive 2002/96/EC of the European Parliament and of the Council of 27 January 2003 on waste electrical and electronic equipment (WEEE), the separate collection environmental managed of equipment is mandatory. It is necessary to return the used equipment to the distributor or to inquire about the presence of a local empowered system for collection and disposal of WEEE. The in-observance of Directive 2002/96/EC or of the local law which acknowledge it can have potential effects on the environment and human health This symbol indicates separate collection for electrical and electronic equipment 66