This patch is compatible with Windows XP SP3 (32-bit) and Windows 7 (32 or 64 -bit) operating systems

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1 DISCLAIMER This software has not undergone extensive formal testing at this time. It will be included in the next version of the Analyst software, at which time it will have been subjected to such testing. AB SCIEX assumes no liability or responsibility for any loss howsoever caused in connection with using this software. Analyst Patch for Peak Hopping Issue The Analyst Patch for Peak Hopping Issue addresses the following issue: the Peak Hopping scan mode might produce results with masses that are shifted or of a lower intensity than expected. The results are method-dependent and persistent, which means that a method that results in either shifted peaks or lower-than-expected intensities will always produce this result. A new mass spectrometer firmware file (MIL3003) has been released to resolve this issue. This application file will supersede the currently shipping MIL3002 version. The solution is limited to scans using Peak Hopping. No existing methods will be affected, and any results obtained for non-peak Hopping scans remain unchanged. Where to Get Help Support For support, contact AB SCIEX support@absciex.com Web: Prerequisites This patch requires the Analyst software to be installed. This patch is compatible with Windows XP (SP3) and Windows 7 (SP1) operating systems. Install the Patch This patch is compatible with Windows XP SP3 (32-bit) and Windows 7 (32 or 64 -bit) operating systems 1. Deactivate the hardware profile and then close the Analyst software. 2. Double-click Analyst Patch for Peak Hopping Issue.exe file and then follow the instructions. Updated files The patch installs the following Analyst software new files in the C:\Program Files\Analyst\Firmware folder: RUO-IDV A July 2014 Page 1 of 5

2 MIL3003 ConfigUpdater.exe ConfigUpdater.ini The new shortcut to ConfigUpdater.exe is installed in Start > All Programs > AB SCIEX > Analyst > ConfigUpdater. Remove the Patch 1. Deactivate the hardware profile. 2. Open Control Panel and then double-click Add/Remove Programs. 3. Select the Analyst Patch for Peak Hopping Issue from the list and then click Remove. Uninstalling this patch removes the newly installed files. However, the new firmware file stays on the system. The service engineer can downgrade the firmware to the original MIL3002 version. Known Limitations None Notes on Use 1. Start Config Updater from Start > All Programs > AB SCIEX > Analyst > ConfigUpdater. The ConfigUpdater opens. 2. Follow the instructions on the screen. The Configuration Update Program identifies the new firmware version it will install. RUO-IDV A July 2014 Page 2 of 5

3 3. Click Next. The ConfigUpdater program starts uploading the new firmware. During this process, the ConfigUpdater program appears un-responsive but it is uploading the new firmware, therefore, do not close the dialog. Wait for 10 minutes RUO-IDV A July 2014 Page 3 of 5

4 Note: During the firmware upload process, the following message \ is shown indicating that the mass spectrometer (system controller) will be reset. Do not click OK in the message until 10 minutes have elapsed. 4. Click OK. Wait for two minutes 5. Manually reset the mass spectrometer (power off, wait for 10 seconds, power back on). Wait 30 seconds for the mass spectrometer to power on. RUO-IDV A July 2014 Page 4 of 5

5 This document is provided to customers who have purchased AB SCIEX equipment to use in the operation of such AB SCIEX equipment. This document is copyright protected and any reproduction of this document or any part of this document is strictly prohibited, except as AB SCIEX may authorize in writing. Software that may be described in this document is furnished under a license agreement. It is against the law to copy, modify, or distribute the software on any medium, except as specifically allowed in the license agreement. Furthermore, the license agreement may prohibit the software from being disassembled, reverse engineered, or decompiled for any purpose. Warranties are as stated therein. Portions of this document may make reference to other manufacturers and/or their products, which may contain parts whose names are registered as trademarks and/or function as trademarks of their respective owners. Any such use is intended only to designate those manufacturers' products as supplied by AB SCIEX for incorporation into its equipment and does not imply any right and/or license to use or permit others to use such manufacturers' and/or their product names as trademarks. AB SCIEX warranties are limited to those express warranties provided at the time of sale or license of its products, and are AB SCIEX s sole and exclusive representations, warranties, and obligations. AB SCIEX makes no other warranty of any kind whatsoever, expressed or implied, including without limitation, warranties of merchantability or fitness for a particular purpose, whether arising from a statute or otherwise in law or from a course of dealing or usage of trade, all of which are expressly disclaimed, and assumes no responsibility or contingent liability, including indirect or consequential damages, for any use by the purchaser, or for any adverse circumstances arising therefrom. The trademarks mentioned herein are the property of AB Sciex Pte. Ltd. or their respective owners. AB SCIEX is being used under license AB Sciex Pte. Ltd Printed in Canada. AB Sciex Pte. Ltd. Blk 33, #04-06 Marsiling Ind Estate Road 3 Woodlands Central Indus. Estate SINGAPORE RUO-IDV A July 2014 Page 5 of 5