THE GLOBAL MARKET FOR INTRAVASCULAR ULTRASOUND TOOLS AND ANCILLARY EQUIPMENT. HLC145A July Himani Singhi Wadhwa Project Analyst

Transcription

1 THE GLOBAL MARKET FOR INTRAVASCULAR ULTRASOUND TOOLS AND ANCILLARY EQUIPMENT HLC145A July 2013 Himani Singhi Wadhwa Project Analyst ISBN: X BCC Research 49 Walnut Park, Building 2 Wellesley, MA , Custom Reports: carol.laverty@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 3 REASONS FOR DOING THE STUDY 3 SCOPE OF REPORT 3 INTENDED AUDIENCE 4 INFORMATION SOURCES AND METHODOLOGY 4 ANALYST CREDENTIALS 5 RELATED BCC REPORTS 5 BCC ONLINE SERVICES 5 DISCLAIMER 5 CHAPTER 2 SUMMARY 7 SUMMARY TABLE GLOBAL IVUS PRODUCTS MARKET BY REGION, THROUGH 2017 ($ SUMMARY FIGURE GLOBAL IVUS PRODUCTS MARKET BY REGION, ($ 7 7 CHAPTER 3 OVERVIEW 10 IVUS TECHNOLOGY EVOLUTION AND INDUSTRY LIFE CYCLE STAGE 10 IVUS INDUSTRY IN JAPAN - RELATIVELY MATURE MARKET 10 IVUS INDUSTRY WORLDWIDE (EXCEPT JAPAN) - GROWING PHASE 11 IVUS PRODUCT MARKET ANALYSIS 11 FIGURE 1 MARKET SHARE OF KEY PRODUCTS IN IVUS MARKET, 2012 (%) 11 PRODUCT DIFFERENTIATION - IVUS IMAGING SYSTEMS 12 IVUS KEY APPLICATIONS MARKET ANALYSIS 13 FIGURE 2 KEY APPLICATIONS AREAS OF IVUS VERSUS TOTAL APPLICATION, ($ IVUS END-USER MARKET ANALYSIS 14 FIGURE 3 MARKET SHARE OF KEY END USERS IN IVUS MARKET, 2012 (%) 14 REGULATORY ENVIRONMENT 15 MARKET DYNAMICS 16 DRIVERS 16 Emergence of Favorable and Positive IVUS Clinical Data 16 Competitive Edge of IVUS over Angiography 17 Technology Advancements, Product Developments and Innovations 17 Collaborations of Some Market Players with Leading Laboratory Suppliers Growing and Expanding Applications Coupled with a Rise in Stent Deployments Growing Patient Population, Increasing Burden of Diseases and Rise in Global Aging Population Lower Penetration of IVUS Worldwide and Declining PCI Rate 20 TABLE 1 APPROXIMATE GLOBAL IVUS PENETRATION IN PCI 2012, BY REGION (THOUSANDS/%) RESTRAINTS AND CHALLENGES 21 Reimbursement Issues

3 High Cost of Products and Low Average Selling Prices 22 Two-Way Growing Competition 22 Stringent Regulatory Environment 23 Other Restraints 23 OPPORTUNITIES 24 Products 24 Applications and Geographic Expansion 24 IVUS VERSUS OTHER COMPETITIVE TECHNOLOGIES 25 IVUS VS OPTICAL COHERENCE TOMOGRAPHY (OCT) 25 IVUS VS FRACTIONAL FLOW RESERVE (FFR) 26 COST BENEFIT ANALYSIS 26 MARKET TRENDS 27 COMPETITIVE SCENARIO AND MARKET SHARE ANALYSIS 28 FIGURE 4 GLOBAL IVUS MARKET SHARE BY KEY MARKET PLAYERS, 2012 (%) 29 FIGURE 5 JAPANESE IVUS MARKET SHARE BY KEY MARKET PLAYERS, 2012 (%) 29 FIGURE 6 U.S. IVUS MARKET SHARE BY KEY MARKET PLAYERS, 2012 (%) 30 IVUS MARKET: THE ROAD AHEAD 30 RECOMMENDATIONS/STRATEGIES 31 CONSIDER MAKING EFFORTS TOWARD BETTER IMAGE INTERPRETATION 32 EXPLORE WAYS TO DEVELOP COMPETITIVE EDGE OVER COMPETING TECHNOLOGIES IN THEIR OBSTACLE AREAS INVESTIGATE THE TRAINING REQUIREMENTS OF DIFFERENT REGIONS REGULARLY AND CONSIDER DEVELOPING TRAINING SERVICES ACCORDINGLY CONSIDER INVESTMENTS IN EMERGING ECONOMIES 32 FOCUS ON DEVELOPING MULTIMODALITY SYSTEMS 33 EXPLORE MARKETING AND PRODUCT DEVELOPMENT COLLABORATIONS 33 EVALUATE THE OPTIMAL SALES MODEL FOR RELATIVELY MORE POTENTIAL REGIONS FOCUS MORE ON DISSEMINATING IVUS BENEFITS THROUGH MULTIPLE CHANNELS CONSIDER INPUT OF KEY STAKEHOLDERS WHILE DEVELOPING PRODUCTS 34 PATENT ANALYSIS 34 FIGURE 7 PATENT ANALYSIS BY REGION, 2010-FEBRUARY 2013 (%) CHAPTER 4 PRODUCTS MARKET 37 INTRODUCTION 37 DRIVERS 37 MARKET SCENARIO/INSIGHTS 37 TABLE 2 GLOBAL IVUS MARKET BY PRODUCTS, THROUGH 2017 ($ 38 TABLE 3 GLOBAL IVUS PRODUCTS MARKET BY REGION, THROUGH 2017 ($ IVUS CONSOLES 39 KEY COMPETITIVE FACTORS 39 TABLE 4 GLOBAL IVUS CONSOLES MARKET BY TYPE OF CONSOLE, THROUGH 2017 ($ TABLE 5 GLOBAL IVUS CONSOLES MARKET BY REGION, THROUGH 2017 ($ DRIVERS, RESTRAINTS AND CHALLENGES

4 INTEGRATED VERSION - IVUS CONSOLES 41 TABLE 6 GLOBAL IVUS INTEGRATED CONSOLES MARKET BY REGION, THROUGH 2017 ($ CART IVUS CONSOLES 42 TABLE 7 GLOBAL CART IVUS CONSOLES MARKET BY REGION, THROUGH 2017 ($ IVUS CATHETERS MARKET 43 DRIVERS AND RESTRAINTS 45 KEY COMPETITIVE FACTORS 45 TABLE 8 GLOBAL IVUS CATHETERS MARKET BY TYPE OF CATHETER, THROUGH 2017 ($ TABLE 9 GLOBAL IVUS CATHETERS MARKET BY REGION, THROUGH 2017 ($ MECHANICAL (ROTATORY) CATHETERS 46 TABLE 10 GLOBAL IVUS MECHANICAL ROTATORY CATHETERS MARKET BY REGION, THROUGH 2017 ($ STATIC ELECTRONIC (PHASED ARRAY) CATHETERS 47 TABLE 11 GLOBAL IVUS STATIC ELECTRONIC (PHASED ARRAY) CATHETERS MARKET BY REGION, THROUGH 2017 ($ ACCESSORIES MARKET 48 TABLE 12 GLOBAL IVUS ACCESSORIES MARKET BY TYPE OF ACCESSORY, THROUGH 2017 ($ TABLE 13 GLOBAL IVUS ACCESSORIES MARKET BY REGION THROUGH 2017 ($ PULLBACK DEVICES 49 GUIDEWIRES AND INTRODUCER SHEATH 50 OTHER DEVICES 50 SOFTWARE 50 DRIVERS 51 TABLE 14 GLOBAL IVUS SOFTWARE MARKET BY REGION, THROUGH 2017 ($ SERVICES 52 TABLE 15 GLOBAL IVUS SERVICES MARKET BY REGION, THROUGH 2017 ($ CHAPTER 5 END-USER MARKET 55 INTRODUCTION 55 DRIVERS AND RESTRAINTS 55 TABLE 16 GLOBAL IVUS MARKET BY END USERS, THROUGH 2017 ($ 56 TABLE 17 GLOBAL IVUS END-USER MARKET BY REGION, THROUGH 2017 ($ HOSPITALS 56 DRIVERS AND RESTRAINTS 57 TABLE 18 IVUS HOSPITAL END-USER MARKET BY REGION, THROUGH 2017 ($ STAND-ALONE LABS 58 TABLE 19 GLOBAL IVUS STAND-ALONE LABS END-USER MARKET BY REGION, THROUGH 2017 ($ RESEARCH CENTERS/ORGANIZATIONS

5 TABLE 20 IVUS RESEARCH CENTERS AND ORGANIZATIONS END-USER MARKET BY REGION, THROUGH 2017 ($ COMMERCIAL ORGANIZATIONS 60 TABLE 21 IVUS COMMERCIAL ORGANIZATIONS END-USER MARKET BY REGION, THROUGH 2017 ($ CHAPTER 6 APPLICATION MARKET 63 INTRODUCTION 63 TABLE 22 GLOBAL IVUS APPLICATION MARKET BY TYPES OF APPLICATIONS, THROUGH 2017 ($ TABLE 23 GLOBAL IVUS APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ DRIVERS AND RESTRAINTS 64 CORONARY APPLICATIONS MARKET 64 TABLE 24 GLOBAL IVUS CORONARY APPLICATION MARKET BY TYPE OF APPLICATION, THROUGH 2017 ($ TABLE 25 GLOBAL IVUS CORONARY APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ IVUS CORONARY DIAGNOSTIC MARKET 65 TABLE 26 GLOBAL IVUS CORONARY DIAGNOSTIC APPLICATIONS MARKET BY TYPE OF APPLICATION, THROUGH 2017 ($ TABLE 27 GLOBAL IVUS CORONARY DIAGNOSTIC APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Lesion Characterization/Decision on PCI Sizing and Strategy 67 TABLE 28 GLOBAL LESION CHARACTERIZATION/DECISION ON PCI SIZING AND STRATEGY IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Assessment of Angiographically Indeterminate Lesions or Lesion Significance TABLE 29 GLOBAL ANGIOGRAPHICALLY INTERMEDIATE LESIONS/LESION SIGNIFICANCE IVUS CORONARY DIAGNOSTIC APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Other Coronary IVUS Diagnostic Applications 69 TABLE 30 GLOBAL OTHER IVUS CORONARY DIAGNOSTIC APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ IVUS CORONARY INTERVENTION MARKET 70 TABLE 31 GLOBAL IVUS CORONARY INTERVENTIONS APPLICATIONS MARKET BY TYPE OF APPLICATION, THROUGH 2017 ($ TABLE 32 GLOBAL IVUS CORONARY INTERVENTIONS APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Guidance for Angioplasty 71 TABLE 33 GLOBAL GUIDANCE FOR ANGIOPLASTY IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Guidance for Plaque Modification 72 TABLE 34 GLOBAL GUIDANCE FOR PLAQUE MODIFICATION IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Stent Thrombosis and Restenosis 73 TABLE 35 GLOBAL STENT THROMBOSIS AND RESTENOSIS IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Other Coronary Interventional Applications

6 TABLE 36 GLOBAL OTHER IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ IVUS CORONARY RESEARCH MARKET 75 TABLE 37 GLOBAL IVUS CORONARY RESEARCH APPLICATIONS MARKET BY TYPE OF AREA OF RESEARCH, THROUGH 2017 ($ TABLE 38 GLOBAL IVUS CORONARY RESEARCH APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Drug Discovery and Development 76 TABLE 39 GLOBAL DRUG DISCOVERY AND DEVELOPMENT IVUS CORONARY RESEARCH APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Angioplasty/Stent Evaluation 77 TABLE 40 GLOBAL ANGIOPLASTY/STENT EVALUATION IVUS CORONARY RESEARCH APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ Atherosclerosis Process and Others 78 TABLE 41 GLOBAL ATHEROSCLEROSIS AND OTHER IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ IVUS NONCORONARY/PERIPHERAL APPLICATIONS MARKET 80 DRIVERS 80 TABLE 42 GLOBAL IVUS NONCORONARY/PERIPHERAL APPLICATION MARKET BY TYPE OF APPLICATION, THROUGH 2017 ($ TABLE 43 GLOBAL IVUS NONCORONARY/PERIPHERAL APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ IVUS Peripheral Diagnostics Applications 81 IVUS Peripheral Intervention Applications 82 IVUS Peripheral Research Applications CHAPTER 7 COMPETITIVE DEVELOPMENTS 84 INTRODUCTION 84 FIGURE 8 DEVELOPMENTS IN GLOBAL INTRAVASCULAR ULTRASOUND MARKET, 2010-APRIL 15, 2013 (%) TABLE 44 DEVELOPMENTS-PRODUCT LAUNCHES/INTRODUCTIONS, 2010-APRIL 2013 TABLE 45 DEVELOPMENTS - PARTNERSHIP, AGREEMENTS AND COLLABORATIONS, 2010-APRIL 2013 TABLE 46 DEVELOPMENTS - GEOGRAPHIC, SALES OR MANUFACTURING EXPANSION, 2010-APRIL 2013 TABLE 47 DEVELOPMENTS - ACQUISITIONS, 2010-APRIL CHAPTER 8 GEOGRAPHICAL ANALYSIS 93 INTRODUCTION 93 JAPAN 93 DRIVERS AND RESTRAINTS 93 FIGURE 9 IVUS MARKET, JAPAN VERSUS GLOBAL, ($ 95 TABLE 48 JAPANESE IVUS MARKET BY PRODUCTS, THROUGH 2017 ($ 96 TABLE 49 JAPANESE IVUS MARKET BY APPLICATIONS, THROUGH 2017 ($ 96 TABLE 50 JAPANESE IVUS MARKET BY END USERS, THROUGH 2017 ($ 97 UNITED STATES (U.S.) 97 DRIVERS AND RESTRAINTS 97 FIGURE 10 U.S. IVUS MARKET, U.S. VERSUS GLOBAL, ($ 98 TABLE 51 U.S. IVUS MARKET BY PRODUCTS, THROUGH 2017 ($ 99

7 TABLE 52 U.S. IVUS MARKET BY APPLICATION, THROUGH 2017 ($ 100 TABLE 53 U.S. IVUS MARKET BY END USER, THROUGH 2017 ($ 100 EUROPE 100 DRIVERS AND RESTRAINTS 101 FIGURE 11 IVUS MARKET, EUROPE VERSUS GLOBAL, ($ 101 TABLE 54 EUROPEAN IVUS MARKET BY PRODUCT, THROUGH 2017 ($ 103 TABLE 55 EUROPEAN IVUS MARKET BY APPLICATION, THROUGH 2017 ($ 103 TABLE 56 EUROPEAN IVUS MARKET BY END USER, THROUGH 2017 ($ 104 ASIA AND REST OF THE WORLD (ROW) 104 DRIVERS AND RESTRAINTS 104 FIGURE 12 IVUS MARKET, ASIA AND ROW VERSUS GLOBAL, ($ TABLE 57 ASIAN AND ROW IVUS MARKET BY PRODUCT, THROUGH 2017 ($ TABLE 58 ASIAN AND ROW IVUS MARKET BY APPLICATION, THROUGH 2017 ($ TABLE 59 ASIAN AND ROW IVUS MARKET BY END USER, THROUGH 2017 ($ CHAPTER 9 PATENTS 110 TABLE 60 LIST OF U.S. PATENTS, TABLE 61 LIST OF EUROPE PATENTS, TABLE 62 LIST OF JAPAN PATENTS, CHAPTER 10 COMPANY PROFILES 117 AVINGER, INC. 117 COMPANY OVERVIEW 117 BUSINESS AND PRODUCTS OVERVIEW 117 BUSINESS STRATEGY 117 BOSTON SCIENTIFIC CORPORATION 118 COMPANY OVERVIEW 118 BUSINESS OVERVIEW 118 PRODUCTS OVERVIEW 118 TABLE 63 BOSTON SCIENTIFIC CORPORATION IVUS AND RELATED PRODUCT PORTFOLIO FINANCIAL OVERVIEW 119 TABLE 64 BOSTON SCIENTIFIC CORPORATION NET SALES AND R&D EXPENDITURE, ($ TABLE 65 BOSTON SCIENTIFIC CORPORATION NET SALES BY REGION, ($ TABLE 66 BOSTON SCIENTIFIC CORPORATION NET SALES BY BUSINESS SEGMENTS, ($ BUSINESS STRATEGY 121 EV3 (COVIDIEN) 121 COMPANY OVERVIEW 121 BUSINESS AND PRODUCTS OVERVIEW 121 BUSINESS STRATEGY 122 GE HEALTHCARE 122 COMPANY AND FINANCIAL OVERVIEW

8 BUSINESS AND PRODUCTS OVERVIEW 122 BUSINESS STRATEGY 123 INFRAREDX, INC. 123 COMPANY OVERVIEW 123 BUSINESS AND PRODUCTS OVERVIEW 123 TABLE 67 INFRAREDX IVUS AND RELATED PRODUCT PORTFOLIO 124 BUSINESS STRATEGY 124 MEDTRONIC 125 COMPANY OVERVIEW 125 BUSINESS AND PRODUCTS OVERVIEW 125 BUSINESS STRATEGY 125 PHILIPS HEALTHCARE 126 COMPANY AND FINANCIAL OVERVIEW 126 BUSINESS AND PRODUCTS OVERVIEW 126 BUSINESS STRATEGY 126 PIE MEDICAL IMAGING BV 127 COMPANY OVERVIEW 127 BUSINESS AND PRODUCTS OVERVIEW 127 BUSINESS STRATEGY 128 SIEMENS HEALTHCARE DIAGNOSTICS, INC. (U.S.) 128 COMPANY AND FINANCIAL OVERVIEW 128 BUSINESS AND PRODUCTS OVERVIEW 128 BUSINESS STRATEGY 129 SILICON VALLEY MEDICAL INSTRUMENTS, INC. (SVMI) 129 COMPANY AND BUSINESS OVERVIEW 129 BUSINESS AND PRODUCTS OVERVIEW 129 BUSINESS STRATEGY 130 ST. JUDE MEDICAL 130 COMPANY OVERVIEW 130 BUSINESS OVERVIEW 131 PRODUCTS OVERVIEW 131 FINANCIAL OVERVIEW 131 BUSINESS STRATEGY 132 TERUMO CORPORATION 132 COMPANY OVERVIEW 132 BUSINESS OVERVIEW 132 PRODUCTS OVERVIEW 133 TABLE 68 TERUMO CORPORATION IVUS AND RELATED PRODUCT PORTFOLIO 133 TABLE 69 TERUMO CORPORATION NET SALES AND R&D EXPENDITURE, (YEN MILLION) TABLE 70 TERUMO CORPORATION NET SALES BY REGION, (YEN BILLION) 134 TABLE 71 TERUMO CORPORATION NET SALES BY BUSINESS SEGMENTS, (YEN BILLION) BUSINESS STRATEGY 134 VOLCANO CORPORATION 135 COMPANY OVERVIEW 135 BUSINESS OVERVIEW 135 PRODUCTS OVERVIEW

9 TABLE 72 VOLCANO CORPORATION IVUS AND RELATED PRODUCT PORTFOLIO 136 FINANCIAL OVERVIEW 136 TABLE 73 VOLCANO CORPORATION REVENUES AND R&D EXPENDITURE, , AS OF DECEMBER 2012 ($ TABLE 74 VOLCANO CORPORATION REVENUES BY BUSINESS SEGMENTS, ($ TABLE 75 VOLCANO CORPORATION REVENUES BY REGION, ($ BUSINESS STRATEGY

10 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL IVUS PRODUCTS MARKET BY REGION, THROUGH 2017 ($ TABLE 1 APPROXIMATE GLOBAL IVUS PENETRATION IN PCI 2012, BY REGION (THOUSANDS/%) TABLE 2 GLOBAL IVUS MARKET BY PRODUCTS, THROUGH 2017 ($ 38 TABLE 3 GLOBAL IVUS PRODUCTS MARKET BY REGION, THROUGH 2017 ($ 39 TABLE 4 GLOBAL IVUS CONSOLES MARKET BY TYPE OF CONSOLE, THROUGH 2017 ($ TABLE 5 GLOBAL IVUS CONSOLES MARKET BY REGION, THROUGH 2017 ($ 40 TABLE 6 GLOBAL IVUS INTEGRATED CONSOLES MARKET BY REGION, THROUGH 2017 ($ TABLE 7 GLOBAL CART IVUS CONSOLES MARKET BY REGION, THROUGH 2017 ($ TABLE 8 GLOBAL IVUS CATHETERS MARKET BY TYPE OF CATHETER, THROUGH 2017 ($ TABLE 9 GLOBAL IVUS CATHETERS MARKET BY REGION, THROUGH 2017 ($ TABLE 10 GLOBAL IVUS MECHANICAL ROTATORY CATHETERS MARKET BY REGION, THROUGH 2017 ($ TABLE 11 GLOBAL IVUS STATIC ELECTRONIC (PHASED ARRAY) CATHETERS MARKET BY REGION, THROUGH 2017 ($ TABLE 12 GLOBAL IVUS ACCESSORIES MARKET BY TYPE OF ACCESSORY, THROUGH 2017 ($ TABLE 13 GLOBAL IVUS ACCESSORIES MARKET BY REGION THROUGH 2017 ($ TABLE 14 GLOBAL IVUS SOFTWARE MARKET BY REGION, THROUGH 2017 ($ TABLE 15 GLOBAL IVUS SERVICES MARKET BY REGION, THROUGH 2017 ($ 53 TABLE 16 GLOBAL IVUS MARKET BY END USERS, THROUGH 2017 ($ 56 TABLE 17 GLOBAL IVUS END-USER MARKET BY REGION, THROUGH 2017 ($ TABLE 18 IVUS HOSPITAL END-USER MARKET BY REGION, THROUGH 2017 ($ TABLE 19 GLOBAL IVUS STAND-ALONE LABS END-USER MARKET BY REGION, THROUGH 2017 ($ TABLE 20 IVUS RESEARCH CENTERS AND ORGANIZATIONS END-USER MARKET BY REGION, THROUGH 2017 ($ TABLE 21 IVUS COMMERCIAL ORGANIZATIONS END-USER MARKET BY REGION, THROUGH 2017 ($ TABLE 22 GLOBAL IVUS APPLICATION MARKET BY TYPES OF APPLICATIONS, THROUGH 2017 ($ TABLE 23 GLOBAL IVUS APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 24 GLOBAL IVUS CORONARY APPLICATION MARKET BY TYPE OF APPLICATION, THROUGH 2017 ($ TABLE 25 GLOBAL IVUS CORONARY APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 26 GLOBAL IVUS CORONARY DIAGNOSTIC APPLICATIONS MARKET BY TYPE OF APPLICATION, THROUGH 2017 ($ TABLE 27 GLOBAL IVUS CORONARY DIAGNOSTIC APPLICATIONS MARKET BY REGION, THROUGH 2017 ($

11 TABLE HEADING TABLE 28 GLOBAL LESION CHARACTERIZATION/DECISION ON PCI SIZING AND STRATEGY IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 29 GLOBAL ANGIOGRAPHICALLY INTERMEDIATE LESIONS/LESION SIGNIFICANCE IVUS CORONARY DIAGNOSTIC APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 30 GLOBAL OTHER IVUS CORONARY DIAGNOSTIC APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 31 GLOBAL IVUS CORONARY INTERVENTIONS APPLICATIONS MARKET BY TYPE OF APPLICATION, THROUGH 2017 ($ TABLE 32 GLOBAL IVUS CORONARY INTERVENTIONS APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 33 GLOBAL GUIDANCE FOR ANGIOPLASTY IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 34 GLOBAL GUIDANCE FOR PLAQUE MODIFICATION IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 35 GLOBAL STENT THROMBOSIS AND RESTENOSIS IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 36 GLOBAL OTHER IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 37 GLOBAL IVUS CORONARY RESEARCH APPLICATIONS MARKET BY TYPE OF AREA OF RESEARCH, THROUGH 2017 ($ TABLE 38 GLOBAL IVUS CORONARY RESEARCH APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 39 GLOBAL DRUG DISCOVERY AND DEVELOPMENT IVUS CORONARY RESEARCH APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 40 GLOBAL ANGIOPLASTY/STENT EVALUATION IVUS CORONARY RESEARCH APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 41 GLOBAL ATHEROSCLEROSIS AND OTHER IVUS CORONARY INTERVENTION APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 42 GLOBAL IVUS NONCORONARY/PERIPHERAL APPLICATION MARKET BY TYPE OF APPLICATION, THROUGH 2017 ($ TABLE 43 GLOBAL IVUS NONCORONARY/PERIPHERAL APPLICATIONS MARKET BY REGION, THROUGH 2017 ($ TABLE 44 DEVELOPMENTS-PRODUCT LAUNCHES/INTRODUCTIONS, 2010-APRIL TABLE 45 DEVELOPMENTS - PARTNERSHIP, AGREEMENTS AND COLLABORATIONS, 2010-APRIL 2013 TABLE 46 DEVELOPMENTS - GEOGRAPHIC, SALES OR MANUFACTURING EXPANSION, 2010-APRIL 2013 TABLE 47 DEVELOPMENTS - ACQUISITIONS, 2010-APRIL TABLE 48 JAPANESE IVUS MARKET BY PRODUCTS, THROUGH 2017 ($ 96 TABLE 49 JAPANESE IVUS MARKET BY APPLICATIONS, THROUGH 2017 ($ 96 TABLE 50 JAPANESE IVUS MARKET BY END USERS, THROUGH 2017 ($ 97 TABLE 51 U.S. IVUS MARKET BY PRODUCTS, THROUGH 2017 ($ 99 TABLE 52 U.S. IVUS MARKET BY APPLICATION, THROUGH 2017 ($ 100 TABLE 53 U.S. IVUS MARKET BY END USER, THROUGH 2017 ($ 100 TABLE 54 EUROPEAN IVUS MARKET BY PRODUCT, THROUGH 2017 ($ 103 TABLE 55 EUROPEAN IVUS MARKET BY APPLICATION, THROUGH 2017 ($ 103 TABLE 56 EUROPEAN IVUS MARKET BY END USER, THROUGH 2017 ($ 104 TABLE 57 ASIAN AND ROW IVUS MARKET BY PRODUCT, THROUGH 2017 ($

12 TABLE HEADING TABLE 58 ASIAN AND ROW IVUS MARKET BY APPLICATION, THROUGH 2017 ($ TABLE 59 ASIAN AND ROW IVUS MARKET BY END USER, THROUGH 2017 ($ TABLE 60 LIST OF U.S. PATENTS, TABLE 61 LIST OF EUROPE PATENTS, TABLE 62 LIST OF JAPAN PATENTS, TABLE 63 BOSTON SCIENTIFIC CORPORATION IVUS AND RELATED PRODUCT PORTFOLIO TABLE 64 BOSTON SCIENTIFIC CORPORATION NET SALES AND R&D EXPENDITURE, ($ TABLE 65 BOSTON SCIENTIFIC CORPORATION NET SALES BY REGION, ($ TABLE 66 BOSTON SCIENTIFIC CORPORATION NET SALES BY BUSINESS SEGMENTS, ($ TABLE 67 INFRAREDX IVUS AND RELATED PRODUCT PORTFOLIO 124 TABLE 68 TERUMO CORPORATION IVUS AND RELATED PRODUCT PORTFOLIO 133 TABLE 69 TERUMO CORPORATION NET SALES AND R&D EXPENDITURE, (YEN MILLION) TABLE 70 TERUMO CORPORATION NET SALES BY REGION, (YEN BILLION) 134 TABLE 71 TERUMO CORPORATION NET SALES BY BUSINESS SEGMENTS, (YEN BILLION) TABLE 72 VOLCANO CORPORATION IVUS AND RELATED PRODUCT PORTFOLIO 136 TABLE 73 VOLCANO CORPORATION REVENUES AND R&D EXPENDITURE, , AS OF DECEMBER 2012 ($ TABLE 74 VOLCANO CORPORATION REVENUES BY BUSINESS SEGMENTS, ($ TABLE 75 VOLCANO CORPORATION REVENUES BY REGION, ($

13 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL IVUS PRODUCTS MARKET BY REGION, ($ FIGURE 1 MARKET SHARE OF KEY PRODUCTS IN IVUS MARKET, 2012 (%) 11 FIGURE 2 KEY APPLICATIONS AREAS OF IVUS VERSUS TOTAL APPLICATION, ($ FIGURE 3 MARKET SHARE OF KEY END USERS IN IVUS MARKET, 2012 (%) 14 FIGURE 4 GLOBAL IVUS MARKET SHARE BY KEY MARKET PLAYERS, 2012 (%) 29 FIGURE 5 JAPANESE IVUS MARKET SHARE BY KEY MARKET PLAYERS, 2012 (%) 29 FIGURE 6 U.S. IVUS MARKET SHARE BY KEY MARKET PLAYERS, 2012 (%) 30 FIGURE 7 PATENT ANALYSIS BY REGION, 2010-FEBRUARY 2013 (%) 34 FIGURE 8 DEVELOPMENTS IN GLOBAL INTRAVASCULAR ULTRASOUND MARKET, 2010-APRIL 15, 2013 (%) FIGURE 9 IVUS MARKET, JAPAN VERSUS GLOBAL, ($ 95 FIGURE 10 U.S. IVUS MARKET, U.S. VERSUS GLOBAL, ($ 98 FIGURE 11 IVUS MARKET, EUROPE VERSUS GLOBAL, ($ 101 FIGURE 12 IVUS MARKET, ASIA AND ROW VERSUS GLOBAL, ($