Cavro robotics overview EXCELLENCE IN THE WORLD OF OEM COMPONENTS

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1 Cavro robotics overview EXCELLENCE IN THE WORLD OF OEM COMPONENTS

2 02 CAVRO ROBOTICS OVERVIEW BROCHURE Cavro robotics family OEM liquid handling robots for molecular diagnostics, life sciences, and analytical chemistry ACCELERATING INSTRUMENT DEVELOPMENT Time-to-market is a major consideration for instrument designers in today s fast-paced laboratory environment. The need for extensive component testing and validation can hold up release of new products, potentially harming your position in the marketplace. The use of modular, verified OEM liquid handling components can dramatically shorten development cycles and reduce risk. PRECISION LIQUID HANDLING FOR EVERY JOB We are a world-leading supplier of OEM pumps, robotics and other liquid handling components for laboratory automation, giving you peace of mind and complete confidence in the performance, workmanship and dependability of our products. QUALITY SYSTEMS FOR REGULATED MARKETS The use of pre-validated OEM components can minimize the need for extensive testing which can potentially delay the release of new products particularly in the IVD market. Tecan Cavro components are designed and manufactured to the highest quality standards under ISO 13485, ISO 9001 and FDA 21 CFR Part 820 requirements are UL recognized, and comply with Europe s 2011 RoHS Directive, REACH and Conflict Minerals requirements. STRAIGHTFORWARD COMMUNICATION Tecan Cavro components are specifically designed to offer seamless integration and work in harmony with one another. Each robot can be operated through a variety of communication interfaces, using Tecan Cavro s industry-leading OEM command sets. KEY BENEFITS Industry-proven solutions lower the technology risk in the development process High accuracy, precision and durability optimized for repetitive liquid handling tasks Integrated capacitive liquid level detection for maximum process security and reduced carry-over Faster time-to-market shorter development times using UL recognized and RoHS compliant components Quality and regulatory compliance designed and manufactured under ISO and 21 CFR 820 standards Easily configured large number of options and modules, including single-, dual and eight-channel pipetting, plus a gripper Choice of pipetting options using fixed and/or disposable tips Compatible with other Tecan Cavro components enabling faster system design Easy integration with modular electronics and a sophisticated command set Flexible configuration offering a choice of pumps, probes and accessories

3 CAVRO ROBOTICS OVERVIEW BROCHURE 03 CAVRO OMNI ROBOT The Cavro Omni Robot is an OEM liquid handling robotic component that provides reliable pipetting for a wide range of applications. Designed to offer flexible integration and rapid prototyping, a large number of configurations are available, making it easy to integrate into almost any instrument design. This allows you to quickly and easily set up and run the robot, with a broad range of options to match your automated pipetting needs. Developed with ease of integration in mind, the optimized firmware and command set on the Omni Robot offer precise control and coordination of axis movements and liquid handling operations with features such as single point worktable calibration and arm collision avoidance allowing you to build a complete system with minimal effort. The availability of both Windows -based and OSindependent command sets allow communication and control from any computer or custom control board. This ease of use allows instrument designers to concentrate on applications rather than control of individual robotic axes, enabling fast prototyping, shorter development cycles and faster time-to-market. KEY BENEFITS Easily configured more than 675 standard combinations available Wide range of pipetting options including single-, dual- and fixed eight-channel pipetting options, or a gripper Easy to operate can be controlled using a dedicated PC command set or directly from various operating systems Choice of liquid handling technologies air- and/or liquid-displacement pipetting

4 04 CAVRO ROBOTICS OVERVIEW BROCHURE CAVRO OMNI FLEX The Cavro Omni Flex provides OEM instrument designers with a complete development solution for liquid handling tasks, simplifying the development, testing and regulatory approval of new automated solutions. Combining the proven liquid handling performance of the Cavro Omni Robot with a purpose-built chassis and worktable, it provides a modular, convenient solution for automation of pipetting and sample handling activities. KEY BENEFITS Scalable with three deck sizes to match your throughput needs Choice of liquid handling technologies allowing air- or liquid-displacement pipetting on a single instrument High process security integrated liquid level detection and position encoder for each axis All benefits of the Cavro Omni Robot plus Integrated power supply for liquid handling components and additional modules Finished look and feel with optional skins and shields Space for integration of application-specific modules on or below the worktable

5 CAVRO ROBOTICS OVERVIEW BROCHURE 05 CAVRO ROBOTIC SAMPLE PROCESSOR (RSP) The workhorse of the Tecan Cavro range, the Cavro RSP is the perfect OEM robotic component to automate liquid handling tasks. Available with one or two arms and a variety of pipetting options with integrated liquid level sensing, it offers a cost-effective solution for virtually any application. The Cavro RSP is available in a number of sizes and configurations and is compatible with other Cavro components such as pumps and smart valves to allow easy integration. The Central Control Unit (CCU) provides on-board handling of functions such as rack and tube positions, single point worktable calibration and arm collision avoidance, allowing you to build a complete sample handling system with minimal effort. KEY BENEFITS Established and trusted design proven reliability and performance Independent axis control with smart control and individual stepper motor for each axis Off-the-shelf robotics 16 standard configurations available Exceptional value offering a great balance of price and functionality

6 06 CAVRO ROBOTICS OVERVIEW BROCHURE CAVRO MINI SAMPLE PROCESSOR (MSP) The Cavro MSP brings together the mechanical components necessary to develop an automated sample processor in a single unit. Its compact design delivers straightforward automation of sample preparation or assays. The Cavro MSP s modular construction to enable quick and easy configuration for performing specific sample handling tasks. It offers the same benefits and pipetting options as the Cavro RSP in a compact package, enabling faster integration of pumps and accessories, and provides a highly configurable worktable for sample containers and labware. KEY BENEFITS Complete sample prep automation capable of performing a wide variety of liquid handling operations Two sizes available with a choice of one or two robotic arms on the larger Cavro MSP 9500

7 CAVRO ROBOTICS OVERVIEW BROCHURE 07 OPTIONS FOR ROBOTICS Tecan offers a range of Cavro brand accessories including valves, syringes, racks, carriers, consumables and probes to further simplify device integration and product development, ensuring we can provide the right solution for your application. Air displacement pipettor (ADP) Compact, air-driven pipetting solution for easy integration and advanced process security, ensuring long life and reproducible pipetting for your instrument. Broad pipetting range from <1 to 1,000 μl High resolution pipetting up to 25 nl/increment (40,000 increments for 1,000 μl) Advanced process security disposable tip detection and ejection, capacitive liquid level detection (clld), and integrated pressure sensor for liquid level detection and streaming of pressure data Range of tip sizes including 10, 50, 200, and 1,000 μl volumes (filtered and unfiltered) Syringe pumps Tecan Cavro brand syringe pumps are world-renowned for their precision, accuracy and reliability. With a choice of 30 and 60 mm pumps offering various performance characteristics as well as a range of syringe and valve options, plus the multi-channel Cavro XMP you can be sure to find a Tecan Cavro syringe pump to suit your application. Cavro Centris ideal for microfluidics, chromatography and flow cytometry Cavro XCalibur (XC) compact solution for desktop systems Cavro XLP a broad volume range for maximum flexibility Cavro XMP reliable parallel pipetting from two to eight channels Cavro XE entry level performance for basic liquid handling MiniWash (MW) pump Easy-to-use, continuous flow diaphragm pump for fast system priming, tip washing or bulk fluid dispensing. Available in three flow rates to suit your application. Smart Valve The compact stepper motor-driven valve module with user selectable direction of rotation and a choice of ceramic and plastic valve options. Wash station An integrated probe washing station allows the use of fixed pipetting probes while minimizing the risk of carry-over and contamination.

8 08 CAVRO ROBOTICS OVERVIEW BROCHURE OPTION COMPATIBILITY OMNI OMNI FLEX RSP MSP MiniWash pump Smart Valve pump Smart IO board LO board Carriers, racks and trays Multifunction Controller board (MFC board) Liquid-based pipetting Disposable tip adaptor Eight-channel head Gripper ADP Liquid level detection Syringe pumps Skins Full shield with sensors Door locks (Full shield) Door locks (Front door) Task lighting Bottles Housing for pumps Wash station Tubing routing Integration kits Ethernet Ethernet Basic Basic or Power

9 CAVRO ROBOTICS OVERVIEW BROCHURE 09 ACCESSORIES AND OPTIONS FOR ROBOTICS Tecan offers a full range of accessories, consumable and spare parts including fixed pipetting probes, rotary valves, syringes, syringe seals, racks and trays for all Cavro brand OEM liquid handling robots. Tubing assemblies Tecan offers high quality tubing in a wide range of lengths, diameters, materials, colors and end configurations with a various fitting assemblies to meet the needs of your life science and diagnostic applications. Racks and carriers Ready to dispense into a microplate or sample tube? Choose from a variety of Tecan racks and carriers to meet the needs of your application. Racks for various tube sizes Microplate racks in portrait or landscape orientations Reagent racks Disposable tip racks Deep-well racks Microcentrifuge tube racks Integration kit Cavro Fusion The Cavro Fusion Software application gives users the ability to easily connect to and operate Tecan Cavro modules through any Windows-based PC. Reagent troughs We offer a range of high quality reagent troughs of various shapes and volumes to fit your system design and application needs. Fixed probes Tecan offers a range of probes to help you optimize your application, including: Wide bore, mid-range and small ID probes Cap-piercing probes Dual-lumen probes Eight-channel probes Most probes are made of PTFE-coated stainless steel and provide liquid detection capabilities.

10 10 CAVRO ROBOTICS OVERVIEW BROCHURE CAVRO DISPOSABLE TIPS Cavro Disposable Tips are designed for use with the Omni Robot and ADP, and are manufactured to the same high quality standards as Tecan s broad portfolio of consumables for life sciences customers. Using state-of-the-art production processes and integrated quality control procedures, these tips ensure consistent pipetting performance and provide complete peace of mind. DISPOSABLE TIP OPTIONS Tecan Standard Tecan Pure Application examples ELISA: Sample handling, Genomics research: customer segments Biochemical screening Forensics, Molecular Diagnostics Features Non-filtered Filtered Non-filtered Filtered 10 µl P P 50 µl P P 200 µl P P P P 1000 µl P P P P The conductive polypropylene tips are available in a variety of tip volumes, and can be supplied in customer-branded packaging for large volume orders, providing a complete liquid handling solution to enhance your instrument design. KEY BENEFITS Range of tip sizes including 10, 50, 200, and 1,000 μl volumes Various formats including economical hanging trays, space-saving nested tips and flexible SLAS format Filtered and non-filtered options to suit various applications and avoid contamination Purity levels Tecan Standard and Tecan Pure options available Cavro Synonymous with excellence Tecan Cavro brand components have provided innovative and reliable liquid handling for instrument designers for over 40 years. Our life sciences and diagnostics applications knowledge is unmatched among full-service OEM partners, helping you to create products that are perfectly suited to your customers workflows. Our solutions are designed to accelerate, automate and enhance the development of state-of-the-art instrumentation, working in harmony to provide modular and scalable liquid handling devices which can be easily developed into complete solutions. From individual components to complete automated solutions, OEM customers can benefit from our in-depth understanding of diagnostic and life sciences research laboratory workflows as well as our regulatory and training expertise supporting their instrument development from the initial design phase through to market launch.

11 CAVRO ROBOTICS OVERVIEW BROCHURE 11 SPECIFICATIONS CAVRO OMNI ROBOT CAVRO OMNI FLEX CAVRO RSP MSP 9250 AND 9500 POWER REQUIREMENTS Operating voltage 24 V DC (+10/-2%) 100 to 240VAC, 50/60Hz 24 V DC (±10 %) MSP 9250: Auto-selecting 110/230VAC ±10% Hz MSP 9500: Auto-selecting 110/230VAC ±10% Hz Maximum power/current consumption Approx. 3 A (in XYZ single arm configuration) Approx. 6 A (in XYZ dual arm configuration) 10A (Including 3A for power output receptacles) 2.5 A (single arm) 4 A (dual arms) MSP 9250: 300 W MSP 9500: 350 W COMMUNICATIONS To host TCP/IP, RS-232 (9,600 or 38,400) TCP/IP RS-232 (9,600 baud) RS-232 (9,600 baud) To other Cavro devices CAN, RS-485 Tecan CAN RS-485 RS-485 Protocol TCP/IP or Tecan OEM protocol TCP/IP Tecan OEM protocol Tecan OEM protocol MOTOR DRIVER TECHNOLOGY Axis Control Stepper Motor Drive: X/Y-axis: Closed loop positioning with step loss detection based on linear encoder feedback Z-axis: FOC closed loop control based on rotary encoder feedback Provides full servo capabilities including adjustable force control High efficiency Stepper Motor Drive X/Y-axis: Closed loop positioning with step loss detection based on linear encoder feedback Z-axis: FOC closed loop control based on rotary encoder feedback. Provides full servo capabilities including adjustable force control. High efficiency Stepper Motor Drive (Open loop) Step loss detection feature Stepper Motor Drive (Open loop) Step loss detection feature PROCESS SECURITY Liquid Level Detection Capacitive Liquid Level Detection Highly variable sensitivity (117 levels, expanding to less sensitive levels compared to the RSP/MSP) Pressure-based Liquid Level Detection* Hybrid Liquid Level Detection* Capacitive Liquid Level Detection Highly variable sensitivity (117 levels) Pressure-based Liquid Level Detection* Hybrid Liquid Level Detection* Capacitive Liquid Level Detection Variable sensitivity (3 levels) Capacitive Liquid Level Detection Variable sensitivity (3 levels) Pressure Monitoring Available with optional ADP Available with optional ADP Not available Not available SOFTWARE AND PROGRAMMING Evaluation software Fusion Fusion Fusion Fusion Command set PC-based command processor interface or embedded one-letter command set PC-based command processor interface or embedded one-letter command set 2-letter command set 2-letter command set MECHANICAL Travel length X-axis: 500, 750 or 1,250 mm (19.7, 29.5 or 49.2 in) Y-axis: 150 or 300 mm (5.9 or 11.8 in) Z-axis: 210 mm (8.27 in) (Note: Restrictions apply depending on configuration.) X-axis (Single arm): 500, 750 or 1,250 mm (19.7, 29.5 or 49.2 in) Y-axis: 300 mm (11.8 in) Z-axis: 210 mm (8.27 in) X-axis: mm ( in) Y-axis: 150 or 300 mm (5.9 or 11.8 in) Z-axis: 165 mm (6.5 in) MSP 9250 (w x d x h): 383 x 300 x 165 mm (15.1 x 11.8 x 6.5 in) MSP 9500 (w x d x h): 643 x 300 x 165 mm (25.3 x 11.8 x 6.5 in) with one arm, standard tip Overall dimensions X-axis: 700, 950 or 1,450 mm (27.6, 37.4 or 57.1 in) Y-axis: 405 or 555 mm (15.9 or 21.9 in) Z-axis (from top of flexible mesh sleeve to bottom of X axis): 655 mm (25.8 in) Width: 715, 965 or 1,465 mm (28.1, 38.0 or 57.7 in) Depth: 638 mm (25.1 in) Height: 1047 mm (41.2 in) (Standard Z, from top of flexible mesh sleeve to bottom of the chassis including feet) X-axis: 520 1,332 mm ( in) Y-axis: 408 or 558 mm (16.1 or 22.0 in) Z height excluding rack: 183 mm (7.2 in) MSP 9250 (w x d x h): 595 x 610 x 525 mm (23.4 x 24.0 x 20.7 in) MSP 9500 (w x d x h): 825 x 610 x 525 mm (32.5 x 24.0 x 20.7 in) Maximum payload for each axis X-axis: 6.6 kg (incl. Y- and Z-axes) Y-axis: 3.2 kg (incl. Z-axis) Z-axis: Universal Z: 1.5 kg Standard Z : Tecan tip options X-axis: 6.6 kg (incl. Y- and Z-axes) Y-axis: 3.2 kg (incl. Z-axis) Z-axis: 1.5 kg (Universal Z) Tecan tip options (Standard Z / Dual Z) Tecan tip options only Z-axis : 0.1 kg Tecan tip options only Z-axis : 0.1 kg Cap piercing Yes Yes Yes (with 2:1 gear ratio) Yes (with 2:1 gear ratio)

12 SPECIFICATIONS CAVRO OMNI ROBOT CAVRO OMNI FLEX CAVRO RSP MSP 9250 AND 9500 Accuracy for each axis X-axis (at the tip): ±0.3 mm, up to 1,000 mm (±0.010 in) ±0.4 mm, up to 1,250 mm Y-axis (at the tip): ±0.3 mm Z-axis: Universal Z: ±0.25 mm Standard Z : ±0.4 mm X/Y/Z-axis (bidirectional at the tip): X: ±0.3 mm, up to 1,000 mm travel X: ±0.4 mm, up to 1,250 mm travel Y: ±0.3 mm Z: ±0.4 mm (Standard Z / Dual Z) Z: ±0.25 mm (Universal Z) X-axis (unidirectional): ±1.0 mm (±0.040 in) Y-axis (unidirectional): ±1.0 mm (±0.040 in) Z-axis (unidirectional): ±0.4 mm (±0.016 in) X-axis (unidirectional): ±1.0 mm (±0.040 in) Y-axis (unidirectional): ±1.0 mm (±0.040 in) Z-axis (unidirectional): ±0.4 mm (±0.016 in) X/Y-axis (bidirectional at the carriage): X: ±0.2 mm Y: ±0.2 mm Repeatability XYZ (bidirectional at tip): X: 0.2 mm Y: 0.2 mm Z: 0.4 mm (Standard Z) Z: 0.15 mm (Universal Z) XYZ (at the carriage): X: 0.12 mm Y: 0.12 mm X/Y/Z-axis (bidirectional at the tip): X: 0.2 mm Y: 0.2 mm Z: 0.4 mm (Standard Z / Dual Z) Z: 0.15 mm (Universal Z) X/Y-axis (bidirectional at the carriage): X: 0.12 mm Y: 0.12 mm X-axis (unidirectional): ±0.10 mm (±0.004 in) Y-axis (unidirectional): ±0.10 mm (±0.004 in) Z-axis (unidirectional): ±0.10 mm (±0.004 in) X-axis (unidirectional): ±0.10 mm (±0.004 in) Y-axis (unidirectional): ±0.10 mm (±0.004 in) Z-axis (unidirectional): ±0.10 mm (±0.004 in) Resolution X-axis: 0.02 mm Y-axis: 0.02 mm Z-axis: 0.02 mm X-axis: 0.02 mm Y-axis: 0.02 mm Z-axis: mm (Standard Z / Dual Z); mm (Universal Z) X-axis: 0.22 mm (0.009 in) Y-axis: 0.14 mm (0.006 in) Z-axis: 0.10 mm (0.004 in) X-axis: 0.22 mm (0.009 in) Y-axis: 0.14 mm (0.006 in) Z-axis: 0.10 mm (0.004 in) Maximum speed X-axis: 800 mm/s (31.5 in/s) Y-axis: 600 mm/s (23.6 in/s) Z-axis: 600 mm/s (23.6 in/s) X-axis: 800 mm/s (31.5 in/s) Y-axis: 600 mm/s (23.6 in/s) Z-axis: 600 mm/s (23.6 in/s) X-axis: 894 mm/s (35.2 in/s) Y-axis: 569 mm/s (22.4 in/s) Z-axis: 394 mm/s (15.5 in/s) X-axis: 894 mm/s (35.2 in/s) Y-axis: 569 mm/s (22.4 in/s) Z-axis: 394 mm/s (15.5 in/s) ENVIRONMENTAL Operating temperature C ( F) 10 to 35 C (50 to 95 F) C ( F) C ( F) Storage temperature C ( F) -20 to 60 C (-4 to 140 F) C ( F) C ( F) Relative humidity % 30 to 80 % at 35 C (95 F) 30 80% at 40 C (104 F), non-condensing 30 80%, non-condensing *with ADP option only Australia Austria Belgium China France Germany Italy Japan Netherlands Singapore Spain Sweden Switzerland UK USA Other countries Tecan Group Ltd. makes every effort to include accurate and up-to-date information within this publication, however, it is possible that omissions or errors might have occurred. Tecan Group Ltd. cannot, therefore, make any representations or warranties, expressed or implied, as to the accuracy or completeness of the information provided in this publication. Changes in this publication can be made at any time without notice. All mentioned trademarks are protected by law. In general, the trademarks and designs referenced herein are trademarks, or registered trademarks, of Tecan Group Ltd., Männedorf, Switzerland. A complete list may be found at Product names and company names that are not contained in the list but are noted herein may be the trademarks of their respective owners. For technical details and detailed procedures of the specifications provided in this document please contact your Tecan representative. Tecan is in major countries a registered trademark of Tecan Group Ltd., Männedorf, Switzerland Tecan Trading AG, Switzerland, all rights reserved V

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