2016 PRODUCT CATALOG October edi on

Transcription

1 2016 PRDUCT CATALG ctober edi on Molecular Innova on for Medicine 1

2 Place your order: or Macrocyclics has been the global leader in chelating agent technologies for medicine since The Macrocyclics team is dedicated to providing its clients with both established and innovative chelating agents and services to meet the challenges of molecular imaging and nuclear medicine. uclear Medicine Process chemistry and ligand design Feasibility studies for process optimization Bioconjugation development and cgmp production Custom design, manufacture, and cgmp production of chelates Identification and selection of appropriate chelating agent and specific applications 1

3 Place your order: or ABUT MACRCYCLICS Macrocyclics, a manufacturer of customized chelating agents, is dedicated to leading-edge development of new chelation chemistry platforms critical for advancement of diagnostic and therapeutic medicine. ur strong commitment to customer service and quality products are key components in our ongoing pursuit of excellence. ABUT YUR RDER SIPPIG Most of the compounds we sell are stable under normal laboratory conditions. It is not necessary to refrigerate our compounds during short-distance transportation. Therefore, we ship our compounds via FedEX, unless otherwise specified by the customer. If the compound requires special shipping conditions (such as dry ice) you will be notified in advance. STRAGE CDITIS We recommend storing Macrocyclics products in the freezer at 20 C. TECICAL QUESTIS If you have a technical question about a product you have received, or would like to know more before you place an order, please contact us: info@macrocyclics.com or. MATERIAL SAFETY DATA SEETS MSDSs are available on our website under the Individual product pages. We can also fax a hardcopy if you prefer. Please mention your request on the purchase order. 2

4 Place your order: or PRDUCT AALYSIS Macrocyclics expertise in ligand synthesis is complemented by our quality control systems, guaranteeing the highest possible quality for all our products. CERTIFICATE F AALYSIS Certificates of analysis will be sent with your products if requested. The C of A provides the test method used and the results. If you need further information about a compound, please contact us and we will try to accommodate your request. W T RDER If you are new customer placing your first order, please provide: Purchase order or credit card number Shipping and billing addresses Phone and fax numbers address nce your order is processed, you will receive a confirmation by fax or . nline: By Fax: By Phone: Payment: Please fax your order to (972) Go to and click on the catalog. Call in your order with the information listed above:. We accept VISA, MasterCard, and American Express. There is a $20 service charge for international bank transfers. Please see Macrocyclics bank information on your original invoice. 3

5 Place your order: or Product List Bifunctional Chelators (BFCs) Page B-110 p- 2 -Bn-Cyclen... 7 B-170 DTAM-mono-acid... 7 B-199 p- 2 -Bn-DTA... 7 B-200 p- 2 -Bn-DTA... 8 B-201 p- 2 -Bn-DTA-tetra(t-Bu ester)... 8 B-205 p-sc-bn-dta... 8 B-260 DTA-tris (t-bu ester)... 8 B-264 DTAGA-tetra (t-bu ester)... 9 B-270 DTA-mono-S-tris (t-bu ester)... 9 B-271 Maleimido-mono-amide-DTA-tris (t-bu ester)... 9 B-272 Maleimido-mono-amide-DTA... 9 B-275 Fmoc-L-Lys-mono-amide-DTA-tris (t-bu ester) B-276 Butyne-DTA-tris(t-butyl ester) B Aminoethyl-mono-amide DTA-tris (t-bu ester) B Azidopropyl-mono-amide-DTA-tris(t-Bu ester) B Aminobutyl-DTA-tris (t-butyl ester) B-280 DTA-S-ester B-281 D3A-Thiol B-286 Butyne-DTA B Azidopropyl-mono-amide-DTA B Aminobutyl-DTA B-300 p- 2 -Bn-DTPA B-301 p- 2 -Bn-DTPA-penta (t-bu ester) B-305 p-sc-bn-dtpa B-351 p- 2 -Bn-CX-A -DTPA B-355 p-sc-bn-cx-a -DTPA B-365 DTPA-tetra (t-bu ester) B-372 Maleimido-mono-amide-DTPA B-401 p- 2 -Bn-PCTA B-405 p-sc-bn-pcta B-501 p- 2 -Bn-oxo-D3A B-505 p-sc-bn-oxo-d3a

6 Place your order: or Product List Bifunctional Chelators (BFCs) Page B-601 p-2-bn-ta...15 B-605 p-sc-bn-ta...15 B-616 2A-Butyne-bis (t-butyl ester)...15 B-620 TA-bis (t-bu ester)...16 B-622 Maleimido-mono-amide-TA...16 B-626 2A-Butyne B-628 2A-Azide B-705 p-sc-bn-deferroxamine...17 B-772 Deferroxamine-maleimide...17 B-1005 p-sc-bn-tcmc...17 S-100 Bifunctional Starter Pack...17 Conjugates Page C-100 DTA-Biotin-Sarcosine...18 C-210 D3A-Serotonin C-220 DTATATE Macrocyclic Ligands Page M-090 TAC...19 M-100 Cyclen...19 M-125 D2A...19 M-135 D3A...20 M-140 DTA...20 M-150 DTP...20 M-160 DTMA...20 M-170 TETA...21 M-180 DTAM...21 M-190 DiAmSar...21 M-200 CB-Cyclam...21 M-220 CB-TE2A...22 M-400 DTA-4AMP...22 M-600 TA...22 M-650 TP

7 Place your order: or Product List Magnetic Resonance Reagents Page M-145 Tm-DTA M-147 Gd-DTA M-155 Tm-DTP M-165 Tm-DTMA M-503 Eu-DTA 4AmC X-205 Tm-p-SC-Bn-DTA X-207 Gd-p-SC-Bn-DTA X-209 o-p-sc-bn-dta X-275 Tm-Maleimido-DTA X-279 o-maleimido-dta X-287 Gd-D3A-Butylamine Reactive Intermediates Page M-120 D2A-tert-butyl ester M-130 D3A-tert-butyl ester I-121 Bis-CBZ-Cyclen I-131 Tris-Boc-Cyclen I-623 2A-(t-Bu ester) Fluorescent Probes Page D-100 EAM D-110 EAM

8 Formula: FW: Bifunctional CAS umber: Chelators (BFCs) Purity: p-2-bn-cyclen B Formula:C₁₅₂₅₅₂ FW: CAS umber: $ mg $1, S-2-(4-itrobenzyl)-1,4,7,10-tetraazacyclododecane DTAM-mono-acid 2 2 B Formula:C₁₆₃₁₇₅ FW: CAS umber: /A $ mg $ ,4,7,10-Tetraazacyclododecane-1,4,7-tri(carbamoylmethyl)-10-acetic acid p-2-bn-dta B Cl Formula:C₂₃₃₃₅₁₀ 4Cl FW: CAS umber: $ $ S-2-(4-itrobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid 7

9 p-₂-bn-dta B Cl Formula:C₂₃₃₅₅₈ 4Cl FW: CAS umber: $ $ mg $1, S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid p-₂-bn-dta-tetra(t-bu ester) B-201 tbu tbu tbu 2 TFA tbu Formula:C₃₉₆₇₅₈ TFA FW: CAS umber: /A $ mg $1, S-2-(4-Aminobenzyl)-1,4,7,10-tetraazacyclododecane tetra-tert-butylacetate p-sc-bn-dta B-205 CS 2.5Cl Formula:C₂₄₃₃₅₈S 2.5Cl 2.5₂ FW: CAS umber: $ $ mg $2, S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid DTA-tris (t-bu ester) tbu tbu B-260 tbu Formula:C₂₈₅₂₄₈ FW: CAS umber: mg $ g $ g $1, ,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-acetic acid 8

10 DTAGA-tetra (t-bu ester) tbu tbu B-264 tbu tbu Formula:C₃₅₆₄₄₁₀ FW: CAS umber: $ mg $ g $ [1,4,7,10-Tetraazacyclododecane-4,7,10-tris(t-butyl acetate)]-pentanedioic acid-1t-butyl ester DTA-mono-S tris (t-bu ester) tbu tbu B-270 tbu PF 6 Formula:C₃₂₅₅₅₁₀ PF₆ FW: CAS umber: $ mg $ g $ ,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-succinimidyl acetate Maleimido-mono-amide-DTA-tris (t-bu ester) tbu tbu B-271 tbu PF 6 Formula:C₃₄₅₈₆₉ PF₆ FW: CAS umber: /A $ $ mg $ ,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-maleimidoethylacetamide Maleimido-mono-amide-DTA B-272 PF 6 TFA Formula:C₂₂₃₄₆₉ PF₆ TFA FW: CAS umber: $ $ mg $1, ,4,7,10-Tetraazacyclododecane-1,4,7-tris-acetic acid-10-maleimidoethylacetamide 9

11 Fmoc-L-Lys-mono-amide-DTA-tris(t-Bu ester) tbu tbu B-275 PF 6 Fmoc tbu (C 2 ) 4 Formula:C₄₉₇₄₆₁₁ PF₆ FW: CAS umber: mg $ mg $ mg $ ,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-(-a-fmoc--e-acetamido-l-lysine) Butyne-DTA-tris(t-butyl ester) tbu tbu B-276 tbu PF 6 Formula:C₃₂₅₇₅₇ PF₆ FW: CAS umber: /A $ mg $ ,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)-10-(3-butynylacetamide) 2-Aminoethyl-mono-amide-DTA-tris(t-Bu ester) tbu tbu B-277 tbu Br 2 Formula:C₃₀₅₈₆₇ Br FW: CAS umber: /A 500 mg $ g $ g $2, ,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl-acetate)-10-(aminoethylacetamide) Azido-mono-amide-DTA-tris(t-Bu ester) tbu tbu B-278 tbu Br 3 Formula:C₃₁₅₈₈₇ Br FW: CAS umber: /A $ mg $ g $1, ,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-(azidopropyl ethylacetamide) 10

12 Aminobutyl-DTA-tris (t-butyl ester) B-279 tbu tbu tbu PF 6 2 Formula:C₃₂₆₂₆₇ PF₆ FW: CAS umber: /A $ mg $ ,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate)-10-(4-aminobutyl)acetamide DTA-S-ester B-280 PF 6 TFA Formula:C₂₀₃₁₅₁₀ PF₆ CF₃C₂ FW: CAS umber: Purity: 90% $ mg $ g $ ,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid mono--hydroxysuccinimide ester D3A-Thiol B-281 2TFA S Formula:C₁₈₃₃₅₇S 2CF₃C₂ FW: CAS umber: $ mg $2, ,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(2-thioethyl)acetamide Butyne-DTA B-286 2TFA Formula:C₂₀₃₃₅₇ 2CF₃C₂ FW: CAS umber: /A $ mg $1, ,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(3-butynylacetamide) 11

13 Azido-mono-amide-DTA B-288 3Cl 3 Formula:C₁₉₃₄₈₇ 3Cl FW: CAS umber: $ mg $1, g $2, ,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(azidopropyl ethylacetamide) 4-Aminobutyl-DTA B-289 PF 6 4Cl 2 Formula:C₂₀₃₈₆₇ PF₆ 4CI FW: CAS umber: /A $ mg $1, ,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(4-aminobutyl)acetamide p-₂-bn-dtpa 2 B-300 4Cl Formula:C₂₁₃₀₄₁₀ 4Cl FW: CAS umber: $ mg $ S-2-(4-Aminobenzyl)-diethylenetriamine pentaacetic acid p-₂-bn-dtpa-penta (t-bu ester) 2 B-301 tbu tbu tbu tbu tbu Formula:C₄₁₇₀₄₁₀ FW: CAS umber: g $1, S-2-(4-Aminobenzyl)-diethylenetriamine penta-tert-butyl acetate 12

14 p-sc-bn-dtpa CS B-305 3Cl Formula:C₂₂₂₈₄₁₀S 3Cl FW: CAS umber: $ mg $ S-2-(4-Isothiocyanatobenzyl)-diethylenetriamine pentaacetic acid p-₂-bn-cx-a"-dtpa 2 2Cl 2 2 Formula:C₂₅₃₆₄₁₀ 2Cl 2₂ FW: CAS umber: B-351 $ mg $1, [(R)-2-Amino-3-(4-aminophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid p-sc-bn-cx-a"-dtpa CS 3Cl Formula:C₂₆₃₄₄₁₀S 3Cl FW: CAS umber: B-355 $ $ mg $1, [(R)-2-Amino-3-(4-isothiocyanatophenyl)propyl]-trans-(S,S)-cyclohexane-1,2-diamine-pentaacetic acid DTPA-tetra (t-bu ester) B-365 tbu tbu tbu tbu Formula:C₃₀₅₅₃₁₀ FW: CAS umber: mg $ g $1, Diethylenetriamine-,,","-tetra-tert-butyl acetate-'-acetic acid 13

15 Maleimido-mono-amide-DTPA Formula:C₂₀₂₉₅₁₁ 3CF₃C₂ FW: CF 3 C CAS umber: /A Diethylenetriamine-,,","-tetra- acetic acid-'-maleimidoethylacetamide B-372 $ $ mg $1, p-₂-bn-pcta B Cl 2 2 Formula:C₂₄₃₁₅₆ 2Cl 2₂ FW: CAS umber: /A $ $ ,6,9,15-Tetraazabicyclo[9.3.1] pentadeca-1(15),11,13-triene-4-s-(4-aminobenzyl)-3,6,9-triacetic acid p-sc-bn-pcta B-405 3Cl CS Formula:C₂₅₂₉₅₆S 3Cl FW: CAS umber: /A $ $ ,6,9,15-Tetraazabicyclo[9.3.1] pentadeca-1(15),11,13-triene-4-s-(4-isothiocyanatobenzyl)-3,6,9- triacetic acid p-₂-bn-oxo-d3a B Cl 2 2 Formula:C₂₁₃₂₄₇ 2Cl 2₂ FW: CAS umber: /A $ $ xa-4,7,10-tetraazacyclododecane-5-S-(4-aminobenzyl)-4,7,10-triacetic acid 14

16 p-sc-bn-oxo-d3a B-505 3Cl CS Formula:C₂₂₃₀₄₇S 3Cl FW: CAS umber: /A $ $ xa-4,7,10-tetraazacyclododecane-5-S-(4-isothiocyantobenzyl)-4,7,10-triacetic acid p-2-bn-ta B-601 4Cl 2 Formula:C₁₉₂₈₄₆ 2Cl 2₂ FW: CAS umber: $ $ S-(4-Aminobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid p-sc-bn-ta B-605 3Cl CS Formula:C₂₀₂₆₄₆S 3Cl FW: CAS umber: $ $ S-(4-Isothiocyanatobenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic acid 2A-Butyne-bis (t-butyl ester) B-616 tbu tbu Formula:C₂₄₄₂₄₅ FW: CAS umber: /A Purity: $ mg $2, ,4,7-Triazacyclononane-1,4-bis(t-butylacetate)-7-(3-butynylacetamide) 15

17 TA-bis(t-Bu ester) B-620 tbu tbu Formula:C₂₀₃₇₃₆ FW: CAS umber: $ mg $ g $1, ,4,7-Triazacyclononane-1,4-bis-tert-butyl acetate-7-acetic acid Maleimido-mono-amide-TA Formula:C₁₈₂₇₅₇ CF₃C₂ FW: CAS umber: /A CF 3 C 2 1,4,7-Triazacyclononane-1,4-bis-acetic acid-7-maleimidoethylacetamide B-622 $ mg $1, A-Butyne B-626 Formula:C₁₆₂₆₄₅ FW: CAS umber: /A $1, mg $4, ,4,7-Triazacyclononane-1,4-bis(acetic acid)-7-(3-butynylacetamide) 2A-Azide B-628 3Cl 3 Formula:C₁₅₂₇₇₅ 3Cl FW: CAS umber: /A $ mg $1, ,4,7-Triazacyclononane-1,4-bis(acetic acid)-7-(3-azidopropylacetamide) 16

18 p-sc-deferoxamine B-705 S CS Formula:C₃₃₅₂₈₈S₂ FW: CAS umber: $ $ mg $1, (4-isothiocyanatophenyl)-3-[6,17-dihydroxy-7,10,18,21-tetraoxo-27-(-acetylhydroxylamino)- 6,11,17, 22- tetraazaheptaeicosine] thiourea Deferoxamine-maleimide Formula:C₃₂₅₃₇₁₁ FW: CAS umber: /A 50mg B-772 $ mg $ mg $1, (3,11,14,22,25,33-hexaoxo-4,10,15,21,26,32-hexaaza-10,21,32- trihydroxytetratriacontane)maleimide p-sc-bn-tcmc 2 2 B-1005 CS 2 2 4Cl Formula:C₂₄₃₇₉₄S 4Cl FW: CAS umber: $ $ S-2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraaza-1,4,7,10-tetra(2-carbamoylmethyl)cyclododecane Bifunctional Starter Pack S-100 p-sc-bn-dta DTA-S-ester FW: p-sc-bn-dtpa p-sc-bn-cx-a"-dtpa Formula: CAS umber: Purity: B-205 B-280 B-305 B-355 mg $ Samples of our most popular bifunctional chelators 17

19 Formula: FW: CAS Conjugates umber: Purity: DTA-Biotin-Sarcosine S 2Cl 2 2 Formula:C₃₆₅₄₈₁₁S 2Cl 2₂ FW: CAS umber: /A 20 mg C-100 $ $ $1, (-methyl--(hexahydro-2-oxo-1-thieno[3,4-d]-imidazol-4-yl)-oxopentyl)glycyl-2-(s)-(4-aminobenzyl)- 1,4,7,10-tetraacetic acid-1,4,7,10-tetraazacyclododecane D3A-Serotonin. 2TFA Formula:C₂₆₃₈₆₈ 2CF₃C₂ FW: CAS umber: /A C-210 $ mg $1, (5-ydroxyindole-3-ethylacetamide)-4,7,10-triacetic acid-1,4,7,10-tetraazacyclododecane DTATATE C 2 2 C 2C S S 3 TFA Formula:C₆₅₉₀₁₄₁₉S₂ 3TFA 3₂ FW: CAS umber: mg C-220 $ DTA-d-Phe-Cys-Tyr-d-Trp-Lys-Thr-Cys-Thr 18

20 Formula: FW: Macrocyclic CAS umber: Ligands Purity: TAC Formula:C₆₁₅₃ FW: CAS umber: g M-090 $ g $ ,4,7-Triazacyclononane Cyclen Formula:C₈₂₀₄ FW: CAS umber: Purity: Crystalline 5 g M-100 $ g $ g $1, ,4,7,10-Tetraazacyclododecane D2A 4Cl Formula:C₁₂₂₄₄₄ 4Cl FW: CAS umber: Purity: /A 500 mg M-125 $ g $ ,4,7,10-Tetraazacyclododecane-1,7-diacetic acid 19

21 D3A a a M-135 a 2 2 Formula:C₁₄₂₃₄₆a₃ 2₂ FW: CAS umber: mg $ g $ ,4,7,10-Tetraazacyclododecane-1,4,7-triacetic acid trisodium salt DTA M Formula:C₁₆₂₈₄₈ 6₂ FW: CAS umber: g $ g $ g $2, ,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid DTP M P 2 3 P P 3 2 P 3 2 Formula:C₁₂₃₂₄₁₂P₄ FW: CAS umber: g $ g $ g $ ,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylene phosphonic acid) DTMA a a M-160 a 4 2 a Formula:C₂₀₃₂₄₈a₄ 4₂ FW: CAS umber: $ mg $ g $ (1R, 4R, 7R, 10R)-α, α, α, α -Tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid tetrasodium salt 20

22 TETA M-170 4Cl 4 2 Formula:C₁₈₃₂₄₈ 4₂ 4Cl FW: CAS umber: mg $ g $ g $3, ,4,8,11-Tetraazacyclotetradecane-1,4,8,11-tetraacetic acid DTAM 2 2 M Formula:C₁₆₃₂₄₈₄ FW: CAS umber: mg $ g $ g $ ,4,7,10-Tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane DiAmSar M Formula:C₁₄₃₄₈ 5₂ FW: CAS umber: Purity: Crystalline $ mg $1, ,8-Diamino-3,6,10,13,16,19-hexaazabicyclo[6,6,6]-eicosane CB-Cyclam Formula:C₁₂₂₆₄ FW: CAS umber: Purity: /A 500 mg M-200 $ g $ ,4,8,11-Tetraazabicyclo[6.6.2]hexadecane 21

23 CB-TE2A M-220 4Cl Formula:C₁₆₃₀₄₄ 4Cl FW: CAS umber: Purity: /A $ mg $ ,4,8,11-Tetraazabicyclo[6.6.2]hexadecane-4,11-diacetic acid DTA-4AMP 2 3 P 2 3 P P 3 2 Br 2 2 P 3 2 Formula:C₂₀₄₄₈₁₆P₄ 2₂ Br FW: CAS umber: /A M-400 $ mg $ ,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(acetamido-methylenephosphonic acid) TA M-600 3Cl Formula:C₁₂₂₁₃₆ 3Cl FW: CAS umber: mg $ g $ ,4,7-Triazacyclononane-1,4,7-triacetic acid TP P P P Formula:C₉₂₄₃₉P FW: CAS umber: g M-650 $ g $ ,4,7-Triazacyclononane-1,4,7-tri(methylene phosphonic acid) 22

24 Formula: FW: Magnetic CAS Resonance umber: Reagents Purity: Tm-DTA - M-145 Tm Formula:TmC₁₆₂₅₄₈ 4₂ FW: CAS umber: /A 500 mg $ g $ Thulium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate Gd-DTA - a M-147 Gd Formula:GdC₁₆₂₄₄₈a 4₂ FW: CAS umber: /A Purity: /A 500 mg $ g $ Gadolinium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetate Tm-DTP M-155 a 3 P a 2 3 P Tm 3+ P 3 a 5 2 Formula:TmC₁₂₂₄₄₁₂P₄a₅ 5₂ FW: P 3 a CAS umber: Purity: /A 1 g $ g $1, g $11, Thulium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetra(methylenephosphonate) 23

25 Tm-DTMA - M-165 Tm Formula:TmC₂₀₃₃₄₈ 4₂ FW: CAS umber: /A 500 mg $ g $1, Thulium (III) (1R, 4R, 7R, 10R)-α, α, α, α -Tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10- tetraacetic acid Eu-DTA-4AmC 2 C - 2 C Eu 3+ C C 2 - Formula:EuC₂₄₃₇₈₁₂ 9₂ FW: CAS umber: /A M-503 $ $ mg $ Europium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrakis(acetamidoacetic acid) Tm-p-SC-Bn-DTA X-205 Tm. TFA CS Formula:TmC₂₄₃₀₅₈ TFA FW: CAS umber: /A $ $1, Thulium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraacetic acid Gd-p-SC-Bn-DTA X-207 Gd. TFA CS Formula:GdC₂₄₃₀₅₈ TFA FW: CAS umber: /A $ $1, Gadolinium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid 24

26 o-p-sc-bn-dta X-209 o. TFA CS Formula:₀C₂₄₃₀₅₈ TFA FW: CAS umber: /A $ $1, olmium (III) S-2-(4-isothiocyanatobenzyl)-1,4,7,10- tetraazacyclododecane-1,4,7,10-tetraacetic acid Tm-Maleimido-DTA X-275 Tm. Formula:TmC₂₂₃₁₆₉ TFA TFA FW: CAS umber: /A $ $ Thulium (III) 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid)-10- maleimidoethylacetamide o-maleimido-dta X-279 o. Formula:oC₂₂₃₁₆₉ TFA TFA FW: CAS umber: /A $ $ olmium (III) 1,4,7,10-tetraazacyclododecane-1,4,7-tris(acetic acid)- 10-maleimidoethylacetamide Gd-D3A-Butylamine Cl X-287 Gd 2 Formula:GdC₂₀₃₅₆₇ Cl FW: CAS umber: /A $ mg $1, Gadolinium (III) 1,4,7,10-Tetraazacyclododecane-1,4,7-tris(acetic acid)-10-(4-aminobutyl)acetamide 25

27 Formula: FW: Reactive CAS umber: Intermediates Purity: D2A-tert-butyl ester tbu Formula:C₂₀₄₀₄₄ FW: CAS umber: tbu 1,4,7,10-Tetraazacyclododecane-1,7-bis(t-butyl acetate) 500 mg M-120 $ g $ g $1, D3A-tert-butyl ester tbu tbu M-130 tbu Formula:C₂₆₅₀₄₆ FW: CAS umber: mg $ g $ g $ ,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butyl acetate) Bis-CBZ-Cyclen I-121 Formula:C₂₄₃₂₄₄ FW: CAS umber: /A 1 g $ g $1, ,4,7,10-Tetraazacyclododecane-1,7-bis(benzylcarbamide) 26

28 Tris-BC-Cyclen tbu tbu tbu Formula:C₂₄₄₄₄₆ FW: CAS umber: /A 1 g I-131 $ g $ ,4,7,10-Tetraazacyclododecane-1,4,7-tris(t-butoxycarbonyl) 2A-(t-Bu ester) I-623 tbu tbu Formula:C₁₈₃₅₃₄ FW: CAS umber: mg $ g $ ,4,7-Triazacyclononane-1,4-bis(t-butyl acetate) Formula: FW: CAS umber: Purity: Formula: FW: CAS umber: Purity: 27

29 Formula: FW: Fluorescent CAS umber: Probes Purity: EAM-1 D I Formula:C₁₁₁₆₅₃I FW: CAS umber: mg $352.00,,-Trimethyl-2[(7-nitro-1,2,3-benzoxadiazol-4-yl)amino] ethanaminium iodide EAM-2 D Br Formula:C₁₂₁₈₅₄Br FW: CAS umber: /A 10 mg $352.00,-Dimethyl--(2-hydroxyethyl)-2[(7-nitro-1,2,3-benzoxadiazol-4-yl)amino] ethanaminium bromide Formula: FW: CAS umber: Purity: 28

30 Formula: FW: CAS umber: Purity: Formula: FW: CAS umber: Purity: Formula: FW: CAS umber: Purity: Formula: FW: CAS umber: Purity: 29

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