H3 System Tele-Healthcare Solution Wearable Sensors. April. 2018

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1 H3 System Tele-Healthcare Solution Wearable Sensors April. 2018

2 Table of Contents I. Company Introduction II. Tele-Healthcare Solution 1. Service Delivery Model 2. Selected Customers 3. Technology Overview 4. Telehealth Modem 5. Glucometer Adapter III. Wearable Sensors - Heart Rate Monitor I. Contact Us 2

3 3 I. Company Introduction

4 4 I. Company Introduction Company CEO Business Focus Headquarters H3 System Co., Ltd. Min-Joon Kim Tele-Healthcare Solution Wearable Sensors Daejeon, Korea(South) No. of Employees 14 Corporate History Established H3 System Co., Ltd Provided GlucoAutoCheck, a tele-healthcare solution for KT u-diabetes Management Service Acquired government grant for developing Motion Artifact Free Wearable Pulse Sensor Provision of GlucoAutoCheck-Data Collection S/W to government for elderly people care service Passed the first official test on the standard WAN interface Started to export GSM/GPRS Gateway (H3G-700) in US KGMP Certification for quality control TTA Certification s Award of Excellence Venture capital investment Developed wearable patient monitor for pilot tests Official launch of chest strap free heart rate monitor(hrm-3200) Provided Heart Rate monitor (HRM-3200) to the disabled care service Launched 3G Tele-health Modem(H3G-800) in US after Verizone certification Established a branch office in US Official launch of the BLE Adapter (BA-300) Designated as a Promising Export Firm by the Small & Medium Business Administration, R.O. Korea Official launch of the All-In-One BLE Adapter (BA-400) Launched LTE Tele-health Modem(H3G-900) in US after Verizon certification

5 5 II. Tele-Healthcare Solution

II-1. Service Delivery Model Overview H3 System provides high

Healthcare Consulting Education Doctor / Care provider At-home

Internet Visit the Website Thermometer Home Healthcare Modem Wireless

6 II-1. Service Delivery Model Overview H3 System provides high quality, cost effective tele-healthcare solutions. Healthcare Consulting Education Doctor / Care provider At-home Patient Devices Blood pressure monitor Glucometer Wireless connection Internet Visit the Website Thermometer Home Healthcare Modem Wireless Connection Secure data center Weight scale Mobile Networks Main Server Oximeter Data Collection Server 6

7 7 II-1. Service Delivery Model How it works Monitoring Devices Download Data Transmit Data to Server Healthcare Provider Blood glucose Blood pressure Weight scale Thermometer Bluetooth Automatically transmit patient data via Mobile networks Provides patient data reports to healthcare provider Pulse oximeter

8 8 II-1. Service Delivery Model Competitive Advantages Easy to use Measure blood glucose, blood pressure, weight and other medical data as usual. Data transmission is fully automatic. Installation is very easy as well. No additional equipment needed You don t have to have a PC. You can use a phone line, an Internet line, or mobile networks. All you need is electric power. Multi-device compatibility Glucometer, blood pressure monitor, weight scale, heart rate monitor, thermometer, pulse oximeter, and inhaler. Additional devices are in development. Cost effective and reliable Cost effective tele-healthcare solution. Widely deployed in US since Also commercialized and evaluated in Korea and the other countries.

9 9 II-1. Service Delivery Model Value Proposition (Example) Medical Insurance (HMO, Medicare, etc.) Pay insurance Patient Tele-Healthcare Service Manage risks associated with patient aggravations or complications Reduce cost of care Pay for healthcare service Prevention of aggravations and complications Active patient participation in managing health Provides healthcare service Healthcare Provider Improve patient care Increase productivity Ability to treat patients before conditions become acute

10 10 II-2. Selected Customers Company A in US Bluetooth Adapter (BA series) Remote Patient Monitoring Service Commercialized Since 2011 Blood glucose Tele-Health Modem (H3G series) Blood pressure Thermometer Bluetooth GPRS, CDMA, 3G, LTE Mobile Networks Care provider Weight scale

11 11 II-2. Selected Customers Qualcomm Outreach project Users at Home Bluetooth 3G Modem Quality of care service for diabetes 2012 ~ 2013 Take a blood glucose reading SMS Healthcare Center Doctor App Web

for the Elderly Aging Independently Since Nov.

elderly person care system Automatic emergency

Fire station Installation of sensors in a house of

information Emergency data Activity data System

Rescue Rescue support Rescue work Fire extinction

12 12 II-2. Selected Customers Korean Government U-Care Service for the Elderly Aging Independently Since Nov Current Subscriber Base: > 100,000 Single elderly person care system Automatic emergency report Emergency call Fire detection Gas detection Fire station Installation of sensors in a house of of a single elderly person Local agencies User information Emergency data Activity data System operation data Heart rate monitoring Report receipt Rescue Rescue support Rescue work Fire extinction Life support Safety checkup Life education Services Activity monitoring Data monitoring Helper dispatched in case of an abnormal sign

glucose Mobile Networks Data Collection Server

13 13 II-3. Technology Overview System Configuration : H3 System s business Users at Home Blood Pressure Secure Data Center Healthcare Provider Blood glucose Mobile Networks Data Collection Server Main Server Internet SpO2 Weight Server System Data Collection SW Patient Info DB Web Application

II-4. Telehealth Modem Modem Specifications H3G-700 H3G-800 H3G-850 H3G-900 Images General functions Remote firmware upgrade Automatic transmission of measured health records Real time and

Blood Pressure Monitor Blood Pressure Monitor Blood Pressure Monitor Devices Weight scale Thermometer Weight scale Thermometer Weight scale Thermometer Weight scale Thermometer Pulse oximeter Pulse

14 II-4. Telehealth Modem Modem Specifications H3G-700 H3G-800 H3G-850 H3G-900 Images General functions Remote firmware upgrade Automatic transmission of measured health records Real time and store-and-forward data transmission Alive signal N/A Supported Supported Supported Remote Pairing N/A Supported Supported Supported Glucometer Glucometer Glucometer Glucometer Blood Pressure Monitor Blood Pressure Monitor Blood Pressure Monitor Blood Pressure Monitor Devices Weight scale Thermometer Weight scale Thermometer Weight scale Thermometer Weight scale Thermometer Pulse oximeter Pulse oximeter Pulse oximeter Pulse oximeter Inhaler Inhaler Inhaler Device Interface Bluetooth Classic Bluetooth Classic Bluetooth Classic and Low Energy Bluetooth Classic and Low Energy Communication networks Mobile (GSM/GPRS) Mobile (3G, Verizon) Mobile (3G, Verizon) Mobile (LTE, Verizon) Countries Europe and other countries with GSM/GPRS Networks US US US 14

Functions Automatic transmission of measured health records Real time and store-and-forward data transmission Alive signal Remote

15 II-4. Telehealth Modem BLE only Tele-Health Modem (H3G-1000) Specifications Cost Effective Bluetooth Low Energy Only Countries: Almost all countries (Model could vary on mobile networks) Communication Networks: 2G or 4G (LTE) Power supply: AC Adapter (5V/3A) Functions Automatic transmission of measured health records Real time and store-and-forward data transmission Alive signal Remote Firmware Upgrade Applicable devices Glucometer (with BLE Adapter) Blood Pressure Monitor Weight scale Thermometer Pulse oximeter Inhaler 15

16 16 II-4. Telehealth Modem Data Collection Software Specifications Functions Receives data from gateways Integrates information into database, generates XML files, or sends XML files over Web service Generates communication logs Exception handling: communication, DB access Sends new configurations to gateways WAN Interfaces Web service Continua WAN interface DB access File I/O OS: MS windows XP 2000 and later versions Platform: JAVA,.NET Framework Database: MySQL, MS SQL, Oracle <?xml version="1.0" encoding="utf-8"?> <Measure serial=" " dc="0" battery="1.2"> <Device type="glucose"> <Data id="zhz306cby" measuretime=" " result="103" unit="0" model="1" adapter="1" /> </Device> <Device type="pressure"> <Data id="61102dm2" measuretime=" " sys="139" dia="091" pul="094" /> </Device> <Device type="weight"> <Data id=" " measuretime=" " result="066.90" unit="kg" battery="2.32" /> </Device> Data collection software (XML files)

17 17 II-4. Telehealth Modem Web-based Application Software Specifications Functions Manages patient information Manages blood glucose data, blood pressure data, weight data, and other medical data Generates charts, tables, and statistics with stored data Supports 4 user groups Patient Doctor (Healthcare provider) Consumable supplier System administrator Provides a smart log viewer Provides convenient user interface for setup of environmental variables OS: Platform independent but MS Windows 2003 server is recommended Database: MySQL, MS SQL, Oracle Languages: English, Korean Customization/localization support is available

18 18 II-4. Telehealth Modem Applicable Devices * Additional devices in development Device Manufacturer Interface Image Glucometer Blood Pressure Monitor Weight Scale Thermometer Pulse Oximeter Johnson & Johnson (USA) Bayer (Germany) Abbott (USA) Nipro (USA) Roche (Switzerland) A&D Medical (Japan) OMRON (Japan) Welch (USA) A&D Medical (Japan) OMRON (Japan) Welch (USA) Fora Care (Taiwan) A&D Medical (Japan) Beijing Choice (China) Nonin (USA) BT Classic, BLE (with Adapter) BT Classic, BLE (with Adapter) BT Classic, BLE (with Adapter) BT Classic, BLE (with Adapter) BT Classic, BLE (with Adapter) BT Classic, BLE BLE BLE BT Classic BLE BLE BT Classic BT Classic BT Classic BT Classic, BLE Pedometer P1ng (Taiwan) BLE Inhaler Nexus6 (New Zealand) Propeller (USA) BT Classic BLE

19 19 II-4. Telehealth Modem Trial Methods: Telehealth Modem and remote server in Korea H3 System Office in Korea Glucometer + Glucometer Adapter + Telehealth Modem Main Server Mobile Networks Data Collection SW Patient Info DB Web Application We provide Requirements Telehealth Modem Glucometer(OneTouch Ultra) by J&J Glucometer Adapter(BA-110) by H3 System Set of ID: patient, doctor, service provider Util S/W (Configuration software for a modem) NDA should be signed before installation.

II-5. Glucometer Adapter Bluetooth Adapter (BA-110 / BA-300) Specifications Model BA-110 BA-300 Functions Receives readings from a glucometer Sends the readings to other devices such as a mobile

Devices OneTouch Ultra OneTouch Ultra2 OneTouch Ultra mini/easy Contour Contour Next EZ Contour XT Contour TS FreeStyle Lite FreeStyle Freedom Lite TRUE Track TRUE Balance TRUE Result Aviva Aviva

20 II-5. Glucometer Adapter Bluetooth Adapter (BA-110 / BA-300) Specifications Model BA-110 BA-300 Functions Receives readings from a glucometer Sends the readings to other devices such as a mobile phone, a gateway and so on Empowers a glucometer with cable connection only to send data via wireless communication (From serial to Bluetooth) Johnson & Johnson Bayer Abbott Nipro Roche (for BA-110) Devices OneTouch Ultra OneTouch Ultra2 OneTouch Ultra mini/easy Contour Contour Next EZ Contour XT Contour TS FreeStyle Lite FreeStyle Freedom Lite TRUE Track TRUE Balance TRUE Result Aviva Aviva plus Device Interface Serial IR Communication networks Wireless (Bluetooth Classic) Wireless (Bluetooth Low Energy) Certification FCC, CE, FDA and Bluetooth FCC, CE* and Bluetooth* Power supply Dry Cells (AAA Size) 2EA * will be certified by JULY,

Interface: Serial and IR (For Roche) Functions Receives readings from a glucometer.

Empowers a glucometer with cable connection only to send data via wireless communication (from serial to Bluetooth 4.0).

21 21 II-5. Glucometer Adapter BLE Adapter All-In-One Model (BA-400) Specifications Bluetooth Low Energy standard glucose profile Device Interface: Serial and IR (For Roche) Functions Receives readings from a glucometer. Sends the readings to other devices such as a mobile phone, a gateway and so on. Empowers a glucometer with cable connection only to send data via wireless communication (from serial to Bluetooth 4.0). Applicable devices Glucometer (J&J): OneTouch Ultra, OneTouch Ultra2, OneTouch Ultra mini/easy. Glucometer (Bayer): Contour, Contour Next EZ, Contour XT, Contour TS. Glucometer (Abbott): FreeStyle Lite, FreeStyle Freedom Lite. Glucometer (Nipro): TRUE Track, TRUE Balance, TRUE Result. Glucometer (Roche): ACCU CHECK Avia, ACCU CHECK Avia Plus

22 22 III. Wearable Sensors

various kinds of exercises including running, cycling, and extreme sports Functions Measures

Bluetooth 4.0 provides connectivity to iphone and Android.

23 23 III. Heart Rate Monitor Overview Purposes Monitoring heart rate to maximize training efficiency For various kinds of exercises including running, cycling, and extreme sports Functions Measures heart rate continuously during exercise or normal life Sends heart rate readings wirelessly Bluetooth 4.0 provides connectivity to iphone and Android. Special features No chest-belt and No finger-touch Do not need to stop exercising to measure HR (since it is motion artifact free and continuous) You can concentrate on exercising, not on smart phones. Store-and-forward feature is supported.

* Ring and wrist-watch type will be ready soon.

24 24 III. Heart Rate Monitor Specifications Measurement Method: PPG(Photo PlethysmoGraphy) Measurement site: Fore-arm (Arm-band type) * Ring and wrist-watch type will be ready soon. Form factor and user interface Size : 55 x 57 x 16 mm LCD display with backlight, 2 buttons, and a vibrator Wireless communication Bluetooth 4.0 (Low energy) Zigbee is optional. Battery Rechargeable Lithium polymer and micro-usb connector Battery life 12 hours for continuous measurement and real-time communication

ECG base device Polar electrode(n2965) Subject : 10 persons Test Environment Indoor

25 Measurement signal 25 III. Heart Rate Monitor Measurement Analysis Model: HRM-1000, HRM-3100 Reference device ECG base device Polar electrode(n2965) Subject : 10 persons Test Environment Indoor Exercises Treadmill Cycling Interval training Error: 10% 140 Error: 5% Reference signal

26 26 III. Heart Rate Monitor Measurement Analysis Interval Training at 4, 6, and 10km/h on Treadmill

27 27 IV. Contact Us

28 IV. Contact Us H3 System Co., Ltd. Homepage: Kim, Min-Joon, Ph.D., CEO TEL: Fax:

29 29

3G Gateway Instruction

3G Gateway Instruction (H3G-800) H3 System Co., Ltd < Revision Notes > No. Date Version Content Author USA-Federal Communications Commission (FCC) This device complies with part 15 of the FCC Rules. Operation