The Libra Range of UV/Visible Spectrophotometers

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1 The Libra Range of UV/Visible Spectrophotometers YOUR PARTNER IN SCIENCE

2 Biochrom Ltd and UV/Visible spectrophotometry Biochrom has been a leading supplier of quality instrumentation to science and industry for more than 30 years. Tens of thousands of our analytical instruments have been supplied around the world, sold as own-label brands through our distribution partners. UV/Visible Spectrophotometry is a popular analytical technique used in most laboratories for a whole host of applications. Biochrom manufactures well known industry standard products such as WPA, Novaspec, Ultrospec and GeneQuant UV/Visible spectrophotometers. Biochrom has developed the Libra range of affordable and easy to use UV/Visible spectrophotometers. With its long experience of manufacturing reliable and proven products, you can be sure that the new range of Libra instruments will be built for longevity, ease of use and versatility. Offering such innovations as Press To Read (PTR) lamps for reduced cost of ownership, Reference Beam Compensation (RBC) for accurate measurement and Instrument Performance Validation (IPV) for GLP compliance, the Libra Spectrophotometers are worthy additions to the laboratory bench. Spectrophotometer selection guide Product Lamp sources Optical system Instrument Parameters Comment Wavelength Range, Libra S2 tungsten filters 440, 470, 490, 520, 550, 580, 590, 680 Absorbance Range, A Bandwidith Stray Light at 340, %T <1% at filter wavelength colorimeter for student and field use Libra S4+ tungsten CMOS array < 7 < 1%T ideal for teaching labs Libra S6+ tungsten CMOS array < 7 < 1%T ideal for QC labs Libra S22 xenon press to read split beam, reference beam compensation < 3 < 0.05%T laboratory workhorse All products have safety certifications ((CE 2014/30/EU (EMC directive); CE 2014/35/EU (LVD); EN (IEC1010-1). As part of our policy of continuous instrument development, we reserve the right to alter specifications without notice.

3 Libra S2 and Libra S2B Colorimeters Designed with student, QC and field users in mind Rugged, portable and easy to use Extremely versatile Rechargeable battery version available The Libra S2 colorimeter is a small, robust, easy to use instrument that has been designed with both the student user and field user in mind. It is ideal for teaching the principles of science and analysis in schools and secondary education colleges, as well as being rugged enough for measurements in, for example, remote location health clinics where simple diagnostic tests need to be made. The instrument surface is designed for ease of cleaning and decontamination. Rechargeable batteries are included in the Libra S2B and the system will operate for almost 1 month on a single charge to provide complete portability. filters at 440, 470, 490, 520, 550, 580, 590 and 680. These are made from coloured gelatin and are encased in glass, so that the instrument can be used in tropical conditions. A filter is selected by moving the wheel until the required wavelength is displayed in the window above the cell compartment. The instrument may be linked via a serial lead to either a serial printer for hardcopy output or to a PC for download of results to spreadsheet. It has an analogue output, and may also be connected to a chart recorder using a standard 2 x 4 mm socket to output absorbance-time data when in kinetics mode. The instrument measures in Absorbance and % Transmission mode as well as in simple kinetics, enabling changes in Absorbance over time and reaction rates to be determined (readings are taken approx. every second). It may be used to cover the wavelength range as it has an integral, colour coded rotating wheel containing Instrument Part Number Lamps Optics Wavelength range, Libra S2 mains only Libra S2B mains and battery operated Tungsten FIlters , 520, 550, 580, 590, Tungsten FIlters , 520, 550, 580, 590, 680 Absorbance range, A Bandwidth,

4 Libra S4 + Visible spectrophotometer Visible spectrophotometer covering Save data on a USB memory stick PVC (Print Via Computer) software is included to transfer data to your PC from the instrument Absorbance, % Transmission, Concentration, and Rate Ease of use and low maintenance are just some of the benefits of the Libra S4 +. It is a flexible visible spectrophotometer suitable for a wide range of applications. Its small footprint makes it ideal for laboratories where space is at a premium and its rugged lightweight construction with no moving parts makes it both portable and highly reliable. Great functionality such as the automatic calibration at start-up gives you the confidence you need in your measurements. With no lid or moving parts, this robust instrument is easy to use, clean and store. Conveniently save your data to a USB memory stick or transfer immediately to your PC using the PVC (Print Via Computer) software, supplied as standard and export your data to Excel and other formats. Increase your measurement flexibility with the optional test tube cell holder which allows you to measure 10 to 18 mm test tubes. The standard cell holder accepts 10 mm glass and disposable cuvettes and is easily removed for cleaning. An optional thermostatted cell holder is also available giving you the added capability of measurements at 37 C. Instrument Part Number Lamps Optics Wavelength range, Libra S Pulsed Tungsten Hologen Absorbance range, A Bandwidth, CMOS array < 7

5 Libra S6 + Visible spectrophotometer Visible spectrophotometer covering Save data on a USB memory stick Comprehensive 99 method storage PVC (Print Via Computer) software is included to transfer data to your PC from the instrument More onboard applications such as Bradford, BCA, Biuret and Lowry assays Wavelength scanning and pre stored methods are just some of the great benefits of the Libra S6 +, which gives outstanding functionality from an instrument with a small footprint. This is an easy to use, low maintenance visible spectrophotometer. Which includes stored methods for Bradford, BCA, Biuret, and Lowry protein quantitation, in addition to absorbance, transmittance, OD600, and concentration modes. Great features such as the automatic calibration at start-up gives you the confidence you need in your measurements. With no lid or moving parts, this robust instrument is easy to use, clean and store. Conveniently save your data to a USB memory stick or transfer immediately to your PC using the PVC (Print Via Computer) software, supplied as standard and export your data to Excel and other formats. Increase your measurement flexibility with the optional test tube cell holder which allows you to measure 10 to 18 mm test tubes. The standard cell holder accepts 10 mm glass and disposable cuvettes and is easily removed for cleaning. An optional thermostatted cell holder is also available giving you the added capability of measurements at 37 C. Instrument Part Number Lamps Optics Wavelength range, Libra S Pulsed Tungsten Hologen Absorbance range, A Bandwidth, CMOS array < 7

6 Libra S21 Visible and Libra S22 UV/Visible spectrophotometers Press To Read (PTR) xenon lamp technology Reference Beam Compensation (RBC) Instrument Performance Validation (IPV) facility 8-position sample changer as standard Rapid System Operation Libra S21 and S22 are simple-to-use instruments with advanced performance, incorporating xenon lamp technology for longer source lifetime and lower maintenance costs. A further benefit of this design is optical noise compensation to improve signal to background measurements. Instrument Performance Validation (IPV) is included as standard, and will benefit any laboratory that needs to prove the quality of their results; the GLP results can be viewed on the display or printed out. In addition to measuring absorbance, transmittance and concentration, they provide a standard curve routine for analyte determination. Wavelength scan (with zoom), absorbance changes with time, reaction rate determinations and standard curves can be displayed as graphics and printed out. User defined equations can be entered using multi-wavelength mode and up to 18 methods can be saved in separate operator folders. The instrument can be upgraded for more sophisticated applications, as well as data manipulation, with Acquire Software and a PC. With its large sample compartment and wide range of accessories, Libra S21 and S22 are versatile and reliable instruments for use in any laboratory performing general-purpose measurements. Wavelength scan Kinetics Instrument Part Number Lamps Optics Wavelength range, Libra S Xenon Press to read (PTR) Libra S Xenon Press to read (PTR) Reference beam compensation (RBC) Reference beam compensation (RBC) Absorbance range, A Bandwidth, to < to < 3

7 Resolution PC Software Resolution PC Software is an easy to use software platform with powerful modules for measurement and analysis. Resolution can be used with your Libra spectrophotometer for instrument control, increasing your options for working with your spectrophotometer outside of the lab. Resolution PC Software was developed with an applications focus for superior usability. Resolution PC software is for use with all Biochrom UV/Vis Spectrophotometers. Four versions for your analysis: Resolution Lite - data acquisition using a Quick Read module Resolution - for all routine measurements Resolution Life Science - for nucleic acid, proteins and cell density measurements Resolution CFR - if you need full 21 CFR part 11 compliance Key Features include: Quick Read and Quick Scan for fast measurements with limited setup Bespoke method development for your unique laboratory requirements Powerful graphical data display and manipulation options Microsoft look and feel for intuitive use Resolution Life Science version has pre-programmed methods for fast measurements of common methods like protein and DNA/RNA/ quantification and purity measurements as well as cell density measurements and CyDye quantification Library of reference material if your laboratory enviroent requires regular verification Compatible with Windows XP, Windows Vista and Windows 7 Save, print or export your analysis as an Excel, Extended Metafile, HTML, pdf, rich text format, text, Word or XPS file types Nucleic Acid Quantitation Software Part Number Use With Application Modules Resolution Lite Libra S21, S22 Quick Read, Quick Scan, Validation Resolution Libra S21, S22 Quick Read, Quick Scan, Validation, Fixed Wavelength, Wavelength Scanning, Quantitative Analysis, Kinetics, Methods Developer Resolution Life Science Libra S21, S22 Quick Read, Quick Scan, Validation, Fixed Wavelength, Wavelength Scanning, Quantitative Analysis, Kinetics, Methods Developer, Life Science Methods Resolution CFR Libra S21, S22 Quick Read, Quick Scan, Validation, Fixed Wavelength, Wavelength Scanning, Quantitative Analysis, Kinetics, Methods Developer, Life Science Methods, 21 CFR Part 11 compliance Upgrade Resolution to Libra S21, S22 Upgrade Resolution to Resolution Life Science Resolution Life Science Upgrade Resolution to Resolution CFR Libra S21, S22 Upgrade Resolution to Resolution CFR

8 IQ/OQ Installation Qualification/Operational Qualification Protocols & Validation for UV/Vis Spectrophotometers In many industries, compliance with local and international measurement standards and regulations is of increasing importance. Pharmaceutical companies are subject to the most stringent regulations of all industries. Laboratory instruments must meet manufacturers specifications throughout their lifecycle to ensure ongoing compliance, quality performance and successful laboratory audits. As a full service provider, let Biochrom verify that your instrument and software are installed and operating to specification, helping you meet your regulatory requirements and giving you confidence in your day to day results. Comprehensive IQ/OQ documentation and service support is available for our range of UV/Vis spectrophotometers, following approved European and US Pharmacopoeia guidelines for wavelength accuracy, wavelength repeatability, photometric accuracy, stray light, resolution, noise and drift. We offer expert support from our trained service engineers, who are available to perform the IQ/OQ and validate your spectrophotometer using NIST (National Institute of Standards and Technology) traceable standards, allowing laboratories to demonstrate evidence of quality control according to ISO/IEC Service Plans Different levels of service plans are offered to ensure your instrument is always performing to specification. We are committed to support you for the lifetime of your instrument. When to Perform IQ/OQ First use, during a new instrument installation Re-validating when you relocate your instrument or your business operation changes regulations Changing your PC Adding new accessories to the instrument Test Procedure Includes IQ (Installation Qualification) is a step by step procedure to ensure that the hardware and software are installed in a controlled manner, covering location, enviroent, PC set up and accessory connection OQ (Operational Qualification) validates the hardware and software functionality according to our specification once installed PQ (Performance Qualification) protocols and advice guides you through use and ongoing validation of your instrument IQ/OQ validation for our 21 CFR part 11 compliant PC software European and US Pharmacopoeia guidance A robust log book to store your instrument history through its life Flexible test templates referencing certified calibration standards How to get Started Contact us via or phone to discuss your needs and schedule your installation. support@hbiosci.com USA: (800) United Kingdom: +44 (0) Description Part Number Libra S21/S22 IQ/OQ Documents Libra S50/S60/S70/S80 IQ/OQ Documents IQ/OQ Installation & Validation visits -priced per day (Not including documentation)

9 UV/Visible spectrophotometry UV/Visible Spectrophotometry is a fundamental analytical technique and, together with suitable sample handling accessories, is used in laboratories for absorbance and transmission measurements of samples in all application areas. Biochrom, using its Novaspec, Ultrospec, GeneQuant, Libra and WPA brand names, manufactures an extensive range of attractive UV/Visible products and accessories, with performance and reliability guaranteed by over 20 years experience in the field. Amongst other technological advances, these instruments feature PTR (Press To Read) capability, which dramatically extends the lifetime of the source lamps. Microtitre plate readers, washers and dispensers In the food testing, clinical, biotech and pharmaceutical industries, the demand is for ever increasing sample throughput and smaller and smaller volumes. This is where the microtitre plate comes into its own and Biochrom offer an excellent range of fast, versatile and reliable plate readers with robot friendly designs, via our EZ Read brand. In addition, a range of washers is available, with a unique manifold design for minimised residual volumes and digitally controlled aspiration and dispensing pumps for high accuracy and low noise performance. To minimize human intervention and possible error, there is a growing requirement to dispense low volumes of liquids rapidly, accurately and reproducibly. Biochrom s liquid dispensers meet these needs exactly, with units for two or six, any well format, microtitre plates and the ability to deliver volumes of liquid down to two microlitres using a non-contact delivery technique, thereby eliminating cross contamination. Gel electrophoresis Gel Electrophoresis remains one of the most important techniques in the life sciences. Biochrom, via its Hoefer and Scie-Plas sister companies, offers a full range of electrophoresis products for analytical and preparative nucleic acid studies and manual DNA sequencing, including both horizontal and vertical units together with all appropriate buffers, sampling and blotting accessories. Amino Acid Analysis Biochrom has been in the field of dedicated Amino Acid Analysis for over 30 years using established ion exchange chromatography to provide rapid, specific amino acid analysis for clinical, pharmaceutical, proteomics, food and feedstuff industries. These state-of-the-art bench top products feature proven ninhydrin detection technology fully integrated into a complete package utilising the latest graphical software, active components in ceramic and PEEK for long life and elimination of contamination and a range of robust ion exchange columns for customised applications.

10 Contact Us USA Biochrom US 84 October Hill Road Hollisttton, Massachusetts Telephone (508) Toll Free (800) Fax (508) Website United Kingdom Biochrom Building 1020 Cambourne Business Park Cambourne Cambridge, CB23 6DW, United Kingdom Telephone +44 (0) Fax +44 (0) Website China Biochrom Room 1902E 19F, Building B Zhongshan Plaza 1065 West Zhogshan Road Changning District Shanghai, China Telephone support@hbiosci.com Website If you want to know more about us, or our products, please get in touch.... Distributor Information Rev