IDdb3 Reports 12 Drug Reports 12 Patent Reports 16 Company Reports 18 Reference Reports 21

Transcription

1 IDdb3 Miniguide - Contents Introduction 3 Database Content 3 Source Material 4 Logging Into IDdb3 5 Remember Password Option 5 Navigating IDdb3 6 Left-hand Navigation Bar 6 Breadcrumb Trail 6 Searching for a Word or Phrase 6 IDdb3 Alerts 7 Viewing and Navigating Alerts 8 Searching Alerts (word or phrase) 8 Get Alerts by 8 Enhanced Alerts 8 Personal Alerts 9 Creating Personal Alerts 10 Viewing Personal Alerts 11 Alerts 11 Manage Personal Alerts 11 IDdb3 Reports 12 Drug Reports 12 Patent Reports 16 Company Reports 18 Reference Reports 21 Searching & Browsing 22 An Introduction 22 Quick Search 23 Browse Database 24 Browse Indexes 26 Text Search & Guided Search 27 Advanced Search 28 Write your Own in Advanced Search 31 Editing & Saving Advanced Searches 32 1

2 Displaying Results 33 Results Summary 33 Cutomise Display 33 Exporting to Excel and BizInt 34 IDdb Portal 35 Additional Services 37 Personal 38 IDdb3 Helpdesk 41 2

3 Introduction The Investigational Drugs database (IDdb) has been developed to provide comprehensive information about all aspects of drug development worldwide, from first patent application to eventual launch or discontinuation. IDdb3 Release 2, launched in February 2002, is the most recent and advanced version of the database, with an improved design and enhanced functionality. Updated on a daily basis, IDdb3 provides timely and up-to-date pharmaceutical R&D information which can be filtered by topics and criteria relevant to you. Several new alerting features enable you to create and receive alerts about specific changes in the database, making it even easier to monitor the database for new information in your field. Database Content The information in IDdb3 is presented in the following main report types: Alerts Drug Reports (with associated Reference Reports) Patent Reports Company Reports Meeting reports The data in these reports is continuously collected from a diverse range of sources including patents, meetings, scientific and commercial literature, news services and direct company communications. Hypertext links between these reports fully integrate the information. Daily Updates Each day, pharmaceutical news stories are selected for significance by experienced editors and added to the database as IDdb3 Alerts. This together with the continuous updating of Drug and Company Reports, provides users with current information about a drug's development, licensing and marketing status. New reports are added at the approximate rate of 150 new patents, new drugs, 5-20 new start-up companies and new meeting reports per week. Commissioned Intelligence Over 2000 international subject specialists, from industry and academia, are commissioned to continually interpret, review and evaluate the gathered information for scientific and commercial interest. This intelligence is available in the form of literature evaluations, expert opinions, authoritative reviews and meeting reports. The IDdb Advisory Board oversees this process of upgrading data to intelligence. IDdb3 Source Material News Services and Commercial Sources Commercial information sources are scanned routinely for news of company and drug developments, including: Newswires Specialist industry newsletters and publications Analyst reports Company and industry online databases Scientific Meetings Some scientific meetings are covered each year by a unique commissioning system. Scientists who are attending meetings are commissioned to write a report to highlight the key presentations and poster sessions and to provide an overview of the meeting. The most significant meetings are also attended by IDdb editors and reports from such meetings will be posted in IDdb3 "Overnight". In addition to these reports, the conference proceedings are also scanned for new drug data. Scientific Literature Over 5500 individual journals are scanned, primarily through searching of scientific abstracting databases such as Medline (PubMed), EMBASE Alert, BIOSIS and Derwent Drug File. 3

4 Therapeutic Patents Therapeutic patents filed through the five major patent authorities; the World (PCT), European, US, Japanese and United Kingdom patent offices, are selected for abstracting and inclusion in IDdb3 using the following criteria: Novel compounds claiming potential therapeutic use Diagnostics claiming potential therapeutic indications Known compounds claiming novel therapeutics indications Novel formulations for named drugs Novel preparation processes of therapeutic compounds or intermediates Novel biotechnology methods and discoveries Where possible a sample chemical structure is drawn. The following three levels of criteria are used to select the sample structures: A specifically claimed compound, with due regard to biological potency A specifically claimed compound A compound exemplified by synthesis, with due regard to scope of the generic claim. In addition, since October 1996, generic structures have been included where applicable. Company Communications Frequent direct contact is made with companies by IDdb editors to validate information and product portfolios. Press releases, company websites, annual reports, company brochures and interviews are all scanned regularly for new data. 4

5 Logging into IDdb3 The IDdb3 internet site is located at: The system requires a unique username and password for each user. This ensures full utilization of the database's personalization features. To obtain a username and password, please contact your internal IDdb3 administrator; if you are unsure of this contact, mailto:help@current-drugs.com for assistance. Customers accessing IDdb3 via their company's Intranet, should consult their Intranet administrator or IDdb3 contact for registration and login instructions, or mailto:help@current-drugs.com for assistance. Remember Password Option The login page includes a "Remember password" option which can be activated by checking the box. This will set a permanent cookie which means that in the future: You will not need to login before going to a bookmarked page within IDdb3 You will not need to login when clicking on links to IDdb3 from Alerts If you do not use the "Remember password" facility, you will still be able to bookmark IDdb3 pages and link to IDdb3 from Alerts, as IDdb3 will present a pop-up login box where you can enter your username and password. 5

6 Navigating IDdb3 Release 2 IDdb3 has been totally redesigned to provide a simpler and clearer interface. Left-hand navigation bar The left-hand bar is the main navigation area and is available throughout the database. From here you can access: QuickSearch IDdb Alerts Browse Database Browse Indexes Search Center IDdb Portal Personal Breadcrumb Trail The "Breadcrumb Trail" is a new navigation feature within IDdb3. It is shown at the top of every page, plotting activity through the database. Clicking on any link of the "trail" will navigate back to that page. Searching for a word or phrase A standard facility is available in IDdb Alerts and Browse Database to search for a single word or phrase ONLY across that particular section of the database. A radio button option allows the search to be restricted to the latest update. The truncation % is supported, but not Boolean operators. 6

7 IDdb3 Alerts IDdb3 Alerts is a unique, daily pharmaceutical news service, incorporating the most relevant and significant news on drug R&D, company business information, scientific meetings and patents. The majority of Alerts are generated from Press Releases/Newswires and Meeting Reports. The Alerts open by default when you first log in to the database and are divided into 5 categories: Drugs Companies Meetings Patents Personal Viewing and Navigating Alerts By default, the Drug Alerts will display first upon logging in to IDdb3. A Priority Alert, which has been selected for significance by IDdb editors, is displayed at the top of each Alerts screen. Further stories are displayed below the Priority Alert. Any drug names, company names and patent numbers mentioned in the text of an Alert will be hypertext linked to corresponding Drug Report, Company Report and Patent Report, respectively (if available within the database). Click on the reference numbers displayed in square brackets within Alerts to view the source of the information To display another Alert, click on its title To view multiple Alerts on one page, check the boxes beside the Alert titles and click on SHOW CHECKED To view other Alert categories (Companies, Meetings, Patents and Personal) click on the links on the left-hand navigation bar 7

8 Use the drop-down menu to view Alerts from the past five days Searching Alerts (word or phrase) On each Alerts screen there is a search text box to find news stories containing a single word or phrase in that particular category of Alerts (ie, Search Company Alerts, ONLY searches across the Company Alerts). A radio button option allows the search to be restricted to the latest update. The truncation % is supported, but not Boolean operators. Get Alerts by For each category of Alert, Drugs, Companies, Meetings and Patents, you can choose to receive each day s Alerts by . Simply click on the link BY A separate window will display where you can choose the frequency you wish to be ed. Ensure the address is correct in the Send to box and click CONFIRM to activate. You will then receive an with links to all the Alerts in that category at the frequency chosen. Note: The address does not have to be your personal address - you can send Alerts to friends, colleagues or a work group address. However, remember that they will only be able to link to the Alerts in IDdb3 if they have a username and password. Enhanced Alerts Significant news stories are selected for enhancement by IDdb editors, with detailed analysis being undertaken, to give the background and commercial significance for that story, putting the disclosure into context. Enhanced Alerts detail: The novelty of the disclosure Other significant trials, indications and funding Licensing and patent position Company comment Competition Commercial impact, including analyst comments, drug potential and market size and potential Selection is made from the following news types: Significant new drug approvals or launches Significant clinical trial results Significant drug discontinuations Significant company mergers and acquisitions Approximately 25 enhanced stories are added each month. 8

9 Personal Alerts You can choose to personalize the Alerts service by filtering the news to only receive Alerts on specific topics relevant to you. These Personal Alerts will be displayed in the database; however, you also have the option to receive notice of new Personal Alerts by . Creating Personal Alerts To set up Personal Alerts, click on the CREATE button. Personal Alert profiles can be formed from a combination of topics, index terms and/or free text. Topics broadly categorize the content of Alerts. Each Alert is assigned one or more topics. Use the list of topics to select terms to define your Alert profile. The Actions, Indications and Technologies terms are chosen from indexes presented as a hierarchy. When you choose a broad index term, you will automatically retrieve stories classified by any narrower term; eg, selecting the indication term Respiratory disease will also retrieve items about drugs indexed for narrower terms, such as asthma. If you would prefer NOT to include these narrower terms in your search, click on Personal in the left-hand navigation bar, choose Preferences and Search and indicate that you would not like cumulative counts in your searches by deselecting the boxes for the indexing terms as desired. See more about Personal Preferences on page 38. Clicking on this node located next to a broad index term will expand out the hierarchy to allow selection of more specific index terms. Alternatively you can search for index terms by entering a term in the Look up box and clicking on LOOK UP. Clicking on the term you want will add it to the Personal Alerts Profile Builder. The COMPANIES and DRUG NAMES options can be used to look up company and drug names to add to the Personal Alert Profile Builder. Enter a name in the Look up box and click on LOOK UP. This will bring up a list of companies or drugs containing the name entered, click on your chosen name to add it to the Alert profile. NB: When entering terms in the Look up boxes you do not need to type in the complete word nor use the truncation symbol. Look up will automatically expand the search to include any further characters that may be found after or before the root of the word. Eg, typing in pyscho in "Look up an indication" will automatically retrieve Pyschomotor disorder, Pyschosis, Paranoid psychosis and Psychosexual disorder. The Alert Topics index can be used to choose which type of news story you are interested in. The Topics that are used broadly categorize the content of Alerts and each Alert is assigned one or more topics. 9

10 Example Set up a Personal Alert to find news stories discussing any clinical phase change for drugs in development for respiratory disease. Click on CREATE Then click on INDICATIONS Look down the list and click on Respiratory disease to add it to the Personal Alerts Profile Builder. Click on ADD MORE to add further terms. This returns to the Create Personal Alerts menu. Next click on Alert Topics and then click on Clinical phase change to add this to the Alerts Profile Builder. To remove any term from the Alert profile, simply click on it (to remove all the terms click on CLEAR ALL) The Alert is now ready to save, to do this, use the SAVE button. Clicking on SAVE will prompt you to enter a name for your profile, do this and then click on CONFIRM. This will take you to your Personal Alerts page, and display the results of the new Personal Alert. To access the full story simply click on the title of the Alert. 10

11 Viewing Personal Alerts All your Personal Alerts can be viewed from the Personal submenu of the Alerts section. Click on title of Alert to view results Use drop-down menu to view last 5-days of Personal Alerts Alerts To receive your Personal Alerts by , you then need to click on the BY option under Manage Alerts. This takes you to a list of all your saved Personal Alerts, where you can use the drop-down menu to choose the frequency you wish to be ed. The choice is daily, weekly, or monthly. The you receive will provide the titles of any relevant Alerts found. Each title is a link, and clicking on it will take you directly into IDdb3 to that particular story. Alternatively, you can use the View Alerts link at the bottom of the to view all the stories. If you are not currently logged in to IDdb3, or have not set the "Remember Password option" you will be prompted to enter your username and password. Note: Your system must be HTML-enabled to view links. If your service does not have this facility, your will contain plain text, and you will need to log in manually to view the full Alert stories. Click on Personal then Preferences and then Results to change your alerts from plain text to HTML-enabled. Manage Personal Alerts 11

12 To edit your saved Personal Alerts click on the options in the Manage Alerts box. This will take you to the Manage Alerts page. From here you can change the frequency of your alerts and also edit the alert by clicking on the relevant Alert number. To delete any of your Personal Alerts check the box next to the alert under the Delete heading. Remember to use the SAVE ALL CHANGES button after making your change. 12

13 IDdb3 Reports Information within IDdb3 is presented in a series of integrated reports, each connected by numerous links for ease of use and navigation. Drug Reports A Drug Report provides a complete picture of a single investigational drug. It details the drug s commercial development, development status and licensing position, and provides chemical, biological, pharmacological and clinical data. The very first table shown in a Drug Report will give information on: The company which originated the drug plus a hypertext link to the Company Report (NB: this is not always necessarily the company which is actively developing the drug) The highest stage of development that the drug has reached Indications for which the drug has been indexed Actions (pharmacological mechanism of action) for which the drug has been indexed Technologies for which the drug has been indexed Listed directly beneath this table will be the date of when the report was last updated and the reason why. Reasons include: Development Status Updated Chemical Structure Added/Updated Reference Added Literature Evaluation Added Indexing Updated Licensing Information Updated Minor Editorial Amendment 13

14 Related information The box at the top right-hand side of the report provides links to related information. Click on COMPANY to view the Company Report of the originator Click on REFERENCES to view the entire bibliography for the drug Click on NEWS to view recent news stories (ie Alerts) on the drug Click on PATENT to view the associated Patent Report (if available) Actions The Actions box provides three options: if Updated; Add to Library; and, Print View. If Updated Click on this link for the ability to receive an whenever the Drug Report is updated due to the reason(s) that you select. This enables you to continually monitor a drug of interest without even having to login to the database. Having clicked on the link, ensure the recipient's address is correct, use the check boxes to select which changes to the report you wish to be notified of, and click Confirm. Print View Selecting Print View will open a new window containing a Printer-friendly version of the Drug Report, containing just plain text with none of the navigation bars or gifs from the browser view. Add to Library Clicking on Add to Library adds the Drug Report to your own personal Library, so that in future instead of having to search for the report, you can simply locate and retrieve it from Library (a submenu of Personal). For more information on this, see the Personal section on page 38. Summary Each Drug Report contains a Summary, which is a plotted history of the drug's development. It will contain information on development status, indications for which the drug is being developed for, the companies involved in its development, clinical trial data, preclinical data, analysts estimates and predictions and so forth. Throughout the Summary are links to the references from which the information was derived - references are represented by numbers contained within square brackets, eg [345678]. 14

15 Development Status The Development Status table groups the activity of the drug by company. At a quick glance you can see which company is developing the drug, at what stage of development, for which indication and where in the world it is being developed. The development record can be from a publication, company website, company brochure, annual report, company prospectus, internet site, press release, company communication. If the development record if from any other source the confidence level will be listed as "Not Evaluated", otherwise, the confidence level will be based on the following rules: High Confidence = the status shown was announced within the last 6 months. If the status is Withdrawn, Discontinued, Suspended or Launched the confidence level with be High; Medium Confidence = the status shown was announced within the last 6-18 months; Low Confidence = the status shown was announced over 18 months ago. Licensing All licensing and collaboration agreements related to the drug are summarized within the Licensing section of the Drug Report. Chemistry A chemical structure for the drug, if known, will be displayed in the Chemistry section of the Drug Report. Structures are assigned confidence levels as a measure of validity based on the following criteria: Level 1 - Confirmed by the company or Chemical Abstracts Service (CAS) as correct structure Level 2 - Structure identified in 2 or more individual peer reviewed journals Level 3 - Structure identified in peer reviewed journal Level 4 - Structure identified in a non-peer reviewed printed source Level 5 - Hand-drawn (from a meetings poster) or sample patent structure Chemical structures are stored in IDdb3 as MOLfiles and Gifs. In which format the structure will display in the Chemistry section of a Drug Report depends on your personal settings (see Personal on page 38). By default, structures will display as Gifs, with a link to VIEW MOLFILE. 15

16 A Gif is simply a picture of the structure, whereas a MOLfile is a chemically meaningful file which can be copied into a chemical drawing package such as ISIS Draw and ChemDraw. (The MOLfile is also what is searched for during a substructure search). See page 30 for information on the plug-in required to view MOLfiles. Compound names associated with a drug This section of a Drug Report lists all known names associated with a drug. These may be research codes, generic names, trade names and CAS registry numbers. All the names associated with a drug are linked, so that when searching for a particular drug, you can search for any one of the names and the same Drug Report will be retrieved. Literature Evaluations Literature Evaluations are written for drugs that are in active development. They are a review of the available literature and act as an expert guide to the published information and personal communications on the drug, highlighting references of particular scientific or commercial interest. Evaluations are essentially mini-reviews which provide unique insight into the commercial potential of a drug, its therapeutic and economic viability. They are written by commissioned experts (industrial and academic scientists) within a relevant field and may also be subject to peer review. 16

17 IDdb3 Reports Patent Reports A Patent Report provides a summary of a pharmaceutical patent. An enhanced title is accompanied by a structured abstract, comprising information on the invention s novelty, and summary of any biological and chemical data presented. Related information The box at the top right-hand side of the report provides links to related information. Click on COMPANY to view the Company Report of the assignee Click on DRUGS to view the associated Drug Report (if available) Click on GET DOCUMENT to download the full patent document as a pdf file via Thomson Patent Store (NB: this service is only available to customers who subscribe to Thomson Patent Store through IDdb3) Actions The Actions box provides two options: Add to Library; and, Print View Add to Library Clicking on Add to Library adds the Patent Report to your own personal Library, so that in future instead of having to search for the report, you can simply locate and retrieve it from Library (a submenu of Personal). For more information on this, see the Personal section on page 38. Print View Selecting Print View will open a new window containing a Printer-friendly version of the Patent Report, containing just plain text with none of the navigation bars or gifs from the browser view. 17

18 Structure Standard IDdb3 Patent Reports often contain chemical structures taken from the published patent document. A specific structure is chosen, selected according to three criteria: 1. A specifically claimed compound, with due regard to biological potency; or 2. A specifically claimed compound; or 3. A compound exemplified by synthesis, with due regard to the scope of the generic claim. In addition, since October 1996, generic structures have been included where applicable. Publication details The Patent Report also contains information on dates of filing and publication, inventors, estimated expiry date, priority details and country coverage. 18

19 IDdb3 Reports Company Reports A Company Report provides a complete commercial picture of the organization, whether it be a pharmaceutical or biotechnology company, a university or academic institute. Any organization for which a therapeutic patent and/or investigational drug has been identified will be included within IDdb3. It presents financial data provided by Thomson Financial, outlines R&D activities, licensing and collaboration agreements, lists of directors and other key contacts, a link to the company's website, and gives easy access to the company s drug and patent portfolios. The very first table shown in a Company Report will give information on: The company's registered headquarters A hypertext link to the company's website (if available) Listed directly beneath this table will be the date of when the report was last updated and the reason why. Reasons include: Profile updated Financial information updated Reference added Minor editorial amendment 19

20 Related information The box at the top right-hand side of the report provides links to related information: Click on REFERENCES to view references associated with the company Click on NEWS to view recent news stories (ie Alerts) on the company Click on INVESTEXT to view analyst reports on the company provided by Thomson Financial (NB: additional subscription required) Click on PATENT ANALYSIS to view a unique review on the company's patenting activity, provided by Current Patents Ltd (NB: additional subscription required) Click on WORLDSCOPE PLUS to view detailed financial & stock information provided by Thomson Financial (NB: additional subscription required) Actions The Actions box provides three options: if Updated; Add to Library; and, Print View Click if Updated to set the database to send you an when certain areas of the Company Report are updated. Click Add to Library to add the report to your personal Library Click Print View for a Printer-friendly version of the report IDdb Profile Each Company Report has a profile written by IDdb editors. It provides a chronological history of the company, containing information on when the company was founded, major areas of research, licensing and collaboration agreements, mergers & acquistions, stocks & financing and any other relevant business information. Throughout the Profile are links to the references from which the information was derived - references are represented by numbers contained within square brackets, eg [345578]. Product Portfolios The Company Report contains the company's product portfolios, represented by three bar charts: Investigational dugs by therapeutic category Patents by therapeutic category Drugs by stage of development 20

21 Click on the number in brackets, eg (175), to view ALL investigational drugs in the company's portfolio which are in active development Click on an individual bar within the chart to view investigational drugs in a particular therapeutic category Click on the number in brackets, eg (965), to view ALL patents in the company's portfolio Click on an individual bar within the chart to view patents in a particular therapeutic category Click on the number in brackets, eg (378), to view ALL drugs in company's portfolio (includes drugs in active development, as well as those that have been suspended, withdrawn, discontinued etc). Click on an individual bar within the chart to view drugs in that particular stage of development 21

22 IDdb3 Reports Reference Reports A Reference Report provides bibliographic details of a reference quoted elsewhere within IDdb. Links to Reference Reports are seen throughout the database in the form of a number in square brackets, eg [456789]. To view an entire list of references associated with a drug or company, click on the REFERENCES link within a Drug/Company Report. Depending on the source type, there may be an abstract available, links to the full text, or indeed a link to the source itself (externally) via LitLink. If the reference is a Press Release, click on GET ARTICLE to retrieve the full text If the reference is an IDdb Meeting Report, an Abstract containing the entire report will automatically display If the reference is a journal available within PubMed/Medline, the PubMed abstract of that article will automatically display If the reference is a journal, click on GET ARTICLE to retrieve the full article via LitLink (NB: this facility requires an additional subscription, see Additional Services section for more information on LitLink). Displaying & Sorting Reference Reports When you click on the REFERENCES link within a Drug/Company Report, the first screen that will display is the Drug Bibliography, a list of all the references associated with the drug/company. It gives the total number of references associated, and from here there are a number of ways in which they can be displayed. Individual references can be viewed by simply clicking on the title of the reference. To view and sort multiple references, first check the boxes of the references that are of interest to you (by default ALL the check boxes are selected). Then click on CUSTOMISE DISPLAY 1) Under Sort by, use the radio buttons to select how you want to sort the references: by Reference number; First author; Date added; or, Type. 2) Under Display in, choose whether you want your references displayed in a Browser view or Printer friendly view. 3) Decide if you would like your references displayed as: List View; Full reports - concatenated; or, Full report - individual. 4) Finally, click on SHOW to display your references From the Customise Display window you can select the number of results per page by changing the drop-down menu (20, 50 or 100). By checking the box "For a drug/company bibliography, show all" over-rides any previous selection of references and will display the entire bibliography of references instead (ie, ALL references associated with the drug/company, not just the ones you checked on the previous screen). 22

23 Searching & Browsing - An Introduction There are six ways to search and browse information within IDdb3 - each method is specifically tailored to help you find particular reports. QuickSearch: easy and quick way to locate a specific drug, company or patent report. Can also be used to find references written by a certain author and finally to conduct a free text word or phrase search across the entire database (including portal databases). Wild card % truncation is supported in QuickSearch. Browse Database: allows you to browse through the most recent drug, company, patent and meeting reports added to the database. Browse Indexes: a way of browsing through the indexing terms used within IDdb3 (Actions, Indications and Technologies) and to display the drugs and patents that are indexed by a particular term of interest. Text Search: a free text word or phrase search to find information across the entire database, or within specific reports. Wild card % truncation is supported in Text Search. Guided Search: a simple, pre-defined search used to find specific information that s been recently added or changed in IDdb3 within the last day, last 7 days or last 30 days. Advanced Search: enables you to create very specific searches across Drug and Patent reports by combining the indexing terms (Actions, Indications & Technologies), company names, development status, drug names, chemical structures, word/phrase and countries/regions. Also, available within Advanced Search is the ability to "Write Your Own" boolean queries to search across the entire database. All searches created in Advanced Search can be saved for future use, or set to be re-run automatically on a daily, weekly or monthly basis, with the results sent straight to your . Wild cards - truncation symbols The wild card symbol, %, may be used to extend a search to words where the precise spelling is not known, to include the singular or plural forms of words and to include all words with a common root. Wild card truncation can be used at the end of a string of characters (ie, right-hand truncation), and also in the middle. Left-hand truncation is not supported within IDdb3. Examples: Searching for immunomodulat% finds: immunomodulator, immunomodulators, immunomodulatory etc. Searching for a%statin finds: atorvastatin, antistatin, angiostatin. Wild cards can be used in QuickSearch, Text Search and in any text Search box within the database. 23

24 Searching & Browsing - QuickSearch QuickSearch QuickSearch is located at the top of the left-hand navigation bar. To find a specific drug report, type in the drug name and make sure the drop-down menu is set to Drug, then click on TIPS: You can search for a drug using either the research code, generic name or trade name, as drug names and all their synonyms are mapped within the database. The database ignores hyphenation, so when searching for a research code, eg MDL , you can search for either: MDL MDL MDL To find a specific company report, type in the company name, change the drop-down menu to Company, then click on To find a specific patent report, type in the patent number, change the drop-down menu to Patent, then click on TIPS: Patent numbers appear in IDdb3 in a standard format, which comprises a two-letter country code, followed by a hyphen, followed by an eight-digit number. Leading zeros are added to the number as necessary to give eight digits, eg, WO However, you can search patent numbers in QuickSearch with or without the hyphen, and you can also omit the twoletter country code: WO WO To find references written by a specific author, type in the author's name, change the drop-down menu to Author, then click on TIPS: When searching for author names in QuickSearch, you will be searching any IDdb3 reference, ie, references associated to a Drug report, Company Report, as well as searching Alerts and Meeting Reports. QuickSearch for authors; however, does not search the Portal databases (eg, PubMed, Current Opinion journals etc) To find a word or phrase, across the entire database, including the Portal databases, change the drop-down menu to Anywhere, then click on 24

25 Searching & Browsing Browse Database Browse Database Browse Database can be used to find reports recently added to the database across four categories; Drugs, Companies, Meetings and Patents. For Drugs, Companies and Meetings you can browse those reports which have been added within the last 7 days. The Patents category incorporates Patent fast-alert and hence is updated upon publication (Patent fastalert is available as a stand-alone product and is published on a weekly basis). Browse Database can also be used to look up any Drug/Company/Patent/Meeting report within IDdb3. In each section of Browse Database there is a text Search box which can be used to search for a word or phrase in that particular category of Reports (ie, Search Drugs, ONLY searches across the Drug Reports). Click on the radio button to choose whether to search all the reports in the database, or just just those in the latest update. The truncation % is supported in these Search boxes, but not Boolean operators. Finally, Browse Database provides an alternative place to choose the option to receive each day's Alerts by for each category (Drugs, Companies, Meetings & Patents). Simply click on the link BY Browse Database - Drugs The Drugs section of Browse Database lists all the Drug Reports added to the database within the last 7 days. Click on a drug name to view the associated Drug Report To view multiple Drug Reports, check boxes beside drug names and then click on SHOW CHECKED Use Browse by Drug Name to find any Drug Report by typing all or part of a drug name and clicking on LOOK UP Use Search Drugs to search for a single word or phrase across the Drug Reports (use radio button to restrict search to latest update) Click on Get Drug Alerts BY to receive all Drug Alerts on a daily, weekly or monthly basis. Browse Database - Companies The Companies section of Browse Database lists all the Company Reports added to the database within the last 7 days. Click on a company name to view the associated Company Report To view multiple Company Reports, check boxes beside company names and then click on SHOW CHECKED Use Browse by Company Name to find any Company Report by typing all or part of a company name and clicking on LOOK UP Use Search Companies to search for a single word or phrase across the Company Reports (use radio button to restrict search to latest update) Click on Get Companies Alerts BY to receive all Company Alerts on a daily, weekly or monthly basis. Browse Database - Meetings The Meetings section of Browse Database lists all the Meeting Reports added to the database within the last 7 days Click on a meeting title to view the associated Meeting Report To view multiple Meeting Reports, check boxes beside meeting titles and then click on SHOW CHECKED Use Browse by Meeting Name to find any Meeting Report by typing all or part of a meeting title, selecting the year from the drop-down menu and clicking on LOOK UP Use Search Meetings to search for a single word or phrase across the Meeting Reports (use radio button to restrict search to latest update) Click on Get Meetings Alerts BY to receive all Meeting Alerts on a daily, weekly or monthly basis. There are also links, under Related Information, to Meeting Alerts and a Meetings Diary (a pdf document of meetings that IDdb3 plans to cover over the coming months) Browse Database - Patents The Patents section of Browse Database is slightly different from the other sections, in that it incorporates Patent fastalert, a weekly published product which is also available as a stand-alone journal/database. Hence this section of Browse Database shows the latest update, or issue, of that product, providing links to all the most recent Patent Reports added to the database (All Patent Reports within IDdb3 are generated in conjunction with Patent fast-alert). 25

26 Instead of providing just a list of the patents, a Table of Contents is displayed, grouping the patents into 6 categories. Simply click on a category, eg Anti-Infectives, to view all patents in that therapeutic area. The patents are displayed in a brief summary format, providing details of: Patent title Patent publication date and patent number Company that the patent is assigned to Indication, Action and Technology terms for which the patent has been indexed Structure (if available) The patents in this summary format can be resorted by Patent number or Company by selecting the corresponding radio button and clicking on RE-SORT Click on a patent title or patent number to view full IDdb Patent Report To view multiple Patent Reports, check boxes beside patent titles and then click on SHOW CHECKED To navigate between the 6 sections, click on Previous Section/Next Section, or simply click on a category title within the Table of contents Use Search Patents to search for a single word or phrase across the Patent Reports (use radio button to restrict search to latest update) Click on Get Patents Alerts BY to receive all Patent Alerts on a daily, weekly or monthly basis. In the Patents section of Browse Database there is the additional option to view patents added in the last 10 previous updates/issues. Use the drop-down menu to select the update you wish to view. Finally, there are links under Related Information, to both Patent Alerts and Current Patents Gazette from this section of Browse Database. 26

27 Searching & Browsing Browse Indexes Browse Indexes The Browse Indexes section enables you to browse through the IDdb3 Indexing terms and view the drugs and patents associated with each term. IDdb3 uses three indexing categories: Actions; Indications; and, Technologies. Each index is arranged as a hierarchical tree, with the broadest terms listed at the top of a tree and more specific terms lower down in a tree. Throughout IDdb3, lower-level terms are included by default when you use any higher-level index term in a search. (This default can be changed in Personal, see page 38 for more information). To find a term, simply type all or part of an index term in the box and then click on LOOK UP (truncation is added automatically) Alternatively use the + next to a term to expand the tree and drill down to your chosen term. Beside each term is listed the number of Drugs and Patents that are indexed within IDdb3 for that term. Clicking on these numbers will take you to the corresponding results. Clicking on the Total number will show you both sets of results (ie, Drugs and Patents). 27

28 Searching & Browsing Text Search & Guided Search Text Search Text Search allows quick and easy searching for free text. You can search for a word or phrase across the entire database (including Portal options) or you can limit the search to particular report types. You can also limit the search to specific fields within the reports, eg, Title or Abstract. Enter a single word or phrase in the text box. Up to five combinations of text may be entered and truncation (%) is supported. Use the drop-down menu to select the field that you wish to search. The default is Any Field. Use the radio button to select Any of the above or All of the above words. Selecting Any is equivalent to searching with a logical OR, so each result will contain at least one of the terms entered. Selecting All is equivalent to searching with a logical AND so each result must contain all the terms entered. Use the check boxes to select which type(s) of IDdb report you wish to search in or alternatively select Any IDdb report to search across all reports. You can also choose to include IDdb Portal databases in your search, or to search the Portal on its own. Use the Date drop-down box to restrict the search to only include data which has been added or updated within the dates shown, for example last 7 days, 30 days, or 90 days. The default is no date limit. Finally click SEARCH to initiate the search. All text in the selected sources will be searched for the word(s) entered in the text box. Guided Search Guided Search is used to find specific information that has been recently added or changed within the database. Recently is defined as being in the Latest update (ie, within the last day), within the Last 7 days, or Last 30 days. Select a search by checking the appropriate radio button and select a time period from the drop-down menu. Click on SEARCH. 28

29 Searching & Browsing Advanced Search Advanced Search The Advanced Search section allows you to build complex queries through a simple interface. In Advanced Search you can combine index terms, company and drug names, development status, structures, countries/regions and also free text. To build a search: Select your search terms from the 9 index options provided. Add any additional text or a structure. Review the search in the Search Builder window. Name and save the search if you wish to run the search again in the future Run the search and view the results. For the IDdb Indexes: Use the ACTIONS, INDICATIONS or TECHNOLOGIES tabs to display the hierarchical trees. Use the Look up box to go directly to a term by entering text and clicking LOOK UP. Truncation is added automatically. Use + or alongside a term to collapse or expand the tree below this term. Click on the terms to add them to your search. For Companies: Click the COMPANIES tab. Use the Look up box to go directly to a company by typing in all or part of a company name and clicking LOOK UP. Click on company name to add to your search. For Development Status: Click the DEVELOPMENT STATUS tab. Click on an individual phase of development to add to your search. Click on one of the four sub-headings to incorporate all the status s below it. For Structures: Click on the STRUCTURES tab. Double click on the structure window to automatically launch ISISDraw (ChemDraw needs to be opened manually) For Word/Phrase: Click on the WORD/PHRASE tab. Type a single word or phrase you wish to search in the Search for box. Restrict the search to the Summary or Title by using the drop-down menu; the default is Any Field. Boolean logic cannot be used; however, truncation (%) is supported. Click to add the words/phrases to the search builder. For Countries/Regions: Click on the COUNTRIES/REGIONS tab. Click on the country(s) or region to add to your search. Looking up a Drug Name Click on the DRUG NAMES tab. Use the Look up box to search for a drug name by typing in all or part of a drug name and clicking LOOK UP. Click on the drug name to add to the Search Builder window. Click in the Advanced Search Builder window to retrieve the reports for the drugs selected. 29

30 The Advanced Search Builder Window Each time a term is selected it is added to the Search Builder Standard View. This is a separate window and you may toggle between the Search Builder window and the pick list pages. As you select additional terms the Search Builder will refresh and be displayed. In Standard View the logic is automatically applied. Updating the Search Strategy Click on a term to remove it from the search. Click on ADD MORE to add more search terms Click on CLEAR ALL to remove all items from the search. Saving the Search Searches may be saved for re-running or editing at a later date by clicking Enter a descriptive name for the search and click CONFIRM. Retrieve the search for re-running or updating in the EDIT/SAVE SEARCHES section of Advanced Search. You can also select an frequency to have your search run automatically and the results sent to you by . Running your search Limit the search to Drugs or Patents using the drop-down menu. The default includes both (All) Enter a date to restrict the search to data updated or added since that date. To run the search click Example: What 5-HT antagonists are in phase I clinical trials in the US for the potential treatment of depression? Click on the ACTIONS tab. Type 5-ht in the text box and click on LOOK UP Click on the term 5-HT antagonist. This will add it to the Search Builder. Click on the INDICATIONS tab. Type depression in the text box and click on LOOK UP Click on the term Depression to add to search Click on the DEVELOPMENT STATUS tab. Click on Phase I clinical trials (C1) to add to search Click the COUNTRIES/REGIONS tab. Click on US to add to search Click to run. Table View In most cases, the standard view will be sufficient for user requirements. However, in some cases where you want to be more specific about which terms are linked with which others, or where you may wish to manipulate the logic, then the advanced logic available in Table View can be used. 30

31 Example: What 5-HT antagonists are in phase I clinical trials for depression and in phase II clinical trials for anxiety disorder. Click on the ACTIONS tab. Type 5-ht into Look up box. Click on 5-HT antagonist to add to the Search Builder. In Search Builder window click on TABLE VIEW. Click INDICATIONS tab. Type depression in Look up box and select term by clicking on it. Click on DEVELOPMENT STATUS tab and select Phase I clinical trials (C1). Click INDICATIONS tab. Type anxiety in Look up box and select Anxiety disorder by clicking on it. Click on DEVELOPMENT STATUS tab and select Phase II clinical trials (C2). Click to run. NOTE: Terms can be added to the search which when selected will automatically populate the correct vacant cell in the table. There is no limit to how many terms can be removed or added to the table. The logic between terms can be varied using the drop-down menu. Structure searching In order to conduct structure searching in IDdb3 you will need to make sure that you have downloaded and installed the Chime Pro plug-in available from the Advanced Search page (Click on the Chime Pro icon). Once you have installed the plug-in correctly the structure searching window will appear a pale blue/green colour. NB: This version of Chime Pro is specifically designed for use with IDdb3 and can only be downloaded from within IDdb3. Other versions of Chime/Chime Pro will NOT work correctly. You will also need a structure drawing package, either ISIS Draw or ChemDraw. The procedure for structure searching will vary slightly depending on which drawing package you have. Procedure with ISIS Draw: Double click in the structure search box to launch ISIS Draw Draw structure and then click on the Transfer Mode button in the ISIS Draw tool bar This will transfer the structure into IDdb3 Procedure with ChemDraw Double click on the desktop ChemDraw icon to launch ChemDraw Draw structure in the ChemDraw window Copy the structure in Chemdraw by using the Edit -> Select All and Edit -> Copy options in ChemDraw Paste the structure into the search screen by right mouse clicking in the structure box and selecting Paste from the list of options Once the correct procedure has been used then click the Add to Search button to add the structure to the Search Builder 31

32 Searching & Browsing Write Your Own in Advanced Search Write Your Own This section of Advanced Search allows users to type in a search using words, phrases, Boolean operators and field tags with an option of including a structure. Using this function the user can search all of IDdb3 (ie, they are not restricted to just seaching across Drugs/Patents as in other parts of Advanced Search). The logic of [AND], [OR], and [NOT] is supported.. Round brackets ( ) must be used to force the order of execution in mixed searches; eg, (asthma [OR] allergic rhinitis) [AND] glaxo. A structure can be pasted into the structure box and searched for as a substructure or exact match. The search can be restricted using field tags selected from the Available fields pop-up window. The search can also be restricted to search particular IDdb3 Reports and IDdb Portal databases selected from the Available reports and databases pop-up window. A date can be entered using the drop-down boxes to restrict the search to data updated or added since this date. In order to save a search created in Write Your Own, you first need to run the search and then go into the EDIT/SAVE SEARCHES section of Advanced Search. It can easily identified as a Write Your Own search in the list of Latest Searches. From here you can permanently save the search (see Editing & Saving Advanced Searches for more information on how to do this). 32

33 Searching & Browsing Editing & Saving Advanced Searches Editing and Saving Advanced Searches The EDIT/SAVE SEARCHES section of Advanced Search is where all your saved Advanced Searches are stored. This section will also keep track of the last 10 searches that were run but not saved at the time that they were created. Latest Searches In the top half of the EDIT/SAVED SEARCHES screen are listed the last 10 searches that you have run but did not save. It provides information of the date on which the search was last run and also the number of hits it retrieved. To re-run or edit one of these searches, simply click on the hypertext-linked number alongside the search. This will open up the search strategy in the Search Builder window, where you can edit and/or re-run the search To permanently save one of these searches, check the Save checked box alongside the search and click on SAVE CHECKED. This will move your search from Latest Searches to Saved Searches (in the bottom half of the screen) Saved Searches In the bottom half of the EDIT/SAVED SEARCHES screen are stored all your saved searches. Dates on which the searches were last run and the number of hits retrieved are also provided. To re-run or edit a saved search, simply click on the hypertext-linked number alongside the search. This will open up the search strategy in the Search Builder window, where you can edit and/or re-run the search To re-name a saved search, type in the Search name box To set a saved search to run automatically and have the the results ed to you, change the drop-down menu under Update from NEVER to DAILY, WEEKLY or MONTHLY. To delete a saved search, check the Delete box alongside the search and click on SAVE ALL CHANGES 33

34 Displaying Results Results Summary Whenever you perform a QuickSearch, Text, Guided or Advanced search within IDdb3, the search results always appear initially in a screen referred to as the Results Summary page. This page provides details of the total number of results and then a breakdown of the number of results in each particular category that you searched across. This page also provides results in the form of a list for each category. By default, the list will display those results from the first category shown in the grey Results Summary table. In the example above, the drug results are listed by default. To view results from each of the other categories, click on the corresponding links within the table. Depending on the type of results retrieved, there may be the additional option to: Merge Drugs and Patents Merge Alerts, Meetings and References To view an individual report, click on the corresponding hypertext link. Eg, in the example above, clicking on AG will open the associated Drug Report. Customise Display Customise Display can be used to display multiple results in a number of different formats. With Customise Display you can re-sort results, display in Smartsheet Views, Print Views and also have the ability to export to Excel and BizInt. First, select those reports that you wish to display further by using the check boxes. By default, all the check boxes are selected. Click on the CUSTOMISE DISPLAY link 34

35 1) Under Sort by, use the radio buttons to select how you want to sort the results: by Drug name; Company name; Highest development status; Patent publication date; or Patent number. 2) Under Display in choose whether you want your results displayed in a Browser view or Printer friendly view. 3) Decide if you would like your results displayed as: List View; Smartsheet standard view, Smartsheet export view; or Full Report by checking the radio buttons. 4) Finally, click on SHOW to display your results. Smartsheet standard view provides a summary report for each result, including originator, highest development status, actions, indications, technologies, structure and the full Development Status table. Smartsheet export view is a simple table view of the results, which can in addition be exported to Excel and BizInt Smartsheets for Pharmaceuticals. Exporting to Excel and BizInt Select the desired Sort options; Ensure that the display format is set to Browser view and the output format is set as SmartSheet export view Once the desired format has been set, select whether you would like to export to either Excel or BizInt using the radio buttons at the bottom left of the screen. NB: checking the Export all results box over-rides any previous selection of from the Results Summary page and will instead export all the results (up to a limit of 2500) Use the Customise format table to remove and/or change the order of the columns before exporting Click SHOW to export your results 35

36 IDdb Portal IDdb Portal The IDdb Portal is a gateway to a collection of databases available as additional subscriptions through the IDdb3 interface. These databases can be searched individually from this section of the database; however, they can also be included in searches conducted in QuickSearch, Text Search or Write Your Own (Advanced Search), even if you do not subscribe to them. In this situation, you will be able to view the number of hits for each database and also the titles, you simply will not be able to access the full articles. The PubMed Gateway is available to ALL IDdb3 users at no additional charge. Currently Available: Current Patents Gazette (CPG) Comprehensive, ultra-fast alerting service to all new pharmaceutical patents. CPG is the essential source for tracking competitor patent activities with commentary & analysis on patent applications. CPG enables any researcher to learn of the latest drug patent applications every week within days of their publication. Publishers: Current Patents Ltd - a Thomson Scientific company The Current Opinion Library The authoritative review of drug R&D compiled from the highly acclaimed Current Opinion series including Current Opinion in Investigational Drugs and Current Opinion in Drug Discovery and Development. Publishers: Current Drugs Ltd - a Thomson Scientific company PubMed Gateway Access to the complete Medline database and more through this fully integrated gateway to the US National Library of Medicine's PubMed service. Investext PharmaSelect The world's leading investment analysts provide forecasts and insights in this specially selected collection of company and industry research reports. Publishers: Thomson Financial Patent Analysis - Drug Patents 2001 This unique review analyses pharmaceutical patent data from 1995, presenting comprehensive intelligence on a company's patenting activity. There are more than 47,000 patents in the five-year analysis, including some 8,000 published during the year 2001 Publishers: Current Patents Ltd - a Thomson Scientific company 36

37 DOLPHIN The Database of all Pharmaceutical Inventions covers patents with relevance to pharmaceutical R&D published from 1968 to date. Combines a wealth of data, with detailed analysis presented in graphical and tabular formats. Publishers: Current Patents Ltd - a Thomson Scientific company AsunoShinyaku The prestigious Japanese language database of drug R&D from Technomics, AsunoShinyaku covers new drugs under development worldwide with particular emphasis on development in Japan. AsunoShinyaku is fully searchable with links to IDdb Drug and Company reports. Derwent World Drug Alerts Plus Published by Thomson Derwent, Derwent World Drug Alerts Plus covers a mixture of patents, journal references and conference reports from 1994 to date. It contains over 150,000 abstracts; over 300 added per week. Publishers: Derwent Information - a Thomson Scientific company Derwent Drug File Also from Thomson Derwent, Derwent Drug File covers abstracts of journal literature from 1964 to date. It contains over 1.75 million abstracts; over 1000 added per week and covers 1200 journals. It covers all aspects of drug research, from chemical synthesis to manufacture and use, with abstracts specially written by Thomson Derwent staff. Publishers: Derwent Information - a Thomson Scientific company IDeals IDeals is a convenient business intelligence tool designed for use by Licensing Executives and New Business Development Executives. Powered by IDdb, this product has three core components: DealWatch; DealFinder; and, DealAssessor, providing fast and easy identification of business opportunites and licensing deals in the pharmaceutical and biotechnology industries. Publishers: Current Drugs Ltd - a Thomson Scientific company Coming soon... Strategic Drugs database (SDdb) SDdb is the competitor intelligence service that analyses the predicted impact of new drugs on the current market. Strategically important drugs - with current or forecasted sales of over $100 million - form the basis of analysis by company or franchise. SDdb is already available as an independent service to IDdb, and will soon also be available via the IDdb Portal. Publishers: Current Drugs Ltd - a Thomson Scientific company 37

38 Additional Services Additional Services Thomson Patent Store (from Thomson Derwent) From each Patent Report within IDdb3 clicking on the GET DOCUMENT link will enable you to download the full patent document from the Thomson Patent Store. This contains 40 million patent documents from the major patent offices including US, World PCT, European, Japanese and German, that are updated within one week of publication. Clicking the link displays all of the Derwent Patent family, indicating subsequent publications related to the original application, and allows you to download each as a PDF document. Worldscope Plus (from Thomson Financial) Within Company Reports in IDdb3, basic financial data is included from Worldscope. However, Worldscope Plus offers a premium service and is available as an additional subscription. The additional data provided with Worldscope Plus includes: Detailed breakdown of financials for last five years Consensus recommendation from stock analysts (with number of contributing analysts) Consensus EPS forecast for next three years, where available Momentum (number of estimates "up vs down" over last month, percentage change) 15-minute delayed stock price (US exchanges only) Major shareholders LitLink (from MDL Information Services) LitLink is an additional service which can be purchased from MDL and allows your company to set up a local server that holds details of your preferences for getting full-text journal articles. For example, the MDL LitLink server may route a request for: Journal A to the web, where your company has a paid electronic subscription Journal B to the in-house library, where the journal is held in hard copy Journal C to the web, where there is pay-as-you-go access to the journal Journal D to your company's preferred document delivery service, such as the British Library. IDdb3 is "LitLink-enabled" which means that if you have a LitLink server, you can simply click on the GET ARTICLE button from a reference to retrieve full-text journal articles from document sources that your company has obtained access to. Derwent Discovery (from Thomson Derwent) When doing a QuickSearch and selecting Anywhere from the drop-down menu, or performing a Text Search including IDdb Portal Databases, you will receive results from Derwent World Drug Alerts Plus and Derwent Drug File which together make up the Derwent Discovery service. Derwent World Drug Alerts Plus covers a mixture of patents, journal references and conference reports from 1994 to date. It contains over 150,000 abstracts; over 300 added per week. Derwent Drug File covers abstracts of journal literature from 1964 to date. It contains over 1.75 million abstracts; over 1000 added per week and covers 1200 journals. It covers all aspects of drug research, from chemical synthesis to manufacture and use, with abstracts specially written by Derwent staff. In order to link to these results you will need to be a subscriber to Derwent Discovery. 38

39 Personal The Personal Section allows you to customise IDdb3 to fit better with your own requirements or preferences. It consists of four sections: Profile Preferences Library Profile This section can be used to change your personal details such as address, as well as your IDdb3 password. To make any changes complete the required section and click SAVE. Preferences The Preferences section can be used to customise the way IDdb3 performs tasks and displays the results, it is split into four areas. Results This screen allows you to choose the way in which results are displayed. You can choose the number of items per results page - 20, 50 or 100 Select the format in which to display chemical structures - Gifs or Molfiles Choose how you would like your s delivered - in Plain text or HTML format. Also, whether you would prefer not to receive an notifying you of zero results Set a default view for Smartsheets in terms of number of results per Smartsheet page and the order of columns Make sure you click SAVE to confirm any changes. Reports This screen allows you to select which sections to include in Drug and Company reports. Use the check boxes to choose which sections you wish to display in each report and click SAVE to confirm any changes. 39

40 Starting Points This screen is used to decide which page you wish to display as default when you first login to the database and when entering each individual section. Use the radio buttons to make your selections and click SAVE. Search This section can be used to change the way the indexes are searched in Advanced Search and Browse Indexes. It also gives you the choice to set which date is used when searching for patents. Having the cumulative count boxes checked means that when you search using a higher level index term, the search will automatically include lower level terms. This is the default. If you do not wish to include lower level terms in your search, uncheck the boxes. Some of the terms within the IDdb3 Actions, Indications and Technologies indexes have associated synonyms. When Looking Up a term in an index tree you can find the preferred index term by also entering the synonym. Checking the Show synonyms boxes will notify you when you have used a synonym. e.g. If you look up stroke in the Indications index, the database will retrieve Cerebrovascular ischemia is the preferred term for stroke. If the boxes are unchecked you will still retrieve the preferred term by entering a synonym. When limiting a patent search by date you have the option to use the Added, Updated, Publication or Priority date as the default search field. 40

41 Use this section to manage your notifications for Personal and Standard Alerts, Saved Searches, Report Updates and journal Table of Contents. You can change address where appropriate, delete or change the frequency of your alerts. Library The Personal library enables you to store the reports in which you are continually interested in one convenient place. To add a drug or company to the library click on the Add to Library button in the selected report. To view a report simply click on the title. You can sort the reports by Report type or Update date by using the Re-Sort option. 41