High Performance Devices for Flow Chemistry
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1 High Performance Devices for Flow Chemistry Effective and robust tools for lab and production scale
2 High Performance Devices for Flow Chemistry Ehrfeld Mikrotechnik BTS Global challenges for MRT MMRS: Highly flexible and robust R&D tool Integrated upscale-design Lonza: Ready for GMP tool Miprowa : Highly scalable lab, pilot and production tool Summary
3 A leading provider of services & products related to microreaction technology Offers the complete package, from an idea in lab scale to production plants A 100 % subsidary of Bayer Technology Services Flexibility & speed of an innovative technology specialist with comprehensive backing of a globally-active company
4 Sales activities of Ehrfeld Mikrotechnik BTS North America Baytown, TX, USA BTS Headquarter Leverkusen, Germany EMB Headquarter Wendelsheim, Germany Application Centers Russia Moscow, Russia Asia Shanghai, China Application Center UK & Ireland Solihull, UK Asia Tokyo, Japan Switzerland Visp, CH India Mumbai, India Israel Ramat Hasharon, Israel Asia Singapore Sales activities of EMB in cooperation with BTS Sales activities of EMB with other partners Headquarters of EMB and BTS
5 Introduction of Ehrfeld Mikrotechnik BTS Global challenges for MRT suppliers MMRS: Highly flexible and robust R&D tool Interface modules Lonza: Ready for GMP tool Miprowa : Highly scalable lab, pilot and production tool Summary
6 Global challenges for MRT supplier Do we have a Problem with Product Diversification? from lab... via pilot scale to production Capability for lab feasibility and MRT training Devices for lab, pilot and production Broad application range (e.g. deep temperature reactions, heterogeneous processes, high temperature and pressure, etc.) Integrated scalable design from lab to large production Robust and reliable design for harsh conditions in industrial fabrication
7 MMRS Laboratory research tools Lonza Lonza Development & production systems for Pharma - in cooperation with Lonza Customer service, MRT-training & basic feasibility studies Development & production units for (fine & bulk) Chemistry Service Miprowa
8 Introduction of Ehrfeld Mikrotechnik BTS Global challenges for MRT suppliers MMRS: Highly flexible and robust R&D tool Interface modules Lonza: Ready for GMP tool Miprowa : Highly scalable lab, pilot and production tool Summary
9 Modular MicroReaction System MMRS Lab Research System for Chemistry, Pharma, etc.! Modular design, highly flexible! Easy to adapt to a wide range of applications! Simple to disassemble and to maintain! Robust and accurate made of metal for harsh conditions! Pressure range: bar! Temperature range: C! Flow range: 0.1 >100 ml/min! Materials: SS, Hastelloy, Ta, glass, etc!
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11 Particle Precipitation Homogeneous & heterogeneous Chemistry Cryo Chemistry Photo Chemistry Heat Exchange Multi-phase (catalysis) Basic Starter Set Process Control Actuators & Valves Miprowa Interface modules Mixing & Emulsifying Lonza Interface modules Sensors
12 Basic Starter Set 1 x MMRS module configuration 2 x HPLC pumps 1 x Laboratory thermostat optional with PC control
13 Pump Unit M&C Sampling Unit Automated screening research tool MMRS Process Unit
14 Introduction of Ehrfeld Mikrotechnik BTS Global challenges for MRT suppliers MMRS: Highly flexible and robust R&D tool Interface modules Lonza: Ready for GMP tool Miprowa : Highly scalable lab, pilot and production tool Summary
15 MMRS upscale strategy MMRS MMRS Interface Modules Production Scale Modules
16 Introduction of Ehrfeld Mikrotechnik BTS Global challenges for MRT suppliers MMRS: Highly flexible and robust R&D tool Interface modules Lonza: Ready for GMP tool Miprowa : Highly scalable lab, pilot and production tool Summary
17 Development and production of pharmaceuticals Lean scale-up-concept Simple disassembly and maintenance Suitable for GMP processes Lonza Flexible, versatile & modular Preclinical Phase Clinical Phase I - III Production Phase Preclinical Clinical Phase I - III Commercial Production
18 Exemplary Microstructure of Lonza of Lonza MicroReactors LabPlate Different structures for several applications are available!
19 Reactor unit consists of plates for process media and plates for heat exchange Heat Exchange Plate Reactor Plate: No sealing required Effective cleaning by flushing Various plates are available Lonza Lonza
20 Exemplary Reactor Plate of Lonza MicroReactors Lonza Lonza Different plates for several applications are available!
21 Preclinical Phase Clinical Phase I - III Production Phase Preclinical Clinical Phase I - III Commercial Production LabPlate Reactors A6 & A5 Reactor A4 Lonza Lonza estimated design Lonza 1-50 g/min & g/min g/min
22 Introduction of Ehrfeld Mikrotechnik BTS Global challenges for MRT suppliers MMRS: Highly flexible and robust R&D tool Interface modules Lonza: Ready for GMP tool Miprowa : Highly scalable lab, pilot and production tool Summary
23 MIPROWA Development and production units High Performance production units for Chemistry & Pharma Easy-Upscale-Concept Easy to adapt to a wide range of applications Simple to disassemble and to maintain Robust and accurate, made of metal Pressure range: bar Temperature range: C Flow range: Materials: 1 > L/h SS, Hastelloy, Zr, Ta etc.
24 Advantages: Fast and effective heat transfer Careful heating of sensitive fluids Easy cleaning and maintenance Low installation costs
25 Channel width Rectangular Miprowa channels: D C Equaling-up B Numbering-up A < 3 < 50 < 150 < 350 Flow rate (L/h) Combination of numbering-up and equaling-up leads to cost efficient bundle and plate-type units
26 Numbering-up upscaling concept Miprowa Lab scale: No. of channels: 1-8 Channel size: 12 x 1.5 mm Throughput: 3-10 L/h Pilot scale: No. of channels: Channel size: 12 x 1.5 mm & 18 x 3 Throughput: L/h Production scale: No. of channels: Channel size: 18 x x 3 Throughput: L/h
27 Introduction of Ehrfeld Mikrotechnik BTS Global challenges for MRT suppliers MMRS: Highly flexible and robust R&D tool Interface modules Lonza: Ready for GMP tool Miprowa : Highly scalable lab, pilot and production tool Summary
28 Summary EMB offers High Performance Flow Devices from lab to production scale for a wide range of applications and process conditions EMB provides large customer service, process feasibility tests in own laboratories, MRT training events and a comprehensive after sales-support EMB design principles: - Easy access of inner parts, simple cleaning and maintenance - Robust design made of metal for use under harsh industrial conditions - Integrated scalability, interface modules for lab trials available
29 Ehrfeld Mikrotechnik BTS GmbH Mikroforum-Ring Wendelsheim Tel.: /
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