BEHAVIORAL SOFTWARE & PRODUCTS CATALOG

Transcription

1 BEHAVIORAL SOFTWARE & PRODUCTS CATALOG instrumentation and software for research

2 INTRODUCTION Welcome to the Med Associates Behavioral Software and Products Catalog. This catalog is designed around systems from starter to add-on packages for a variety of behavioral testing. We assemble any selection of modular components and pride ourselves on the ability to design and manufacture custom components to meet your exact research and testing requirements. For more information and a listing of new products, please visit our website at or request our catalog on CD. Stay current with experiments in our lab and other relevant topics to Med Associates by receiving our quarterly electronic newsletter, MedLines. This catalog is organized into the following sections: test packages, components, power control and interfaces, and software used to run and analyze your experiments. Most of the systems listed in this catalog do not include a computer. Med Associates products require one or two PCI slots, a USB connection, or some combination of these connections. When you order a computer from Med Associates we install all interface cards and software purchased at that time, making the set up of your new equipment go smoothly. The computer specifications are updated regularly and an example of units shipped can be found in the computer section and is current at the time of printing this catalog. Please check with Med Associates if you wish to purchase your computer elsewhere to make sure it will accommodate and run the software and hardware needed. Put together a Med Associates Test Package in three easy steps: STEP 1 Choose a Test Chamber for more information on: Operant Conditioning Behavior Test Packages see pages , 97, and or Self Administration Test Packages see pages

3 YOUR OPERANT BEHAVIOR TEST PACKAGE IS COMPLETE! STEP 3 Choose a Computer for more information see page...3 STEP 2 Choose an Interface System for more information on: Standalone PCI Packages see page Standalone USB Packages see page Interface Software Package see page i

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5 CUSTOMER INFORMATION ORDERING INFORMATION AND WARRANTY CONTACT MED ASSOCIATES Ordering Information: Orders are F.O.B. Georgia, Vermont. Med Associates has a minimum order policy of $ (Terms are Net 30 days with written purchase order to accounts approved for credit by Med; all others are advanced pay by VISA, MasterCard, American Express, Electronic Transfers of Funds, or Bank Check.) All payments must be in U.S. Funds. Please note that all orders placed over the phone require a hard copy of the Purchase Order before the order can be processed and confirmed. Shipping: We will use the most efficient and/or economical method for shipping, unless otherwise specified. Add 3% to prices for FOB Destination. Important Notice: These products are designed to be used while under the supervision of a research scientist in an experimental application. At no time should they be used in a medical treatment protocol, relied upon in a life support function used to inform or alert medical personnel concerning the condition of a patient, or used to make a diagnosis or decision concerning medical treatment. Returns and Repairs (Limited Warranty): Med Associates Inc. (Med) warrants the products bearing its name and trademark against all defects in material, workmanship and performance to the original using purchaser for a period of five (5) years from the date of shipment by Med. Med warrants that its products will meet the electronic and mechanical specification stated in Med s catalog. Although the specifications in the catalog are subject to change without notice, Med at its opinion will repair or replace a product which is found to be defective during the warranty period. Defective merchandise must be received at Med Associates Inc., Georgia Regional Industrial Park, 166 Industrial Park Road, Fairfax, VT 05454, no more than sixty-one (61) months from the date of original shipment by Med. All shipments must include a Return Authorization Number (RMA#), obtainable from Med s Vermont office and must be sent freight prepaid by the sender. Med holds the right to charge a 15% restocking fee on items purchased and returned due to any circumstances other than a malfunction. Limitations of Warranty: This warranty is nontransferable. This warranty does not apply to any defects or damages resulting from alteration, modification, neglect, misuse, usage of an improper power source, damage in transportation, abuse, or any cause other than the normal use of the equipment. This warranty does not apply to products resold by Med that are manufactured by other companies. No warranty or claim is made by Med regarding the efficacy of any product for any particular application. This warranty does not apply to custom-fabricated products manufactured according to user specifications. This warranty gives you specific legal rights and you may also have other rights, which vary from state to state. Except for the limited warranty stated above, Med disclaims any and all other warranties, express or implied, oral or written, including any implied warranties or merchantability or fitness for a particular purpose. Some states do not allow limitations on implied warranties, so the above limitation may not apply to you. In no event, shall Med be liable for any damages whatsoever arising out of the use of its products, including without limitation any direct, incidental or consequential damages, any damages for loss of profit, business interruption, loss of information or any pecuniary loss even if Med has been advised of the possibility of such damages. Some states do not allow the exclusion or limitation of liability for incidental or consequential damages, so the above limitation may not apply to you. Billing Address (USPS Delivery) Med Associates Inc. PO Box 319 St. Albans, VT Shipping Address (UPS, Fed Ex, etc.) Med Associates Inc. Georgia Regional Industrial Park 166 Industrial Pard Road Fairfax, VT Sales phone: fax: sales@med-associates.com Tech Support phone: support@med-associates.com Other Information phone: info@med-associates.com International Sales Europe Sandown Scientific phone: +44(0) info@sandownsci.com web: Israel New Biotechnology Ltd. phone: nbtsales@nbtltd.com web: Brazil Sellex, Inc. phone: (011) USA: (202) vendas@sellex.com web: China Please contact Med Associates directly for sales, support, and product information. To the best knowledge of Med Associates Inc., the specifications, descriptions and photos of the material contained herein are accurate as the date of printing (2/2009). Med Associates Inc. reserves the right without prior notice to discontinue at any time, at its discretion any of the parts and accessories depicted herein or change specifications or designs or prices without incurring obligation to the customer iii

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7 TABLE OF CONTENTS OPERANT CONDITIONING BEHAVIOR TEST PACKAGES Interface & Software Computers Rat Behavioral Test Packages Mouse Behavioral Test Packages Five Hole Nose Poke Wall Test Packages Nine Hole Nose Poke Wall Test Packages Self Administration Test Packages for Rat Oral Self Administration Test Packages for Rat Self Administration Test Packages for Mouse Pigeon or Small Primate Test Packages Primate Test Packages COMPONENTS FOR OPERANT BEHAVIOR TEST PACKAGES Modular Test Chambers & Accessories , 102 Filler Panel Packages , 24, 30, 32, 102 Shuttle Box Test Packages, Chambers & Components Sound Attenuating Cubicles & Accessories Stimulus & Response Devices (Levers, Nose Pokes, Auditory Stimulus and Olfactory). 44 Pellet & Liquid Receptacles & Accessories Liquid Rewards & Accessories Pellet Dispensers Photobeam Sensors Aversive Stimulators & Accessories Drug Delivery & Accessories Syringe Pumps ICSS Stimulators & Accessories Components for Pigeon, Rat or Small Primate Test Packages Components for Primate Test Packages POWER, CONTROL AND INTERFACE EQUIPMENT Power, Supplies and Accessories SmartCtrl Packages and Components Standalone Interface Packages Interface Modules for 28 V DC Cables, Connection Panels and TTL Devices SOFTWARE SOF-735: MED-PC IV SOF-731 MPC2XL Data Transfer Utility SoftCr Pro and SoftCr MedState Notation Procedures Shuttle Box Packages SOF-706 Schedule Manager Input and Output from MedState Notation INDEX Numeric Alphabetic ABOUT MED ASSOCIATES INC ORDERING INFORMATION AND WARRANTY iii LOOK FOR THIS ICON TO FIND PACKAGES THROUGHOUT THIS CATALOG

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9 OPERANT CONDITIONING BEHAVIOR TEST PACKAGES Med Associates can assemble an operant behavior test package to meet virtually any research requirement. The packages in the following sections are just a few of the more common configurations that we have assembled over the years for our customers. All use the versatile MED-PC IV interface support and software. To simplify ordering, we have listed two interface and software packages below. For most applications, the MED-SYST-8 will run up to eight test stations and the MED-SYST-16 will run up to sixteen test stations (exceptions: Nine Hole Nose Poke Wall Test Packages, ANL-926 audio generators). Interface and Software Both interface packages (MED-SYST-8 and MED-SYST-16) include an interface cabinet with a built in 28 V DC power supply. The MED-SYST-8 package includes an interface cabinet that is capable of housing up to eight interface cards. The MED-SYST-16 is capable of housing up to sixteen interface cards. This package also features our interface connection package which includes a PCI card to be installed in the computer, decode card, ribbon cable, power cable, and the most popular software used for behavioral testing: MED-PC IV, MED-PC to Excel, SoftCr and a corresponding MedState Notation code. For further information on the software, please refer to the Software section of this catalog. Computers PACKAGE COMPONENTS : INTERFACE AND SOFTWARE MODEL DESCRIPTION MED-SYST-8 SG-6080D Small Interface Cabinet with 6 Amp 28 V DC MED-SYST-16 SG-6510D Large Interface Cabinet with 16 Amp 28 V DC MED-SYST-8 and MED-SYST-16 DIG-700P2 PCI Interface Package SOF-735 MED-PC IV Control and Data Collection Software SOF-731 MPC2XL Data Transfer Utility SOF-721 SoftCr Cumulative Record Utility SOF-700RA Sample Standard Research Application Code in MedState Notation Add a Med Associates computer to any behavioral test package and the interface card, drivers, and all software will be factory installed. Specifications are subject to change. Contact Sales for the latest specifications at the time of order. PACKAGE COMPONENTS : COM-103A-GP Intel P4 3.2 GHz Processor Multiple PCI slots 80 GB Hard Drive 512 MB RAM 52 x 32 x 52 CD-RW 3.5 Floppy Drive 17" Color Monitor LCD Windows XP Pro OPERANT CONDITIONING BEHAVIOR TEST PACKAGES : INTERFACE & SOFTWARE, COMPUTERS

10 OPERANT CONDITIONING BEHAVIOR TEST PACKAGES FOR RAT Med Associates offers more components for testing in rats than any other manufacturer. The following packages are just a few of the more common configurations that we have assembled over the years for rat operant testing. Feel free to custom design your own chamber configuration using any of these designs as your guide to meet virtually any research requirement. Additional items to consider include an audio generator, infusion pump, scrambled foot aversive stimulation, lickometer, movement detector, and constant current square wave stimulator. Each operant package for rat is a complete single test station including the SmartCtrl interface. This does not include the interface and software package that must be ordered separately. Interface, computer and software are sold separately. MED-008-B1 : Basic Rat Behavioral Test Package MDF Cubicle, Standard Modular Test Chamber, Fixed Levers, Pellet Reward This basic package features a standard modular test chamber with a value-pak top and a deep standard MDF sound attenuating cubicle. The modular components included in this package are two fixed response levers, two stimulus lights, and 45 mg food reward. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-008-B1 MODEL DESCRIPTION ENV-022MD Deep Standard MDF Sound Attenuating Cubicle ENV-008-VP Standard Modular Chamber with Value-Pak Top and Waste Pan ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V DC ENV-221M Stimulus Light 1" white lens, mounted on modular panel (2) ENV-110M Standard Response Lever (2) ENV-203M-45 Modular Pellet Dispenser 45 mg ENV-200R2M Pellet Receptacle Trough Style DIG-716P1 SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) 4

11 MED-008-D1 : Deluxe Rat Behavioral Test Package PVC SAC, Standard Modular Test Chamber, Retractable Levers, Dual Liquid/Pellet Reward This deluxe package features an expanded PVC sound attenuating cubicle, a standard modular test chamber with two retractable levers and both pellet and liquid reinforcement in addition to the other components listed. The FR Tra ining Procedure provided with the interface package uses convenient named variables to select the correct lever, the reward dispenser, reward time and time out, the FR value and session time. It can also automatically create a time stamp file for the Soft Cumulative Record Utility. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-008-D1 MODEL DESCRIPTION ENV-022V Deep Standard Expanded PVC Sound Attenuating Cubicle ENV-008 Standard Modular Test Chamber with Pan ENV-005 Standard Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V DC ENV-221M Stimulus Light 1" white lens, mounted on modular panel (2) ENV-112CM Retractable Response Lever, Low Profile (2) ENV-203M-45 Modular Pellet Dispenser 45mg ENV-202RM-S Pellet/Dipper Combined Receptacle ENV-223AM Sonalert Attachment with Volume Control: 2,900 Hz DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) MED-007-B1 : Basic Rat Behavioral Test Package MDF SAC, Extra Tall Modular Test Chamber, Fixed Levers, Pellet Reward This basic package features an extra tall modular test chamber with a value-pak top and a deep extra tall MDF sound attenuating cubicle. The modular components included in this package are: two fixed response levers, two stimulus lights, and 45 mg food reward. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-007 -B1 MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-007-VP Extra Tall Modular Test Chamber with Value-Pak Top and Waste Pan ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V DC ENV-221M Stimulus Light 1" white lens, mounted on modular panel (2) ENV-110M Standard Response Lever (2) ENV-203M-45 Modular Pellet Dispenser 45 mg ENV-200R2M Pellet Receptacle Trough Style DIG-716P1 SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) OPERANT CONDITIONING BEHAVIOR : RAT BEHAVIORAL TEST PACKAGES

12 MED-007-D1 : Deluxe Rat Behavioral Test Package PVC SAC, Extra Tall Modular Test Chamber, Retractable Levers, Dual Liquid/Pellet Reward This deluxe package features an expanded PVC sound attenuating cubicle, an extra tall modular test chamber with two retractable levers and both pellet and liquid reinforcement in addition to the other components listed. The FR Training Procedure provided with the interface package uses convenient named variables to select the correct lever, the reward dispenser, reward time and time out, the FR value and session time. It can also automatically create a time stamp file for the Soft Cumulative Record Utility. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-007-D1 MODEL DESCRIPTION ENV-018V Expanded PVC Sound Attenuating Cubicle ENV-007 Extra Tall Modular Chamber and Waste Pan ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V DC ENV-221M Stimulus Light 1" white lens, mounted on modular panel (2) ENV-112CM Retractable Lever, Low Profile (2) ENV-203M-45 Modular Pellet Dispenser 45 mg ENV-202RM-S Liquid Dipper with Dual Liquid Pellet Receptacle ENV-223AM Sonalert Attachment with Volume Control: 2,900 Hz DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) 6

13 OPERANT CONDITIONING BEHAVIOR TEST PACKAGES FOR MOUSE Med Associates offers more components for testing mice than any other manufacturer. The following packages are just a few of the more common configurations that we have assembled over the years for mouse operant testing. Feel free to custom design your own chamber configuration using any of these designs as a guide to meet virtually any research requirement. Additional items to consider include an audio generator, infusion pump, scrambled foot aversive stimulation, lickometer, movement detector, and constant current square wave stimulator. Each mouse operant package is a complete single test station including the SmartCtrl interface. This does not include the interface and software package that must be ordered separately. Interface, computer and software are sold separately. MED-307A-B1 : Basic Mouse Behavioral Test Package MDF SAC, Classic Modular Test Chamber, Fixed Levers, Pellet Reward This basic package features a standard MDF sound attenuating cubicle with a classic modular test chamber. This size was first proposed by Galen Wenger and Peter Dews. It has the advantage over our other chamber sizes of a smaller area that provides less distractions for the mouse, thus improving shaping and performance. The modular components included in this package are two ultra sensitive fixed levers and 20 mg pellet reward. The 14 mg pellet dispenser (ENV P) is available by request in place of the 20 mg pellet dispenser. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-307A-B1 MODEL DESCRIPTION ENV-022MD Standard MDF Sound Attenuating Cubicle ENV-307A Classic Modular Test Chamber with Pan ENV-307A-GF Stainless Steel Grid Floor ENV-315M House Light, hooded, 28V ENV-321M Stimulus Light, Yellow LED (2) ENV-310M Ultra Sensitive Mouse Lever with Photobeam Sensor (2) ENV Pellet Dispenser 20 mg ENV-303M Pellet Receptacle Mouse DIG-716P1 SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) OPERANT CONDITIONING BEHAVIOR : MOUSE BEHAVIORAL TEST PACKAGES

14 MED-307A-D1 : Deluxe Mouse Behavioral Test Package PVC SAC, Classic Modular Test Chamber, Retractable Levers, Dual Liquid/Pellet Reward This deluxe package features an expanded PVC cubicle, two ultra sensitive retractable levers, with a dual liquid/pellet receptacle in a classic modular test chamber. The test chamber size was first proposed by Galen Wenger and Peter Dews. It has the advantage over our other chamber sizes of a smaller area that provides less distractions for the mouse, thus improving shaping and performance. The 14 mg pellet dispenser (ENV P) is available by request in place of the 20 mg pellet dispenser. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-307A-D1 MODEL DESCRIPTION ENV-022V Expanded PVC Sound Attenuating Cubicle ENV-307A Classic Modular Test Chamber with Pan ENV-307A-GF Stainless Steel Grid Floor ENV-315M House Light, hooded, 28V ENV-321M Stimulus Light, Yellow LED (2) ENV-312-2M Retractable Ultra Sensitive Lever (2) ENV Pellet Dispenser 20 mg ENV-302RM-S Liquid Dipper with Dual Pellet/Dipper Receptacle for ENV-307A ENV-323AM Sonalert, 2,900 Hz Tone Module DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) MED-307W-B1 : Basic Mouse Behavioral Test Package MDF SAC, Wide Modular Test Chamber, Fixed Levers, Pellet Reward This basic package features a chamber with wider modular panels then the classic modular test chamber. This package also contains a MDF cubicle, two ultra sensitive fixed levers and pellet reward. The 14 mg pellet dispenser (ENV P) is available by request in place of the 20 mg pellet dispenser. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-307W-B1 MODEL DESCRIPTION ENV-022MD Deep Standard MDF Sound Attenuating Cubicle ENV-307W Wide Modular Test Chamber with Pan ENV-307W-GF Stainless Steel Grid Floor ENV-315W House Light, hooded, 28V ENV-321W Stimulus Light, Yellow LED (2) ENV-310W Ultra Sensitive Lever with Photobeam Sensor (2) ENV Pellet Dispenser 20 mg ENV-303W Pellet Receptacle Mouse DIG-716P1 SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) 8

15 MED-307W-D1 : Deluxe Mouse Behavioral Test Package PVC SAC, Wide Modular Test Chamber, Retractable Levers, Dual Liquid/Pellet Reward This deluxe package features an expanded PVC sound-attenuating cubicle, a wide modular test chamber with two ultra sensitive retractable levers and both pellet and liquid reinforcement. The 14 mg pellet dispenser (ENV P) is available by request in place of the 20 mg pellet dispenser. The FR Training Procedure provided with the interface package uses convenient named variables to select the correct lever, reward dispenser, reward time and time out, FR value and session time. It can also automatically create a time stamp file for the SoftCr or Cumulative Record Utility. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-307W-D1 MODEL DESCRIPTION ENV-022V Expanded PVC Sound Attenuating Cubicle ENV-307W Wide Modular Test Chamber with Waste Pan ENV-307W-GF Stainless Steel Grid Floor ENV-315W House Light, hooded, 28V ENV-321W Stimulus Light, Yellow LED (2) ENV-312-2W Retractable Ultra Sensitive Lever (2) ENV-323AW Sonalert, 2,900 Hz Tone Module ENV Pellet Dispenser 20 mg ENV-302RW-S Pellet/Dipper Combined Receptacle DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) OPERANT CONDITIONING BEHAVIOR : MOUSE BEHAVIORAL TEST PACKAGES

16 FIVE HOLE NOSE POKE WALL TEST PACKAGES The five hole nose poke chamber has been used extensively to assess attention and stimulus control. Med Associates offers the following packages in both rat and mouse sizes. The application software (SOF-700RA-8A) available for the following packages features flexible user settings for trials to run, limited hold (duration of the serial choice phase), time out, reward duration, session time, cue duration, and ITI duration. Sixteen elements of data are documented for each trial. Summary data includes correct responses, incorrect responses, omissions, premature responses, perseverant responses, time out responses, total receptacle head entries, percent correct, percent incorrect, percent omission, average latency to correct responses, average latency to incorrect responses, and average latency to reward. MedState Notation may be modified by the user or custom code may be ordered from Med Associates. Please contact Sales for details. Interface, computer and software are sold separately. MED-NP5L-B1 : Basic Five Hole Nose Poke Wall Test Package for Rat This basic package features a five choice wall installed in an extra tall modular test chamber and an extra tall MDF cubicle. The modular components included are a pellet dispenser, pellet receptacle, head entry detection, and receptacle light. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Order MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-NP5L-B1 MODEL DESCRIPTION ENV-018MD ENV-007-VP ENV-115A-07 ENV-005 ENV-215M ENV-203M-45 ENV-200R2M ENV-200RL ENV-254-CB DIG-716P2 Deep Extra Tall MDF SAC Value-Pak Extra Tall Modular Test Chamber with Waste Pan Five Unit Curved Nose Poke Wall, Holes 1" x 1" Square Stainless Steel Grid Floor Standard Rat House Light, hooded, 100 ma, 28 V DC Modular Pellet Dispenser 45mg Pellet Receptacle Trough Type Receptacle Light Head Entry Detector Package SmartCtrl 8 In/16 Out Package (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) 10

17 MED-NP5L-D1 : Deluxe Five Hole Nose Poke Wall Test Package for Rat This deluxe package features an extra tall modular test chamber fitted with five nose pokes containing single stimulus lights on a curved back wall, grid floor, and a stainless waste pan. Also included are an extra tall expanded PVC sound attenuating cubicle, pellet dispenser, and pellet receptacle with head entry detection and receptacle light. The addition of the fader on the control package allows for variable intensity of the nose poke stimulus lights. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Order the MED-SYST-8 interface and software package to run up to four test chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-NP5L-D1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-018V ENV-007-VP ENV-115A-07V ENV-005 ENV-215M ENV-203M-45 ENV-200R2M Expanded PVC Sound Attenuating Cubicle Value-Pak Extra Tall Modular Test Chamber with Waste Pan Five Unit Curved Nose Poke Wall, Vertical mount IR s Stainless Steel Grid Floor Standard Rat House Light, hooded, 100 ma, 28 V DC Modular Pellet Dispenser 45mg Pellet Receptacle Trough Type ENV-254-CB Head Entry Detector ENV-200RL Receptacle Light DIG-712 SuperPort 16 Input Module DIG-726 SuperPort 16 Output Module SG-226C Connection Panel, 16 In/12 Out, & Fader SG-210CB SmartCtrl Cable 25' (2) SG-210CP-25 Power Cable with Polarized Molex Connectors, 25' MED-NP5M-B1 : Basic Five Hole Nose Poke Wall Test Package for Mouse This basic package features a five choice wall installed in a wide modular test chamber and a deep standard MDF cubicle. The modular components included are a pellet dispenser, pellet receptacle, head entry detection and receptacle light. The 14 mg pellet dispenser (ENV P) is available by request in place of the 20 mg pellet dispenser. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Order MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-NP5M-B1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-022MD Deep Standard White MDF Sound ENV-303W Pellet Receptacle Mouse Attenuating Cubicle ENV-303RL Receptacle Light ENV-307W Wide Mouse Modular Chamber ENV-303HDW Head Entry Detector with Waste Pan, 2" wide panels DIG-716P2 SmartCtrl 8 In/16 Out ENV-115C Five Unit Curved Nose Poke Wall Package (includes 1 DIG-716B, ENV-307W-GF Grid Floor for ENV-307W 1 SG-716B, 1 SG-210CB, ENV-315W House Light Mouse 1 SG-210CP-XX) ENV Pellet Dispenser 20 mg MED-NP5M D1 : Deluxe Five Hole Nose Poke Wall Test Package for Mouse This deluxe package features an expanded PVC cubicle with a wide modular test chamber with a five choice nose poke wall installed. The 14 mg pellet dispenser (ENV ) is available by request in place of the 20 mg pellet dispenser. The addition of the fader on the control package allows for variable intensity of the nose poke stimulus lights. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Order the MED- SYST-8 interface and software package to run up to four test chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-NP5M-D1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-022V Expanded PVC Sound Attenuating ENV-303RL Receptacle Light Cubicle ENV-303HDW Head Entry Detector ENV-307W Wide Mouse Modular Chamber DIG-726 SuperPort 16 Output Module with Waste Pan, 2" wide panels DIG-712 SuperPort 16 Input Module ENV-115C Five Unit Curved Nose Poke Wall SG-226C Connection Panel, 16 In/12 Out ENV-307W-GF Grid Floor for ENV-307W SG-210CB SmartCtrl Cable 25' (2) ENV-315W House Light Mouse SG-210CP-25 Power Cable with Polarized Molex ENV Pellet Dispenser 20 mg Connectors, 25' ENV-303W Pellet Receptacle Mouse OPERANT CONDITIONING BEHAVIOR : FIVE HOLE NOSE POKE WALL TEST PACKAGES

18 NINE HOLE NOSE POKE WALL TEST PACKAGES The nine hole nose poke chamber has been used extensively to assess attention and stimulus control. Med Associates offers the following packages in both rat and mouse sizes. The application software (SOF-700RA-8) available for the following packages features flexible user settings for trials to run, limited hold (duration of the serial choice phase), time out, reward duration, session time, cue duration, and ITI duration. Twenty elements of data are documented for each trial. Summary data includes correct responses, incorrect responses, omissions, premature responses, perseverant responses, time out responses, total receptacle head entries, percent correct, percent incorrect, percent omission, average latency to correct responses, average latency to incorrect responses, and average latency to reward. MedState Notation may be modified by the user or custom code ordered from Med Associates. Please contact Sales for details. Interface, computer and software are sold separately. MED-NP9L-B1 : Basic Nine Hole Nose Poke Wall Test Package for Rat This basic package includes a nine choice wall installed in an extra tall modular test chamber. Also included in this package is an extra tall MDF cubicle, a pellet dispenser, pellet receptacle, head entry detection, and receptacle light. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Order the MED-SYST-8 interface and software package to run up to four chambers or the MED-SYST-16 to run up to eight chambers. PACKAGE COMPONENTS : MED-NP9L-B1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-018MD ENV-NPW-9L ENV-215M ENV-203M-45 ENV-200R2M ENV-200RL Deep Extra Tall MDF Sound Attenuating Cubicle Nine Nose Poke Chamber Package Rat (includes Waste Pan and Grid Floor) House Light, hooded, 100 ma, 28 V DC Modular Pellet Dispenser 45mg Pellet Receptacle Trough Type Receptacle Light ENV-254-CB DIG-716P3 Head Entry Detector 16 In/16 Out Control & Cable Package (includes 1 DIG-712, 1 DIG-726, 1 SG-215D4, 2 SG-210CB, 1 SG-210CP-XX) This package requires two open slots in cabinet. MED-NP9L-D1 : Deluxe Nine Hole Nose Poke Wall Test Package for Rat This package features the extra tall modular test chamber which has been fitted with a nine nose poke curved wall containing single stimulus lights, grid floor, and a stainless steel waste pan. Also included are an extra tall expanded PVC sound attenuating cubicle, pellet dispenser, and pellet receptacle with head entry detection and receptacle light. The addition of the fader on the control package allows for variable intensity of the nose poke stimulus lights. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Since two SuperPort modules are needed for each test chamber, the large interface cabinet recommended for this system supports a total of eight chambers while the small interface cabinet supports four chambers. Order the MED-SYST-8 interface and software package to run up to four test chambers or the MED-SYST-16 to run up to eight test chambers. 12

19 PACKAGE COMPONENTS : MED-NP9L-D1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-018V ENV-NPW-9L ENV-215M DIG-712 DIG-726 Expanded PVC Sound Attenuating Cubicle Nine Nose Poke Chamber Package Rat (includes Waste Pan and Grid Floor) House Light, hooded, 100 ma, 28 V DC SuperPort 16 Input Module SuperPort 16 Output Module SG-226C Connection Panel, 16 In/12 Out, & Fader SG-210CB SmartCtrl Cable 25' (2) ENV-203M-45 Modular Pellet Dispenser 45mg ENV-200R2M Pellet Receptacle Trough Type SG-210CP-25 Power Cable with Polarized Molex Connectors, 25' ENV-200RL Receptacle Light ENV-254-CB Head Entry Detector MED-NP9M-B1 : Basic Nine Hole Nose Poke Wall Test Package for Mouse This basic package includes a nine choice wall installed in a wide modular test chamber in an extra tall MDF cubicle. In addition it features a pellet dispenser, pellet receptacle, head entry detection, and a receptacle light. The 14 mg pellet dispenser (ENV P) is available by request in place of the 20 mg pellet dispenser. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Order the MED-SYST-8 interface and software package to run up to four test chambers or the MED-SYST-16 to run up to eight test chambers. PACKAGE COMPONENTS : MED-NP9M-B1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-022MD Deep Standard White MDF Sound ENV-303RL Receptacle Light Attenuating Cubicle ENV-303HDW Head Entry Detector ENV-NPW-9M Nine Nose Poke Chamber Package DIG-716P3 16 In/16 Out Control & Cable Mouse (includes Waste Pan and Package (includes 1 DIG-712, Grid Floor) 1 DIG-726, 1 SG-215D4, 2 SG-210CB, ENV-315W House Light Mouse 1 SG-210CP-XX) ENV Pellet Dispenser 20 mg This package requires two open ENV-303W Pellet Receptacle Mouse slots in cabinet. MED-NP9M-D1 : Deluxe Nine Hole Nose Poke Wall Test Package for Mouse This package features the wide modular test chamber that has been fitted with a nine nose poke curved wall containing single stimulus lights, grid floor, and a stainless steel waste pan. Also included are an extra tall expanded PVC cubicle, pellet dispenser, pellet receptacle, head entry detection and pellet receptacle light. The 14 mg pellet dispenser (ENV P) is an available option when a smaller dispenser is needed. The addition of the fader on the control package allows for variable intensity of the nose poke stimulus lights. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Since two SuperPort modules are needed for each test chamber, the large interface cabinet recommended for this system supports a total of eight chambers, while the small interface cabinet supports four chambers. Order the MED-SYST-8 interface and software package to run up to four chambers or the MED-SYST-16 to run up to eight test chambers. PACKAGE COMPONENTS : MED-NP9M-D1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-022V Expanded PVC Sound Attenuating Cubicle SG-226C Connection Panel, 16 In/12 Out, & Fader ENV-NPW-9M Nine Nose Poke Chamber Package Mouse (includes Waste Pan and Grid Floor) ENV-215M House Light, hooded, 100 ma, 28 V DC DIG-712 SuperPort 16 Input Module DIG-726 SuperPort 16 Output Module SG-210CB SmartCtrl Cable 25' (2) ENV Pellet Dispenser 20 mg ENV-303W Pellet Receptacle Mouse SG-210CP-25 Power Cable with Polarized Molex Connectors, 25' ENV-303RL Receptacle Light ENV-303HDW Head Entry Detector OPERANT CONDITIONING BEHAVIOR : NINE HOLE NOSE POKE WALL TEST PACKAGES

20 SELF ADMINISTRATION TEST PACKAGES FOR RAT The self-administration test packages for rat include the following features: a modified top to allow the tether system to exit the chamber, a drug delivery arm assembly, and a rat self-infusion package containing a high-quality disposable plastic swivel, drug delivery line, metal spring tether, and plastic belly harness that the rat wears like a vest. All components are connected using luer-lock fixtures, providing ease of use. A wide range of drug delivery options is available including variable speed and high-speed micro-liter pumps (ideal for nicotine) and pump swivels and tethers. An optional piece of equipment is a scrambled foot aversive stimulator. Please refer to Aversive Stimulators and Drug Delivery sections for details on these products. Interface, computer and software are sold separately. MED-008-CT-B1 : Basic Rat Drug Self Administration Test Package MDF SAC, Standard Modular Test Chamber, Fixed Levers, Standard Pump This basic package features an extra tall MDF sound attenuating cubicle with a standard modular test chamber. Also included are these modular components: two fixed levers, two stimulus lights, a 45 mg pellet dispenser, and our standard single speed syringe pump with a 3.33 RPM motor. Order the MED-SYST-8 interface and software package to run up to eight test chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-008-CT-B1 MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-008CT Standard Modular Test Chamber with Drug Infusion Top and Waste Pan ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V ENV-221M Stimulus Light. 1", White Lens (2) ENV-110M Standard Response Lever (2) ENV-203M-45 Modular Pellet Dispenser 45 mg ENV-200R2M Pellet Receptacle Trough Style DIG-716P1 SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) PHM-100 Syringe Pump, 3.33 RPM PHM-110-SAI Drug Delivery Arm PHM-119B-D Rat Self Infusion Package (includes swivel, tether, belly strap and delivery line) 14

21 MED-008-CT-D1 : Deluxe Rat Drug Self Administration Package PVC SAC, Standard Modular Test Chamber, Retractable Levers, Variable Speed Pump This deluxe package consists of our standard modular test chamber with modified top to allow for self-administration work. This package also contains an extra tall expanded PVC sound attenuating cubicle to isolate the animal from environmental disturbances during testing. This package also consists of our variable speed syringe pump, a high quality disposable plastic swivel, drug delivery line, metal spring tether and plastic belly harness that the animal wears like a vest. Luer-lock fitting are provided on all drug delivery components included in this package. Other features include two stimulus lights, two retractable response levers, and our 45 mg modular pellet dispenser. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-008-CT-D1 MODEL DESCRIPTION ENV-018V Extra Tall Expanded PVC Sound Attenuating Cubicle ENV-008CT Standard Modular Test Chamber with Drug Infusion Top ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V ENV-221M Stimulus Lights, 1", White Lens (2) ENV-112CM Retractable Response Levers Low Profile (2) ENV-203M Modular Pellet Dispenser 45 mg MODEL ENV-200R2M ENV-254-CB DIG-716P2 PHM-100VS PHM-110-SAI PHM-119B-D DESCRIPTION Pellet Receptacle Trough Style Head Entry Detector Package SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) Variable Speed Syringe Pump Drug Delivery Arm Assembly Rat Self Infusion Package (includes swivel, tether, belly strap and delivery line) MED-007-CT-B1 : Basic Rat Drug Self Administration Package MDF SAC, Extra Tall Modular Test Chamber, Fixed Levers, Standard Pump This basic package consists of our extra tall modular test chamber with modified top to allow for self-administration work. This package also contains an extra tall MDF sound attenuating cubicle to isolate the animal from environmental disturbances during testing. This package also consists of our standard single speed syringe pump with a 3.33 RPM motor, a high quality disposable plastic swivel, drug delivery line, metal spring tether and plastic belly harness that the animal wears like a vest. Luer-lock fitting are provided on all drug delivery components included in this package. Other features of this package include two stimulus lights, two fixed response levers, and our 45 mg modular pellet dispenser. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-007-CT-B1 MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-007CT Extra Tall Chamber with Drug Infusion Top ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V ENV-221M Stimulus Light. 1", White Lens (2) ENV-110M Standard Response Lever (2) ENV-203M-45 Modular Pellet Dispenser 45 mg MODEL ENV-200R2M DIG-716P1 PHM-100 PHM-110-SAI PHM-119B-D DESCRIPTION Pellet Receptacle Trough Style SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) Syringe Pump, 3.33 RPM Drug Delivery Arm Assembly Rat Self Infusion Package (includes swivel, tether, belly strap and delivery line) OPERANT CONDITIONING BEHAVIOR : RAT SELF ADMINISTRATION TEST PACKAGES

22 MED-007-CT-D1 : Deluxe Rat Drug Self Administration Package PVC SAC, Extra Tall Modular Test Chamber, Retractable Levers, Variable Speed Pump This deluxe package consists of our standard modular test chamber with modified top to allow for self-administration work. This package also contains an extra tall expanded PVC sound attenuating cubicle to isolate the animal from environmental disturbances during testing. This package also consists of our variable speed syringe pump, a high quality disposable plastic swivel, drug delivery line, metal spring tether and plastic belly harness that the animal wears like a vest. Luer-lock fitting are provided on all drug delivery components included in this package. Other features of this package include two stimulus lights, two retractable response levers, and our 45 mg modular pellet dispenser. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-007-CT-D1 MODEL DESCRIPTION ENV-018V Expanded PVC Sound Attenuating Cubicle ENV-007CT Extra Tall Modular Test Chamber with Drug Infusion Top ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V ENV-221M Stimulus Lights, 1", White Lens (2) ENV-112CM Retractable Response Levers Low Profile (2) ENV-203M-45 Modular Pellet Dispenser 45 mg ENV-200R2M Pellet Receptacle Trough Style ENV-254-CB Head Entry Detector DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) PHM-100VS Variable Speed Syringe Pump PHM-110-SAI Drug Delivery Arm Assembly PHM-119B-D Rat Self Infusion Package (includes swivel, tether, belly strap and delivery line) 16

23 ORAL SELF ADMINISTRATION TEST PACKAGES FOR RATS Interface, computer and software are sold separately. MED-008-CT-B3 : Oral Drug Self Administration Test Package for Rat Syringe Pump This is the package of choice when precision delivery of liquid reinforcers is required. This package features our standard syringe pumps for liquid delivery, offering more precise control over our liquid dipper delivery system. This package consists of our standard rat modular operant conditioning chamber with the self administration top modification, a house light, two stimulus lights, two fixed response levers, and our 45 mg pellet dispenser, a standard in the industry. Oral reinforcement delivery is accomplished using two syringe pumps, drug delivery lines, and a dual cup liquid receptacle. This allows two different liquid reinforcements to be delivered into one receptacle. A deep extra tall MDF sound attenuating cubicle encloses the operant conditioning chamber, keeping the experimental animal isolated from environmental disturbances during an experiment. By featuring the extra tall sound attenuating cubicle and the chamber top modification on the standard modular test chamber, this package allows the possibility of future upgrades to expand the use of this system for intravenous self administration work where the extra room is necessary to accommodate the drug infusion hardware. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-008-CT-B3 MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-008CT Standard Modular Test Chamber with Drug Infusion Top ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V ENV-221M Stimulus Lights, 1", White Lens (2) ENV-110M Standard Response Levers (2) ENV-200R3AM Dual Cup Liquid Receptacle DIG-716P1 SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) PHM-100 Syringe Pump, 3.33 RPM (2) PHM-122 Drug Delivery Delivery Line (2) OPERANT CONDITIONING BEHAVIOR : ORAL RAT SELF ADMINISTRATION TEST PACKAGES

24 MED-008-CT-B4 : Oral Drug Self Administration Test Package for Rat Liquid Dipper This package is designed for delivery of liquid reinforcers using a liquid dipper. The package consists of our standard modular test chamber with the chamber top modification, a house light, two stimulus lights, and two fixed response levers. Oral reinforcer delivery is accomplished using a liquid dipper. A deep extra tall MDF sound attenuating cubicle encloses the test chamber, keeping the experimental animal isolated from environmental disturbances during an experiment. By featuring the extra tall sound attenuating cubicle and the chamber top modification on the standard test chamber, this package allows the possibility of future upgrades to expand the use of this system for intravenous self administration work where the extra room is necessary to accommodate the drug infusion hardware. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-008-CT-B4 MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-008CT Standard Modular Test Chamber with Drug Infusion Top and Waste Pan ENV-005 Stainless Steel Grid Floor ENV-215M House Light, hooded, 28V ENV-221M Stimulus Lights, 1", White Lens (2) ENV-110M Standard Response Levers (2) ENV-202M-S Liquid Dipper DIG-716P1 SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) 18

25 SELF ADMINISTRATION TEST PACKAGES FOR MOUSE The self-administration test packages for mouse include the following features: a modified top to allow the tether system to exit the chamber, a syringe pump, mouse drug delivery arm that supports the 25 gauge mouse swivel, a polysulfone button and spring that serves as the leash/tether assembly, and a 25 gauge drug delivery line. Interface, computer and software are sold separately. MED-307A-CT-B1 : Basic Mouse Drug Self Administration Test Package MDF SAC, Classic Modular Test Chamber, Fixed Levers, Standard Pump This basic package consists of our mouse classic modular test chamber with modified top allowing the drug delivery tether to exit the chamber. This size was first proposed by Galen Wenger and Peter Dews. It has the advantage over our other chamber sizes of a smaller area that provides less distractions for the mouse, thus improving shaping and performance. The operant conditioning chamber is fitted with a house light, two stimulus lights, two ultra sensitive mouse fixed response levers, and our pellet dispenser (20 mg). The 14 mg pellet dispenser (ENV P) is an available option when a smaller dispenser is needed. In addition, the package includes our standard syringe pump with 3.33 RPM motor, mouse drug delivery arm that supports the 25 gauge mouse swivel, a polysulfone button and spring that serves as the leash/tether assembly, and 25 gauge drug delivery line. A deep MDF sound attenuating cubicle keeps the animal in the operant conditioning chamber isolated from external disturbances. Order the MED-SYST-8 interface and software package to run up to eight chambers, or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-307A-CT-B1 MODEL DESCRIPTION ENV-022MD Deep Standard MDF Sound Attenuating Cubicle ENV-307A- CT Classic Modular Test Chamber with Drug Delivery Top and Waste Pan ENV-307A-GF Stainless Steel Grid Floor ENV-315M House Light, hooded, 28V ENV-321M Stimulus Lights, 1/4" Yellow LED (2) ENV-310M Ultra Sensitive Mouse Levers (2) ENV Pellet Dispenser 20 mg ENV-303M Pellet Receptacle Mouse DIG-716P1 SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) PHM-100 Syringe Pump, 3.33 RPM PHM-124MA Multi-Axis Lever Arm Mouse PHM-124B 25 Gauge Swivel Assembly Mouse PHM-124C Polysulfone Button and Spring PHM Gauge Delivery Line OPERANT CONDITIONING BEHAVIOR : MOUSE SELF ADMINISTRATION TEST PACKAGES

26 MED-307A-CT-D1 : Deluxe Mouse Drug Self Administration Test Package PVC SAC, Classic Modular Test Chamber, Retractable Levers, Variable Speed Pump This deluxe package consists of our mouse classic modular test chamber with modified top allowing the drug delivery tether to exit the chamber. The mouse classic modular test chamber is the size first proposed by Galen Wenger and Peter Dews. It has the advantage over our other chamber sizes of a smaller area that provides less distractions for the mouse, thus improving shaping and performance. The operant conditioning chamber is fitted with a house light, two stimulus lights, two ultra sensitive mouse retractable response levers, and our 20 mg pellet dispenser. The 14 mg pellet dispenser (ENV P) is an available option when a smaller dispenser is needed. In addition, this package includes our variable speed syringe pump, mouse drug delivery arm that supports the mouse swivel, a polysulfone button and spring that serves as the leash/tether assembly, and drug delivery line. An expanded PVC sound attenuating cubicle keeps the animal in the operant conditioning chamber isolated from external disturbances. Order the MED-SYST-8 interface and software package to run up to eight chambers, or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-307A-CT-D1 MODEL DESCRIPTION ENV-022V Expanded PVC Sound Attenuating Cubicle ENV-307A-CT Classic Modular Chamber with Drug Delivery Top and Waste Pan ENV-307A-GF Stainless Steel Grid Floor ENV-315M House Light, 28V ENV-321M Stimulus Light, 1/4" Yellow LED (2) ENV-312-2M Ultra Sensitive Retractable Levers (2) ENV Pellet Dispenser 20 mg MODEL ENV-303M DIG-716P2 PHM-100VS PHM-124MA PHM-124B PHM-124C PHM DESCRIPTION Pellet Receptacle Mouse SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) Variable Speed Syringe Pump Multi-Axis Lever Arm Mouse 25 Gauge Swivel Assembly Mouse Polysulfone Button and Spring 25 Gauge Delivery Line MED-307W-CT-B1 : Basic Mouse Drug Self Administration Test Package MDF SAC, Extra Wide Modular Test Chamber, Fixed Levers, Standard Pump This basic package consists of our extra wide mouse modular test chamber with modified top allowing the drug delivery tether to exit the chamber. The operant conditioning chamber is fitted with a house light, two stimulus lights, two ultra sensitive mouse fixed response levers, and our 20 mg pellet dispenser. The ENV P pellet dispenser (14 mg) is an available option when a smaller dispenser is needed. In addition, the package includes our standard syringe pump with 3.33 RPM motor, mouse drug delivery lever arm that supports the mouse swivel, a polysulfone button and spring that serves as the leash/tether assembly, and drug delivery line. A deep MDF sound attenuating cubicle keeps the animal in the operant conditioning chamber isolated from external disturbances. Order the MED-SYST-8 interface and software package to run up to eight chambers, or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-307W-CT-B1 MODEL DESCRIPTION ENV-022MD Deep Standard MDF Sound Attenuating Cubicle ENV-307W-CT Extra Wide Modular Test Chamber with Drug Delivery Top and Waste Pan ENV-307W-GF Stainless Steel Grid Floor ENV-315W House Light, 28V ENV-321W Stimulus Light, 1/4" Yellow LED (2) ENV-310W Ultra Sensitive Mouse Levers ENV Pellet Dispenser 20 mg MODEL ENV-303W DIG-716P1 PHM-100 PHM-124MW PHM-124B PHM-124C PHM DESCRIPTION Pellet Receptacle Mouse SmartCtrl Package 4 In/8 Out (includes 1 DIG-716, 1 SG-716, 1 SG-210CB, 1 SG-210CP-XX) Syringe Pump, 3.33 RPM Multi-Axis Lever Arm Mouse 25 Gauge Swivel Assembly Mouse Polysulfone Button and Spring 25 Gauge Delivery Line 20

27 MED-307W-CT-D1 : Deluxe Mouse Drug Self Administration Test Package PVC SAC, Extra Wide Modular Test Chamber, Retractable Levers, Variable Speed Pump This package consists of our extra wide mouse modular test chamber with modified top allowing the drug delivery tether to exit the chamber. The operant conditioning chamber is fitted with a house light, two stimulus lights, two ultra sensitive mouse retractable response levers, and our 20 mg pellet dispenser. The 14 mg pellet dispenser (ENV P) is an available option when a smaller dispenser is needed. In addition, the package includes our variable speed syringe pump, mouse drug delivery arm that supports the mouse swivel, a polysulfone button and spring that serves as the leash/tether assembly, and drug delivery line. An expanded PVC sound attenuating cubicle keeps the animal in the operant conditioning chamber isolated from external disturbances. Order the MED-SYST-8 interface and software package to run up to eight chambers, or the MED-SYST-16 to run up to sixteen chambers. PACKAGE COMPONENTS : MED-307W-CT-D1 MODEL DESCRIPTION ENV-022V Expanded PVC Sound Attenuating Cubicle ENV-307W-CT Extra Wide Modular Test Chamber with Drug Delivery Top and Waste Pan ENV-307W-GF Stainless Steel Grid Floor ENV-315W House Light, 28V ENV-321W Stimulus Light, 1/4" Yellow LED (2) ENV-312-2W Retractable Ultra Sensitive Mouse Levers (2) ENV Pellet Dispenser 20 mg ENV-303W Pellet Receptacle Mouse DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) PHM-100VS Variable Speed Syringe Pump PHM-124MW Multi-Axis Lever Arm Mouse PHM-124B 25 Gauge Swivel Assembly Mouse PHM-124C Polysulfone Button and Spring PHM Gauge Delivery Line OPERANT CONDITIONING BEHAVIOR : MOUSE SELF ADMINISTRATION TEST PACKAGES

28 MODULAR TEST CHAMBERS AND ACCESSORIES Each modular test chamber includes a stainless steel waste pan; the corresponding grid floor is sold separately. ENV-008 : Standard Modular Test Chamber This standard height chamber is recommended for most rodent work. Both end walls are identical with three sturdy aluminum channels designed to securely hold any modular component. The unique top design with a clear polycarbonate center and two hinged stainless steel flap makes changing modules quick and easy, while holding them securely in place. This unit includes a door and rear panel of 0.22" (0.6 cm) clear polycarbonate, and a base of white polypropylene. Dimensions: Base: 21.0" L x 13.75" D x 0.50" H (53.3 cm x 34.9 cm x 1.3 cm) Interior: 12.0" L x 9.5" W x 8.25" H (30.5 cm x 24.1 cm x 21.0 cm) Exterior: 12.5" L x 10" W x 13.5" H (31.8 cm x 25.4 cm x 34.3 cm) ENV-008-VP : Standard Modular Test Chamber with Value-Pak Top This unit provides a lower cost alternative to the standard modular test chamber (ENV-008). The difference is that the hinged top of the ENV-008 has been replaced by a solid clear polycarbonate top that is screwed in place. Instead of opening a flap to change components you must now remove the top to change components. Dimensions: Base: 21.0" L x 13.75" D x 0.50" H (53.3 cm x 34.9 cm x 1.3 cm) Interior: 12.0" L x 9.5" W x 8.25" H (30.5 cm x 24.1 cm x 21.0 cm) Exterior: 12.5" L x 10" W x 13.5" H (31.8 cm x 25.4 cm x 34.3 cm) ENV-008CT : Standard Modular Test Chamber with Drug Infusion Top This chamber is typically used for drug self administration studies. By combining it with an extra tall sound attenuating cubicle, you will be guaranteed sufficient space for a counter balance arm and drug delivery swivel. The top modification consists of a 2.0" (5.1 cm) diameter hole in the center with a 0.25" (0.6 cm) access slot cut from the hole to the front edge. This allows the user to place an animal in the test chamber with a drug delivery leash, or other harness system, attached. This standard height chamber is recommended for most rodent work. Both end walls are identical with three sturdy aluminum channels designed to securely hold any modular component. The unique top design with a clear polycarbonate center and two hinged stainless steel flap makes changing modules quick and easy, while holding them securely in place. This unit includes a door and rear panel of 0.22" (0.6 cm) clear polycarbonate, and a base of white polypropylene. Dimensions: Base: 21.0" L x 13.75" D x 0.50" H (53.3 cm x 34.9 cm x 1.3 cm) Interior: 12.0" L x 9.5" W x 8.25" H (30.5 cm x 24.1 cm x 21.0 cm) Exterior: 12.5" L x 10" W x 13.5" H (31.8 cm x 25.4 cm x 34.3 cm) 22

29 ENV-008CTC : Cover Insert for Drug Infusion Tops Use this clear polycarbonate cover when not using an infusion tether to prevent animals from exploring the opening in the top. This cover will fit all standard drug infusion rat chamber tops. Simply slide onto chamber top and it is locked in place by the door. Dimensions: 2.5" x 6.0" (6.4 cm x 15.2 cm) Special Note: One cover is included with each rat modular test chamber with drug infusion top. ENV-008-FP : Filler Panel Package Filler panel packages are required with all initial orders of modular test chambers. Assorted sizes are provided as needed and may be supplied at no cost provided that a minimum number of accessories are also ordered with chamber. All panels are 3.0" (7.6 cm) wide. The panel height may be specified as follows: ENV P: 3/4 Size (9.75" cm) ENV-007-2P: 1/2 Size (6.50" 16.5 cm) ENV P: 3/8 Size (4.875" 12.4 cm) ENV-007-4P: 1/4 Size (3.25" 8.25 cm) ENV-007-8P: 1/8 Size (1.625" 4.0 cm) ENV P: 1/16 Size (0.8125" 2.0 cm) ENV-007 : Extra Tall Modular Operant Test Chamber This extra tall modular test chamber features a versatile size that is recommended for work with pigeons, rodents, or small, unrestrained primates. Both end walls are identical with triple aluminum channels to securely hold any modular accessory. The unique top design makes changing modules quick and easy, holding them securely while running experiments. The center of the top is clear polycarbonate and each end features a hinged stainless steel panel with individual spring steel clips to hold modular panels securely in place. This unit includes a door and rear panel of 0.22" (0.6 cm) clear polycarbonate and a base white polypropylene. Dimensions: Base: 21.0" L x 13.75" W x 0.50" H (53.3 cm x 34.9 cm x 1.3 cm) Interior: 12.0" L x 9.5" W x 11.5" H (30.5 cm x 24.1 cm x 29.2 cm) Exterior: 12.5" L x 10.0" W x 13.5" H (31.8 cm x 25.4 cm x 34.3 cm) OPERANT CONDITIONING BEHAVIOR : MODULAR TEST CHAMBERS & ACCESSORIES

30 ENV-007-VP : Extra Tall Modular Test Chamber with Value-Pak Top This chamber is offered as a lower cost alternative to the extra tall modular test chamber for those applications that do not require frequent changing of accessories. The top is made of a single piece of polycarbonate held in place with eight standard screws which must be removed to change modules. Dimensions: Base: 21.0" L x 13.75" W x 0.50" H (53.3 cm x 34.9 cm x 1.3 cm) Interior: 12.0" L x 9.5" W x 11.5" H (30.5 cm x 24.1 cm x 29.2 cm) Exterior: 12.5" L x 10.0" W x 13.5" H (31.8 cm x 25.4 cm x 34.3 cm) ENV-007CT : Extra Tall Modular Test Chamber with Drug Infusion Top This is the extra tall modular test chamber with the top modified for drug delivery. This unit is used for rodent studies using drug self administration. The top modification consists of a 2.0" (5.1 cm) diameter hole in the center with a 0.25" (0.64 cm) access slot cut from the hole to the front edge. This allows the user to place an animal in the test chamber with a drug delivery leash or other harness system, attached. Both end walls are identical with triple aluminum channels to securely hold any modular accessory. The unique top design makes changing modules quick and easy, holding them securely while running experiments. The center of the top is clear polycarbonate and each end features a hinged stainless steel panel with individual spring steel clips to hold modular panels securely in place. This unit includes a door and rear panel of 0.22" (0.6 cm) clear polycarbonate and a base of white polypropylene. Dimensions: Base: 21.0" L x 13.75" W x 0.50" H (53.3 cm x 34.9 cm x 1.3 cm) Interior: 12.0" L x 9.5" W x 11.5" H (30.5 cm x 24.1 cm x 29.2 cm) Exterior: 12.5" L x 10.0" W x 13.5" H (31.8 cm x 25.4 cm x 34.3 cm) ENV-007-FP : Filler Panel Package Filler panels are used to close those spaces not occupied by chamber components on the modular test chamber. A filler panel package is required with all initial orders of modular test chambers. This includes assorted sizes as needed and may be supplied at no cost depending on the accessories ordered with the chamber. All panels are 3" (7.6 cm) wide. The panel height may be specified as follows: ENV-007-1P: Full Size (13.0" 33.0 cm) ENV P: 3/4 Size (9.75" cm) ENV-007-2P: 1/2 Size (6.5" 16.5 cm) ENV P: 3/8 Size (4.875" 12.4 cm) ENV-007-4P: 1/4 Size (3.25" 8.25 cm) ENV-007-8P: 1/8 Size (1.625" 4.0 cm) ENV P: 1/16 Size (0.8125" 2.0 cm) 24

31 ENV-005 : Stainless Steel Grid Floor for Rat or Small Primate Use this stainless steel grid floor if running rats and small primates in all 008 and 007 series modular test chambers. It consists of nineteen " (0.48 cm) rods placed on 0.625" (1.6 cm) centers in a white polypropylene frame. The floor is easily removed via two thumbscrews for cleaning. Add the quick disconnect harness (ENV-005-QD) for aversive stimulation and/or contact lickometer applications. Dimensions: 12.5" W x 10.0" D x 2.0" H (31.8 cm x 25.4 cm x 5.1 cm) ENV-005A : Stainless Steel Grid Floor for Mouse This stainless steel grid floor for mouse contains thirty-six 0.125" (0.32 cm) rods are placed on 0.31" (0.79 cm) centers in a removable polypropylene frame. This floor is used for fear conditioning systems or custom applications using mouse components in the 007 or 008 series modular test chambers. Refer to our mouse wide modular test chamber (ENV-307W) for most mouse operant work. For special mouse applications not suitable for the wide mouse modular test chamber, use stainless steel grid floor for mouse (ENV-005A) with the quick disconnect harness for mouse (ENV-005A-QD). Dimensions: 12.5" W x 10.0" D x 2.0" H (31.8 cm x 25.4 cm x 5.1 cm) ENV-005-QD : Quick Disconnect Harness for ENV-005 This harness is used with 008 and 007 series modular test chambers. It attaches to the rear of the chamber and remains in place even when the floor is removed. The DB-9 cable going from the harness to a grid floor scrambler or to a lickometer circuit must be ordered separately. Dimensions: 12.5" W x 0.5" D x 2.5" H (31.8 cm x 1.3 cm x 6.35 cm) Special Note: Quick Change Floor and Waste Collection Assembly, US Pat. No B1, Canadian Pat. No. 2,368,344, UK Pat. No , Australian Patent , France 1,226,750, Germany , Italy 1,226,750, The Netherlands 1,226,750, European Pat. No , Other Foreign Patents Pending. ENV-005A-QD : Quick Disconnect Harness for ENV-005A This harness is used with 008 and 007 series modular test chambers when fitted with a mouse grid floor. The DB-9 cable going from the harness to a grid floor scrambler or from the harness to a lickometer must be ordered separately. Dimensions: 12.5" W x 0.5" D x 2.5" H (31.8 cm x 1.3 cm x 6.35 cm) Special Note: Quick Change Floor and Waste Collection Assembly, US Pat. No B1, Canadian Pat. No. 2,368,344, UK Pat. No , Australian Patent , France 1,226,750, Germany , Italy 1,226,750, The Netherlands 1,226,750, European Pat. No , Other Foreign Patents Pending. OPERANT CONDITIONING BEHAVIOR : MODULAR TEST CHAMBERS & ACCESSORIES

32 ENV-007A3 : Stainless Steel Waste Pan This stainless steel waste pan is designed to fit our 007 and 008 series modular test chambers. This pan features a stainless steel knob for easy removal of the pan beneath the floor. These pans are autoclavable. Dimensions: 11.5" L x 9.75" W x 0.75" H (29.2 cm x 24.5 cm x 1.9 cm) ENV-007A3D : Disposable Waste Pan This wax-covered cardboard pan is offered for applications where it is not practical to clean the stainless pan. Sold in packages of 25. Dimensions: " L x 9.5" W x 0.75" H (29.5 cm x 24.1 cm x 1.9 cm) ENV-007-P3 : Reusable Waste Pan This reusable waste pan can be used on its own or as a liner for our standard stainless rat waste pan (ENV-007A3, ordered separately). These pans are not autoclavable. Dimensions: 11.3" L x 9.5" W x 0.6 H" (29 cm x 24.5 cm x 2 cm) ENV-115A-07 : Five Hole Nose Poke Wall with Stimulus Lights for Rat in 007 Series Modular Test Chambers ENV-115A-08 : Five Hole Nose Poke Wall with Stimulus Lights for Rat in 008 Series Modular Test Chambers This curved wall is available with the five hole nose poke wall packages (MED-NP5L-D1 and MED-NP5L-B1). It may be ordered with the 008 or 007 series modular test chambers sold separately, to implement a five choice serial reaction task in rats. An infrared detector is located across each nose poke unit, 0.41" (1.0 cm) from the front and a yellow stimulus light is mounted flush behind the back wall. Both operate on 28 V DC. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Dimensions: Nose Poke Holes: 1.0" W x 1.0" H x 0.875" D (2.5 cm x 2.5 cm x 2.2 cm) Stimulus Light: 0.25" (0.64 cm) diameter 26

33 ENV-115C : Five Hole Nose Poke Wall with Stimulus Lights for Mouse in 307W Series Modular Test Chambers This curved wall is included with the mouse five nose poke test packages (MED-NP5M-D1 and MED-NP5M-B1). It includes five illuminated nose pokes on a curved wall. This wall must be used with the wide modular mouse test chamber (ENV-307W). Entry of the animal s nose 0.25" (0.64 cm) into the nose poke hole defines the response. This unit includes yellow LED stimulus lights that are mounted flush at the back of the access port, and an I/R control, source and detector. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Dimensions: Nose Poke Holes: 0.5" (1.3 cm) diameter x 0.4" (1.0 cm) deep ENV-NPW-9L : Nine Nose Poke Chamber Package for Rat This package features a 10.25" (26.0 cm) modular test chamber with a nine hole nose poke curved wall. An infrared detector is located across each nose poke unit, " (1.0 cm) from the front and a yellow stimulus light is mounted flush behind the back wall. Both operate on 28 V DC. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Select a control package found in the Power, Control and Interface Equipment section to go with this chamber. Dimensions: Base: 21" W (53.3 cm) x 13.75" D (34.9 cm) Nose Poke Holes: 1.0" W x 1.0" H x 0.875" D (2.5 cm x 2.5 cm x 2.2 cm) Stimulus Light: 0.25" (0.64 cm) diameter ENV-NPW-9M : Nine Nose Poke Chamber Package for Mouse This package features an extra wide version of the mouse modular test chamber 7.375" (18.7 cm) and a nine nose poke curved wall. Entry of the animal s nose 0.25" (0.64 cm) into the nose poke hole defines the response. This unit includes yellow LED stimulus lights that are mounted flush at the back of the access port, and an I/R control, source and detector. Both operate on 28 V DC. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Select a control package found in the Power, Control and Interface Equipment section to go with this chamber. Dimensions: Base: 21" W (53.3 cm) x 13.75" D (34.9 cm) Nose Poke Holes: 0.5" (1.3 cm) diameter x 0.4" (1.0 cm) deep OPERANT CONDITIONING BEHAVIOR : MODULAR TEST CHAMBERS & ACCESSORIES

34 EXTRA WIDE TEST CHAMBERS ENV-009 : Five Bay Modular Test Chamber This unique test chamber features five aluminum channels to securely hold modular accessories. A solid polycarbonate clear lid is held in place by twelve screws. The door and back wall of this chamber are made of 0.22" (5.6 cm) clear polycarbonate and a base made of 0.5" (1.3 cm) thick white polypropylene. This chamber is ideal for special applications with multiple response levers and/or dispensers or when the size of the test animal requires additional space. Dimensions: Base: 21.0" L x 20.0" W x 0.50" H (53.3 cm x 50.8 cm x 1.3 cm) Inside: 12.0" L x 15.5" W x 11.5" H (30.5 cm x 39.4 cm x 29.2 cm) Outside: 12.5" L x 16.5" W x 13.5" H (31.8 cm x 41.9 cm x 34.3 cm) ENV-009A : Four Bay Modular Test Chamber This unique test chamber features four aluminum channels to securely hold modular accessories. A solid polycarbonate clear lid is held in place by ten screws. The door and back wall of this chamber are made of 0.22" (5.6 cm) clear polycarbonate and a base made of 0.5" (1.3 cm) thick white polypropylene. This chamber is ideal for special applications with multiple response levers and/or dispensers or when the size of the test animal requires additional space. Dimensions: Base: 21.0" L x 13.75" W x 0.50" H (53.3 cm x 35 cm x 1.3 cm) Inside: 12.0" L x 12.5" W x 11.5" H (30.5 cm x 31.8 cm x 29.2 cm) Outside: 12.5" L x 13.5" W x 13.5" H (31.8 cm x 34.3 cm x 34.3 cm) ENV-009-GF : Five Bay Stainless Steel Grid Floor ENV-009A-GF : Four Bay Stainless Steel Grid Floor These removable grid floors feature nineteen 0.19" (0.48 cm) rods placed on 0.63" (1.6 cm) centers in a white polypropylene frame suitable for the four or five bay modular test chambers (ENV-009 or ENV-009A) respectively. Dimensions: ENV-009-GF: 12.5" L x 16.5" W x 2.0" H (31.8 cm x 41.9 cm x 5.1 cm) ENV-009A-GF: 12.5" L x 13.5" W x 2.0" H (31.8 cm x 34.3 cm x 5.1 cm) 28

35 MOUSE MODULAR OPERANT CONDITIONING CHAMBERS ENV-307A : Classic Mouse Modular Test Chamber Med Associates is pleased to offer our classic mouse modular operant conditioning chamber. This size was first proposed by Galen Wenger and Peter Dews. An advantage of this size over our other chamber sizes is the dimensions of the chamber have been reduced to limit distractions for the mouse, thus improving shaping and performance. This modular mouse chamber features three 1.5" (3.81 cm) wide channels on both end walls for easy and convenient placement of any mouse modular accessory, including nose pokes, ultra sensitive standard or retractable levers, stimulus modules, and reinforcement devices. The cage unit is mounted on a durable, easily cleaned white polypropylene base. The front, back, and top are constructed of 0.22" (0.56 cm) polycarbonate. The front loading door of this unit folds down, leaving an extra high lip to restrain the animal until removed. Order the grid floor (ENV-307A-GF) separately. Dimensions: Base: 16.0" L x 11.5" W x 0.50" H (40.6 cm x 29.2 cm x 1.3 cm) Interior: 6.25" L x 5.5" W x 5.0" H (15.9 cm x 14.0 cm x 12.7 cm) Exterior: 7.0" L x 6.0" W x 7.25" H (17.8 cm x 15.2 cm x 18.4 cm) ENV-307A-CT : Classic Mouse Modular Test Chamber with Drug Infusion Top This chamber is used for mouse studies using drug self administration. The top modification consists of a 1.5" (3.81 cm) diameter hole in the center with a 0.25" (0.64 cm) access slot cut from the hole to the front edge. This allows the user to place an animal in the test chamber with a drug delivery leash or other harness system attached. This modular mouse chamber features three 1.5" (3.81 cm) wide channels on both end walls for easy and convenient placement of any mouse modular accessory, including nose pokes, ultra sensitive standard or retractable levers, stimulus modules, and reinforcement devices. The cage unit is mounted on a durable, easily cleaned white polypropylene base. The front, back, and top are constructed of 0.22" (0.56 cm) polycarbonate. The front loading door of this unit folds down, leaving an extra high lip to restrain the animal until removed. Order the grid floor (ENV-307A-GF) separately. Dimensions: Base: 16.0" L x 11.5" W x 0.50" H (40.6 cm x 29.2 cm x 1.3 cm) Interior: 6.25" L x 5.5" W x 5.0" H (15.9 cm x 14.0 cm x 12.7 cm) Exterior: 7.0" L x 6.0" W x 7.25" H (17.8 cm x 15.2 cm x 18.4 cm) OPERANT CONDITIONING BEHAVIOR : MOUSE MODULAR OPERANT CONDITIONING CHAMBERS & ACCESSORIES

36 ENV-307A-GF : Classic Mouse Modular Grid Floor This stainless steel grid floor features nineteen 0.13" (0.32 cm) rods, placed on 0.31" (0.79 cm) centers mounted in clear polycarbonate supports. Order additional floors to simplify routine cleaning and maintenance. To use a contact lickometer or scrambled grid floor aversive stimulator with the classical mouse modular test chamber you will also need the quick disconnect harness (ENV-307A-QD). Dimensions: 5" L x 4.5" W x 2.25" H (12.7 cm x 11.4 cm x 5.7 cm) ENV-307A-FP : Filler Panel Package Filler panels are used to close those spaces not occupied by chamber components on the classic mouse modular test chamber. A filler panel package is required with all initial orders of modular test chambers. This includes assorted sizes as needed and may be supplied at no cost depending on the accessories ordered at the same time. All panels are 1.5" (3.8 cm) wide. The panel height may be specified as follows: ENV-307-1: Full Size (7.0" 17.8 cm) ENV-307-2: 1/2 Size (3.5" 8.9 cm) ENV-307-4: 1/4 Size (1.75" 4.4 cm) 30

37 ENV-307W : Wide Mouse Modular Test Chamber This wide mouse modular test chamber is on a durable and easily cleaned base of white polypropylene. The front, back, and top are constructed of 0.22" (0.56 cm) polycarbonate. The front loading door of this unit folds down, leaving an extra high lip to restrain the animal until removed. Dimensions: Base: 21" L x 13.75" D x 0.50" H (53.3 cm x 34.9 cm x 1.3 cm) Interior: 8.5" L x 7.0" W x 5.0" H (21.6 cm x 17.8 cm x 12.7 cm) Exterior: 9.5" L x 8.0" W x 7.25" H (24.1 cm x 20.3 cm x 18.4 cm) ENV-307W-CT : Wide Mouse Modular Test Chamber with Drug Infusion Top This chamber is used for mouse studies using drug self-administration. The top modification consists of a 1.5" (3.8 cm) diameter hole in the center with a 0.25" (0.64 cm) access slot cut from the hole to the front edge. This allows the user to place an animal in the test chamber with a drug delivery leash or other harness system, attached. This wide mouse modular test chamber is on a durable and easily cleaned base of white polypropylene. The front, back, and top are constructed of 0.22" (0.56 cm) polycarbonate. The front loading door of this unit folds down, leaving an extra high lip to restrain the animal until removed. Dimensions: Base: 21" L x 13.75" D x 0.50" H (53.3 cm x 34.9 cm x 1.3 cm) Interior: 8.5" L x 7.0" W x 5.0" H (21.6 cm x 17.8 cm x 12.7 cm) Exterior: 9.5" L x 8.0" W x 7.25" H (24.1 cm x 20.3 cm x 18.4 cm) ENV-307W-GF : Wide Mouse Modular Grid Floor This stainless steel grid floor features twenty-four 0.13" (0.32 cm) rods, placed on 0.31" (0.79 cm) centers mounted in clear polycarbonate supports. Order additional floors to simplify routine cleaning and maintenance. To use a contact lickometer or scrambled grid floor aversive stimulator with the wide mouse modular test chamber you will also need the quick disconnect harness (ENV-307W-QD). Dimensions: 7.0" L x 6.0" W x 2.25" H (17.8 cm x 15.2 cm x 5.7 cm) OPERANT CONDITIONING BEHAVIOR : MOUSE MODULAR OPERANT CONDITIONING CHAMBERS & ACCESSORIES

38 ENV-307W-FP : Filler Panel Package Filler panels are used to close those spaces not occupied by chamber components on the wide mouse modular test chamber. A filler panel package is required with all initial orders of modular test chambers. This includes assorted sizes as needed and may be supplied at no cost depending on the accessories ordered at the same time. All panels are 2.36" (6.0 cm) wide. The panel height may be specified as follows: ENV-307-1W: Full Size (7.0" 17.8 cm) ENV-307-2W: 1/2 Size (3.5" 8.9 cm) ENV-307-4W: 1/4 Size (1.75" 4.4 cm) 32

39 SHUTTLE BOX TEST PACKAGES FOR ACTIVE AND PASSIVE AVOIDANCE AND LEARNED HELPLESSNESS Several modular shuttle box packages are offered in this section for avoidance and learned helplessness studies. Each features the modular shuttle chamber (ENV-010MC) with a single center panel designed to hold a stimulus light and tone stimulus. A two-panel end wall is available in the dual channel modular shuttle box (ENV-010MD). This does not change the dimensions of the chamber itself. The same modular box is used for rats and mice, the only difference being the floor and height of the photobeam sensors changes. The shuttle box can be purchased with a pivot floor, where the floor rests on a center pivot point. The standard shuttle avoidance application supplied with the interface package (SOF-700RA-7) allows the user to define the number of trials to run, the stimuli (tone, light or both), the avoid interval, the escape interval, optional CS/UCS overlap, the option to punish ITI crossings and the maximum session duration. A row of data is created for each trial with the trial number, an avoid or escape tag with the corresponding latency, left and right chamber activity, crossings, and punished crossings. A summary file includes total values as well as the mean avoid and escape latency. Please contact Sales if you have any questions on these packages or require assistance in designing a package to meet your specific research requirements. Interface, computer and software are sold separately. OPERANT CONDITIONING BEHAVIOR : SHUTTLE BOX TEST PACKAGES

40 MED-APA-B1R : Basic Shuttle Avoidance Test Package for Rat This basic package is designed primarily for active avoidance studies. A small hurdle can be used to separate the two sides of the chamber when the manual guillotine door is not installed. Also featured in this package is a MDF sound attenuating cubicle to enclose the chamber and prevent distractions during testing. Each chamber comes equipped with two stimulus lights and two sonalert tone generators. Each side of the chamber will have one light and one tone generator. The grid floor is equipped with a harness, which allows aversive stimulation to be delivered to either side of the chamber floor, at different times. This package also includes the aversive stimulation controllers. The interface and operating software are not included in this package. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-APA-B1R MODEL DESCRIPTION MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-010MC Standard Modular Shuttle Chamber with Waste Pan ENV-010MB-GF Quick Disconnect Grid Floor Rat ENV-010MB-QD Quick Disconnect Harness for Rat Shuttle Chamber ENV-010A Manual Guillotine Door ENV-010C Shuttle Box Opaque Cover ENV-256-8S Photobeam Shuttle Box Sensors ENV-253C Eight Channel I/R Control for Shuttle ENV-221M Stimulus Light, 1", White Lens (2) ENV-223AM Tone Generator, 2900 Hz (2) SG-6080C Table Top Module Cabinet ENV-410B Constant Current Aversive Stimulator ENV-415 A/B Grid Switch ENV-412 Grid Scrambler (2) SG-216A-2 Extension Cable, 18" (45.7 cm), 3-pin Molex (8) SG-219SA Shuttle Cable SG-219G-10 Shuttle Cable DB-9/DB-9, 10' (2) DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) MED-APA-D1R : Deluxe Shuttle Avoidance Test Package for Rat This deluxe package contains a single station for active or passive avoidance, as well as many learned helplessness paradigms. By using four independent photo-beams on each of the chamber an excellent measurement of movement activity is obtained. This chamber is divided into two sections by a removable auto guillotine door. This package also includes a MDF sound attenuating cubicle to enclose the chamber and prevent distractions during testing. Each chamber comes equipped with two stimulus lights and two sonalert tone generators. Each side of the chamber will have one light and one tone generator. The grid floor is equipped with a harness, which allows aversive stimulation to be delivered to either side of the chamber floor, at different times. This package also includes the aversive stimulation controllers. The interface and operating software are not included in this package. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-APA-D1R MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-010MC Center Channel Modular Shuttle Chamber with Waste Pan ENV-010MB-GF Quick Disconnect Grid Floor Rat ENV-010MB-QD Quick Disconnect Harness ENV-010B Auto Guillotine Door ENV-010C Opaque Cover ENV-256-8S Photobeam Shuttle Box Sensors ENV-253C Eight Channel I/R Control for Shuttle ENV-221M Stimulus Light, 1" White Lens (2) ENV-223AM Tone Generator, 2900 Hz (2) MODEL DESCRIPTION SG-6080C Table Top Module Cabinet ENV-410B Constant Current Aversive Stimulator ENV-415 A/B Grid Switch ENV-412 Grid Scrambler (2) SG-216A-2 Extension Cable, 18" (45.7cm), 3-pin Molex (8) SG-219SA Aversive Stimulation Control Cable SG-219G-10 Shuttle Cable DB-9/DB-9, 10' (2) DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) 34

41 MED-APA-B1M : Basic Shuttle Avoidance Test Package for Mouse This basic package is designed primarily for active avoidance studies. A small hurdle can be used to separate the two sides of the chamber when the manual guillotine door is not installed. Also featured in this package is a MDF sound attenuating cubicle to enclose the chamber and prevent distractions during testing. Each chamber comes equipped with two stimulus lights and two sonalert tone generators. Each side of the chamber will have one light and one tone generator. The grid floor is equipped with a harness, which allows aversive stimulation to be delivered to either side of the chamber floor, at different times. This package also includes the aversive stimulation controllers. The interface and operating software are not included in this package. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-APA-B1M MODEL DESCRIPTION MODEL DESCRIPTION ENV-018MD ENV-010MC ENV-010MA-GF Deep Extra Tall MDF Sound Attenuating Cubicle Standard Modular Shuttle Chamber with Waste Pan Quick Disconnect Grid Floor Mouse ENV-010MA-QD Quick Disconnect Harness ENV-010A Manual Guillotine Door ENV-010C Shuttle Box Opaque Cover ENV-256-8S Photobeam Shuttle Box Sensors ENV-253C Eight Channel I/R Control for Shuttle ENV-221M Stimulus Light, 1", White Lens (2) ENV-223AM Tone Generator, 2900 Hz (2) MED-APA-D1M : Deluxe Shuttle Avoidance Test Package for Mouse This deluxe package contains a single station for active or passive avoidance, as well as many learned helplessness paradigms. By using four independent photo-beams on each of the chamber an excellent measurement of movement activity is obtained. This chamber is divided into two sections by a removable auto guillotine door. This package also includes a MDF sound attenuating cubicle to enclose the chamber and prevent distractions during testing. Each chamber comes equipped with two stimulus lights and two sonalert tone generators. Each side of the chamber will have one light and one tone generator. The grid floor is equipped with a harness, which allows aversive stimulation to be delivered to either side of the chamber floor, at different times. This package also includes the aversive stimulation controllers. The interface and operating software are not included in this package. Order the MED-SYST-8 interface and software package to run up to eight chambers or the MED-SYST-16 to run up to sixteen test chambers. PACKAGE COMPONENTS : MED-APA-D1M MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-010MC Center Channel Mouse Modular Shuttle Chamber with Waste Pan ENV-010MA-GF Quick Disconnect Grid Floor Mouse ENV-010MA-QD Quick Disconnect Harness for Mouse Shuttle Chamber ENV-010B Auto Guillotine Door ENV-010C Opaque Cover ENV-256-8S Photobeam Shuttle Box Sensors ENV-253C Eight Channel I/R Control for Shuttle ENV-221M Stimulus Light, 1" White Lens (2) SG-6080C Table Top Module Cabinet ENV-410B Constant Current Aversive Stimulator ENV-415 A/B Grid Switch ENV-412 Grid Scrambler (2) SG-216A-2 Extension Cable, 18" (45.7 cm), 3-pin Molex (8) SG-219SA Shuttle Cable SG-219G-10 Shuttle Cable, DB-9/DB-9, 10' (2) DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, 1 SG-716B, 1 SG-210CB, 1 SG-210CP-XX) MODEL DESCRIPTION ENV-223AM Tone Generator, 2900 Hz (2) SG-6080C Table Top Module Cabinet ENV-410B Constant Current Aversive Stimulator ENV-415 A/B Grid Switch ENV-412 Grid Scrambler (2) SG-216A Extension Cable, 18" (45.7cm), 3-pin Molex (8) SG-219SA Aversive Stimulation Control Cable SG-219G-10 Shuttle Cable DB-9/DB-9, 10' (2) DIG-716P2 SmartCtrl Package 8 In/16 Out (includes 1 DIG-716B, SG-716B, 1 SG-210CB, 1 SG-210CP-XX) OPERANT CONDITIONING BEHAVIOR : SHUTTLE BOX TEST PACKAGES

42 SHUTTLE BOX CHAMBERS AND COMPONENTS Each shuttle box includes a stainless steel waste pan; the grid floor is sold separately. Appropriate filler panels are included. ENV-010MC : Center Channel Modular Shuttle Box This modular test chamber features two compartments separated by a removable 1.5" (3.8 cm) high shuttle barrier, not shown. The end walls feature a single standard module size bay with a half size bay on each side. This configuration is generally used when a single stimulus light and sonalert tone generator are mounted on each end wall. For an arched doorway measuring 3.0" W x 4.0" H (8.9 cm x 11.4 cm) add the optional manual or auto guillotine door (ENV-010A or ENV-010B). The chamber is mounted on a sturdy white polypropylene base. Dimensions: Base: 21.0" L x 13.5" D x 0.5" H (53.3 cm x 34.3 cm x 1.3 cm) Interior Compartment: 8.0" W x 6.25" D x 8.375" H (20.3 cm x 15.9 cm x 21.3 cm) Overall Exterior: 17.25" W x 6.75" D x 10" H (43.8 cm x 17.1 cm x 25.4 cm) 36 ENV-010MD : Dual Channel Modular Shuttle Box This modular test chamber features two compartments separated by a removable 1.5" (3.8 cm) high shuttle barrier, not shown. The end walls feature two modular channels. This provides sufficient space for response levers and reward receptacles as well as other modular accessories if needed. For an arched doorway measuring 3.0" W x 4.0" H (8.9 cm x 11.4 cm) add the optional manual or auto guillotine door (ENV-010A or ENV-010B). The chamber is mounted on a sturdy white polypropylene base. Dimensions: Base: 21.0" L x 13.5" D x 0.5" H (53.3 cm x 34.3 cm x 1.3 cm) Interior Compartment: 8.0" W x 6.25" D x 8.375" H (20.3 cm x 15.9 cm x 21.3 cm) Overall Exterior: 17.25" W x 6.75" D x 10" H (43.8 cm x 17.1 cm x 25.4 cm) ENV-010P-R : Shuttle Box with Pivot Floor for Rat Pivot floor systems are available in place of the photobeam sensor package. The chamber floor rests on a central pivot point. Depending on which side of the chamber the animal is on, the floor will tilt slightly to one side or the other, engaging a microswitch that is used to determine which side of the chamber the animal is on. The pivot floor is useful when the shuttle box is set-up for video monitoring with a face-on view, as there are no infrared beam sensors to obstruct the view of the camera. Dimensions: Base: 21.0" L x 13.5" D x 0.5" H (53.3 cm x 34.3 cm x 1.3 cm) Interior Compartment: 8.0" W x 6.25" D x 8.375" H (20.3 cm x 15.9 cm x 21.3 cm) Overall Exterior: 17.25" W x 6.75" D x 10" H (43.8 cm x 17.1 cm x 25.4 cm) ENV-010P-M : Shuttle Box with Pivot Floor for Mouse Pivot floor systems are available in place of the photobeam sensor package. The chamber floor rests on a central pivot point. Depending on which side of the chamber the animal is on, the floor will tilt slightly to one side or the other, engaging a microswitch that is used to determine which side of the chamber the animal is on. The pivot floor is useful when the shuttle box is set-up for video monitoring with a face-on view, as there are no infrared beam sensors to obstruct the view of the camera. Dimensions: Base: 21.0" L x 13.5" D x 0.5" H (53.3 cm x 34.3 cm x 1.3 cm) Interior Compartment: 8.0" W x 6.25" D x 8.375" H (20.3 cm x 15.9 cm x 21.3 cm) Overall Exterior: 17.25" W x 6.75" D x 10" H (43.8 cm x 17.1 cm x 25.4 cm)

43 ENV-010MB-GF : Stainless Steel Grid Floor for Rat The shuttle box grid floor for rats is comprised of twenty-six " (0.48 cm) diameter stainless steel grid rods placed on 0.625" (1.6 cm) centers in a removable white polypropylene frame. Dimensions: 16.0" W x 7.25" D x 2.0" H (40.6 cm x 18.4 cm x 5.1 cm) ENV-010MB-QD : Patented Quick Disconnect Shuttle Grid Floor Harness for Rat Applying scrambled foot aversive stimulation to the rat modular shuttle chamber has never been easier. The connection block stays attached to the back of the chamber, so that the floor may be removed for cleaning completely free of all wires, circuit boards, or other connections. The connection block consists of two circuit boards that have individual spring-loaded contacts mounted in a protective strip and wired in sequence to two DB-9 connectors. When the floor is installed each rod presses firmly against a contact for reliable delivery. Order two output cables (SG-219G-10) separately. Note, this harness will not work with older floors that have been drilled and tapped. See ENV-406A for older floors that are drilled and tapped. Dimensions: 17.25" L x 2.5" H x 0.5" D (43.8 cm x 6.4 cm x 1.3 cm) Special Note: Quick Change Floor, US Pat. No B1, Canadian Pat. No. 2,368,344, UK Pat. No , Australian Patent , France 1,226,750, Germany , Italy 1,226,750, The Netherlands 1,226,750, European Pat. No , Other Foreign Patents Pending. ENV-406A : Shuttle Grid Floor Harness for Rat This shuttle grid floor harness is used on older style grid floors that have drilled and tapped rods (cannot be used with ENV-010MGB-GF floor). Two harnesses are required per floor for active avoidance. The short pigtail harness terminates in a DB-9 connector. Order the aversive stimulation output cable (SG-219G-10) separately. Dimensions: 17.25" L x 2.5" H x 0.5" D (43.8 cm x 6.4 cm x 1.3 cm) ENV-010MA-GF : Stainless Steel Grid Floor for Mouse This stainless steel grid floor is designed for mouse testing. This floor consists of fifty stainless steel rods. The stainless steel grid rods measure 0.125" (0.32 cm) in diameter and are placed on 0.31" (0.79 cm) centers. The frame is 0.22" (0.56 cm) polycarbonate. Dimensions: 16.0" W x 7.25" D x 2.0" H (40.6 cm x 18.4 cm x 5.1 cm) OPERANT CONDITIONING BEHAVIOR : SHUTTLE BOX CHAMBERS & COMPONENTS

44 ENV-010MA-QD : Patented Quick Disconnect Shuttle Grid Floor Harness for Mouse Applying scrambled foot aversive stimulation to the mouse modular shuttle chamber has never been easier. The connection block stays attached to the back of the chamber, so that the floor may be removed for cleaning completely free of all wires, circuit boards, or other connections. The connection block consists of two circuit boards that have individual spring-loaded contacts mounted in a protective strip and wired in sequence to two DB-9 connectors. When the floor is installed each rod presses firmly against a contact for reliable delivery. Order two output cables (SG-219G-10) separately. Note, this harness will not work with older floors. On the newer style stainless steel mouse shuttle floors (ENV-010MA-GF) the rods extend out further from the back of the grid floor then in the past, allowing for a better connection into the quick disconnect harness. See ENV-406AM for older floors. Dimensions: 17.25" L x 2.5" H x 0.5" D (43.8 cm x 6.4 cm x 1.3 cm) Special Note: Quick Change Floor, US Pat. No B1, Canadian Pat. No. 2,368,344, UK Pat. No , Australian Patent , France 1,226,750, Germany , Italy 1,226,750, The Netherlands 1,226,750, European Pat. No , Other Foreign Patents Pending. ENV-406AM : Shuttle Grid Floor Harness for Mouse This shuttle grid floor harness is used with older style mouse shuttle box floors (not recommended for use with the ENV-010MA-GF style floors). Two harnesses are required per chamber for active avoidance. The short pigtail harness terminates in a DB-9 connector. Order the aversive stimulation output cable (SG-219G-10) separately. Dimensions: 17.25" L x 2.5" H x 0.5" D (43.8 cm x 6.4 cm x 1.3 cm) ENV-256-8S : Shuttle Box Photobeam Sensors Two polypropylene strips, one containing eight infrared photobeam detectors and the other containing eight infrared photobeam sources, detect responses and general activity in the modular shuttle box. The strips are adjustable in height to accommodate either rat or mouse. These strips must be used with the eight channel I/R control (ENV-253C). This control may be used with the fourinput SmartCtrl package (DIG-716P1) or eight-input SmartCtrl package (DIG-716P2). When using only four inputs, pairs of beams are yoked to a single input with a Y-Cable (SG-216C). This approach is well suited to response detection but may not prove adequate for activity measurements. With photobeam sensors and MED-PC software, response parameters may be clearly defined to prevent errant behaviors such as freezing in the middle and rocking a pivot floor back and forth. Dimensions: 15.0" L x 2.5" H x 0.5" D (38.1 cm x 6.4 cm x 1.3 cm) 38

45 ENV-253C : Eight Channel I/R Control for Shuttle This control was specifically designed for the photobeam shuttle box sensors (ENV-256-8S) used on modular shuttle boxes. Eight independent channels output on mini-molex connectors for input to standard SmartCtrl connection panels. Dimensions: 4.0" W x 2.0" D x 7.0" H (10.2 cm x 5.1 cm x 17.8 cm) ENV-010C : Opaque Cover This black cloth cover is supplied with Velcro straps to wrap around and block outside light on one half of the test chamber. This cost effective cover gives the user the option of using the shuttle box for passive avoidance testing. Dimensions: 8.5" W x 6.75" D x 10" H (21.6 cm x 17.1 cm x 25.4 cm) ENV-010M-17 : Shuttle Box Hurdle This small hurdle can be use to separate the two sides of a shuttle box when no door is installed. Dimensions: 6.25" L x 2.25" H x 0.25" D (15.9 cm x 5.7 cm x 0.64 cm) ENV-010A : Manual Guillotine Door The manual guillotine door provides an arched doorway opening measuring 4.5" W x 3.5" H (11.4 cm x 8.9 cm) with a sliding door that can be raised and locked. This door is easily raised and lowered by hand, which is ideal for passive avoidance applications. Dimensions: Doorway Opening: 4.5" W x 3.5" H (11.4 cm x 8.9 cm) ENV-010B : Auto Guillotine Door This motor driven door may be operated from a single 28 V DC control line. Operate ON raises and holds the door open without continuous demand on the power supply. Operate OFF slowly lowers the door. A safety mechanism releases the door if blocked by the animal. The weight of the door however, rests on the animal and will finish closing as soon as the animal moves from under the door. Dimensions: Doorway Opening: 4.5" H x 3.5" W (11.4 cm x 8.9 cm) OPERANT CONDITIONING BEHAVIOR : SHUTTLE BOX CHAMBERS & COMPONENTS

46 SOUND ATTENUATING CUBICLES Each unit features a 28 V DC ventilation fan (rated at 46 cfm and produces a background noise reaching 75 db), a side port for feeding cables through and a magnifying peep hole style viewing port. ENV-018V : Extra Tall Expanded PVC Sound Attenuating Cubicle This sound attenuating cubicle features a truly remarkable new material, which is a rigid, lightweight board of moderately expanded closed cell PVC that is resistant to moisture and many chemicals. Chamber walls are 0.75" (1.9 cm) thick. The walls of these units are 100% PVC with a smooth white surface similar to rigid PVC cubicles, but much lighter in weight. The sound properties are consistent with other sound attenuating cubicles. At 2 KHz, measured 2.0" (5.1 cm) in front of a closed door, this cubicle is 34 db down compared with 25 db down for an equivalent MDF cubicle. At 10 KHz, it is 54 db down, better than the 51 db attenuation of the MDF cubicle. Dimensions: Interior: 22.0" W x 22.0" H x 14.0" D (55.9 cm x 55.9 cm x 35.6 cm) Exterior: 25.0" W x 23.5" H x 15.5" D (63.5 cm x 59.7 cm x 39.4 cm) Special Note: Recommended for 007 and 008 series rodent modular test chambers (Highly recommended when using chambers for self administration to allow clearance for the drug delivery arm ENV-007CT and ENV-008CT). ENV-018MD : Deep Extra Tall MDF Sound Attenuating Cubicle This extra tall sound attenuating cubicle is manufactured using MDF, a high density wood composite with thermally infused high pressure white colored laminate inside and out. Sound attenuation levels measured between two enclosures average db from 100 Hz 10 KHz, increasing to 80 db above 10 KHz. The double door construction with self-closing hinges prevents door sag. This design also permits convenient animal loading where space is at a premium. This cubicle measures two inches deeper than the expanded PVC cubicle (ENV-018V), making it more flexible to add components to the modular test chambers and still allows the cubicle doors to close without interference. Dimensions: Interior: 22.0" W x 22.0" H x 16.0" D (55.9 cm x 55.9 cm x 40.6 cm) Exterior: 25.0" W x 23.5" H x 17.5" D (63.5 cm x 59.7 cm x 44.4 cm) Special Note: Recommended for 007 and 008 series rodent modular test chambers (Highly recommended when using chambers for self administration to allow clearance for the drug delivery arm ENV-007CT and ENV-008CT). ENV-022V : Standard Expanded PVC Sound Attenuating Cubicle This sound attenuating cubicle features a truly remarkable new material, which is rigid, lightweight board of moderately expanded closed cell PVC that is resistant to moisture and many chemicals. Chamber walls are 0.75" (1.9 cm) thick. The walls of these units are 100% PVC with a smooth white surface similar to rigid PVC cubicles, but much lighter in weight. The sound properties are consistent with other sound attenuating cubicles. At 2 KHz, measured 2.0" (5.1 cm) in front of a closed door, this cubicle is 34 db down compared with 25 db down for an equivalent MDF cubicle. At 10 KHZ, it is 54 db down, better then the 51 db attenuation of the MDF cubicle. Dimensions: Interior: 22.0" W x 15.0" H x 14.0" D (55.9 cm x 38.1 cm x 35.6 cm) Exterior: 25.0" W x 16.5" H x 15.5" D (63.5 cm x 41.9 cm x 39.4 cm) Special Note: Recommended for 008 series standard rodent modular test chambers and 307 series mouse modular test chamber. 40

47 ENV-022MD : Standard MDF Sound Attenuating Cubicle This sound attenuating cubicle is manufactured using MDF, a high density wood composite with thermally infused high pressure white colored laminate inside and out. Sound attenuation levels measured between two enclosures average db from 100 Hz 10 KHz, increasing to 80 db above 10 KHz. The double door construction with self-closing hinges prevents door sag. This design also permits convenient animal loading where space is at a premium. This cubicle measures two inches deeper then the expanded PVC cubicle (ENV-018V), making it more flexible to add components to the modular test chambers and still allow the cubicle doors to close without interference. Dimensions: Interior: 22.0" W x 15.0" H x 16.0" D (55.9 cm x 38.1 cm x 35.6 cm) Exterior: 25.0" W x 16.5" H x 17.5" D (63.5 cm x 41.9 cm x 39.4 cm) Special Note: Recommended for 008 series standard rodent modular test chambers and 307 series mouse modular test chamber. ADDITIONAL SOUND ATTENUATING CUBICLES ENV-016MD : Extra Wide MDF Cubicle Dimensions: Interior: 26.0" W x 22.0" H x 16.0" D (66.0 cm x 55.9 cm x 35.6 cm) Exterior: 29.0" W x 23.5" H x 17.5" D (73.7 cm x 59.7 cm x 39.4 cm) Special Note: Recommended for 007 and 008 series modular test chambers that have retractable levers and/or sippers on both the front wall and the back wall of the chambers. (The ENV-016MD is slightly wider than the ENV-018MD) ENV-017M : Extra Large MDF Cubicle Dimensions: Interior: 26.0" W x 22.0" H x 22.0" D (66.0 cm x 55.9 cm x 55.9 cm) Exterior: 29.0" W x 23.5" H x 23.5" D (73.7 cm x 59.7 cm x 59.7 cm) Special Note: Recommended for ENV-009 and ENV-009A modular test chambers. ENV-020M : MDF Cubicle for Place Preference Dimensions: Interior: 36.5" W x 22.0" H x 14.0" D (92.7 cm x 55.9 cm x 35.6 cm) Exterior: 39.5" W x 23.5" H x15.5" D (100.3 cm x 59.7 cm x 39.4 cm) Special Note: Recommended for mouse and rat place preference chambers. (Mouse: ENV-3013; Rat: ENV-013) ENV-022S : Foam-Lined Acoustic Cubicle with Viewing Port This acoustic cubicle uses a standard MDF sound attenuating cubicle lined with acoustical foam to eliminate resonance and reverberation as well as improve sound attenuation. Dimensions: Interior: 20.0" W x 13.0" H x 12.0" D (50.8 cm x 33.0 cm x 30.5 cm) Exterior: 25.0" W x 16.5" H x 15.5" D (63.5 cm x 41.9 cm x 39.4 cm) Special Note: Foam lined standard MDF cubicle (ENV-022SD), also available by request for use with 008 and 007 modular series chambers. OPERANT CONDITIONING BEHAVIOR : SOUND ATTENUATING CUBICLES

48 CUBICLE ACCESSORIES ENV-025WM-F : Single MDF Door with Full Viewing Window It is possible to place a single MDF door with a full size window on the MDF cubicles however, this will cause a slight decrease in sound attenuation. This is suitable for group viewing or videotaping applications. Special Note: Not recommended for expanded PVC cubicles. ENV-025WM : Expanded PVC and Melamine Viewing Window Option This option adds a single pane 0.22" (6.4 cm) polycarb viewing window measuring 8.0" W x 7.0" H (20.3 cm x 17.8 cm) to any expanded PVC or melamine sound attenuating cubicle. Some sound attenuation may be lost in front of the cubicle but this generally has no effect on cubicles placed side by side. The window is shown here is with the deep extra tall MDF cubicle (ENV-018MD). Contact Sales for details. ENV-027-XX : Pull-Out Drawer Options These drawers have a 0.75" (1.9 cm) thick MDF shelf mounted in the cubicle on drawer slides. It is recommended that the back of the cubicle be anchored down with the use of this option. PART NUMBER USE IN DIMENSIONS ENV ENV-022MD 22.0" W x 15.5" D (55.9 cm x 30.5 cm) ENV ENV-018MD 22.0" W x 15.5" D (55.9 cm x 30.5 cm) ENV ENV-017M 26.0" W x 21.5" D (66.0 cm x 54.6 cm) ENV ENV-016MD 26.0" W x 15.5" D (66.0 cm x 30.5 cm) ENV-025FAC : AC Fan Option ENV-025F28 : 28 V DC Fan Option The 28 V DC fan, supplied standard with all sound attenuating cubicles, requires very little current from the control power supply (140 ma) and moves up to 46 cfm of air. The AC fan moves slightly less air. If an AC fan is preferred, however, it can be substituted at a slight additional cost. Dimensions: 3.25" W x 3.25" H x 1.0" D (8.3 cm x 8.3 cm x 8.2 cm) Special Note: AC fans are available in 115V or 230V. ENV-025FAC shown 42

49 HOUSE LIGHTS ENV-221CL : Ceiling Mount House Light These lights are used in cubicles for general illumination. More than one may be necessary to fully illuminate larger cubicles. These may be wired to the fan circuit to be on all the time or connected to a 28 V DC output for computer programmed control. Order standard 100 ma replacement lamps (SG-700A) or 170 ma high intensity replacement lamps (SG-702A). Both sold in packages of ten lamps. Dimensions: 1.75" W x 3.0" H x 7.0" D (4.45 cm x 7.6 cm x 17.8 cm) Panel: 1.75" L x 1.75" W x 1.75" D (4.4 cm x 4.4 cm x 4.4 cm) ENV-215M : House Light for Rat Chambers This 28 V DC, 100 ma light is mounted on a 1/8 size modular panel and features a partially open hood. This hood may be rotated in the test chamber to either direct light down on the working area or up to reflect light off the ceiling. Order standard 100 ma replacement lamps (SG-700A) or 170 ma high intensity replacement lamps (SG-702A). Both sold in packages of ten lamps. Dimensions: Panel: 3.0" W x 1.625" H (7.6 cm x 4.1 cm) ENV-315W : House Light for Wide Mouse Chambers ENV-315M : House Light for Classic Mouse Chambers This 28 V DC, 100 ma light is mounted on a 1/4 size modular panel and features a partially open hood. This hood may be rotated in the test chamber to either direct light down on the working area or up to reflect light off the ceiling. Order standard 100 ma replacement lamps (SG-700A) or 170 ma high intensity replacement lamps (SG-702A). Both sold in packages of ten lamps. Dimensions: Panels: ENV-315W: 2.355" W x 1.75" H (6.0 cm x 4.4 cm) ENV-315M: 1.5" W x 1.75" H (3.8 cm x 4.4 cm) ENV-227M : House/Stimulus Light with Diffuser This unit makes an excellent house light or stimulus light for rat chambers and mazes. It is mounted on a 1/8 size rat modular panel; it is brighter than either the house light (ENV-215M) or stimulus light (ENV-221M), measuring 780 Lux at a distance of 1.0" (2.5 cm). The light is diffused to illuminate the entire chamber measuring over 200 Lux at a distance of 3.0" (7.6 cm). It consists of a 0.31" (0.79 cm) diameter stimulus light inserted in a 0.375" (0.95 cm) clear acrylic beveled diffuser block with outside dimensions of 1.5" (3.8 cm) square and a top surface which is 1.0" (2.5 cm) square. Dimensions: Panel: 3.0" W x 1.62" H (7.6 cm x 4.1 cm) OPERANT CONDITIONING BEHAVIOR : CUBICLE ACCESSORIES & HOUSE LIGHTS

50 STIMULUS AND RESPONSE DEVICES LEVERS ENV-110M : Response Lever This durable stainless steel lever protrudes 0.75" (1.9 cm) from a 1/4 size rat modular panel. The sealed switch is protected against over pressure to provide continuous trouble free operation. The tension is factory set to 25 grams but may be adjusted from 15 to 100 grams. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) Lever: 1.88" W x 0.75" D (4.8 cm x 1.9 cm) ENV-110RM : Rolled Lever This durable stainless steel lever has a rolled edge with a radius of approximately 0.375" (0.95 cm) to match the older design of this lever. The lever protrudes 0.75" (1.9 cm) from a 1/4 size rat modular panel. The tension is factory set to 25 grams but may be adjusted from 15 to 100 grams. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) Lever: 1.88" W x 1.0" D (4.8 cm x 2.54 cm) ENV-112CM : Low Profile Retractable Response Lever This retractable lever features a low profile design that permits placement of the lever just 0.835" (2.1 cm) above the stainless steel grid floor. It can be raised as needed with filler panel inserts. The cycle time of this unit is 700 ms. Separate cables connect to an input to record the response and to a single output to control the position of the lever. An insert report signal is also provided that can be connected to any 28 V DC interface input. The durable stainless steel paddle protrudes 0.75" (1.9 cm) from a 1/4 size rat modular panel into the chamber when extended. The tension is factory set to 25 grams but may be adjusted from 15 to 100 grams. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) Lever: 1.88" W x 0.75" D (4.8 cm x 1.9 cm) ENV-116M : Gerbrands Style Extra Thick Response Lever This unit is supplied on a 1/4 size rat modular panel and is designed to imitate the original Gerbrands lever in all aspects relevant to the animal. The paddle is 0.5" (1.3 cm) thick. The end is rounded and smooth and it is thick enough and hard enough to discourage chewing and biting. Weights are added to the back of the lever to produce a lever resistance of approximately 35 grams. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) Lever: 1.88" W x 1.06" D (4.8 cm x 2.7 cm) 44

51 ENV-116RM : Retractable Gerbrands Style Extra Thick Response Lever This retractable lever features a paddle that is 0.5" (1.3 cm) thick and protrudes 0.75" (1.9 cm) into the chamber when extended. The cycle time of this unit is 700 ms. The thick paddle is rounded and hard to discourage the animals from chewing on the paddle. The tension is factory set to 25 grams but may be adjusted from 15 to 100 grams. This lever is mounted on a 1/2 size rat modular panel. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) Lever: 1.88" W x 1.06" D (4.8 cm x 2.7 cm) ENV-118 : Force Lever This specially designed lever allows one to completely define a lever response of grams. User definitions include upper and lower thresholds, and minimum and maximum durations above upper threshold. This device requires an analogto-digital converter (DIG-744), power supply (SG-506), assorted cables, and an unique software package (all sold separately). The complete system records all critical response parameters and provides a 28 V DC ground response when the defined parameters are met. This response signal is compatible with all Med Associates 28 V DC MED-PC interface systems. ENV-310M : Ultra Sensitive Lever for the Classic Mouse Modular Test Chamber ENV-310W : Ultra Sensitive Lever for the Wide Mouse Modular Test Chamber This stainless steel response lever is designed to protrude 0.375" (1 cm) into the mouse test chamber 0.878" (2.2 cm) above the grid floor. By breaking a photobeam instead of depressing a mechanical switch, the force required has been reduced to two grams. It is mounted on a 1/2 size mouse modular panel. This unit includes an infrared light source and detector and 28 V DC control. Dimensions: Panels: ENV-310W: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) ENV-310M: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) Lever: 0.625" W x 0.375" D (1.6 cm x 0.95 cm) ENV-312-2M : Retractable Ultra Sensitive Lever for the Classic Mouse Modular Test Chamber ENV-312-2W : Retractable Ultra Sensitive Lever for the Wide Mouse Modular Test Chamber This retractable response lever is mounted to a 1/2 size mouse modular panel. The stainless steel response lever protrudes 0.375" (1 cm) into the test chamber when 28 V DC is applied, and quickly and smoothly retracts from the chamber when the ground is removed. This lever is factory installed 0.878" (2.2 cm) above the grid floor, however this distance may be increased with filler panels. The tension of this retractable lever is factory set to 2 grams. Dimensions: Panels: ENV-312-2M: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) ENV-312-2W: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) Lever: 0.625" W x 0.375" D (1.6 cm x 0.95 cm) OPERANT CONDITIONING BEHAVIOR : RESPONSE DEVICES LEVERS

52 ENV-111 : Omnidirectional Ceiling Rod for Rat This stainless steel rod extends from the center of the chamber lid. It provides an alternative response for the chaining experiments that are popular in many student laboratories. It could also substitute for a pole jump avoidance response. It is generally used with the 008 series modular test chambers. Dimensions: Rod: 0.25" (0.64 cm) diameter; 4.75" (12.1 cm) long Special Note: A modified chamber top is required with omni rod. ENV-311 : Omnidirectional Ceiling Rod for Mouse This stainless steel rod extends from the center of the chamber lid. It provides an alternative response for the chaining experiments that are popular in many student laboratories. It could also substitute for a pole jump avoidance response. It is designed for use in both the classical and wide mouse modular test chambers. Dimensions: Rod: " (0.48 cm) diameter; 4.0" (10.2 cm) long Special Note: A modified chamber top is required with omni rod. ENV-111C : Chain Pull Response This unique response device consists of a heavy-duty micro switch, mounting hardware, and stainless steel beaded chain that drops down into any test chamber. Use in chaining experiments or as an escape response. Hanging on the chain to avoid aversive stimulation is also useful in fatigue and motor studies. The chain may be cut to any desired length; factory cut length of chain is 12". Dimensions: 12.0" Long (30.5 cm) Special Note: A modified chamber top is required with chain pull. NOSE POKES ENV-114M : Nose Poke Response with Three Color Cue for Rat This alternative response device is mounted on a 3/8 size rat modular panel and has a 1.0" (2.5 cm) access hole which is bisected by a sensitive infrared detector placed 0.25" (0.64 cm) in from the front edge. The control amplifier operates on 28 V DC and produces a ground output whenever the beam is broken. The back of the unit contains a stimulus display made up of three colored LEDs (red, green, yellow). Dimensions: Panel: 3.0" W x 4.875" H (7.6 cm x 12.4 cm) 46

53 ENV-114AM : Nose Poke Response for Rat This alternative response device is mounted on a 3/8 size rat modular panel and has a 1.0" (2.5 cm) access hole which is bisected by a sensitive infrared detector placed 0.25" (0.64 cm) in from the front edge. The control amplifier operates on 28 V DC and produces a ground output whenever the beam is broken. Dimensions: Panel: 3.0" W x 4.875" H (7.6 cm x 12.4 cm) ENV-114BM : Nose Poke Response for Rat This alternative response device has a single yellow stimulus light at the back of the nose poke opening and is mounted on a 3/8 size modular panel. It has a 1.0" (2.5 cm) access hole which is bisected by a sensitive infrared detector placed 0.25" (0.64 cm) in from the front edge. The control amplifier operates on 28 V DC and produces a ground output whenever the beam is broken. Dimensions: Panel: 3.0" W x 4.875" H (7.6 cm x 12.4 cm) ENV-313M : Illuminated Nose Poke Response for Classic Mouse Modular Test Chamber ENV-313W : Illuminated Nose Poke Response for Wide Mouse Modular Test Chamber This unit includes a yellow LED stimulus light at the back of the access port, and an I/R control, source and detector. This response device is mounted on a 1/2 size mouse modular panel. The access port measures 0.5" (1.3 cm) in diameter by only 0.4" (1.0 cm) deep. Entry of the animal s nose 0.25" (0.64 cm) into this area defines the response. The control amplifier operates on 28 V DC and produces a ground output whenever the beam is broken. Dimensions: Panels: ENV-313W: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) ENV-313M: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) ENV-314M : Triple Cue Nose Poke Response for Classic Mouse Modular Test Chamber ENV-314W : Triple Cue Nose Poke Response for Wide Mouse Modular Test Chamber This mouse nose poke module features individually controlled red, yellow and green LED s mounted flush to the back of the access port, and an I/R control to detect nose pokes. The access port opening is 0.5" (1.3 cm) in diameter by 0.4" (1.0 cm) deep. Entry of the animal s nose 0.25" (0.6 cm) into the opening will register a count. The operating voltage of this device is 28 V DC. This device is mounted on a 1/2 size mouse modular panel. Dimensions: Panels: ENV-313W: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) ENV-313M: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) OPERANT CONDITIONING BEHAVIOR : RESPONSE DEVICES NOSE POKES

54 RODENT NOSE POKE RESPONSE KEYS The standard nose poke key is quickly becoming a staple fixture in rodent operant conditioning chambers however, many researchers feel that standard nose poke devices lack fundamental elements that may be crucial to the conditioning process. By simply poking its nose into a recessed entry well, the animal does not receive any tactile feedback that might otherwise facilitate the shaping and learning process. With this limitation in mind Med Associates has developed the rodent nose poke response keys. Similar in design to our line of pigeon response keys (ENV-123, e.g.), the rodent response keys feature an opaque plastic response key that can be backlit to provide enhanced visual cues. ENV-316W : Opaque Pecking Key for Wide Mouse Modular Test Chambers ENV-316M : Opaque Pecking Key for Classic Mouse Modular Test Chambers This mouse pecking key features a 5/8" (1.6 cm) diameter nose poke hole with opaque white plastic backlit target. It is mounted on a 3/4 size mouse modular panel. The standard backlight color is yellow, however other colors are available upon request. The force required to operate the key is factory set to 3 grams. Dimensions: Panels: ENV-316W: 2.355" W x 5.25" H x 1.25" D (6.0 cm x 13.3 cm x 3.2 cm) ENV-316M: 1.5" W x 5.25" H x 1.25" D (3.8 cm x 13.3 cm x 3.2 cm) ENV-119M-1 : Rodent Pecking Key This rodent pecking key features a 1" (2.5 cm) diameter nose poke hole with opaque plastic backlit target. It is mounted on a 3/8 size rat modular panel. The standard backlight color is yellow, however other colors available upon request. The force required to operate the key is factory set to 15 grams. This key fits into any of our 007, 008, and 009 series modular test chambers. Dimensions: Panel: 3.0" W x 4.875" H (7.6 cm x 12.4 cm) ENV-119M-2 : Large Rodent Pecking Key The large rodent pecking key features a 2" (5.1 cm) diameter nose poke hole with opaque plastic backlit target. It is mounted on a 3/8 size rat modular panel. The standard backlight color is yellow, however other colors available upon request. Perfect for guinea pigs. The force required to operate the key is factory set to 15 grams. This key fits into any of our 007, 008, and 009 series modular test chambers. Dimensions: Panel: 3.0" W x 4.875" H (7.6 cm x 12.4 cm) 48

55 RESPONSE WHEELS ENV-113M : Response Wheel for Rat This response device is patterned after a design by Dr. Conan Kornetsky, Boston University. It is mounted on a 3/8 size rat modular panel and consists of a 2.75" (7.0 cm) wide wheel that is 2.75" (7.0 cm) in diameter and has twenty stainless steel rods placed around the circumference. The wheel is easily turned by a test animal to produce a switch closure for every 90 degrees of rotation. This device is particularly useful in intra-cranial self stimulation studies or any time motor performance may be impaired. Dimensions: Panel: 3.0" W x 4.875" H (7.6 cm x 12.4 cm) ENV-113AW : Response Wheel for Mouse, Wide Panel Mount The width of the wheel is approximately 1.5" (3.8 cm) and is mounted on a 1/2 size mouse modular panel. This wheel has been modeled after the standard rat wheel but proportioned for the mouse. It incorporates a resistance free photobeam detector in place of a micro switch to record a response for every 90 degrees of rotation. The outside diameter of the wheel is 2.25" (5.7 cm) with twenty 0.094" (0.24 cm) diameter rods placed on a 2.0" (5.1 cm) diameter circle. Dimensions: Panel: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) STIMULUS LIGHTS ANL-955 : Light Detector If you have ever wanted an affordable and simple way to measure light levels in your experiments, this light detector is just what you re looking for. Whether it is used in conjunction with MED-PC or as a TTL device, you will find that it will add significant enhancement when you need to have an accurate record of light levels synchronized with other experimental data. This light detector is equipped with a sensitivity adjustment that allows the user to define what is considered a light condition. It can be operated using a 28 V DC power source, or using a standard Med Associates connection panel (e.g. SG-716). An LED will come on and the device will generate an output signal during light conditions. The output is turned off and another LED comes on during dark conditions. Dimensions: 4.5" W x 3.0" D x 1.25" H (11.4 cm x 7.6 cm x 3.2 cm) Special Note: Useful for circadian rhythm studies as well as verifying stimulus light functionality. OPERANT CONDITIONING BEHAVIOR : RESPONSE DEVICES NOSE POKE & STIMULUS LIGHTS

56 ENV-221M : Stimulus Light for Rat This 28 V DC, 100 ma stimulus light consists of a large 1.0" (2.5 cm) diameter light mounted on a 1/8 size rat modular panel for distinct conditioned stimulus presentations. The lens is flat with a metal rim to minimize animal chewing. Order standard 100 ma replacement lamps (SG-700A) or 170 ma high intensity replacement lamps (SG-702A). Both are sold in packages of ten lamps. Dimensions: Panel: 3.0" W x 1.625" H (7.62 cm x 4.1 cm) ENV-321M : Stimulus Light for Classic Mouse Modular Test Chamber ENV-321W : Stimulus Light for Wide Mouse Modular Test Chamber A 0.31" (0.79 cm) bright yellow LED flush mounted behind a 1/4 size mouse modular mouse chamber panel. Unlike incandescent lamps, LEDs have an expected life of approximately 100,000 hours and will probably never need replacing. Dimensions: Panels: ENV-321W: 2.355" W x 1.75" H (6.0 cm x 4.4 cm) ENV-321M: 1.5" W x 1.75" H (3.8 cm x 4.4 cm) ENV-321DM : Dual Stimulus Display for Classic Mouse Modular Test Chamber ENV-321DW : Dual Stimulus Display for Wide Mouse Modular Test Chamber The dual stimulus display is flush mounted on a 1/8 size mouse modular panel and uses one yellow and one green 0.31" (0.79 cm) LED. Unlike incandescent lamps, the LEDs have an expected life of 100,000 hours. Contact Sales for custom layouts, for instance a red LED in place of one or both LEDs. Dimensions: Panels: ENV-321DW: 2.355" W x.88" H (6.0 cm x 2.2 cm) ENV-321DM: 1.5" W x.88" H (3.8 cm x 2.2 cm) ENV-222M : Triple Stimulus Display for Rat The triple stimulus display is flush mounted on a 1/8 size rat modular panel which features three 0.31" (0.79 cm) LEDs placed on 0.53" (1.3 cm) centers to form a horizontal array consisting of a red, green, and yellow light. Unlike incandescent lamps, the LEDs have an expected life of 100,000 hours. Dimensions: Panel: 3.0" W x 1.625" H (7.6 cm x 4.1 cm) 50

57 ENV-322M : Triple Stimulus Display for Classic Mouse Modular Test Chamber ENV-322W : Triple Stimulus Display for Wide Mouse Modular Test Chamber The triple stimulus display is flush mounted behind a 1/4 size mouse modular panel. The lights are slightly smaller, measuring 0.16" (0.4 cm) in diameter. This module features a red, yellow, and green LED stimulus lights wired to independent mini-molex connectors. Unlike incandescent lamps, the LEDs have an expected life of 100,000 hours. Dimensions: Panels: ENV-322W: 2.355" W x 1.75" H (6.0 cm x 4.4 cm) ENV-322M: 1.5" W x 1.75" H (3.8 cm x 4.4 cm) ENV-226 : Stimulus Light Fader Control A precision screwdriver adjustable control and power regulator circuit provide a second stimulus of reduced intensity when used with the stimulus light (ENV-221). It requires two separate outputs to activate a full or reduced intensity stimulus. This unit may also be used with the house light (ENV-215M) or stimulus/house light (ENV-227M). Dimensions: 2.7" W x 1.7" H x 1.18" D (6.9 cm x 4.3 cm x 3.0 cm) ENV-226A : Four Level Fader Control This unit features the ability to deliver up to four different intensities on one stimulus light (ENV-221M) or house light (ENV-215M). Each level of intensity is set by using a small screwdriver and turning a dial located on a small trim-pot. There are four individual trim-pots to allow each level of intensity to be set independently. Each level of intensity requires connection from the three pin Molex connectors on the four level fade control box to four open outputs on a control box, such as a SmartCtrl. Dimensions: 2.7" W x 1.7" H x 1.18" D (6.9 cm x 4.3 cm x 3.0 cm) ENV-226B : Three Channel Light Control This unit consists of three independent light intensity dial controls that allow you to record and repeat settings precisely. Connect each to one or two stimulus lamps with a current rating up to 170 ma at 28 V DC. When used to counter balance natural preferences in multiple compartment chambers, this device can be connected directly to a power supply. When used with stimulus lights or whenever computer control is required each channel may be connected to a separate 28 V DC output. Dimensions: 3.8" W x 2.7" H x 1.4" D (9.7 cm x 6.9 cm x 3.6 cm) OPERANT CONDITIONING BEHAVIOR : STIMULUS LIGHTS

58 OLFACTORY STIMULUS COMPONENTS ENV-275 : Olfactory Stimulus Package This economical package includes everything needed to present olfactory stimuli to a nose poke response or test chamber port (nose poke and port sold separately). This includes two distribution manifolds, three solenoid valves, evaporation jars with barbed fittings and check valves, and a coil of tubing for connecting these components. The standard package uses two normally closed valves for the odor lines and a normally open valve for fresh air. This maintains a continuous flow of air at the nose poke port or at a bulkhead port if desired. By activating two valves simultaneously, odor can be added to the air stream without altering the flow. In this way the only stimulus is the odor, not the presence or absence of the airflow. Operating controls and pumps sold separately. Also available with five manifolds (ENV-275-5). ENV-275-NPP : Nose Poke Port Option for Rat Select from several rat nose poke modules with or without stimulus lights and then add this option to present an odor stimulus inside the nose poke. Two barbed fittings are provided. Attach the second port to a suitable vacuum pump to confine the odor to the nose poke as much as possible. Dimensions: Panel: 3.0" W x 3.25" H x 1.0" D (7.6 cm x 8.3 cm x 2.5 cm) Special Note: Nose poke port shown here installed on the nose poke response for rat (ENV-114BM). ENV-375-NPP : Nose Poke Port Option for Mouse Select from several mouse nose poke modules with or without stimulus lights and then add this option to present an odor stimulus inside the nose poke. Two barbed fittings are provided. Attach the second port to a suitable vacuum pump to confine the odor to the nose poke as much as possible. Dimensions: Panel: 2.355" W x 1.75" W x 1.0" D (6.0 cm x 4.4 cm x 2.5 cm) PHM-275 : Dilution Olfactometer This dilution olfactometer comes with two channels and is expandable to eight channels. It is designed to generate precise concentrations of up to eight separate odors. Airflow to each vertical column saturator is controlled by a sensitive needle valve and monitored by a calibrated flow meter. Valves activated by 28 V DC solenoids are used to mix odors and route airflow to the test chamber. This system is suitable for odor discrimination tasks where flow control is critical, olfactory coding, or any behavioral or neurophysiological study that uses odor as a stimulus. Dimensions: 13.8" L x 15.0" W x 11.5" H (35.0 cm x 38.1 cm x 29.2 cm) 52

59 PHM-276 : Olfactory Column Saturator This expansion olfactory column saturator connects to the dilution olfactometer (PHM-275). Air flow is controlled by a sensitive needle valve and monitored by a calibrated flow meter. Flow out of the column saturator is controlled via a 28 V DC solenoid to mix odor. Dimensions: 3.375" W x 2.5" D x 11.0" H (8.6 cm x 6.4 cm x 27.9 cm) ENV-275-BP : Bulkhead Port for Rat This bulkhead port is mounted on a 1/8 size rat modular panel with a small air port and barbed fitting for presenting odors to the chamber compartment. This could be placed above or below any other modular panel such as a response lever or food cup. Dimensions: Panel: 3.0" W x 1.625" H (7.6 cm x 4.1 cm) ENV-375-BP : Bulkhead Port for Mouse This bulkhead port is mounted on a 1/4 size mouse modular panel with a small air port and barbed fitting for presenting odors to the chamber compartment. This could be placed above or below any other modular panel such as a response lever or food cup. Dimensions: Panel: 2.355" W x 1.75" H (6.0 cm x 4.4 cm) ENV-275-F : Modular Chamber Exhaust Fan for Rat This 28 V DC exhaust fan is mounted on a 1/4 size rat modular panel to increase airflow though the chamber and clears odors quickly. If using a sound-attenuating cubicle, the cubicle fan ensures an ample supply of fresh air around the outside of the chamber. Dimensions: Panel: 3.0" W x 3.25" H x 1.25" D (7.6 cm x 8.3 cm x 3.2 cm) ENV-375-F : Modular Chamber Exhaust Fan for Mouse This 28 V DC exhaust fan is mounted on a 1/4 size mouse modular panel to increase airflow though the chamber and clears odors quickly. If using a sound-attenuating cubicle, the cubicle fan ensures an ample supply of fresh air around the outside of the chamber. Dimensions: Panel: 2.355" W x 3.5" H x 1.25" D (6.0 cm x 8.9 cm x 3.2 cm) OPERANT CONDITIONING BEHAVIOR : OLFACTORY STIMULUS COMPONENTS

60 FIVE HOLE NOSE POKE WALL WITH OLFACTORY STIMULUS Olfactory stimulus is available with the five nose poke wall with stimulus lights. This modified wall (ENV-115A-OF for rat and ENV-115C-OF for mouse) allows individual olfactory stimulus in each nose poke. A pressurized laboratory air supply or air pump (sold separately) provides air to each individual scent source. A check valve between the one-to-five manifold and the scent source container prevents the mixing of scents when the system is not pressurized. A normally closed valve prevents the scent stimulus from reaching the nose poke until the valve is activated. Only one scent source is connected to each nose poke. Activation of the control valve allows the olfactory stimulus to be presented in the nose poke. One or more of the valves may be activated at the same time depending on the protocol of the experiment. The olfactory stimulus is removed from the nose poke cavity via an exhaust port located in the roof of the cavity. All five nose pokes are connected to a five-into-one manifold that is to be connected to a vacuum pump (sold separately). This system provides continuous evacuation of air from all five nose pokes simultaneously when connected to a vacuum source. An extra grid rod which cannot be used for aversive stimulus has also been added to fill the gap formed by the curved wall. Interface, computer and software are sold separately. FEATURES Individual olfactory stimulus in each nose poke. Check valves prevent the mixing of scents. One or more valves may be activated at the same time. Olfactory stimulus is removed from the nose poke via an exhaust port. Packages : Five Hole Nose Poke Wall with Olfactory Stimulus MOUSE: MED-OLF-5NPM MODEL DESCRIPTION: RAT: MED-OLF-5NPR MODEL DESCRIPTION: ENV-115C-OF ENV Mouse Five Hole Nose Poke Wall with Stimulus Lights & Olfactory Ports Five Station Olfactory Ports ENV-115A-OF ENV Rat Five Hole Nose Poke Wall with Stimulus Lights & Olfactory Ports Five Station Olfactory Ports 54

61 AUDIO STIMULUS Use one of each sonalert module for simple high/low tone discrimination Hz TONE GENERATORS ENV-223AM : Sonalert Module for Rat This 2900 Hz tone generator is supplied on a 1/8 size rat modular panel with a screwdriver adjustable volume control. Units without volume control produce a piercing sound at greater than 85 db with considerable variability between units. These units are factory set at approximately 65 db. Dimensions: Panel: 3.0" W x 1.625" H (7.6 cm x 4.1 cm) ENV-323AM : Sonalert Module for Classic Mouse Modular Test Chamber ENV-323AW : Sonalert Module for Wide Mouse Modular Test Chamber This 2900 Hz tone generator is supplied on a 1/4 size mouse modular panel with a screwdriver adjustable volume control. Units without volume control produce a piercing sound at greater than 85 db with considerable variability between units. These units are factory set at approximately 65 db. Dimensions: Panels: ENV-323AM: 1.5" W x 1.75" H (3.8 cm x 4.4 cm) ENV-323AW: 2.355" W x 1.75" H (6.0 cm x 4.4 cm) 4500 HZ TONE GENERATORS ENV-223HAM : Sonalert Module for Rat This 4500 Hz tone generator is supplied on a 1/8 size rat modular panel with a screwdriver adjustable volume control. These units are factory set at approximately 65 db. Dimensions: Panel: 3.0" W x 1.625" H (7.6 cm x 4.1 cm) ENV-323HAM : Sonalert Module for Classic Mouse Modular Test Chamber ENV-323HAW : Sonalert Module for Wide Mouse Modular Test Chamber This 4500 Hz tone generator is supplied on a 1/4 size mouse modular panel with a screwdriver adjustable volume control. These units are factory set at approximately 65 db. Dimensions: Panels: ENV-323HAM: 1.5" W x 1.75" H (3.8 cm x 4.4 cm) ENV-323HAW: 2.355" W x 1.75" H (6.0 cm x 4.4 cm) OPERANT CONDITIONING BEHAVIOR : FIVE HOLE NOSE POKE WALL WITH OLFACTORY & AUDIO STIMULUS

62 ENV-135M : Response Feedback Clicker Module for Rat This response feedback clicker module for rat is a 28 V DC mechanical relay mounted on a 3/8 size rat modular panel with cable and Molex connector. Connect this unit to any SmartCtrl or similar output to produce an audible click each time it is activated. A single click has been found to facilitate shaping and improve response stability when used with response devices that have minimal or no auditory component such as pecking keys, nose poke holes, or ultra sensitive levers. It is also useful as a secondary reinforcer with the virtually silent pellet dispensers currently offered. Use software control to produce click frequencies for discriminative stimuli other than pure tones. Dimensions: Panel: 3.0" W x 4.875" H (7.6 cm x 12.4 cm) ENV-335M : Clicker Module for Classic Mouse Modular Test Chamber ENV-335W : Clicker Module for Wide Mouse Modular Test Chamber This response feedback clicker module for mouse is a 28 V DC mechanical relay mounted on a 1/2 size mouse modular panel with cable and Molex connector. Connect this unit to any SmartCtrl or similar output to produce an audible click each time it is activated. A single click has been found to facilitate shaping and improve response stability when used with response devices that have minimal or no auditory component such as pecking keys, nose poke holes, or ultra sensitive levers. It is also useful as a secondary reinforcer with the virtually silent pellet dispensers currently offered. Use software control to produce click frequencies for discriminative stimuli other than pure tones. Dimensions: Panels: ENV-335W: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) ENV-335M: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) ANL-926 : Programmable Audio Generator This programmable audio generator is a single width module that contains a pure tone, white noise, and click generator under a single microprocessor controller and audio amplifier rated at 675 mw max into 8 ohms. Install into the interface cabinet for each test chamber in the system. The frequency and amplitude specifications may be limited by the cage speaker. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) SPECIFICATIONS : ANL-926 PURE TONE: Frequency: Amplitude: Rise/Fall time: Duration: 10 to 35,000 Hz in 1 Hz Increments 20 to 100 db in 0.5 db Increments ± 1 bit (0.125 db) 1 milliseconds to 1 second in 0.1 ms Increments 1 millisecond to over 1 minute (65,535 ms) Plus Continuous (Timed by MedState Notation ) WHITE NOISE: Frequency: Broad Band White Noise Selected by Freq= 0 All Others: Same as Pure Tone CLICKER: Frequency: Rise/Fall: Amplitude: Duration: 1 to 10 Hz Disabled Fixed Same as Pure Tone 56

63 ENV-223 : Multiple Tone Generator This multiple tone generator uses four 28 V DC outputs to select between 15 different frequencies ranging from 1 KHz to 20 KHz. It employs a fixed rise/fall so there is no speaker click or pop when turning on the tones. The volume of the tones may be adjusted using a screwdriver. This may be used with speakers (ENV-224AM, ENV-224BM, ENV-224CM, ENV-224DM, or ENV-324W) depending on the application and frequencies desired. If greater control over the frequencies, rise/fall time, and volume is desired, refer to the programmable audio generator (ANL-926). Dimensions: 2.4" W x 2.27" L x 1.0" H (6.1 cm x 5.8 cm x 2.5 cm) ENV-230 : Multipurpose Sound Generator This convenient multipurpose sound generator that is able to produce three different types of sound; white noise, clicks and pure tones. Sound type is selected by manually moving switches up or down. Both the volume and duration of each sound are adjustable. Dimensions: 3.1" W x 2.7" L x 1" H (7.9 cm x 6.9 cm x 2.5 cm) ANL-929A-PC : USB Sound Pressure Level Measurement Package This package offers a level of verification and calibration unavailable with sound level meters. The package consists of a microphone, microphone amplifier, analog-to-digital converter, USB interface, and sound pressure level software. The software display provides detailed measurements of either noise or pure tone signals. This package is a cost-effective and accurate approach to sound level measurement. Dimensions: 5" W x 5" D x 1.75" H (12.7 cm x 12.7 cm x 4.4 cm) ENV-224AM : Cage Speaker with Cover for Rat This unit consists of a 3.5" (8.9 cm) speaker mounted on a 1/4 size rat modular panel. Use with the programmable audio generator (ANL-926) or other white noise or audio amplifiers. The recommended range for pure tone applications is 1.0 to 7.0 KHz. At 700 Hz and 7.5 KHz the audio signal is approximately 10 db down. This unit is also available with a cubicle ceiling mount bracket to hold both the speaker and optional light (ENV-224CM). Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) OPERANT CONDITIONING BEHAVIOR : AUDIO STIMULUS

64 ENV-324M : Cage Speaker for Classic Mouse Modular Test Chamber ENV-324W : Cage Speaker for Wide Mouse Modular Test Chamber This cage speaker for modular mouse test chambers is mounted on a 1/2 size panel with a small 2.0" (5.1 cm) 8-ohm speaker and a 25' (7.6 m) cable terminating in a (0.3 cm) phone jack. This device can be used with any of the audio generators and white noise amplifiers for white noise, pure tone, or clicks. The recommended range for this unit is 1.0 to 5.5 KHz. At 700 Hz and 6.5 KHz, the audio signal is approximately 15 db down. Dimensions: Panels: ENV-324M: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) ENV-324W: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) ENV-224BM : Cage Tweeter for Rat This horn tweeter is mounted on a 1/4 size rat modular panel for those applications where higher frequency pure tone stimulation is required. This device can also be used with any of the audio generators and white noise amplifiers with an 8-ohm output. The recommended range for this unit is 5 to 15 KHz. At 2 KHz and 18 KHz, the audio signal is approximately 10 db down. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-224CM : Ceiling Mount Speaker and Light with Enclosure This unit consists of a 3.5" (8.9 cm) speaker mounted to a bracket that would be installed to the top or back of a sound attenuating cubicle. This speaker may be used with the programmable audio generator (ANL-926) or other white noise or audio amplifiers. The recommended range for pure tone applications is 1.0 to 7.0 KHz. At 700 Hz and 7.5 KHz the audio signal is approximately 10 db down. This bracket also includes a stimulus light (ENV-221M). Dimensions: 3.25" W x 7.25" L x 2.0" D (8.3 cm x 43.8 cm x 5.1 cm) 58

65 ENV-225SM : White Noise Amplifier with Cage Speaker for Rat This complete white noise package consists of the cage speaker (ENV-224AM) and a 28 V DC powered white noise amplifier. The white noise amplifier cable connects to any available output on a standard MED connection panel. It is powered by 28 V DC and can be enabled from any interface card with 28 V DC drivers. The frequency response is flat from 10 to 25,000 Hz (-3 db). The amplitude (90 db max.) is controlled by a ten-turn potentiometer. The amp volume is factory set to 80 db. This unit can be used either to generate an auditory stimulus or simply for background masking. Dimensions: Amplifier: 2.0" W x 2.75" D x 1.75" H (5.1 cm x 6.9 cm x 4.4 cm) Panel: 3.0" W x 3.25"H (7.6 cm x 8.3 cm) ENV-325SM : White Noise Amplifier with Cage Speaker for Classic Mouse Chamber ENV-325SW : White Noise Amplifier with Cage Speaker for Wide Mouse Chamber This complete white noise package consists of the cage speaker (ENV-324AM) and a 28 V DC powered white noise amplifier. The white noise amplifier cable connects to any available output on a standard MED connection panel. It is powered by 28 V DC and can be enabled from any interface card with 28 V DC drivers. The frequency response is flat from 10 to 25,000 Hz (-3 db). The amplitude (90 db max.) is controlled by a ten-turn potentiometer. The amp volume is factory set to 80 db. This unit can be used either to generate an auditory stimulus or simply for background masking. Dimensions: Amplifier: 2.0" W x 2.75" D x 1.75" H (5.1 cm x 7.0 cm x 4.4 cm) Panels: ENV-325SM: 1.5" W x 3.5" H (6.0 cm x 8.9 cm) ENV-325SW: 2.355" W x 3.5" H (3.8 cm x 8.9 cm) PELLET RECEPTACLES AND ACCESSORIES ENV-200R2M : Trough Type Pellet Receptacle for Rat ENV-200R1M : Cup Type Pellet Receptacle for Rat These are two of the most popular receptacle cups used with the 45 mg pellet dispensers. Each receptacle is mounted on a 1/4 size rat modular panel and the entrance opening to each measures 2.0" x 2.0" (5.1 cm x 5.1 cm). Both style receptacles are suitable for pellet dispensers. Also available for the trough type is photocell detection of the pellet itself (ENV-200R2MA). Additional components to consider for either receptacle include a receptacle light (ENV-200RL) and head entry detector (ENV-254-CB). Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-200R1M-6 : Extra Tall Cup Type Pellet Receptacle for Rat ENV-200R2M-6 : Extra Tall Trough Type Pellet Receptacle for Rat Extra tall receptacles have been designed for applications where an animal is fitted with headgear for drug infusion or micro dialysis. The receptacle opening on both the trough type and cup type is 6" (15.2 cm) tall and is mounted on a 3/4 size rat modular panel. This photo shows the cup type receptacle. Contact Sales for extra tall receptacles made of all plastic for physiological recording. Dimensions: Panels: ENV-200R1M-6: 3.0" W x 9.75" H (7.6 cm x 24.7 cm) ENV-200R1M-6: 3.0" W x 9.75" H (7.6 cm x 24.7 cm) ENV-200R2M trough type shown OPERANT CONDITIONING BEHAVIOR : AUDIO STIMULUS PELLET RECEPTACLES

66 ENV-200R1AM : External Pellet Cup for Rat This component takes the stainless steel cup from the pellet receptacle (ENV-200R1M) and places it on the outside of a 1/4 size rat modular panel for placement inside the chamber. This may be preferable in applications where an animal is fitted with a head block for drug infusion or micro-dialysis. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-200R7 : Pellet Receptacle, mg This receptacle is mounted on a 1/4 size rat modular panel and used to deliver mg pellets. The receptacle opening measures 2.0" x 2.0" (5.1 cm x 5.1 cm). Additional components to consider include a receptacle light (ENV-200RL) and head entry detector (ENV-254-CB). Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV : Dual Feeder Y Tube This small adapter facilitates connecting two pellet dispensers to a common receptacle. ENV-200RL : Receptacle Light for Rat Add this receptacle light to most rat pellet receptacles at time of order. This top mounted light may limit placing some modules directly above the receptacles. Dimensions: 2.4" W x 1.36" D x 0.96" H (6.1 cm x 3.5 cm x 2.4 cm) ENV-210M : Modular Guillotine Door for Rat Receptacles This 28 V DC controlled motorized door may be placed in front of a standard receptacle cup to limit access to the reinforcer. The door and receptacle are sold separately. The standard door is aluminum; however, a clear acrylic plastic door may also be specified by ordering ENV-210M-CLEAR. It is mounted on a 1/2 size rat modular panel. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) Door Opening: 2.0" W x 2.0" H (5.1 cm x 5.1 cm) 60

67 ENV-200FC : Ad Lib Feeding Food Cup for Rat This receptacle provides a reserve of food for ad lib feeding. It may be used with the modular guillotine door (ENV-210M) to limit access or a head entry detector (ENV-254-CB) to monitor time at the food cup. For more sophisticated data collection, consider a take and replace pellet delivery system or one of the food intake monitors (ENV-200FCW or ENV-200FCW-D). It is mounted on a 1/4 size rat modular panel. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-200FCW : Food Intake Monitor for Rat ENV-200FCW-D : Food Intake Monitor with Retractable Door for Rat This modular unit features a food hopper with a precision sensor to continuously monitor the weight of the food cup to within 0.1 grams. Up to 16 sensors may be connected to an interface package (DIG-745ADC, sold separately). A photobeam sensor which needs to be connected to a MED input, is provided to indicate when the animal is eating. The food intake monitor with retractable door for rat features a retractable door mechanism that allows the researcher to control when the food is available to the animal. The door operates on 28 V DC. Due to the full size of the mounting panel, it can only be installed in the extra tall 007 series modular test chambers. Dimensions: Panel: 3.0" W x 13.0" H x 5.0" D (7.62 cm x 33.0 cm x 12.7 cm) (for both models) ENV-303M : Pellet Receptacle for Classic Mouse Modular Test Chamber ENV-303W : Pellet Receptacle for Wide Mouse Modular Test Chamber This trough style receptacle is mounted on a 1/2 modular mouse panel. The access opening is 1.125" W x 1.0" H x 0.75" D (2.9 cm x 2.5 cm x 1.9 cm). Consider adding these components to the receptacle: head entry detection (ENV-303HD), receptacle light (ENV-303RL), or automatic guillotine door (ENV-340A). Dimensions: Panels: ENV-303M: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) ENV-303W: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) OPERANT CONDITIONING BEHAVIOR : PELLET RECEPTACLES & ACCESSORIES

68 ENV-303RL : Pellet Receptacle Light for Mouse Wide Modular Test Chamber Add this receptacle light to the pellet receptacle for mouse. This top mounted light may limit placing some modules directly above the receptacle. Dimensions: 1.0" W x 1.125" L x 0.375" D (2.5 cm x 2.9 cm x 1.0 cm) ENV-303HDM : Head Entry Detector for Mouse Pellet Receptacles for Wide Mouse Modular Test Chamber ENV-303HDW : Head Entry Detector for Mouse Pellet Receptacles for Classic Mouse Modular Test Chamber Order the head entry detector to go with a mouse pellet receptacle. Each includes modified side panels, infrared light source and detector, and control package. Each unit operates from 28 V DC and may be used with any switch input module to produce a response whenever an animal breaks the beam. Dimensions: Control Box: 1.40" L x 1.00" H x 2.00" D (3.4 cm x 2.5 cm x 5.1 cm) Cable: 30.0" long (76.2 cm) LIQUID REWARDS AND ACCESSORIES ENV-202M-S : Switchable Liquid Dipper for Rat This modular unit has been redesigned so that it can be operated in the normally down or normally up position, and features a 2.0" x 2.0" (5.1 cm x 5.1 cm) receptacle opening. A motor driven dipper arm raises a precise cup to deliver liquids from water to highly viscous fluids such as condensed milk. Arm movement is smooth and consistent. In the normally down position the arm remains up only as long as power is applied. This unit is preferred if the availability of the reinforcer is time limited once earned. In the normally up position the arm remains in the up position until activated by a 28 V DC control line. This unit fills the cup with a short pulse. It remains available for an unlimited time period. A 0.01 cc cup is included. Cup sizes up to 0.5 cc are available. Add head entry detection (ENV-254-CB), and a receptacle light (ENV-200RL) if needed. It is mounted on a 1/2 size rat modular panel. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) 62

69 ENV-202C : Dipper Cups, Set of Five This package includes one each of a 0.02, 0.04, 0.06, 0.08, and 0.10 cc cup, which snap on to any dipper delivery arm without tools. Contact Sales for individual cup purchases. ENV-202C6 : Extra Large Dipper Cup for Rat Dippers This oversized 0.5 cc cup is available for use with rat dippers only. This cup must be specified at the time the dipper is purchased as it requires a modified receptacle. ENV-202RM-S : Switchable Dual Pellet/Dipper Receptacle for Rat This dipper offers a split floor receptacle capable of delivering both pellet and liquid rewards to the same receptacle. Pellet dispensers (ENV ) must be ordered separately. A 0.01 cc cup is included. This dipper can now be used normally up or down by simply sliding a switch in either direction. In the normally down position the arm remains up only as long as power is applied. In the normally up position the arm remains in the up position until activated by a 28 V DC control line. It is mounted on a 1/2 size rat modular panel. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) ENV-202RMA : Dual Pellet/Liquid Cup Receptacle for Rat This cup features a 0.5 cc cup with an 18 gauge delivery pipe for liquid delivery and trough type on the other side for food reward. Add our standard single speed syringe pump (PHM-100) or any other pump for liquid delivery and a pellet dispenser (ENV ) for 45 mg food reward. It is mounted on a 1/4 size rat modular panel. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-302M-S : Switchable Liquid Dipper for Classical Mouse Modular Test Chamber ENV-302W-S : Switchable Liquid Dipper for Wide Mouse Modular Test Chamber This modular unit has been redesigned so that it can be operated in the normally down or normally up position. In the normally down position the arm remains up only as long as power is applied. In the normally up position the arm remains in the up position until activated by a 28 V DC control line. The receptacle hole has been designed to better accommodate mice with a round access opening that measures 0.878" (2.2 cm) diameter by " (1.1 cm) deep. The cup is presented to the animal as close to the front panel as possible. Included is a 0.01 cc cup. Cup sizes up to 0.1 cc are available. Add head entry detection (ENV-302HD), and a receptacle light (ENV-302RL-1) if needed. It is mounted on a 1/2 size rat modular panel. Dimensions: Panels: ENV-302M: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) ENV-302W: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) OPERANT CONDITIONING BEHAVIOR : PELLET & LIQUID REWARDS & ACCESSORIES

70 ENV-302RL-1 : Top Mounted Receptacle Light for Mouse ENV-302RL-2 : Back Mounted Receptacle Light for Mouse Add this receptacle light to the mouse liquid dippers (ENV-302W-S or ENV-302RW-S). The top mounted light may limit placing some modules directly above the receptacle. Dimensions: 1.25" L x 0.5" W x 0.25" D (3.2 cm x 1.3 cm x 0.6 cm) Top mounted receptacle light shown ENV-302RW-S : Switchable Dipper with Dual Pellet Receptacle for Wide Mouse Modular Test Chamber ENV-302RM-S : Switchable Dipper with Dual Pellet Receptacle for Classic Mouse Modular Test Chamber This dipper offers a split floor receptacle capable of delivering both pellets and liquid rewards to the same receptacle. Dippers can be used in both normally up and normally down positions. In the normally down position the arm remains up only as long as power is applied. In the normally up position the arm remains in the up position until activated by a 28 V DC control line. Pellet dispensers (ENV or ENV P) must be ordered separately. It is mounted on a 1/2 size mouse panel. Dimensions: Panels: ENV-303RW: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) ENV-303RM: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) ENV-302HD : Head Entry Detector for Mouse Liquid Dipper Receptacles This head entry detection is for mouse liquid dipper receptacles. It includes modified receptacle side panels and infrared light source and detector pairs. These units operate from 28 V DC and may be used with any input module to produce a response whenever an animal breaks the beam. Dimensions: Control Box: 1.40" L x 1.00" H x 2.00" D (3.4 cm x 2.5 cm x 5.1 cm) ENV-201A : Liquid Dispenser, Drop Type for Rat This dispenser features a miniature solenoid-activated valve to dispense small drops or small quantities of water. The valve is activated by a 28 V DC output that is controlled via an adjustable timer which determines the length of time it is on. The reservoir consists of a syringe tube that is easily removed from the luer fitting on the valve. The syringe tube is partially sealed, so that measurements of total volume can be made. This unit attaches to the top of the pellet/ liquid drop receptacle (ENV-200R3M), sold separately. Dimensions: Controller: 4.0" L x 2.25" W x 2.25" D (10.2 cm x 5.7 cm x 5.7 cm) 64

71 ENV-200R3M : Pellet/Liquid Drop Receptacle, Cup Type for Rat This receptacle is designed for use with the liquid drop dispenser (ENV-201A). It also features a pellet tube on the back with a pellet guide so that a single receptacle may be used for both pellet or liquid drop reward. It is mounted on a 1/4 size rat modular panel. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-200R3AM : Dual Cup Receptacle with Liquid Pipes for Rat This receptacle features the ability to deliver two types of fluid into individual cups that has been molded into the base of the receptacle. Liquids are then delivered through an 18 gauge stainless steel pipe into each cup. This method is more accurate then liquid valve style drop dispensers and does not permit evaporation from the reservoir as with liquid dippers, which is ideal for alcohol studies. Use with any two syringe pumps for precise delivery of liquid reward. Add head entry detection (ENV-254-CB) or a receptacle light (ENV-200RL) as needed. It is mounted on a 1/4 size rat modular panel. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-200R3BM : Single Cup Receptacle with Liquid Pipe for Rat This receptacle features the ability to deliver a single liquid to a small cup that has been molded into the base of the receptacle. The liquid is then delivered into the cup through an 18 gauge stainless steel pipe. This method is more accurate then liquid valve style drop dispensers and does not permit evaporation from the reservoir as with liquid dippers, which is ideal for alcohol studies. Use with any syringe pump for precise delivery of liquid reward. Add head entry detection (ENV-254-CB) or a receptacle light (ENV-200RL) as needed. It is mounted on a 1/4 size rat modular panel. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-303LP : Liquid Pipe Receptacle for Mouse This unit features a single 0.5 cc stainless steel cup with an 18 gauge pipe. If photobeam head entry detection is required, order the mouse liquid pipe receptacle with head entry detector (ENV-303LPHD). This receptacle is mounted on a 1/4 size mouse modular panel. Dimensions: Panel: 1.5" W x 1.75" H (3.8 cm x 4.4 cm) OPERANT CONDITIONING BEHAVIOR : LIQUID REWARDS & ACCESSORIES

72 ENV-303LPHD : Mouse Liquid Pipe Receptacle with Head Entry Detector This unit features a single 0.5 cc stainless steel cup with an 18 gauge pipe, and also comes with photobeam head detection. This receptacle is mounted on a 1/4 size mouse modular panel. Dimensions: Panel: 1.5" W x 1.75" H (3.8 cm x 4.4 cm) ENV-252M : Retractable Sipper for Rat This retractable sipper unit for rat is mounted on a 1/2 size rat modular panel with motor driven sipper tube for program control of animal access to ad lib liquids. This unit uses a standard water bottle and Lixit valve. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) ENV-352AW : Retractable Sipper for Mouse This retractable sipper for mouse uses a 10 ml graduated pipette with a stainless steel Lixit tube. The extended travel of the tube insures that the mouse cannot reach the tube when retracted. It is mounted on a 1/2 size mouse modular panel. This unit requires 10.0" (25.4 cm) of clearance behind the chamber. Dimensions: Panel: 2.355" W x 3.5" H x 10.0" D (6.0 cm x 8.9 cm x 25.4 cm) ENV-252A : Retractable Sipper with Lixit Valve for Rat This unit uses a horizontal Lixit needle valve. The smaller size of this unit provides greater flexibility in placing it with other accessories. It is mounted on a 1/2 size rat modular panel. The valve can be moved in and out quickly with no spillage. It is supplied with 0.25" (0.6 cm) plastic tube for easy connection to a carboy bottle. Bottles may be obtained from a plasticware supplier. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) 66

73 ENV-352W : Retractable Sipper with Lixit Valve for Mouse This unit uses a horizontal Lixit needle valve. This provides greater flexibility in placing the unit with other accessories. The valve can be moved in and out quickly with no spillage. It is mounted on a 3/4 size mouse modular panel. It is supplied with 0.25" (0.6 cm) plastic tube and an 8 oz (236.6 ml) bottle. Dimensions: Panel: 2.355" W x 5.25" H (6.0 cm x 13.3 cm) ENV-251-LIM : Liquid Intake Monitor for Rat This monitor is mounted on a 3/4 size rat modular panel and contains a liquid bottle, Lixit valve sipper and a precision sensor to measure the weight of the bottle and liquid. The output of the sensor connects directly to the input of the interface package (DIG-745ADC, sold separately). A photo sensor head entry detector is provided to indicate when the animal is drinking, and must be connected in order to operate. Dimensions: Panel: 3.0" W x 9.75" H x 5.75" D (7.6 cm x 24.8 cm x 14.6 cm) ENV-252-LIM : Liquid Intake Monitor with Retractable Sipper for Rat This unit contains a liquid bottle, Lixit valve sipper and a precision sensor to measure the weight of the bottle and liquid. It also has the added feature of a retractable sipper mechanism that allows the researcher to control when the Lixit sipper is available to the animal. The output sensor connects directly to the input of the interface package (DIG-745ADC, sold separately). A photobeam sensor is provided to detect beam breaks, and must be connected to an open input to operate correctly. This monitor is mounted on a 1/2 size rat modular panel. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) ENV-250 : Contact Lickometer Controller This contact lickometer controller has both the inputs and outputs which are 28 V DC controlled. Input impedances of up to 10 megaohms are possible with a subject current of only 0.3 microamps. The device and the grid floor cable will connect to the input connector and the output drinking connector will plug directly into an open input on your choice of connection panel, such as SmartCtrl. When the circuit is complete, meaning animal is touching the grid floor and licking the tube, a signal will be sent to the computer and an input count will register. Circuit must be complete to receive an input count. Dimensions: 2.7" W x 3.8" L x 1.4" D (6.9 cm x 9.7 cm x 3.6 cm) OPERANT CONDITIONING BEHAVIOR : LIQUID REWARDS & ACCESSORIES

74 ENV-250B : Dual Contact Lickometer Controller ENV-250C : Triple Contact Lickometer Controller These lickometer controllers allow you to record licks from two or three drinking devices. The drinking devices must all be installed on the same chamber. The grid floor of the chamber must have a harness. A cable connects from the harness to the lickometer control box (SG-219G2, sold separately). The device and the grid floor cable will connect to the input connector and the output drinking connector will plug directly into an open input on your choice of connection panel, such as SmartCtrl. When the circuit is complete, a signal is sent to the computer registering a count. These lickometers are not suitable for aversive stimulation suppression. Dimensions: 2.7" W x 3.8" L x 1.4" D (6.9 cm x 9.7 cm x 3.6 cm) ENV-250A : Switching Contact Lickometer Controller This unit is a complete lickometer unit that will also switch a direct aversive stimulation output to the sipper tube spout. The switching relay is activated by 28 V DC ground. The lickometer input is automatically disabled when aversive stimulation is applied to the sipper tube. Aversive stimulators and cables (SG-219G and SG-219N cables) are sold separately. Dimensions: 2.7" W x 3.8" L x 1.4" D (6.9 cm x 9.7 cm x 3.6 cm) ENV-250S : Lickometer Grid Switch This unit is offered as an alternative to the switching contact lickometer controller (ENV-250A). The lickometer grid switch does not include the lickometer amplifier and must be used with one of the standard lickometers (ENV-250, ENV-250B or ENV-250C). It will switch each of the nine leads of the grid harness between the lickometer amplifier and the nine outputs of the solid state grid floor scrambler (ENV-412). This permits the delivery of scrambled foot aversive stimulation with any of the three lickometers listed. Lick data collection is momentarily interrupted during aversive stimulation delivery. For continuous data collection during aversive stimulation delivery it would be necessary to use one of the photobeam lickometers (ENV-251L or ENV-251M). Dimensions: 5" W x 5" D x 1.75" H (12.7 cm x 12.7 cm x 4.4 cm) 68

75 ENV-250RM : Water Bottle and Sipper Tube for Rat This water bottle and sipper tube for rat is mounted on a 1/4 size rat modular panel. It features a receptacle opening 2.0" x 2.0" (5.1 cm x 5.1 cm) with a standard rat sipper tube protruding from the back. A thumbscrew secures the sipper tube and connects to a lead for the contact lickometer amplifier. Use as is for ad lib water or other liquid, or connect to contact lickometer controller to record lick counts (sold separately). A replacement bottle with stopper and sipper tube can be ordered (ENV-250BT). Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-350CW : Water Bottle and Sipper Tube for Mouse This water bottle and mounted sipper tube is on a 1/2 size modular mouse panel with a drain fitting that may be connected to plastic tubing to collect spilled liquid. A thumbscrew secures the sipper tube and connects to a lead for the contact lickometer amplifier. Use this unit for ad lib delivery of liquids with or without a contact lickometer. Dimensions: Panel: 1.5" W x 3.5" H (3.8 cm x 8.9 cm) ENV-251L : Lickometer with Photobeam Controller for Rat This unique product places the sipper tube behind a V plate so that the animal is forced to lick for liquid delivery. An infrared photobeam is placed between the stainless steel plate and the sipper tube to accurately count each beam break by the tongue. This count may be much less than the count provided by the light pipe configuration where any part of the snout can break the beam. We do not recommend substituting one for the other in an ongoing study. It is mounted on a 1/4 size rat modular panel. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-251M : Light Pipe Lickometer with Photobeam Controller for Rat This device for rat was modeled after the traditional light pipe configuration. Two glass pipes are positioned in front of the sipper tube to record beam breaks. This unit may be preferred to the contact lickometer in applications using scrambled foot aversive stimulation. It is mounted on a 1/4 size rat modular panel. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) OPERANT CONDITIONING BEHAVIOR : LIQUID REWARDS & ACCESSORIES

76 ENV-351W : Light Pipe Lickometer with Photobeam Controller for Mouse This device for mouse was modeled after the traditional light pipe configuration. Two glass pipes are positioned in front of the sipper tube to record beam breaks. This unit may be preferred to the contact lickometer in applications using scrambled foot aversive stimulation. It is mounted on a 1/2 size mouse modular panel. Dimensions: Panel: 2.355" W x 3.5" H (6.0 cm x 8.9 cm) ENV-251FM : Force Lickometer for Rat This unit includes an 8 oz (236.6 ml) bottle and Lixit valve to eliminate leakage at the sipper tube. It may be used with direct sipper tube aversive stimulation or scrambled foot aversive stimulation. Oversized reservoirs may be used with this unit for long term studies without any change in performance. Force lickometry offers a completely different way to monitor licking behavior that defines responses better than contact or photobeam lickometers by adding a second dependent variable, force or motivation, two threshold levels are user-defined and the force lickometer signal is processed for counts and time above each threshold as well as the sum of the points above threshold (area under the curve/force). The range of force is 0 to 50 grams. The data for each bout is stored in an ASCII file. This system consists of a precision force transducer and transducer amplifier that combined with an infrared head entry detector, further defines the lick response. An adjustable threshold control determines when a lick count response signal is issued. The head entry detector and lick response output may be connected to any 28 V DC input. Due to the full size panel this unit can only be used in the extra tall ENV-007 series of modular test chambers. The force lickometer also requires a DIG-744 interface card, SG-506 power supply, assorted cables and SOF-809 software application. Contact sales for additional information. Dimensions: Panel: 3.0" W x 13.0" H (7.6 cm x 33.0 cm) 70

77 VOLUMETRIC DRINKING TUBES FOR LIQUID INTAKE MONITORING Our volumetric drinking tubes are economical solutions that provide accurate and reliable measurements of water intake. They are ideal for drug dosing, phenotyping, and general health monitoring. Two sizes available will handle daily water consumption volumes from just a few milliliters up to 50 milliliters. Drinking tubes feature high quality Lixit valves to minimize problems associated with leaks. Two valve styles are available: Standard Lixit valves, when cost is a factor. Deluxe Lixit valves, featuring a Teflon gasket to prevent bedding from jamming the valve. Both valve styles are highly resistant to leak problems and allow for accurate quantification of daily water intake. Standard valves are easier for the animal to operate, and may be preferable for small mice, or animals that have a weaker lick. PHM : Mouse Volumetric Drinking Tube, Standard Lixit Total water volume: 13 ml Resolution: 0.1 ml Standard Lixit valve PHM-127A-15 : Mouse Volumetric Drinking Tube, Deluxe Lixit Total water volume: 13 ml Resolution: 0.1 ml Deluxe Lixit valve PHM : Rat Volumetric Drinking Tube, Standard Lixit Total water volume: 50 ml Resolution: 0.5 ml Standard Lixit valve PHM-127A-50 : Rat Volumetric Drinking Tube, Deluxe Lixit Total water volume: 50 ml Resolution: 0.5 ml Deluxe Lixit valve OPERANT CONDITIONING BEHAVIOR : LIQUID REWARDS & ACCESSORIES VOLUMETRIC DRINKING TUBES

78 PELLET DISPENSERS ENV-203M-45 : Modular Pellet Dispenser; 45 mg for Rat ENV : Pedestal Mount Pellet Dispenser; 45 mg for Rat Magazine type pellet dispensers as previously offered by the Ralph Gerbrands Co. and others have proven their reliability over the years. This model features a quiet 28 V DC stepper motor that has been tested repeatedly and found to deliver a whole pellet virtually 100% of the time. Our dispenser is significantly better than any other tested, including the original Gerbrands model. This large capacity magazine holds over mg pellets. The modular dispenser is mounted on a 1/4 size rat modular panel. All new systems will be shipped with modular pellet dispensers (ENV-203M-45) unless otherwise requested or in special applications where space does not permit the use of the modular design, the pedestal style feeder will be substituted. When ordering separately, specify modular (ENV-203M-45) or pedestal mount (ENV ) as needed. If audio feedback, like the original Gerbrands feeder is desired, order the response feedback clicker module (ENV-135M). Dimensions: ENV-203M-45: 5.0" W x 7.0" H x 6.0" D (12.7 cm x 17.8 cm x 15.2 cm) Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV : 4.0" W x 9.25" H x 5.0" D (10.2 cm x 23.5 cm x 12.7 cm) ENV-203M-45IR : Modular Pellet Dispenser; 45 mg for Rat with Built-In Infrared Sentry ENV IR : Pedestal Pellet Dispenser; 45 mg for Rat with Built-In Infrared Sentry The concept of an infrared photobeam to detect and confirm the delivery of a pellet was first developed by Med Associates for use with the one gram pellet and candy dispenser. This feature has proven so effective that it is now offered on most of our dispensers. It has been designed for those applications where pellet delivery is absolutely necessary and a non-delivery alarm is desirable. A sensitive infrared photobeam detector has been added to the delivery tube of the dispenser. If pellet delivery is not confirmed, a built-in microprocessor will repeat the delivery sequence up to five times within 150 milliseconds. Five consecutive failures set an alarm signal line that can be detected with any 28 V DC input card. The modular dispenser is mounted on a 1/4 size modular panel. Connection to the control box requires one input and one output. Dimensions: ENV-203M-45IR: 5.0" W x 7.0" H x 6.0" D (12.7 cm x 17.8 cm x 15.2 cm) Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV IR: 4.0" W x 9.25" H x 5.0" D (10.2 cm x 23.5 cm x 12.7 cm) 72

79 ENV P : Pedestal Pellet Dispenser; 14 mg for Mouse This pedestal style dispenser is calibrated for 14 mg Bio-Serve pellets. It features a quiet 28 V DC stepper motor that will not startle the mouse when a reinforcer is delivered. The capacity of this unit is approximately 3850 pellets. Dimensions: 3.0" W x 4.0" H x 6.0" D (7.6 cm x 10.2 cm x 15.2 cm) ENV-203M-20 : Modular Pellet Dispenser, 20 mg for Mouse ENV : Pedestal Mount Pellet Dispenser, 20 mg for Mouse This dispenser features a quiet 28 V DC stepper motor that will not startle the mouse when a reinforcer is delivered. The capacity of this unit is approximately 7000 pellets. The modular dispenser is mounted on a 1/4 size rat modular panel. Dimensions: ENV-203M-20: 5.0" W x 7.0" H x 6.0" D (12.7 cm x 17.8 cm x 15.2 cm) Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV : 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) ENV : Pedestal Pellet Dispenser; 75 mg for Rat or Primate This dispenser features a quiet 28 V DC stepper motor that will not startle the animal when a reinforcer is delivered. This particular feeder is designed specifically for 75 mg pellets. The capacity of this unit is approximately 1750 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) OPERANT CONDITIONING BEHAVIOR : PELLET DISPENSERS

80 ENV IR : Pedestal Pellet Dispenser; 75 mg for Rat or Primate with Built-in Infrared Sentry This dispenser features a quiet 28 V DC stepper motor that will not startle the animal when a reinforcer is delivered. A sensitive infrared photobeam detector has been added to the delivery tube of the dispenser. If pellet delivery is not confirmed, a built-in microprocessor will repeat the delivery sequence up to five times within 150 milliseconds. Five consecutive failures set an alarm signal line that can be detected with any 28 V DC input card. Connection to the control box requires one input and one output. This particular feeder is designed for 75 mg pellets. The capacity of this unit is approximately 1750 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) ENV : Pedestal Pellet Dispenser; 190 mg for Rat or Primate This dispenser features a quiet 28 V DC stepper motor that will not startle the animal when a reinforcer is delivered. This particular feeder is designed specifically for 190 mg pellets. The capacity of this unit is approximately 600 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) ENV IR : Pedestal Pellet Dispenser; 190 mg for Rat or Primate with Built-in Infrared Sentry This dispenser features a quiet 28 V DC stepper motor that will not startle the animal when a reinforcer is delivered. A sensitive infrared photobeam detector has been added to the delivery tube of the dispenser. If pellet delivery is not confirmed, a built-in microprocessor will repeat the delivery sequence up to five times within 150 milliseconds. Five consecutive failures set an alarm signal line that can be detected with any 28 V DC input card. Connection to the control box requires one input and one output. This particular feeder is designed specifically for 190 mg pellets. The capacity of this unit is approximately 600 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) ENV : Pedestal Pellet Dispenser; 300 mg for Rat or Primate This dispenser features a quiet 28 V DC stepper motor that will not startle the animal when a reinforcer is delivered. This particular feeder is designed specifically for 300 mg pellets. The capacity of this unit is approximately 400 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) 74

81 ENV IR : Pedestal Pellet Dispenser; 300 mg for Rat or Primate with Built-in Infrared Sentry This dispenser features a quiet 28 V DC stepper motor that will not startle the animal when a reinforcer is delivered. A sensitive infrared photobeam detector has been added to the delivery tube of the dispenser. If pellet delivery is not confirmed, a built-in microprocessor will repeat the delivery sequence up to five times within 150 milliseconds. Five consecutive failures set an alarm signal line that can be detected with any 28 V DC input card. Connection to the control box requires one input and one output. The dispenser is designed specifically for delivering 300 mg pellets. The capacity of this unit is approximately 400 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) ENV-203-MINI : Mini M&M s Pedestal Dispenser This dispenser features a quiet 28 V DC stepper motor that will not startle the animal when a reinforcer is delivered. This unit is designed specifically for dispensing mini M&M s. The capacity of this unit is approximately 600 mini M&M s. Dimensions: 4.0" W x 9.25" H x 5.0" D (10.2 cm x 23.5 cm x 12.7 cm) ENV-702 : M&M s Pedestal Dispenser This dispenser features a quiet 28 V DC stepper motor that will not startle the animal when a reinforcer is delivered. A sensitive infrared photobeam detector has been added to the delivery tube of the dispenser. If pellet delivery is not confirmed, a built-in microprocessor will repeat the delivery sequence up to five times within 150 milliseconds. Five consecutive failures set an alarm signal line that can be detected with any 28 V DC input card. Connection to the control box requires one input and one output. This unit has a dispensing mechanism designed specifically for M&M s or similarly shaped and sized candies (i.e. Skittles or Reeses Pieces). The capacity of this unit is approximately 850 M&M s. Contact Sales for more information. Dimensions: 4.25" W x 12.0" H x 6.0" D (10.8 cm x 30.5 cm x 15.2 cm) Special Note: Additional dispensers may be found in the Primate Section. OPERANT CONDITIONING BEHAVIOR : PELLET DISPENSERS

82 PHOTOBEAM SENSORS ENV-253 : Four Channel I/R Controller This controller allows up to four pairs of source and detectors (ENV-253SD sold separately) to be placed in a common area. It may be used with any 28 V DC input card. It synchronizes a pulse stream emitted by each light source with the activation of each detector at a very fast rate. Pulsing the light produces a beam that is better focused and casts a sharper shadow. Synchronizing source and detector at very high speed functions as a continuous beam, without interference from adjacent beams. Dimensions: 4.0" W x 2.878" H x 1.5" D (10.2 cm x 7.3 cm x 3.8 cm) ENV-256I : 16 Channel I/R Controller with Individual Sockets ENV-256I-8 : 8 Channel I/R Controller with Individual Sockets This controller is similar to the four channel I/R controller (ENV-253) except that it has been expanded to either eight or sixteen channels and individual Molex connectors provide convenient connection of each individual infrared light source and detector. This control is used with the TTL SuperPort input card (DIG-713A) for the fastest possible response time. Order a cable (SG-210TTL) to complete the connection between the controller and interface module. This unit is recommended for interfacing mazes, runways, conditioned place preference chambers, and multiple nose pokes to any MED-PC behavioral test system. Dimensions: 4.0" W x 2.0" D x 7.0" H (10.2 cm x 5.1 cm x 17.8 cm) ENV-253SD : Individual Infrared Source and Detector Order as many of these IR pairs as needed to go with the four channel (ENV-253), eight channel (ENV-256I-8), or sixteen channel (ENV-256I) controllers. This item consists of two parts. The first is a single infrared light source housed in a plastic cylinder with two holes for mounting screws and two-conductor cable. The second is a single infrared detector, or receiver, housed in a similar plastic cylinder with a three-conductor cable. Individual source and detector units may be placed from 0.25" (0.6 cm) to 30.0" (76.2 cm) apart under most conditions. Dimensions: 0.75" (1.9 cm) diameter x 0.5" (1.3 cm) deep 76

83 ENV-253B : Single Channel I/R Source, Detector, and Control This single channel package and the head entry detector are designed for those applications requiring a single photobeam. This unit consists of a single optical integrated circuit sensor and infrared LED used in pulsed mode complete with a 28 V DC compatible amplifier housed in a plastic case. The source and detector can be separated up to 30.0" (76.2 cm). Multiple units in a common area are not recommended. For such applications, see the four channel I/R controller (ENV-253), or the sixteen channel I/R controller (ENV-256I). Dimensions: Amplifier Housing: 1.75" x 2.75" x 2.0" (4.4 cm x 6.9 cm x 5.1 cm) Source and Detector Housings: 0.75" (1.9 cm) diameter x 0.5" (1.3 cm) deep ENV-254-CB : Head Entry Detector for Rat Receptacles This head entry detection is designed to place a continuous infrared photobeam across the entrance of most pellet or dipper receptacles for rats as well as the grain hopper for pigeons (ENV-205M). The light source and detector are mounted on small circuit boards protected by PVC blocks that mount to the outside of the stainless steel receptacle. The compact control circuit operates from 28 V DC producing a ground signal whenever the beam is broken. This is compatible with all 28 V DC input cards. (For mouse receptacles see ENV-303HD.) Dimensions: Enclosure: 1.4" W x 2.0" D x 1.0" H (3.6 cm x 5.1 cm x 2.5 cm) OPERANT CONDITIONING BEHAVIOR : PHOTOBEAM SENSORS

84 AVERSIVE STIMULATORS AND ACCESSORIES ENV-414 : Aversive Stimulator/Scrambler Module This module combines the dual range constant current aversive stimulation source (ENV-410B) and solid state grid floor scrambler (ENV-412) on a double-width module. For those applications requiring only scrambled foot aversive stimulation, this module saves money in two ways. First, the combined module is less expensive than the individual modules. Second, it is now possible to place four units in the tabletop cabinet (SG-6080C). Use a cable (SG-216A-10) with male to female Molex connectors to connect each of these modules to a 28 V DC output for computer controlled stimulation. Dimensions: 1.75" W x 5.25" H x 7.25" D (4.5 cm x 13.3 cm x 18.4 cm) Special Note: A cable (SG-219G-10) must also be used with this product and is sold separately. ENV-410B : Dual Range Constant Current Aversive Stimulation Source This aversive stimulation module is designed to provide constant current stimulation. Use this unit for direct aversive stimulation output or with the solid state grid floor scrambler (ENV-412) for scrambled foot aversive stimulation. Output is adjustable in two ranges from 0 to 1 or 0 to 5 ma using a two position range switch and an adjustment knob. The current is shown on the digital display. The resolution of the scale is 0.01 ma. Other features include a dummy load/subject switch, LED indicator, front panel operate, precision digital meter, and optically isolated zero crossover activation. Use with interface and module cabinets. Remote activation requires 28 V DC. The panel size is double width. Dimensions: 1.75" W x 5.25" H x 7.25" D (4.5 cm x 13.3 cm x 18.4 cm) Special Note: Use a cable (SG-216A-10) with Molex connectors to connect to any 28 V DC output; sold separately. Higher current aversive stimulators may be ordered. Contact Sales for more information. ENV-412 : Solid State Grid Floor Scrambler This single width module provides nine unique outputs at a DB-9 connector. Each output is a direct semiconductor switch so that the current level remains the same regardless of the number of grids contacted or even if contact is broken. The scrambler frequency is 30 Hz. Use with aversive stimulator modules (ENV-410B or ENV-413). Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) ENV-415 : Dual A/B Scrambler Control This single-width module connects two solid state scramblers (ENV-412) to a single constant current aversive stimulation source for shuttle avoidance and some yoked control designs. This is designed for either/or aversive stimulation applications. If concurrent aversive stimulation is required for multiple grids, separate constant current aversive stimulation sources are required to ensure optimum regulation. Use the aversive stimulator control cable (SG-219SA) to connect this switch and an aversive stimulation module (ENV-410B) to any 28 V DC output. Three outputs are required, one to select scrambler A, one to select scrambler B, and one to the control aversive stimulation. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) 78

85 ENV-413 : Computer Controlled Constant Current Aversive Stimulation Source The computer controlled constant current aversive stimulator gives you the ability to adjust current intensity, as well as onset and duration. This device is easily programmed in Med State Notation. Other programming languages are available. It was designed to operate from MED-PC through a PCI or USB controller (DIG-729). Multiple modules can be installed in a single cabinet with solid-state scramblers (ENV-412). Use control cable (SG-219C-10) to connect the first cabinet to the controller and the shorter control cables (SG-219D) to interconnect modules in the same cabinet. Dimensions: 1.75" W x 5.25" H x 7.25" D (4.5 cm x 13.3 cm x 18.4 cm) SG-219C-10 : DB-15 Control Cable, 10' (3.0 m) This 10' (3.0 m) cable is required for the first computer controlled constant current aversive stimulator (ENV-413) in each modular cabinet. One end of the cable has a male DB-15 connector and the other has a female DB-15 connector. Dimensions: 10.0' (3.0 m) SG-219D : DB-15 Control Cable, 12" (30.5 cm) This short patch cord is used to chain multiple computer controlled constant current aversive stimulator (ENV-413) modules in the same cabinet. One end of the cable has a male DB-15 connector and the other has a female DB-15 connector. Dimensions: 12.0" (30.5 cm) SG-219G-10 : Shock Output Cable This 10' cable is for shock output. One end has a male DB-9 connection and the other a DB-9 female connection. This cable is commonly used with a grid floor harness. Dimensions: 10.0' (3.0 m) OPERANT CONDITIONING BEHAVIOR : AVERSIVE STIMULATORS & ACCESSORIES

86 ENV-414S : Standalone Aversive Stimulator/Scrambler, 115 V AC, 60 Hz ENV-414SA : Standalone Aversive Stimulator/Scrambler, 230 V AC, 50 Hz Add aversive stimulation to virtually any experiment easily with the this standalone aversive stimulator/scrambler. This unit delivers an adjustable, scrambled aversive stimulation within one of two ranges, 0 to 1 or 0 to 5 ma. The grid rod floor harness connects to the aversive stimulator system by a standard DB-9 cable (SG-219G-10, sold separately) and allows for constant current levels even if a connection to a grid rod is lost. This unit has a self-contained power supply and may be controlled by a 28 V DC to ground signal, a 5 volt TTL signal, or a remote switch closure, thus allowing maximum flexibility in standalone application or when connected to existing equipment. Dimensions: 8.25" W x 9" D x 2.75" H (21.0 cm x 22.9 cm x 7.0 cm) ENV-416S : SQUARE WAVE AVERSIVE STIMULATOR The square wave adversive stimulator provides a full range of 0-10 ma aversive stimulation produced by an advanced solid-state current source. The design allows for a much safer lower source voltage. The unit delivers an adjustable two pole or scrambled square wave. It features a 200 ms safety switch that can limit the aversive stimulation to a maximum of 200 ms, or the safety switch may be turned off if longer durations are desired. For grid floor applications, the grid rod floor connects to the system via a standard DB-9 connector. For bi-polar applications, such as tail aversive stimulus electrodes, the electrodes attach to the 3-prong connector on the back panel. The unit has a self-contained power supply and can be controlled by a 28 V DC to ground signal, a 5 V TTL signal, or a remote switch closure, thus allowing maximum flexibility. Dimensions: 8.25" W x 9" D x 2.75" H (21.0 cm x 22.9 cm x 7.0 cm) 80

87 ENV-420 : Aversive Stimulation Current Test Package This test package is available for use with any Med Associates aversive stimulators. The aversive stimulation current test module connects to a USB port on the computer and two clip leads connect to the grid rods. The software supplied with this unit displays an oscilloscope screen with the actual aversive stimulation wave form, while the digital panel reads the RMS current corresponding to the aversive stimulator setting. Two ranges are provided to correspond with most Med Associates aversive stimulators. Dimensions: Test Module: 5" W x 5" D x 1.75" H (12.7 cm x 12.7 cm x 4.4 cm) ENV-005-QD : Patented Quick Disconnect Harness for ENV-005 Applying scrambled foot aversive stimulation to a removable grid floor has never been easier. The connection block stays with the chamber, so that the floor may be removed for cleaning completely free of all wires, circuit boards, or other connections. The connection block consists of individual spring-loaded contacts mounted in a protective polypropylene strip and wired in sequence to a DB-9 connector. When the floor is installed, each rod presses firmly against a contact for reliable aversive stimulation delivery. The DB-9 cable (SG-219G-10) going from the harness to a grid floor scrambler or from the harness to a lickometer circuit (SG-219G) must be ordered separately. + Dimensions: 12.5" W x 0.5" D x 2.5" H (31.8 cm x 1.3 cm x 6.35 cm) ENV-005A-QD : Patented Quick Disconnect Harness for ENV-005A This quick disconnect harness is used with all 008 or 007 series modular test chambers fitted with a mouse grid floor (ENV-005A). The connection block stays with the chamber, so that the floor may be removed for cleaning completely free of all wires, circuit boards, or other connections. The connection block consists of individual spring-loaded contacts mounted in a protective polypropylene strip and wired in sequence to a DB-9 connector. When the floor is installed, each rod presses firmly against a contact for reliable aversive stimulation delivery. The DB-9 cable (SG-219G-10) going from the harness to a grid floor scrambler or from the harness to a lickometer circuit (SG-219G) must be ordered separately. + Dimensions: 12.5" W x 0.5" D x 2.5" H (31.8 cm x 1.3 cm x 6.35 cm) ENV-307W-QD : Patented Quick Disconnect Harness for ENV-307W ENV-307A-QD : Patented Quick Disconnect Harness for ENV-307A These quick disconnect harnesses are designed for use with the 307 series modular mouse chambers. The DB-9 cable (SG-219G-10) going from the harness to a grid floor scrambler or from the harness to a lickometer circuit (SG-219G) must be ordered separately. + Dimensions: 9.5" W x 0.5" D x 1.5" H (24.1 cm x 1.3 cm x 3.8 cm) Special Note: Use the aversive stimulation output cable (SG-219G-10) to complete the connection from the DB-9 socket on these units to the output of an appropriate scrambler or aversive stimulator. Use a cable (SG-219G2) to connect to standard contact lickometers and the cable (SG-219G) to connect to switching lickometers. Cables sold separately. + Quick Change Floor and Waste Collection Assembly, US Pat. No B1, Canadian Pat. No. 2,368,344, UK Pat. No , Australian Patent , France 1,226,750, Germany , Italy 1,226,750, The Netherlands 1,226,750, European Pat. No , Other Foreign Patents Pending OPERANT CONDITIONING BEHAVIOR : AVERSIVE STIMULATORS & ACCESSORIES 81

88 DRUG DELIVERY FOR RAT PHM-110 : Arm Assembly with 3/4" Gimbal Ring PHM-110-SAI : Arm Assembly with 3/8" Gimbal Ring The arm assembly includes an aluminum block for mounting on most rat modular test chambers. The back plastic wall on Med Associates self administration 007 and 008 series modular test chambers are pre-drilled for this block, or it can be mounted on a modular panel. The adjustable post extends up to 8.0" (20.3 cm) above and 7.0" (17.8 cm) over the center of the chamber with a pivot-arm and dual action gimbal. An adjustable counterbalance weight maintains sufficient tension to keep the leash assembly away from the test animal. The PHM-110 gimbal measures 0.75" (1.9 cm) inside diameter for use with the plastic swivel assembly (PHM-115) sold separately. The PHM-110-SAI gimbal measures 0.386" (0.98 cm) inside diameter and is available to fit either the PHM-119B series or Self-Infusion package, or any swivel with the diameter of 0.386" (1.0 cm). PHM-115 : Plastic Swivel Assembly This inexpensive swivel is assembled from high quality syringe components. The inside ring of the arm assembly (PHM-110) screws to the side of the swivel to keep it perpendicular with the top of the chamber. The stainless steel rotator tube and exit needle are 22 gauge. This unit uses our standard gimbal ring (PHM-115F). Dimensions: 2.7" L x 0.375" Diameter (6.9 cm x 0.95 cm) QUICK CONNECT SYSTEM PHM-119B-21 : Kit Without Delivery Line 21 gauge PHM-119B-21-D : Kit With Delivery Line 21 gauge PHM-119B-23 : Kit Without Delivery Line 23 gauge PHM-119B-23-D : Kit With Delivery Line 23 gauge The Quick Connect System is made up of connections featuring Luer fittings. These fittings provide secure connections between components, and they can be easily attached and detached. The Luered connectors facilitate detaching an animal, and they minimize manipulations so that infections can be avoided. Swivels allow free rotation, preventing catheter twisting and kinking. The tether has built-in tubing that is enclosed in a stainless steel shield to protect the tubing from chewing or clawing. The harness attaches to the vascular (or other) catheter via a stainless steel stub. There are two types of packages: one with the delivery tubing going from the swivel to the pump (PHM-119B-23-D or PHM-119B-21-D), and one without the delivery tubing (PHM-119B-23 or PHM-119B-23). Both packages are available in 21 or 23 gauge. Shown with delivery line 82

89 SWIVELS AND CLAMPS PHM-115I : Stainless Steel Swivel Assembly This precision machined swivel is fully autoclavable and can be reused hundreds of times. The design ensures ease of rotation, durability and reliability, minimizes internal dead volume and eliminates stagnant regions along the fluid path. Fluids passing through the swivel touch only stainless steel tubing and special selfadjusting TEFLON seals. The universal swivel-to-tether clamp easily attaches to the stainless steel spring used on button tethers (PHM-123P and PHM-123D). The 22 gauge tubing mates with standard PE50 catheter tubing. Use with the arm assembly (PHM-110-SAI). This unit also requires an optional gimbal ring (PHM-115F1) when used with the support arm (PHM-110). Dimensions: 1.75" L x 0.40" Diameter (4.4 cm x 1.0 cm) PHM-115IP : Disposable Plastic Swivel Assembly This low cost alternative swivel is offered for those individuals wishing to use the button tethers (PHM-123P or PHM-123D) without the expense of the stainless steel swivel (PHM-115I). This unit also requires an optional gimbal ring (PHM-115F1) when used with the support arm (PHM-110). Recommended for use with the arm assembly with 3/8" (1.0 cm) gimbal ring (PHM-110-SAI). Dimensions: 1.75" L x 0.40" Diameter (4.4 cm x 1.0 cm) PHM-123C : Tether Clamp This clamp is designed to hold most stainless steel spring tethers. Use with stainless steel or plastic swivel (PHM-115I and PHM-115IP) and the button tethers (PHM-123D and PHM-123P). The tether is offset slightly from the needle outlet of the swivel to add additional torque with less stress to the animal mount. Dimensions: 0.25" W x 0.50" L x 0.25" D (0.64 cm x 1.3 cm x 0.64 cm) OPERANT CONDITIONING BEHAVIOR : DRUG DELIVERY FOR RAT SWIVELS & CLAMPS

90 TETHERS These tethers are designed for the cannula to pass through the stalk of a button surgically attached to the animal (usually under the skin), into a length of spring, which protects the cannula and transmits torque to the swivel. The spring simply twists into the button, the expansion force of the spring holding it in place. A Tygon tubing coupler 1.0" (2.5 cm) above the animal is provided to disconnect the animal if so desired. PHM-123D : Dacron Mesh Tether This Dacron mesh tether is designed for a single use, long-term implant. After one to two weeks the subcutaneous tissue grows into the Dacron mesh. Dimensions: 0.625" (1.6 cm) diameter x 0.36" H (0.9 cm) PHM-123P : Polysulfone Tether This polysulfone tether is designed for short to mid-term studies (ten days or less). It is autoclavable and will not cause adverse tissue reactions. Dimensions: 0.625" (1.6 cm) diameter x 0.36" H (0.9 cm) PHM-125B : Holding Cage for Saline Infusion This small home cage was designed for use with our triple infusion pump (PHM-102) for periodic infusion. The top lid is split and slotted for easy animal removal while the leash and swivel are attached. Add an arm assembly (PHM-110) and delivery line (PHM-122) to complete a home cage infusion package. Three of these cages may be placed in a single sound attenuating cubicle (ENV-020M). Dimensions: 9.5" W x " L x 8.5" H (24.1 cm x 25.8 cm x 21.6 cm) PHM : 22 Gauge Drug Delivery Line PHM : 25 Gauge Drug Delivery Line This delivery line is 60.0" (1.5 m) in length made of polyethylene tubing with a female luer fitting for easy connection to the syringe pump. The tubing sizes are 22 and 25 gauge. Dimensions: 60.0" L (1.5 m); 0.020" (0.05 cm) ID; 0.075" (0.2 cm) PHM-137 : Drug Delivery Line This drug delivery line is 10' (3.0 m) in length made of thin wall polyethylene tubing which must be used with the modified leash assembly (PHM-120C). Dimensions: 10.0' L (3.0 m); 0.23" (0.06 cm) ID; 0.038" (0.1 cm) OD 84

91 LEASHES AND ACCESSORIES PHM-120A : Modified Leash Assembly This modified leash assembly is designed for easy one-step connection to the head mount (PHM-130) or back mount cannula (PHM-131). It features a polyethylene delivery line encased in an 11.0 (27.9 cm) stainless steel spring tether with an adapter collar on one end that fastens to the swivel assembly exit needle with a small hex head screw. Dimensions: 11.5" Long (29.2 cm) PHM-120C : Modified Leash Assembly This leash assembly is for use with the PHY-015 line of commutators. It features a polyethylene delivery line encased in an 11.0" (27.9 cm) stainless steel spring tether with adapter to fit into the center hole of a commutator and an easy, one-step connection to the head mount (PHM-130) or back mount cannula (PHM-131). Commutators, cables, and cable tether and leash may be found in the ICSS section. Dimensions: 1.25" L x 0.5" Diameter (3.175 cm x 1.27 cm) PHM-130 : Head Mount Cannula Connector Pedestal This head mount cannula connector pedestal is used for connecting cannula tubing extracranially. The head mounted plastic pedestal consists of a threaded cylindrical top on a square base molded around a stainless steel tube that projects to the side of the base. The pedestal is secured with cranioplastic cement and mounting screws. SPECIFICATIONS Total Pedestal Height: 0.315" (0.8 cm) Pedestal Base: 0.118" (0.3 cm) square Upward Projection: 0.12" (0.3 cm) Tubing Size: 22 gauge OPERANT CONDITIONING BEHAVIOR : DRUG DELIVERY TETHERS, LEASHES & ACCESSORIES

92 PHM-131 : Back Mount Cannula Connector Pedestal This back mount cannula connector pedestal has a Dacron screen mesh attached to the base for mounting on the back. The skin will grow into the mesh and secure it. SPECIFICATIONS Pedestal Height: " (1 cm) Upward Projection: 0.12" (0.3 cm) Mesh Diameter: 1.25" (3.2 cm) Tubing Size: 22 gauge ACCESSORIES PHM-132 : Dust Cap Use this cap with head mount cannula connector pedestal (PHM-130) and back mount cannula connector pedestal (PHM-131) to keep connections clean when not in use. PHM : Stainless Steel Mounting Screw; " (0.2 cm) PHM : Stainless Steel Mounting Screw; 0.125" (0.3 cm) These stainless steel mounting screws are self-tapping stainless steel round-head machine screws with sharply cut threads. 86

93 DRUG DELIVERY FOR MOUSE PHM-124MA : Multi-Axis Lever Arm for Classic Mouse Chamber PHM-124MW : Multi-Axis Lever Arm for Wide Mouse Chamber This 3.5" (8.9 cm) multi-axis lever arm generates a light adjustable upward lift that removes tether slack which helps to keep the tether out of the animal s reach, and allows side-to-side and up-and-down motion of the swivel (sold separately) as it follows above the animal. Dimensions: 5.0" H x 3.5" L (12.7 cm x 8.9 cm) PHM-124B : 25 Gauge Swivel This 25 gauge swivel is low torque and is used in both microdialysis and self-infusion applications. Dimensions: 2.0" L x 0.40" Diameter (5.1 cm x 1.0 cm) PHM-124C : Polysulfone Button and Spring This polysulfone button and spring features a lightweight spring and a small twist-in button with four 0.024" (0.1 cm) suture holes. Dimensions: Spring: 6.0" L (15.2 cm) Button: 0.25" diameter (0.6 cm) x 0.025" thickness (0.1 cm) SG-592 : Microprocessor Digital Timer This microprocessor based digital timer is capable of timing intervals between 0.1 seconds and 99.9 seconds in 1/10-second increments. Timing duration is user selectable via front panel three-digit push buttons. The timing cycle can be initiated by using either the START button on the front of the unit, or by sending the timer as an operate signal from our MED-PC software. The output of the timer is a standard 28 volt output. Typical applications for this unit include the timed control (on duration) of a stimulus light, drug infusion pump, or aversive stimulator. Dimensions: 5.0" W x 5.0" D x 1.75" H (12.7 cm x 12.7 cm x 4.4 cm) OPERANT CONDITIONING BEHAVIOR : DRUG DELIVERY ACCESSORIES DRUG DELIVERY FOR MOUSE

94 SYRINGE PUMPS PHM-100 : 120V SINGLE SPEED SYRINGE PUMP PHM-100A : 230V SINGLE SPEED SYRINGE PUMP This is our most popular pump thousands have been successfully used for self administration studies. The standard speed of this pump is 3.33 RPM but other motors are available and can be changed by the user. It is activated by a MED-PC 28 volt output and turned on as long as the output is on. Thus the time on determines the dose. A safety stop switch disconnects power from the motor when the end of the syringe has been reached. FEATURES Flow Rates: cc/hr to cc/min Syringes: Plastic or Glass, 50 cc to Microliter Construction: Stainless Steel and Aluminum Frame Size: 3.25" H 3.25" W 9" L (8.3 cm 8.3 cm 22.9 cm) INFUSION RATES This pump can accommodate plastic or glass syringes ranging from a 50 cc syringe to a microliter syringe. Listed below are the stock motors and their corresponding flow rates for a Multifit syringe. Other motor speeds may be specially ordered. To determine flow rates with other syringes, a calibration sheet is included with every pump. calibrated in cc/min. calibrated in cc/hr. SYRINGE SIZES MOTOR CODE and RPM 1 cc 2 cc 5 cc 10 cc 20 cc 30 cc 50 cc PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM

95 PHM-100VS : VARIABLE SPEED SYRINGE PUMP PHM-100VSA : 220V VARIABLE SPEED SYRINGE PUMP This variable speed syringe pump contains a nine speed motor with switches that allow the user to select the infusion time. This has the benefit of overdose safety protection since the internal circuit limits the infusion time to the preset value. The speed selections for this unit are 0.50, 1.00, 1.50, 2.00, 3.33, 5.00, 10.00, 15.00, RPM providing up to 63 infusion rates when used with seven syringe sizes ranging from 1 ml to 50 ml. The infusion times are 0.1 to 99.9 seconds in 0.1 second increments. Thumb-wheel switches are used to set the infusion rate and time. The pump can be activated by a standard MED-PC 28 volt output, or manually operated. Dimensions: 6.25" W x 9.75" D x 6.5" H (15.9 cm x 24.8 cm x 16.5 cm) calibrated in cc/min. SYRINGE SIZES RPM 1 cc 2 cc 5 cc 10 cc 20 cc 30 cc 50 cc PHM-100VSDT : Variable Speed Pump with Digital Timer This pump was designed for those unique applications where an animal is dosed to effect, for example when working with anti-convulsant drugs. Just as with the variable speed syringe pump (PHM-100VS), thumb-wheel switches set infusion rate and maximum infusion time. The pump is manually activated from the front panel. At the same time, a digital timer starts timing the infusion. A small hand held button is used to stop the pump and the timer. This allows the researcher to focus on the animal while the infusion is being accurately timed. The infusion time is displayed to the nearest 0.01 seconds. A calibration table showing infusion rates for popular syringe types is provided with the pump. Dimensions: 6.25" W x 9.75" D x 6.5" H (15.9 cm x 24.8 cm x 16.5 cm) OPERANT CONDITIONING BEHAVIOR : SYRINGE PUMPS

96 PHM-102 : TRIPLE INFUSION PUMP WITH AUTOMATIC CYCLING TIMERS Although it was originally designed for home cage infusion of saline, this standalone pump may be used for any periodic infusion application. Permanently attached tethers have been found to remain trouble free for longer periods of time when given periodic infusions with saline in the home cage. This unit will infuse up to three animals at the same time. A pair of two digit thumb-wheel switches are used to set a cycle time from 1 to 99 minutes and an infusion time from 1 to 99 seconds. A setting of 60 and 10, for example, will produce a ten second infusion at one hour intervals. Other features include a flush push button, test mode, single injection mode, and indicator lights that identify cycle activation and infusion activation. Dimensions: 6.25" W x 9.75" D x 6.5" H (15.9 cm x 24.8 cm x 16.5 cm) PHM-102A : Triple Infusion Pump with Expanded Cycling Options This standalone pump may be used for any periodic infusion applications. This unit will infuse up to three animals at the same time. The expanded cycling options of this pump include switches that allow the user to select either minutes or hours for the cycle time and seconds or tenths of seconds for the infusion time. Other features of this pump include a flush push button, test mode, single injection mode, and indicator lights that identify cycle activation and infusion activation. Dimensions: 6.25" W x 9.75" D x 6.5" H (15.9 cm x 24.8 cm x 16.5 cm) 90

97 PHM-104A : HIGH/LOW SPEED P RECISION MICROLITER SYRINGE PUMP Our classic PHM-103/104 High Speed Microliter Syringe Pumps have been redesigned. The original pumps were designed to meet the need in laboratories for rapid infusion of addictive compounds, especially nicotine. This new pump takes rapid infusion to a new level. FEATURES Uses high quality Hamilton 1700 Series glass syringes to ensure precise, accurate delivery. Supports three syringe sizes: 10 µl, 100 µl, and 500 µl. Wide range of injection rates are possible. Unprecedented injection speeds are possible. For example, using a 500 µl syringe an injection volume of 100 µl can be delivered in less than 100 ms! Now able to inject the entire syringe volume during a single injection. USB operation facilitates use; no extra controllers are required. Can be controlled directly from MED-PC. Includes one 100 µl syringe. Dimensions: 9.25" W x 5.875" D x 4.0" H (23.5 cm x 15.0 cm x 10.2 cm) TYPICAL MAXIMUM INJECTION SPEEDS Syringe Size (µl) Max Rate at 10% Max Rate at Full Syringe Capacity (µl/sec) Syringe Capacity (µl/sec) (inj. volume 1 µl) 32 (inj. volume 10 µl) (inj. volume 10 µl) 320 (inj. volume 100 µl) (inj. volume 50 µl) 1320 (inj. volume 500 µl) Maximum and minimum injection rates are based on a saline infusion. Performance may vary depending upon viscosity of fluid. Injection rates shown represent the maximum rates achievable when either 10% of the syringe capacity is injected or when the full syringe capacity is injected. OPERANT CONDITIONING BEHAVIOR : SYRINGE PUMPS

98 PHM-107 : Variable Infusion Rate Syringe Pump This variable speed syringe pump (99 speeds) is activated by a MED-PC 28 volt output and remains on as long as the output is on. Infusion rates from 0.25 cc/hr to 143 cc/hr are possible with syringe sizes from 5 cc to 50 cc. The infusion rate is set on a two digit selector switch. A stop switch disconnects power at end of the syringe. A test push button allows the user to turn on the pump to verify operation. A pump on indicator comes on when the pump is operating. Dimensions: 3.25" H 3.25" W 12.0" L (8.3 cm 8.3 cm 30.5 cm) This pump can accommodate glass or plastic syringes ranging from 50 cc to microliter volumes. To determine flow rates with other syringes, a calibration sheet is included with every pump. A few of the available flow rates include: 1.45 to 143 cc/hr with 50 cc syringe 0.95 to 94 cc/hr with 30 cc syringe 0.71 to 70 cc/hr with 20 cc syringe 0.40 to 39 cc/hr with 10 cc syringe 0.25 to 25 cc/hr with 5 cc syringe 92

99 PHM-108 : SINGLE SPEED SAFETY SYRINGE PUMP This single speed safety syringe pump has been provided as an alternative to the single speed syringe pump (PHM-100) to provide extra safety from an overdose. The input circuit allows the user to select the maximum dose time from 1 to 99 seconds. In addition, the output circuit has two redundant on control circuits to compensate for a failure. The standard rate is 3.33 RPM, but other motors are available and can be changed by the user. This pump is activated by a MED-PC 28 volt output and is turned on as long as the output is on. Thus the time on determines the dose. A safety stop switch disconnects power from the motor when the end of the syringe has been reached. calibrated in cc/min. calibrated in cc/hr. FEATURES Safety: Protect from overdose due to computer or power failure Syringes: Plastic or glass, 50 cc to microliter Construction: Stainless steel and aluminum frame Flow Rate:.017 cc/hr to cc/min Size: 6" H X 6" W x 10" L (15.24 cm x cm x 25.4 cm) INFUSION RATES This pump can accommodate plastic or glass syringes ranging from a 50 cc syringe to a microliter syringe. Listed below are the stock motors and their corresponding flow rates for a Multifit syringe. Other motor speeds may be specially ordered. To determine flow rates with other syringes, a calibration sheet is included with every pump. SYRINGE SIZES MOTOR CODE and RPM 1 cc 2 cc 5 cc 10 cc 20 cc 30 cc 50 cc PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM PHM OPERANT CONDITIONING BEHAVIOR : SYRINGE PUMPS

100 PHM-109 : INTRA-CRANIAL SYRINGE PUMP This intra-cranial pump is a head mounted nanoliter injection system for delivering compounds directly into a rat brain. The pump is mounted on the animal s head so that the animal may move freely, since a swivel supports the pump. The short distance between the pump and the animal s brain allows the system to deliver constant volumes. The pump is controlled by a stepper motor either manually or through MED-PC. Reliable infusion volumes of as low as 50 nanoliters can be delivered. Dimensions: Cable: 20.0" L (50.8 cm) Pump Body: 2.5" L x 0.6" diameter (6.4 cm x 1.5 cm) Commutator: 6.0" L x 1.5" W x 2.0" H (15.2 cm x 3.8 cm x 5.1 cm) Controller: 5.0" W x 5.0" D x 1.5" H (12.7 cm x 12.7 cm x 3.8 cm) FEATURES Controlled manually or from MED-PC As low as 50 nanoliters per infusion Short distance from pump to animal Head mounted pump Allows animal to move freely Direct infusion to brain 94

101 PHM-111-EC : ADVANCED SYRINGE PUMP WITH COMPUTER CONTROL This pump offers the user the ability to control the pump via USB. This pump includes USB syringe pump test program software Dimensions: 9.25" W x 5.875" D x 4.0" H (23.5 cm x 15.0 cm x 10.2 cm) 6 INFUSION RATES.145 to 430 cc/hr with 50 cc syringe.095 to 282 cc/hr with 30 cc syringe.071 to 210 cc/hr with 20 cc syringe.040 to 117 cc/hr with 10 cc syringe.025 to 75 cc/hr with 5 cc syringe 1. LCD Display: Displays Selected Syringe Manufacturer, Capacity and Infusion Rate 2. Run/Stop: Stop allows new parameters to be set. 3. Syringe Brand: Becton, Dickinson & Co. (BD) Plastipak, Monoject, BD Glass, Terumo, Unimetrics, Hamilton (µl), Hamilton (ml), and Popper & Sons. MED-PC Computer Control Via USB or Standard MED Outputs The software controls up to 16 pumps. Each pump reads it s own ID from the switch settings on power up. This makes it easy to change pumps without setting internal jumpers, swapping cables, or changing computer connections. Commands available: Simple On, Off, and Reverse commands sends the data with the command once, the pump does the rest. The pump starts then stops after the exact dose is delivered using the Dose command. Two Ramp commands are available, the pump either stops or keeps running when the Ramp Time expires. Read Status command returns extensive diagnostic data including a high resolution pump travel counter and a 20 millisecond timer counter. The Reset command clears the timer and travel counters. The Set Alarm command permanently sets Loud or Low volume and the limit switch alarm repeat rate. The PHM-111-EC pump executes the Dose and Ramp commands using its own internal timing. The PC is not burdened with strict timing functions. The software error status indicates success, pump data out of range, or pump not connected. Eliminates trial and error checking when an error occurs. 4. Capacity: Depends on brand. Value displayed in LCD display. 5. Infusion Rate: Sets the Infusion Rate 6. Out of Range Indicator: Indicates when the infusion rate is out of range OPERANT CONDITIONING BEHAVIOR : SYRINGE PUMPS

102 ICSS STIMULATORS AND ACCESSORIES PHM-150B : Programmable ICSS Stimulator PHM-150B/2 : Dual Programmable ICSS Stimulator This constant current square wave stimulator is designed for intracranial selfstimulation, also referred to as ICSS. Both the single and dual programmable ICSS stimulators function in the same way, with the only difference being the dual ICSS stimulator (PHM-150B/2) is made up of two programmable ICSS stimulators (PHM-150B) housed in the same cabinet with independent power supplies. The single channel stimulator (PHM-150B) is used to deliver PHM-152/2 shown stimulation to one animal and the dual programmable ICSS stimulator (PHM-150B/2) is used to deliver stimulation to two animals. A total of eight dual programmable ICSS stimulators (PHM-150B/2) may be connected to one computer to deliver stimulation for up to sixteen animals. The maximum current possible is related to the impedance of the electrode. Programmable stimulator parameters include pulse # 1 amplitude and duration, pulse delay duration, pulse # 2 amplitude and duration, frequency and train duration. Connection from the stimulator to the computer requires a separate interface card (DIG-729) be purchased along with necessary cables (SG-219ST and SG-219C-10, all sold separately). Dimensions: 1.75" W x 5.25" H x 7.25" D (4.5 cm x 13.3 cm x 18.4 cm) PHM-152 : Programmable ICSS Stimulator with Monitor Output PHM-152/2 : Dual Programmable ICSS Stimulator with Monitor Output This constant current square wave stimulator is designed for intracranial self-stimulation, also referred to as ICSS. Both the single and dual programmable ICSS stimulators with monitor output function in the same way, with the only difference being the dual ICSS stimulator (PHM-152/2) is made up of two programmable ICSS stimulators with monitor output (PHM-152) housed in the same cabinet with independent power supplies. The single channel stimulator (PHM-152) is used to deliver stimulation to one animal and the dual programmable ICSS stimulator with monitor output (PHM-150B/2) is used to deliver stimulation to two animals. A total of eight dual programmable ICSS stimulators with monitor output (PHM-152/2) may be connected to one computer to deliver stimulation for up to sixteen animals. The maximum current possible is related to the impedance of the electrode. Programmable stimulator parameters include pulse # 1 amplitude and duration, pulse delay duration, pulse # 2 amplitude and duration, frequency and train duration. On the front of both the single and dual stimulators there is a BNC connectors that provides an optically isolated output. Two output sensitivities are provided, 20 ua/v or 10 ua/v. This output may be connected to a conventional or storage oscilloscope or analog to digital converter to validate programmed settings as well as monitor actual subject stimulation. Connection from the stimulator to the computer requires a separate interface card (DIG-729) be purchased along with necessary cables (SG-219ST and SG-219C-10, all sold separately). Dimensions: 1.75" W x 5.25" H x 7.25" D (4.5 cm x 13.3 cm x 18.4 cm) PHM-155A : BNC Output Cable, 5' (1.5 m) PHM-155B : BNC Output Cable, 10' (3.0 m) PHM-155D : BNC Output Cable, 2' (0.6 m) These cables feature noise free RG-58 coaxial cable with male BNC connectors on each end. They may be used to connect the stimulator sites to the cable (PHM-155C) or to connect the isolated monitor output to an oscilloscope input. PHM-155C : BNC Adapter This BNC to female banana plug socket adapter is used to connect electrode leads with male banana plugs to the cable (PHM-155A or PHM-155B). 96

103 OPERANT CONDITIONING BEHAVIOR TEST PACKAGES FOR PIGEON OR SMALL PRIMATE The following test packages all feature our extra tall modular test chamber (ENV-007). These chambers are used for pigeon operant testing, but they are also suitable for operant testing for rats and small primates. Feel free to custom design a chamber configuration using any of these packages as a guide. Interface, computer and software are sold separately. MED-007-P1 : Behavioral Test Package for Pigeon This package features the most popular components for a pigeon lab. This includes an expanded PVC sound attenuating cubicle, extra tall modular test chamber, three pecking keys (each with a three color stimulus), a response feedback clicker, a house light and a grain hopper for reinforcement. Order a MED-SYST-8 or MED- SYST-16 interface and software package separately to run up to eight or sixteen test stations, respectively. PACKAGE COMPONENTS : MED-007-P1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-018V Extra Tall Expanded PVC Sound ENV-123AM Pecking Key Three Color Cue (3) Attenuating Cubicle ENV-135M Response Feedback Clicker ENV-007 Modular Test Chamber with Pan ENV-205M Grain Hopper ENV-005P Stainless Steel Grid Floor Pigeon DIG-716P2 SmartCtrl Package 8 In/16 Out ENV-215M House Light MED-007-PR1 : Behavioral Test Package for Small Primate This package is ideally suited to test small, free roaming primates. It includes two standard levers, two triple stimulus lights, and a 75 mg pellet dispenser with I/R sentry. For restraining small primates, refer to the modular primate test chair (ENV-601). Order a MED-SYST-8 or MED-SYST-16 interface and software package separately to run up to eight or sixteen test stations, respectively. PACKAGE COMPONENTS : MED-007-PR1 MODEL DESCRIPTION MODEL DESCRIPTION ENV-018V Extra Tall Expanded PVC Sound ENV-622M Triple Stimulus Display Attenuating Cubicle (red, green and yellow) (2) ENV-007 Modular Test Chamber with Pan ENV IR Pellet Dispenser I/R Sentry 75 mg ENV-005 Stainless Steel Grid Floor ENV-200R7 Pellet Receptacle Trough ENV-215M House Light DIG-716P2 SmartCtrl Package 8 In/16 Out ENV-610M Standard Primate Lever (2) OPERANT CONDITIONING BEHAVIOR : ICSS STIMULATOR & ACCESSORIES, PIGEON, RAT OR SMALL PRIMATE TEST PACKAGES

104 COMPONENTS FOR PIGEON AND SMALL PRIMATE TEST PACKAGES ENV-005P : Stainless Steel Grid Floor for Pigeon Narrow Spacing This grid floor is most often used with pigeons. It consists of twenty-three, 0.188" (0.48 cm) rods, placed on 0.5" (1.3 cm) centers, in a removable white polypropylene frame. This floor is not suitable for aversive stimulation applications. Dimensions: 12.5" W x 10.0" D x 2.0" H (31.8 cm x 25.4 cm x 5.1 cm) ENV-123AM : Pigeon Key with Three Color Display This pigeon key with three color display is mounted on a 3/8 size rat modular panel and contains a 1.0" (2.5 cm) opening. This key also features a beveled plastic ring to protect the bird s beak. Displacement of the 0.875" (2.2 cm) target area is factory set to approximately 0.063" (0.2 cm). The tension of the normally closed contact is factory set between 12 and 15 grams of pressure. Covering the key is a metal enclosure that houses a pair of red, green, and white stimulus lamps to back light the target area. Dimensions: Panel: 3.0" W x 4.875" H (7.62 cm x 12.4 cm) ENV-124AM : Pigeon Key with Multicolor Display This pigeon key with multicolor display is mounted on a 3/8 size rat modular panel and contains 1.0" (2.5 cm) opening. This key also features a beveled plastic ring to protect the bird s beak. The color display is created from a matrix of 24 plug-in lamps on a single printed circuit board with a possibility of twelve independent stimulus pairs. Lens caps are provided in the following standard colors: red, green, white, blue, orange, and yellow. Variations in color may be produced by turning on two colors at the same time. Tension of the normally closed contact is factory set to between 12 and 15 grams of pressure. Dimensions: Panel: 3.0" W x 4.875" H (7.62 cm x 12.4 cm) ENV-123A-O : Pigeon Key Only Opaque ENV-123A-C : Pigeon Key Only Clear These pigeon keys do not have any stimulus provision. The entire unit is mounted on a 3/8 size rat modular panel. The opaque key (shown) uses the same white plastic key as the pigeon key with display (ENV-123AM or ENV- 124AM), or the clear key (ENV-125M). Both keys use a 1.0" (2.5 cm) opening with a 0.875" (2.2 cm) target area. Tension of the normally closed contact is factory set to between 12 and 15 grams of pressure. Dimensions: Panel: 3.0" W x 4.875" H (7.62 cm x 12.4 cm) 98

105 ENV-125M : Clear Pigeon Key This clear pigeon key has an oversized 2.0" (5.1 cm) diameter key designed for those wishing to place a rear projection screen, computer monitor, or other display device behind the key. The key is mounted into a 1/2 size rat modular panel. This unit features both tension and travel adjustments as well as dual normally closed contacts to guarantee that the large surface area would not in any way reduce sensitivity or performance. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) ENV-135M : Clicker Module This clicker module operates by a 28 V DC mechanical relay and is mounted on a 3/8 size rat modular panel with cable and Molex connector. A single click has been found to facilitate shaping and improve response stability when used with response devices that have minimal or no auditory component such as: pecking keys, nose poke holes, or ultra sensitive levers. It is also useful as a secondary reinforcer with the virtually silent pellet dispensers currently offered. Use software control to produce click frequencies for discriminative stimuli other than pure tones. Dimensions: Panel: 3.0" W x 4.875" H (7.6 cm x 12.4 cm) ENV-205M : Grain Feeder for Pigeons The pigeon grain feeder is mounted on a 1/2 size rat modular panel and features a 28 V DC solenoid activated hopper that is designed to insure reliable delivery of grain to the bird. A built in light illuminates the large receptacle area whenever grain is accessible. A single control line activates both the hopper and light. The clear plastic hopper is easily removed for cleaning. All sharp metal edges that may cause damage to the birds beak have been removed from the hopper and the receptacle area. This unit is supplied with two receptacle bases. The standard base (ENV ), is 0.375" (1 cm) thick with a 0.50" (1.3 cm) hole that is tapered 100 degrees to produce a 1.188" (3.0 cm) opening at the top. This is designed to permit average sized birds access to grain only when the hopper is in the up position. A second base (ENV A) is 0.75" (1.9 cm) thick is recommended for birds with longer beaks. Although the hole size is the same at the bottom, the taper now produces a 2.0" (5.1 cm) opening at the top. For birds with thick beaks, the 0.5" (1.3 cm) hole at the bottom can be drilled out as needed. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) OPERANT CONDITIONING BEHAVIOR : COMPONENTS FOR PIGEON AND SMALL PRIMATE TEST PACKAGES

106 OPERANT BEHAVIOR TEST PACKAGES FOR PRIMATE This section features operant behavior test packages for primates. The modular test chair provides both animal restraint and a component wall made of standard modular channels to accept the same modules illustrated in the rat and small primate sections as well as components designed specifically for primates. The wall mount intelligence box serves a similar purpose for restrained large primates. As with previous packages, feel free to custom design a configuration using any of these packages as a guide. Additional items to consider include a programmable audio generator, syringe pump, or a tail aversive stimulation package. Interface, computer and software are sold separately. MED-601-B1 : Basic Behavioral Test Package MDF SAC, Fixed Levers This basic behavioral test package features a MDF sound cubicle and modular primate test chair with two standard response levers and a 97 mg pellet dispenser for reinforcement. Order a MED-SYST-8 or MED-SYST-16 interface and software package separately to run up to eight or sixteen test stations, respectively. PACKAGE COMPONENTS : MED-601-B1 MODEL DESCRIPTION ENV-018MD Deep Extra Tall MDF Sound Attenuating Cubicle ENV-601A Modular Primate Test Chair ENV-610M Standard Primate Lever (2) ENV-621-WH Stimulus Light, White (3) ENV Pellet Dispenser: mg ENV-200R7 Pellet Receptacle: Trough DIG-716P1 SmartCtrl Package 4 In/8 Out 100

107 MED-601-D1 : Deluxe Behavioral Test Package PVC SAC, Retractable Levers, Triple Stimulus Displays This deluxe behavioral test package features a sound cubicle constructed of expanded PVC, two retractable levers, and two triple stimulus displays. It also contains a SmartCtrl package that supports up to eight inputs and sixteen outputs, and the dispenser features the infrared photobeam sentry. Order a MED-SYST-8 or MED-SYST-16 interface and software package separately to run up to eight or sixteen test stations, respectively. PACKAGE COMPONENTS : MED-601-D1 MODEL DESCRIPTION ENV-018V Extra Tall Expanded PVC Sound Attenuating Cubicle ENV-601A Modular Primate Test Chair ENV-612M Retractable Primate Lever (2) ENV-621-WH Stimulus Light, White ENV-622M Triple Stimulus Display (red, green and yellow) (2) ENV IR Pellet Dispenser I/R Sentry: mg ENV-200R7M Pellet Receptacle: Trough DIG-716P2 SmartCtrl Package 8 In/16 Out MED-600-B1 : Basic Behavioral Test Package Large Primate This package is designed to test a large monkey in a mobile restraint chair. This package does not include the chair, but it does include a large cubicle with entry ramp and wall mounted intelligence cabinet with modular operant components. Included are two standard primate levers, two triple stimulus displays, one 1.0" (2.5 cm) stimulus light, a 1 gram pellet dispenser, and a receptacle. Order a MED-SYST-8 or MED-SYST-16 interface and software package separately to run up to eight or sixteen test stations, respectively. PACKAGE COMPONENTS : MED-600-B1 MODEL DESCRIPTION ENV-600A Large Monkey Cubicle ENV-607 Wall Mount Intelligence Cabinet ENV-600R Entry Ramp ENV-221CL Ceiling Mount House Light (2) ENV-610M Standard Primate Lever (2) ENV-621-WH Stimulus Light, White ENV-622M Triple Stimulus Display (red, green and yellow) (2) ENV Pellet Dispenser: 1 gram ENV-200R6-1 Pellet Receptacle: 1 gram DIG-716P2 SmartCtrl Package 8 In/16 Out OPERANT CONDITIONING BEHAVIOR : PRIMATE TEST PACKAGES

108 COMPONENTS FOR PRIMATE TEST PACKAGES ENV-601A : Small Modular Primate Test Chair This modular test chair is designed for small primates. The front panel consists of three modular channels that can hold any modular test chamber component such as a speaker, white noise tone generator, house light, or clicker, as well as modules designed specifically for primates such as levers, stimulus lights, dispensers, and receptacles. The walls and waist plate are made of 0.375" (1.0 cm) clear polycarbonate, while the door is 0.22" (0.6 cm) clear polycarbonate. The animal seat is aluminum rod and the waste pan is stainless steel. The area under the table may be accessed for tail aversive stimulation electrodes or catheters through an open area below the door or through a 4.0" (10.2 cm) diameter hole in the lower rear wall. Above the waist plate, the entire back is open for easy access to drug lines for drug self administration. This area can be blocked during testing with a clear movable partition that may be placed as needed and secured with a variety of clamps (not included). Additional partitions, tables, and restraints may be custom fabricated by Med Associates (sold separately). Contact Sales for more information. Dimensions: 10.0" W x 10.0" D x 20.0" H (25.4 cm x 25.4 cm x 50.8 cm) ENV-611 : Tail Aversive Stimulation Yoke for Small Primates This heavy-duty acrylic yoke may be attached to the base of the modular primate test chair (ENV-601A). Connection to the metal electrodes is made with standard snap connectors. Dimensions: 4.0" W x 3.5" L x 1.25" H (10.2 cm x 8.9 cm x 3.2 cm) ENV-601FP : Primate Chair Filler Panel Package Filler panels are used to close those spaces not occupied by chamber components on the modular test chamber. A filler panel package is required with all initial orders of modular test chambers. This includes assorted sizes as needed and may be supplied at no cost depending on the accessories ordered with the chamber. For individual panels, order by the size needed. All panels are 3" (7.6 cm) wide. The panel height may be specified as follows: ENV-007-1P: Full Size (13.0" 33.0 cm) ENV P: 3/4 Size (9.75" cm) ENV-007-2P: 1/2 Size (6.5" 16.5 cm) ENV P: 3/8 Size (4.875" 12.4 cm) ENV-007-4P: 1/4 Size (3.25" 8.25 cm) ENV-007-8P: 1/8 Size (1.625" 4.0 cm) ENV P: 1/16 Size (0.8125" 2.0 cm) 102

109 ENV-607 : Large Primate Intelligence Modular Cabinet This product consists of a heavy-duty metal cabinet that can be secured to the wall with several bolts. The front of the cabinet features the same aluminum modular channels used on the rat operant chambers and the modular primate test chair (ENV-601A). The pellet dispenser in this setup is inside the cabinet however, it can also be placed outside of a cubicle for more convenient filling. The inside of the cabinet contains sufficient space for a SmartCtrl or passive connection panel for easy connection to a computer interface. This cable may be brought out the top or the back as needed. Contact Sales for more information. Dimensions: 14.0" H x 19.0" W x 8.0" D (35.6 cm x 48.3 cm x 20.3 cm) ENV-600A : Large Primate Cubicle This enclosure is constructed from almond colored MDF with 0.75" (1.9 cm) thick walls. Construction and sound attenuating properties are similar to other MDF enclosures. In addition to a 28 V DC powered fan standard with all enclosures, this unit includes two 28 V DC house lights mounted to the ceiling, and a viewing window with mirror tinting to prevent the animal from seeing out. This unit is also supplied with locking casters. An optional entry ramp (ENV-600R) to simplify animal loading is sold separately. Dimensions: Interior: 30.0" W x 30.0" D x 58.5" H (76.2 cm x 76.2 cm x cm) ENV-600R : Entry Ramp This ramp is provided to simplify animal loading in the large monkey cubicle (ENV-600A). A single ramp may be used with multiple cubicles. ENV-221CL : Ceiling Mount House Light These lights are used in cubicles for general illumination. More than one light may be needed to fully illuminate larger cubicles. These may be wired to the fan circuit to be on all the time or connected to a 28 V DC output for computer programmed control. Dimensions: 1.75" W x 3.0" H x 7.0" D (4.45 cm x 7.62 cm x 17.8 cm) Special Note: Replacement light bulbs (SG-700A for 100 ma) are sold separately and come in packages of ten bulbs. OPERANT CONDITIONING BEHAVIOR : COMPONENTS FOR PRIMATE TEST PACKAGES

110 ENV-612M : Retractable Primate Lever This heavy-duty retractable primate lever is supplied on a 1/2 size modular panel. It features a solid aluminum lever that protrudes 1.125" (2.9 cm) into the chamber when extended. The tension is factory set at 72 grams however, it can be adjusted from 55 grams to 100 grams. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) Lever: 0.25" (0.6 cm) thick x 1.875" (4.8 cm) wide ENV-610M : Standard Monkey Lever This solid aluminum standard monkey lever mounts on a 1/4 size panel. It features heavy-duty pivots, adjustable tension, and microswitch output. The paddle protrudes 1.125" (2.9 cm) into the chamber and the tension is adjustable from 55 grams to 100 grams, with a factory setting of 72 grams. This lever may be used in the 007 series extra tall modular test chambers, modular primate chair (ENV-601), or wall mount intelligence panel cabinet (ENV-607). Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) Lever: 0.25" (0.6 cm) thick x 1.875" (4.8 cm) wide ENV-122 : Lindsley Manipulandum This unique manipulandum consists of a ball-like knob that extends approximately 2.5" (6.4 cm) from the modular panel. A response switch closure is generated by pulling the knob outward approximately 0.5" (1.3 cm). A second microswitch is provided to generate a response when the knob is pushed in. ENV-621L-RD : Primate Stimulus Light (Red) ENV-621L-WH : Primate Stimulus Light (White) ENV-621L-GR : Primate Stimulus Light (Green) This 1.0" (2.5 cm) diameter 28 V DC LED light may be ordered with a choice of lens colors (red, white, or green). These lenses are mounted behind the modular panel so that it is impossible for an animal to remove them. For additional lenses, specify SG-221-RED, WHITE, GREEN. Dimensions: Panel: 3.0" W x 1.625" H (7.62 cm x 4.1 cm) 104

111 ENV-622M : Triple Stimulus Display Primate This triple stimulus display unit features three 0.625" (1.6 cm) incandescent lamps with colored lenses of white, red, and green arranged in a triangular pattern. It is mounted on a 1/4 size modular panel. Each screw type lens is secured by the modular panel in such a way that it can not be removed by the animal. It is designed for the modular primate test chair (ENV-601A); however, it can also be use a with the extra tall 007 series modular test chambers and rat modular maze systems. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV : Pedestal Pellet Dispenser; 190 mg for Rat or Primate This model features a quiet 28 V DC stepper motor that has been tested repeatedly and found to deliver a whole pellet virtually 100% of the time. This large capacity magazine holds approximately 600 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) ENV IR : Pedestal Pellet Dispenser; 190 mg for Rat or Primate with Built-in Infrared Sentry The concept of the infrared photobeam is to detect and confirm the delivery of a pellet. A sensitive infrared photobeam detector has been added to the feeder s delivery tube. If a pellet does not break in this photobeam, the dispenser will try five times to deliver a pellet. If after the fifth attempt a pellet is not delivered, a signal will be sent to the computer via an input signal indicating an error that there was no pellet delivered. Requires one input and one output on control panel. This pellet dispenser can hold about 600 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) ENV : Pedestal Pellet Dispenser; 300 mg for Rat or Primate This dispenser features a quiet 28 V DC stepper motor that will not startle the rat when a reinforcer is delivered. Connection to the control box requires one input and one output. This particular feeder is designed specifically for 300 mg pellets. The capacity of this unit is approximately 400 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) ENV IR : Pedestal Pellet Dispenser; 300 mg for Rat or Primate with Built-in Infrared Sentry The concept of the infrared photobeam is to detect and confirm the delivery of a pellet. A sensitive infrared photobeam detector has been added to the feeder s delivery tube. If a pellet does not break in this photobeam, the dispenser will try five times to deliver a pellet. If after the fifth attempt a pellet is not delivered, a signal will be sent to the computer via an input signal indicating an error that there was no pellet delivered. Requires one input and one output on control panel. This pellet dispenser can hold about 400 pellets. Dimensions: 4.25" W x 9.25" H x 5.0" D (10.8 cm x 23.5 cm x 12.7 cm) OPERANT CONDITIONING BEHAVIOR : COMPONENTS FOR PRIMATE TEST PACKAGES

112 ENV : 1 Gram Pellet Dispenser with Built In Infrared Sentry This one gram pellet dispenser is supplied with the infrared sentry and an oversized hopper to accommodate 1 gram pellets. It features a heavy duty, reliable, silent stepper motor and advanced electronics for superior performance. This 28 V DC stepper motor has been tested repeatedly and found to deliver a whole pellet virtually 100% of the time. The oversized reservoir measures 3.75" (9.5 cm) inside diameter and 5.0" (12.7 cm) high, and has an approximate capacity of 550 pellets. Dimensions: 4.25" W x 12.0" H x 6.0" D (10.8 cm x 30.5 cm x 15.2 cm) ENV-203P : Peanut Dispenser This modified version of the one gram pellet dispenser (ENV ) is designed to dispense whole shelled peanuts. Peanuts must be relatively consistent in size and shape and some sorting of the peanuts may be necessary for reliable delivery. Please contact Sales for additional information. Dimensions: 4.25" W x 12.0" H x 6.0" D (10.8 cm x 30.5 cm x 15.2 cm) ENV-203-MINI : Mini M&M s Dispenser This dispenser features a dispensing mechanism designed specifically for mini M&M s. This model features a quiet 28 V DC stepper motor. This large capacity magazine holds approximately 600 mini M&M s. Dimensions: 4.0" W x 9.25" H x 5.0" D (10.2 cm x 23.5 cm x 12.7 cm) ENV-702 : M&M s Dispenser This dispenser is similar to the one gram pellet dispenser (ENV ) but has a dispensing mechanism designed specifically for M&M s or similarly shaped and sized candies (ie. Skittles or Ree ses Pieces). It features a heavy duty, reliable, silent 28 V DC stepper motor and advanced electronics for superior performance. It also includes IR sensors for detection of candy. The capacity of this unit is approximately 850 M&M s. Contact Sales for more information. Dimensions: 4.25" W x 12.0" H x 6.0" D (10.8 cm x 30.5 cm x 15.2 cm) ENV-200R6 : Pellet Tray, 1 Gram This tray style receptacle was designed to be mounted on the table of most restraining chairs for larger primates or on any flat table-like surface. The tray consists of a 4.125" W x 3.56" D (10.5 cm x 9.0 cm) block of 0.5" (1.3 cm) thick PVC that has been machined to produce a cup 3.0" (7.6 cm) square and 0.41" (1.0 cm) deep. Dimensions: 4.125" W x 3.56" D x 0.5" H (10.5 cm x 9.0 cm x 1.3 cm) 106

113 ENV-200R6-1 : Pellet Receptacle, 1 Gram This trough type receptacle is fitted with a 0.75" (1.9 cm) PVC elbow and adapter to accept the delivery tube from the 1 gram dispenser (ENV ). The entrance opening to the trough measures 2.0" x 2.0" (5.1 cm x 5.1 cm). It is mounted on a 1/4 size modular panel. Dimensions: Panel: 3.0" W x 3.25" H (7.6 cm x 8.3 cm) ENV-652AM : Retractable Sipper with Lixit Valve and Solenoid Primate This modular unit operates on 28 V DC with a ground output causing the dripless Lixit drinking valve to be inserted 0.625" (1.6 cm) into the test area. It is mounted on a 1/2 size modular panel. The Lixit valve connects to a 28 V DC solenoid valve to prevent liquid flow when the Lixit is retracted, even if the needle is displaced. This feature is provided because some primates may be able to reach the Lixit needle with their fingers when the sipper is retracted, which would spill the liquid from the reservoir. Connect this valve to any suitable liquid reservoir with 0.25" (0.6 cm) Tygon tubing. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) ENV-652FM : Sipper with Lixit Valve and Solenoid Primate This sipper with Lixit valve and solenoid contains a fixed Lixit valve. This is recommended for applications that do not require removal of the sipper tube. It is mounted on a 1/2 size modular panel. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) ENV-652M : Retractable Sipper with Lixit Valve Primate This retractable sipper with Lixit valve does not have the added solenoid valve. This is only recommended for animals that are unable to reach the Lixit valve in the retracted position. It is mounted on a 1/2 size modular panel. Dimensions: Panel: 3.0" W x 6.5" H (7.6 cm x 16.5 cm) OPERANT CONDITIONING BEHAVIOR : COMPONENTS FOR PRIMATE TEST PACKAGES

114 POWER, CONTROL AND INTERFACE EQUIPMENT Med Associates interface systems feature PC-compatible connection to the PCI buses. Med Associates offers the greatest flexibility of any manufacturer by placing a single card in the control computer that connects to a modular cabinet with a central power supply. This centralized interfacing strategy supports multiple chamber systems at the most competitive cost. The heart of the Med Associates interface has remained consistent for nearly twenty years and has supported several software and component upgrades without becoming obsolete. Each component is listed individually in this section. Contact Sales to determine a configuration that will best meet your research needs. CABINETS AND CHASSIS SG-6080D : Small Tabletop Cabinet and Power Supply 120V 60 Hz SG-6081D : Small Tabletop Cabinet and Power Supply 230V 50 Hz This tabletop interface cabinet is the most popular cabinet for labs that will not exceed more than eight test chambers and do not require optional modules such as the programmable audio generator (ANL-926). It is the most compact and least expensive unit available. It provides the equivalent of an interface cabinet (SG-6080C) and a power supply (SG-502). SPECIFICATIONS : SG-6080D & SG-6081D CABINET DIMENSIONS: 9.25" W x 15.0" D x 6" H (23.5 cm x 38.1 cm x 15.3 cm) CAPACITY: Nine single width panels, one slot required for the decode card. POWER SPECIFICATIONS: Output Voltages (Tolerance): Ripple and Noise: A (± 2%) 100 mv A (± 6%) 120 mv A (± 6%) 120 mv A (± 1%) 200 mv Operating Temperature: 0 50 degrees Celsius Built-in EMI Filter Short Circuit Protected 108

115 SG-6510D : Large Tabletop Cabinet and Power Supply 120V 60 Hz SG-651ODA : Large Tabletop Cabinet and Power Supply 230V 50 Hz This interface cabinet is the largest available with the capacity and power to support up to sixteen chambers running on SmartCtrl modules or eight SmartCtrl modules with eight programmable audio generators (ANL-926). This unit combines the 28 V DC power supply with the other supplies in one convenient tabletop enclosure. Connections to the 28 V DC supply in this unit are made from convenient two-pin polarized Molex connectors on the front panel. SPECIFICATIONS : SG-6510D & SG-6510DA CABINET DIMENSIONS: 19.0" W x 15.0" D x 6" H (48.3 cm x 38.1 cm x 15.3 cm) CAPACITY: Seventeen single width panels, one slot required for the decode card. POWER SPECIFICATIONS: Input Voltage: 115 V 9.5 A or 230 V 4.75 A Input Frequency: 50/60 Hz Output Voltages (Tolerance): Ripple and Noise: A (± 2%) 80 mv A (± 6%) 150 mv A (± 6%) 150 mv A (± 1%) 200 mv SG-6080C : Tabletop Module/Interface Cabinet 120V 60 Hz SG-6081C : Tabletop Module/Interface Cabinet 230V 50 Hz This tabletop module/interface cabinet does not have the 28 V DC supply. This cabinet can be used for aversive stimulation modules or for interface applications with standalone power supplies (ordered separately). SPECIFICATIONS : SG-6080C & SG-6081C CABINET DIMENSIONS: 9.25" W x 15.0" D x 6" H (23.5 cm x 38.1 cm x 15.3 cm) CAPACITY: Nine single width panels, one slot required for the decode card. POWER SPECIFICATIONS: Input Voltage: 115 V 4.7 A or 230 V 2.4 A Input Frequency: 50/60 Hz Output Voltages (Tolerance): Ripple and Noise: A (± 2%) 100 mv A (± 6%) 120 mv A (± 6%) 120 mv A (± 1%) 240 mv Operating Temperature: 0 50 degrees Celsius Built-in EMI Filter Short Circuit Protected Operating Temperature: 0 50 degrees Celsius Built-in EMI Filter Short Circuit Protected POWER, CONTROL & INTERFACE EQUIPMENT : CABINETS & CHASSIS

116 SG-6010 : Rack Mount Interface Chassis 120V 60 Hz SG-6010A : Rack Mount Interface Chassis 230V 50 Hz This rack mount chassis contains seventeen individual slots. It is mainly used with interface components that do not require 28 V, such as audio generators (ANL-926), programmable shock source (ENV-413), or shocker/scramblers (ENV-414, ENV-410B, ENV-412). This cabinet may also be used with SmartCtrl, Superport or Standard input/output cards. When used with any of these interface cards that require 28 V, a separate power supply will need to be purchased. (See power supply section for a listing of available power supplies). SPECIFICATIONS : SG-6010 & SG-6010A CABINET DIMENSIONS: 19.0" W x 5.25" H x 12.0" D (48.3 cm x 13.3 cm x 30.5 cm) CAPACITY: Eighteen single width panels, one slot required for the decode card. POWER SPECIFICATIONS: Input Voltage: 115 V 2.8A or 230 V 1.6A Input Frequency: 50/60 Hz Output Voltages (Tolerance): Ripple and Noise: A (± 2%) 80 mv A (± 6%) 150 mv A (± 6%) 150 mv Operating Temperature: 0 50 degrees Celsius Thermal Shutdown Provided Built-in EMI Filter Short Circuit Protected 110

117 ADDITIONAL POWER SUPPLIES AND ACCESSORIES SG-500T : Power Supply 28 Volt, 3 A DC This power supply has two individually switched outputs and two unswitched outputs. The switched outputs can be connected to accessories that need to be independently turned on and off. The unswitched outputs can be connected to accessories that are usually always on, like cubicle lights and fans. This is a convenient way to light and ventilate sound attenuating cubicles used with open field activity, of fear conditioning. Dimensions: 8.25" W x 9.0" D x 2.75" H (21.0 cm x 22.8 cm x 7.0 cm) SG-501 : Power Supply 28 Volt, 1 A DC SG-501A : Power Supply 230 Volt, 50 Hz This compact unit is ideal for standalone interfaces connected to a single chamber. It can be used any time current requirements are minimal. Dimensions: 6.0" W x 6.25" D x 3.5" H (2.4 cm x 15.9 cm x 8.9 cm) SG-506 : Regulated Power Supply SG-506A : Regulated Power Supply 230 Volt, 50 Hz This unit provides both ±12 V DC as well as +5 V DC. It features eight individual four pin Molex connectors. This power supply is primarily used for force lever (ENV-118) and force lickometer (ENV-251FM). Dimensions: 9.25" W x 9.0" D x 5.75" H (23.5 cm x 22.9 cm x 14.6 cm) SG-590 : Delayed Onset Power Strip SG-590A : Delayed Onset Power Strip 230 Volt, 50 Hz By connecting 28 V DC power supplies, pumps, and other critical components to this device, power is not restored to these items until a preset time has elapsed or a manual reset is pressed. A timed/manual switch permits permanent suspension of a system until an attendant intervenes. Use this device to protect animals and 28 V DC accessories. Dimensions: 5.0" W x 6.0" L x 4.0" H (12.7 cm x 15.2 cm x 10.2 cm) OPERANT CONDITIONING BEHAVIOR : CABINETS & CHASSIS, ADDITIONAL POWER SUPPLIES & ACCESSORIES

118 POWER SUPPLIES SG-500 : Rack Mount 28 Volts, 3 A DC Power Supply SG-502 : Rack Mount 28 Volts, 6 A DC Power Supply SG-503 : Rack Mount 28 Volts, 10 A DC Power Supply SG-504 : Rack Mount 28 Volts, 16 A DC Power Supply Order any one of the above power supplies when a rack mount system is preferred or when an interface chassis is not needed, for example to power cubicle lights and fans in non-med-pc applications. Use as is, in a relay rack (SG-400) or enclosed in a rack mount enclosure (SG-6500, SG-6501, or SG-6502). Multiple sets of polarized Molex connectors are provided for convenient connection. Order SG-500A, SG-502A, SG-503A, or SG-504A respectively for 230V, 50 Hz operation. Each is engineered for maximum system safety with built-in output current fold back protection and externally fused power lines. All units are short circuit protected. Dimensions: 19.0" W x 5.25" H x 4.5" D (48.3 cm x 13.3 cm x 11.4 cm) ENCLOSURES SG-6500 : Single Rack Mount Enclosure This heavy duty blue metal enclosure will house any single rack mount chassis with Med Associates interface, physiological, aversive stimulation, audio, or special purpose modules, or a rack mount 28 V DC power supply. It improves the appearance of any lab while protecting the ventilated rack mount chassis. It elevates the module front panel for easier monitoring of front panel controls, meters, connectors, and LED indicators. Dimensions: 19.5" W x 5.625" H x 15.0" D (49.5 cm x 14.3 cm x 38.1 cm) SG-6501 : Double Rack Mount Enclosure This unit measures 10.75" (27.3 cm) high to accommodate up two rack mount units. Ideal for one interface cabinet plus one 28 V DC power supply. Dimensions: 19.5" W x 10.75" H x 15.0" D (49.5 cm x 27.3 cm x 38.1 cm) SG-6502 : Triple Rack Mount Enclosure This unit accommodates three rack mount units and measures " (41.6 cm) high. Dimensions: 19.5" W x " H x 15.0" D (49.5 cm x 41.6 cm x 38.1 cm) SG-400 : Relay Rack A conventional tabletop relay rack with 28.0" (71.1 cm) of front panel space that holds up to four standard rack mount units. Dimensions: 19.5" W x 28.0" H x 15.0" D (49.5 cm x 71.1 cm x 38.1 cm) 112

119 INTERFACE CONNECTION PACKAGE DIG-700P2 : Interface Connection Package PCI This interface connection package is required to connect the tabletop interface cabinets (SG-6080D and SG-6510D) to most Windows compatible computers that have an open PCI slot and MED-PC IV software installed. This package includes: one interface card to be installed into the open PCI slot of the computer (DIG-704PCI), one decode card which would be installed into the tabletop cabinet. This decode card sends the signals from the corresponding interface cards also installed in the tabletop cabinet, such as SmartCtrl interface cards, to the computer via a ribbon cable (DIG-700C) which is also included in this package. PACKAGE COMPONENTS : DIG-700P2 MODEL DESCRIPTION DIG-704PCI PCI Interface Card DIG-700C Interface Ribbon Cable, 6' DIG-700F Interface Decoder Card for PCI Interface SMARTCTRL PACKAGES AND COMPONENTS The SmartCtrl system has virtually eliminated all other interface modules because it is the most convenient and easiest to expand, and is quickly becoming the least expensive interface choice for most operant test chamber systems. Med Associates is the only company to offer a full line of standard modules, SuperPort modules, and special purpose couplers and control modules to complement the SmartCtrl system. The key to the SmartCtrl module is that it places both inputs and outputs on a single width module measuring less than one inch (2.5 cm) wide. Up to eight modules controlling eight independent chambers can be placed in the small tabletop cabinet and power supply (SG-6080D) or up to sixteen modules in the large tabletop cabinet and power supply (SG-6510D). A corresponding connection panel mounts directly to the chamber base for easy connection of all chamber components and accessories, while one or more universal data cables and a power cable complete the connection. DIG-716P1 : SmartCtrl 4 Input/8 Output Package This basic SmartCtrl package includes one interface module (DIG-716), connection panel (SG-716), control cable (SG-210CB) and power cable. A 25' (7.6 m) power cable (SG-210CP-25) is supplied for the first test station in each group of four. Subsequent stations are daisy chained together with 8' (2.4 m) cables (SG-210CP-8) and are sold separately. Additional cables may be added or substituted on request. PACKAGE COMPONENTS : DIG-716PI MODEL DESCRIPTION DIG-716 SmartCtrl Interface Module, 4 In/8 Out SG-716 SmartCtrl Connection Panel, 4 In/8 Out SG-210CB Universal Cable, 25' SG-210CP-25 Power Cable with Polarized Molex Connectors, 25' POWER, CONTROL & INTERFACE EQUIPMENT : POWER SUPPLIES, ENCLOSURES, INTERFACE CONNECTION PACKAGE SMARTCTRL PACKAGES & COMPONENTS

120 DIG-716 : SmartCtrl Interface Module, 4 Input/8 Output This SmartCtrl interface module is ideal for simple chamber configurations. Four green LED indicators and eight red LED indicators make it easy to monitor the status of each input or output. All inputs and outputs are optically isolated and 28 V DC compatible. Inputs may be configured in a transition (pulse) or level mode for both normal (NO) switches or inverted (NC) switches. Outputs operate in the level mode only, however, pulsed outputs are easily generated in the software. Use one universal cable (SG-210CB or SG-210CB-50) to connect this unit to the connection panel (SG-716), which is normally mounted on the chamber base plate. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) SG-716 : SmartCtrl Connection Panel, 4 Input/8 Output This connection panel consists of a stainless steel enclosure that mounts securely to the base of the test chamber. Convenient Molex connectors are provided for both inputs and outputs. Each output driver is rated at 28 V DC, 3 A. Inputs and outputs are clearly identified by the same I/O number assigned by the software. If an optional wall mount bracket is desired, order SG-215WMB. Dimensions: 4.0" W x 2.0" D x 7.0" H (10.2 cm x 5.1 cm x 17.8 cm) DIG-716P2 : SmartCtrl 8 Input/16 Output Package This expanded SmartCtrl package includes one interface module (DIG-716B), connection panel (SG-716B), control cable (SG-210CB), and power cable. A 25' (7.6 m) power cable (SG-210CP-25) is supplied for the first test station in each group of four. Subsequent stations are daisy chained together with 8' (2.4 m) cables (SG-210CP-8) and are sold separately. Additional cables may be added or substituted on request. PACKAGE COMPONENTS : DIG-716PZ MODEL DESCRIPTION DIG-716B SmartCtrl Interface Module, 8 In/16 Out SG-716B SmartCtrl Connection Panel, 8 In/16 Out SG-210CB Universal Cable, 25' SG-210CP-25 Power Cable with Polarized Molex Connectors, 25' DIG-716B : SmartCtrl Interface Module, 8 Input/16 Output This SmartCtrl interface module is a single-width and installs easily in any interface cabinet and houses 8 input and 16 output control lines. Front panel indicator LEDs, green for each input and red for each output, make it easy to monitor the status of each control line at all times. All inputs and outputs are optically isolated and 28 V DC compatible. Inputs may be configured in a transition (pulse) or level mode for both normal (NO) switches or inverted (NC) switches. Outputs operate in the level mode only, however, pulsed outputs are easily generated in software. Use one universal cable (SG-210CB or SG-210CB-50) to connect this unit to the connection panel (SG-716B), which is normally mounted on the chamber base plate. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) 114

121 SG-716B : SmartCtrl Connection Panel, 8 Input/16 Output This connection panel consists of a stainless steel enclosure that mounts securely to the base of the test chamber, and features convenient Molex connectors for both inputs and outputs. There are eight input connectors, sixteen output connectors and three power connectors. Each output driver is rated at 28 V DC, 3 A. Inputs and outputs are clearly identified by the same I/O number assigned by the software. If an optional wall mount bracket is desired, order SG-215WMB. Dimensions: 4.0" W x 2.0" D x 7.0" H (10.2 cm x 5.1 cm x 17.8 cm) CABLES SG-210CB : Universal Cable, 25' (7.6 m) SG-210CB-50 : Universal Cable, 50' (15.2 m) This universal control cable may be used to connect any SmartCtrl interface module to the associated connection panel. The cable features molded DB-25 connectors on each end. The round cable is easier to route, the heavy-duty vinyl sheath more durable and the wire less susceptible to damage than flat ribbon cables. Order power cables separately. SG-210CP-25 : Power Cable, 25' (7.6 m) SG-210CP-8 : Power Cable, 8' (2.4 m) These power cables are used to complete the interface connection to the test chamber. The 25' power cable (SG-210CP-25) is generally used for the first test station in each group of four. Subsequent stations are daisy chained together with 8' power cables (SG-210CP-8). Separate power cables were first introduced to expand the control lines for the larger SmartCtrl interface module (DIG-716B), however, a bonus result is the ability to meet higher current demands of multiple chamber accessories, and increased reliability with custom installations requiring cable lengths that are longer than the standard. POWER, CONTROL & INTERFACE EQUIPMENT : SMARTCTRL PACKAGES COMPONENTS & CABLES

122 SUPERPORT PACKAGES DIG-716P3 : 16 Input/16 Output Control and Cable Package This package was designed specifically for the nine nose poke test packages, however, it can be used any time a test chamber requires up to 16 inputs and 16 outputs. It contains: a SuperPort 16 input module (DIG-712), a SuperPort 16 output module (DIG-726), two 25' (7.6 m) universal cables (SG-210CB), one 25' (7.6 m) power cable (SG-210CP-25) and one passive connection panel (SG-215D4). The connection panel is usually mounted on the chamber base. PACKAGE COMPONENTS : DIG-716P3 MODEL DESCRIPTION DIG-712 SuperPort 16 Input Module DIG-726 SuperPort 16 Output Module, 3 Amp Driver SG-210CB Universal Cable 25' (7.6 m) (2) SG-210CP-25 Power Cable with Polarized Molex Connectors, 25' (7.6 m) SG-215D4 Passive Connection Panel, 16 In/16 Out DIG-716P3F : 16 Input/12 Output Fader Control and Cable Package This package was designed specifically for the nine nose poke test chamber package where dimming the intensity of the nose poke lights is required. To allow this feature a special connection panel with the option to fade the intensity of the lights has been designed (SG-226C). Voltage for the first nine outputs is controlled by the fader settings. The next three outputs are generally used for a receptacle light, food or liquid reward, and a house light. The remaining four outputs select the desired fader settings. To sum it all up this package includes: a SuperPort 16 input module (DIG-712), a SuperPort 16 output module (DIG-726), two 25' (7.6 m) universal cables, one 25' (7.6 m) power cable (SG-210CP-25) and a fader connection panel (SG-226C). PACKAGE COMPONENTS : DIG-716P3F MODEL DESCRIPTION DIG-712 SuperPort 16 Input Module DIG-726 SuperPort 16 Output Module, 3 Amp Driver SG-210CB Universal Cable 25' (7.6 m) (2) SG-210CP-25 Power Cable with Polarized Molex Connectors, 25' (7.6 m) SG-226C Connection Panel, 16 In/12 Out, & Fader 116

123 STANDALONE PCI INTERFACE PACKAGES The standalone PCI interface packages combines the functionality of our PCI interface (DIG-704PCI) with the input and output capabilities of our SmartCtrl cards. These inexpensive standalone interface packages are great for student labs or when only one chamber is needed. They will work the Schedule Manager or MED-PC IV software. The Schedule Manager single chamber license makes our single chamber interface one of the most affordable available. The Schedule Manager software s uncomplicated programming interface and the easy to use SmartCtrl connection panel make this system excellent for novice users. MED-SPI-01 : Standalone PCI Interface Package, 4 Input/8 Output This standalone PCI interface package contains all the components needed for a 4 input and 8 output set up. The power supply, connection panel and necessary cables are also included. This would be used for a single station system and requires a desktop PC cannot use a laptop computer (for laptop setup see DIG-703A). PACKAGE COMPONENTS : MED-SPI-01 MODEL DESCRIPTION MODEL DESCRIPTION DIG-750D Standalone PCI Interface Card SG-210CP-25 Power Cable with Polarized SG-716 SmartCtrl Connection Panel, Molex Connectors, 25' 4 In/8 Out SG-210CP-8 Power Cable with Polarized SG-210CB Universal Cable, 25' Molex Connectors, 8' SG-750D 28V Power Cable Adaptor, 6" (2) SG Amp Power Supply MED-SPI-02 : Standalone PCI Interface Package, 8 Input/16 Output This standalone PCI interface package contains all the components needed for an 8 input and 16 output set up. The power supply, connection panel and necessary cables are also included. This would be used for a single station system and requires a desktop PC cannot use a laptop computer (for laptop setup see DIG-703B). PACKAGE COMPONENTS : MED-SPI-02 MODEL DESCRIPTION MODEL DESCRIPTION DIG-750D Standalone PCI Interface Card SG-210CP-25 Power Cable with Polarized SG-716B SmartCtrl Connection Panel, Molex Connectors, 25' 8 In/16 Out SG-750D 28V Power Cable Adaptor, 6" (2) SG-210CB Universal Cable, 25' SG-210CP-8 Power Cable with Polarized SG Volt 4 Amp Power Molex Connectors, 8' Supply (Selectable VAC, VAC) POWER, CONTROL & INTERFACE EQUIPMENT : SUPERPORT PACKAGES, STANDALONE PCI INTERFACE PACKAGES

124 DIG-703B shown STANDALONE USB INTERFACE Our latest line of interface systems takes advantage of the ease of use and flexibility of USB, and is designed to be compact and easy to use. Simply plug the USB interface into a USB port on your desktop or laptop computer, attach the power cable to an AC outlet, and you re ready to interface with your operant conditioning chamber. This new USB device combines the functionality of the PCI interface (DIG-704PCI) with the input and output capabilities of our SmartCtrl cards. This inexpensive standalone interface package is great for student labs or when only one chamber is needed. Both systems provide timed interrupts as required by the MED-PC IV software. These standalone USB interface systems are ideal for student labs. Each student can run his/her own operant conditioning chamber. FEATURES USB Connectivity Fully Compatible with MED-PC IV Build 52 or higher Run MED-PC from your laptop computer Portable Economical 10 ms resolution Ideal for student labs, training systems, or demonstrations DIG-703A : Standalone USB Interface 4 Input/8 Output This standalone USB interface provides four inputs and eight outputs. SPECIFICATIONS : DIG-703A CABINET DIMENSIONS: 9" W x 8.5" D x 2.75" H (22.86 cm x cm x 6.99 cm) DIG-703B : Standalone USB Interface 8 Input/16 Output This standalone USB interface provides eight inputs and sixteen outputs. SPECIFICATIONS : DIG-703B CABINET DIMENSIONS: 10.25" W x 11.5" D x 4.75" H (26.04 cm x cm x cm) 118

125 INTERFACE MODULES FOR 28 V DC INPUT MODULES Any of these input modules may be set to pulse (also know as transition mode) or level mode of operation. In the pulse mode, switch closures are filtered, contact debounced and latched. A single switch closure sets a latch on the card that is held until read and reset by the computer. In the level mode, only an input that is present when the card is read is recognized. With MED-PC IV, and Schedule Manager software, the level mode produces a count every interrupt (typically 10 ms) for as long as the input switch is closed. In general, use pulse mode with response levers or keys to increment a single count for each response, and use level mode with photobeams and nose pokes to determine how long the beam is interrupted or to define beam breaks with specific time values. DIG-711A : Standard 8 Input Module This standard 8 input module contains eight optically isolated input lines, each with a small status indicator lamp. It features screw terminal connections for normally open switches operating from a 24 to 28 V DC power supply. It also includes jumper settings to invert the input function for normally closed switches. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) DIG-712 : SuperPort 16 Input Module This SuperPort 16 input module contains sixteen optically isolated input lines for both normally open and normally closed switches wired to a single DB-25 connector. Use this SuperPort 16 input module (DIG-712) with any passive connection panel. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) DIG-712F : SuperPort Input Module, 10 ms Time Constant The SuperPort 16 input module 10 ms time constant (DIG-712F) has a faster time constant (100 Hz vs. 10 Hz) and is recommended for pigeon keys. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) DIG-710 : Standard 8 Input Module, TTL The standard 8 input module features eight TTL logic inputs respectively. Each input bit is associated with its own LED indicator. These inputs are compatible with sinking 5 volt TTL logic where a logic 1 is 0 volts and logic 0 is 5 volts. Select transition (pulse) or continuous (level) modes using the on board jumpers. Connections to this module are made via 0.080" (0.2 cm) pin jacks. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) POWER, CONTROL & INTERFACE EQUIPMENT : STANDALONE USB INTERFACE MODULES FOR 28 V DC

126 DIG-713A : SuperPort 16 Input Module, TTL This SuperPort 16 input module features sixteen TTL logic inputs respectively. Each input bit is associated with its own LED indicator. These inputs are compatible with sinking 5 volt TTL logic where a logic 1 is 0 volts and logic 0 is 5 volts. Select transition (pulse) or continuous (level) modes using the on board jumpers. This module also includes jumpers for normal and inverted making it compatible with logic where a logic 1 is +5 volts. Connections to this module are made via a single DB-25 connector. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) OUTPUT MODULES DIG-721 : Standard 8 Output Module This single width standard 8 output module provides eight 3 A DC drivers designed to activate a 28 V DC device by providing the ground (-28 V) signal. Each output is optically isolated to protect the computer from external noise in the peripheral power supply or environment. Connections are made on a convenient front panel terminal strip. Eight adjacent indicator lamps report the status of each output. Pulse or level modes of operation are selected with individual jumpers for each output. In the level mode, outputs turned on by the computer remain on until turned off by the computer. In pulse mode, outputs remain on for a user-defined duration (from 40 milliseconds to 4 seconds). The hardware timers are set with a screwdriver through an opening in the front panel for each output. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) DIG-726 : SuperPort 16 Output Module This SuperPort 16 output module is a single width module. It features sixteen optically isolated outputs with 3 A solid state DC drivers however, each output operates in a level mode only. The pulse mode was dropped in this later design because that function is now easily covered in software. Connections are made through a DB-25 connector on the front panel. Sixteen LED indicators designated as either P1 (port 1) or P2 (port 2) provide a visual indicator of the status of each output at all times. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) 120

127 DIG-722A : Relay Output Module This relay output module is a single width module contains eight single-pole double-throw relays rated at 2 A, 30 V DC. Both the normally open (NO) and normally closed (NC) contacts are wired to a female DB-25 connector. A mating connector and hood are provided with each module. This module functions in level mode only. Once a relay is activated by the computer, it remains on until turned off by the computer. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) DIG-720 : Standard 8 Output Module, TTL This standard 8 output module features eight TTL logic outputs respectively. Each output bit is associated with its own LED indicator. These outputs are compatible with sinking 5 volt TTL logic where a logic 1 is 0 volts and logic 0 is 5 volts, and operate in level mode only. A ground (0 volts) is provided at the output when it is turned on. Connections to this module are made via 0.080" (0.2 cm) pin jacks. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) DIG-726TTL : SuperPort 16 Output Module, TTL This SuperPort 16 output module features sixteen TTL logic outputs respectively. Each output bit is associated with its own LED indicator. These outputs are compatible with sinking 5 volt TTL logic where a logic 1 is 0 volts and logic 0 is 5 volts, and operate in level mode only. A ground (0 volts) is provided at the output when it is turned on. Connections to this module is made through a DB-25 connector. Both this module and the SuperPort input module (DIG-712) are particularly useful in connecting a MED-PC interface to a SmartCr real-time cumulative recorder interface. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) DIG-725 : Dual AC Outlet This unit connects to a standard 28 V DC output card to control a 115 V AC device. It consists of an enclosure that houses two noise-free zero crossover AC relays connected to a standard duplex outlet. Each half of the outlet is independently switched ON/OFF by a separate control line, and each has a green LED to indicate its status. Use with a SmartCtrl, Standard, or SuperPort 28 V DC Output Module. A standard power cord is provided to connect to a properly grounded 115 V AC 60 Hz Outlet. The operate connection is made via a three pin Molex connector. Order two 3-pin Molex extension cables (SG-216A-10) to connect to a SmartCtrl or passive connection panel. Contact Sales if a 230 V 50 Hz version of this product is required. Dimensions: 0.875" W x 5.25" H x 7.25" D (2.2 cm x 13.3 cm x 18.4 cm) POWER, CONTROL & INTERFACE EQUIPMENT : INTERFACE MODULES FOR 28 V DC INPUT & OUTPUT

128 ANALOG-TO-DIGITAL INTERFACE PACKAGE DIG-745ADC : 16 Channel PCI ADC and Transducer Interface Package This package consists of three components: the analog-to-digital converter (ADC), transducer interface module, and cable. The ADC PCI card may be installed in the same computer as the MED-PC IV interface card. The supplied cable connects this card to the transducer interface module, which may be installed in the MED-PC interface cabinet (space permitting) or in a separate table top cabinet (SG-6080C). Each of the 16 transducer channels has its own tare control for taring the hopper weight at the beginning of the session. With this package, various analog signals may be measured and added to the MED-PC data file. The food and liquid intake monitoring applications (ENV-200FCW and ENV-251-LIM) use this interface. Dimensions: 3.625" W x 5.25" H x 7.25" D (9.2 cm x 13.3 cm x 18.4 cm) PACKAGE COMPONENTS : DIG-745ADC MODEL DESCRIPTION DIG-744 DIG-745 SG-244 SOF-FIM/LIM National Instruments ADC for 744ADC Transducer Interface for 744ADC Shielded Case Operating Software for Food and Liquid Intake Monitoring Packages CABLES AND CONNECTION PANELS SG-215D3 : Passive Connection Panel This small passive connection panel provides for eight 3-pin Molex connectors. These can be used as inputs or outputs depending on the connection to the interface modules. Use this panel with a cable (SG-211F or SG-210A). Dimensions: 4.25" L x 3.25" W x 1.125" H (10.8 cm x 8.3 cm x 2.9 cm) SG-716D : Passive Connection Panel, 4 Input/8 Output This passive connection panel is used in rare occasions when the standard 4 input/8 output configuration of the SmartCtrl package is not suitable. Although this has the same appearance as the corresponding SmartCtrl connection panel, it can be wired with any combination of inputs or outputs. Contact Sales for information on the cables needed. Dimensions: 4.0" W x 2.0" D x 7.0" H (10.2 cm x 5.1 cm x 17.8 cm) SG-716D2 : Passive Connection Panel, 8 Input/16 Output This passive connection panel is used in rare occasions when the standard 8 input/16 output configuration of the SmartCtrl package is not suitable. Although this has the same appearance as the corresponding SmartCtrl connection panel, it can be wired with any combination of inputs or outputs. Contact Sales for information on the cables needed. Dimensions: 4.0" W x 2.0" D x 7.0" H (10.2 cm x 5.1 cm x 17.8 cm) 122

129 SG-215D4 : Passive Connection Panel, 16 Input/16 Output This panel is generally used with one SuperPort 16 input module (DIG-712) and one SuperPort 16 output module (DIG-726) to provide sixteen inputs and sixteen outputs. It could just as easily be used to provide thirty-two inputs or thirty-two outputs to a single test station or distributed among several test stations as needed. Each connection panel requires two of the universal cables (SG-210B) and one power cable (SG-210CP-25 or SG-210CP-8) Dimensions: 4.0" W x 2.0" D x 7.0" H (10.2 cm x 5.1 cm x 17.8 cm) SG-210A : Universal Cable, 12 Conductor This twelve-conductor extension cable is used to connect from the interface cable (SG-211F) to the passive connection panel (SG-215D3). This cable consists of a male DB-25 connector on one end and female DB-25 connector on the other end. Dimensions: 25.0' (7.6 m) long SG-210CB : Universal Cable, 25 Conductor This twenty five-conductor cable is used as an extension cable between the interface cable (SG-213F) and the corresponding passive connection panel. This cable features a male DB-25 connector on one end and a female DB-25 connector on the other end. Dimensions: 25.0' (7.6 m) long SG-211F : Interface Cable, 12 Conductor This interface cable has a female DB-25 connector on one end and stripped and tinned wires on the other. One cable connects to one passive connection panel and is normally assigned to each test chamber in the system. The tinned ends are typically wired to standard interface modules with a custom selection of inputs and outputs. Dimensions: 3.0' (91.4 cm) long SG-213F : Interface Cable, 25 Conductor This cable has a female DB-25 connector on one end and stripped and tinned wires on the other. One cable connects to one passive connection panel and is normally assigned to each test chamber in the system. The tinned ends are typically wired to Superport interface modules with a custom selection of inputs and outputs. Dimensions: 3.0' (91.4 cm) long POWER, CONTROL & INTERFACE EQUIPMENT : ANALOG-TO-DIGITAL INTERFACE PACKAGE CABLES & CONNECTION PANELS

130 SG-210CP-25 : 25' (7.6 m) 28 V DC Power Cable SG-210CP-8 : 8' (2.4 m) 28 V DC Power Cable These 16 gauge two-conductor power cables come either 25' (7.6 m) or 8' (2.4 m) long. Use a 25' cable (SG-210CP-25) to connect the first connection panel in a group to the 28 V DC supply. Use an 8' (2.4 m) cable (SG-210CP-8) to daisy chain up to three additional connection panels in a group. SG-216A : 18" (45.7 cm) 3-Pin Mini-Molex Extension Cable SG-216A-2 : 2' (61.0 cm) 3-Pin Mini-Molex Extension Cable SG-216A-6 : 6' (1.8 m) 3-Pin Mini-Molex Extension Cable SG-216A-10 : 10' (3.0 m) 3-Pin Mini-Molex Extension Cable SG-216A-20 : 20' (6.1 m) 3-Pin Mini-Molex Extension Cable These cables are used to extend the length of any accessory with a 3-pin mini-molex cable. Most accessories have a 30.0" (76.2 cm) long cable. In some instances, it may be necessary to have a longer cable to reach the connection panel. This is usually the case in systems that share one connection panel between multiple chambers. Accessories ordered with a SmartCtrl system will have extension cables added as needed free of charge. SG-216C : 3-Pin Mini-Molex Y Cable with One Female Connector to Two Male Connectors This cable connects two accessories to one input or output. It can be used for connecting two outputs together that are always turned on together, like a house light and fan or stimulus light and retractable lever. It can also be used for connecting a push button cable and a pellet dispenser or other reward for shaping. Dimensions: 3.0" (7.62 cm) long SG-216C1 : 3-Pin Mini-Molex Y Cable with Two Female Connectors to One Male Connector This cable connects one accessory to two inputs or outputs. It can be used for connecting a lever or nose poke to two inputs for measuring the duration of the input. It can also be used for connecting two photobeam inputs together in systems looking at broad movements. Dimensions: 3.0" (7.62 cm) long 124

131 SG-205 : Hand-Held Push Button Cable This cable has a push button on one end and at the other end we will add the appropriate connector. At time of order, please specify how this cable will be used. It may be used as an input for human studies or connected to an output device with a Y-cable (SG-216C) for shaping. Dimensions: 15.0' (4.6 m) long TTL TO 28 V DC ADAPTERS The following adapters have been provided to permit control of a single device, such as a pellet dispenser, from a 5 V TTL output. An internal jumper allows the user to select active high to turn on the device when the TTL signal transitions from 0 to 5 Volts or active low to turn on the device when the TTL signal transitions from 5 to 0 Volts. Units are shipped from the factory active low unless otherwise requested. These devices do not include the 28 V DC power supply, order separately. For small applications we recommend the power supply (SG-501). SG-230 : TTL to 28 V DC Adapter This device requires 5 V DC power from the controlling device. Connections are made via a convenient terminal strip. The output connector is a three-pin mini Molex, which is compatible with all Med Associates 28 V DC components. The 28 V input connector is a two-pin polarized Molex. Dimensions: 5.0" W x 5.0" D x 1.75" H (12.7 cm x 12.7 cm x 4.4 cm) SG-230R : TTL to 28 V DC Powered Adapter This device does not require a +5 V connection to the controlling device. It does require connection to 28 V DC. Connections with the TTL device are made via a convenient terminal strip, the output connector is a three-pin mini Molex, and the 28 V DC input connector is a two-pin polarized Molex. Dimensions: 5.0" W x 5.0" D x 1.75" H (12.7 cm x 12.7 cm x 4.4 cm) POWER, CONTROL & INTERFACE EQUIPMENT : CABLES & TTL TO 28 V DC ADAPTERS

132 SG-230RC : TTL to 28 V DC Powered Adapter with Coax Connector This device does not require a +5 V connection to the controlling device. Its connection to the controlling device is made via a standard BNC cable. It requires connection to 28 V DC. The output connector is a three-pin mini-molex, and the 28 V DC input connector is a two-pin polarized Molex. Dimensions: 5.0" W x 5.0" D x 1.75" H (12.7 cm x 12.7 cm x 4.4 cm) SG-231 : 28 V DC to TTL Adapter This device is designed to take a 28 V DC output and convert it to a TTL transition. This may be useful to event mark a separate physiological data acquisition system for example. For multiple TTL outputs, see interface modules with eight and sixteen outputs (DIG-720 and DIG-726TTL) respectively. Connections to this device are made via convenient screw terminals. Dimensions: 5.0" W x 5.0" D x 1.75" H (12.7 cm x 12.7 cm x 4.4 cm) 126

133 SOFTWARE SOF-735 MED-PC IV SOF-731 MPC2XL DATA TRANSFER UTILITY SOF-722 SOFTCr-PRO CUMULATIVE RECORD GRAPHICAL SOFTWARE SOF-721 SOFTCr CUMULATIVE RECORD GRAPHICAL SOFTWARE MEDSTATE NOTATION PROCEDURES SOF-700LA-1 MedLab 8 Package SOF-700LA-2 Operant-Conditioning Lab Package SOF-700RA-1 FR Training Procedure SOF-700RA-2 Progressive Ratio SOF-700RA-5 Intra-cranial Self Stimulation (ICSS) Procedures SOF-700RA-8 Nine Choice Serial Reaction Time Task SOF-700RA-8A Five Choice Serial Reaction Time Task SOF-700RA-10 Drug Self Infusion SOF-808 Force Lever SOF-700RA-18 Variable Schedule SOF-700RA-22 Lick Suppression SHUTTLE BOX PACKAGES SOF-700RA-7 Shuttle Source Code Package SOF-700RA-11 Shuttle Box Step Down Protocols SOF-706 SCHEDULE MANAGER INPUT & OUTPUT FROM MEDSTATE NOTATION SOF Graphic Display Routine SOF WAV File Player SOF Control of Med Input/Output Modules from Other Languages SOF-710 Animal Food Intake Monitor

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135 SOF-735 : MED-PC IV SOFTWARE OS Compatibility: Windows 2000, XP and 32 Bit Vista Although some manufacturers may try, it is difficult to compare any other system to MED-PC and other software products developed by Med Associates. Having stood the test of time, MedState Notation continues to be the choice of more laboratories than any other behavioral control language. The simple fact of the matter is that MedState Notation works. It does exactly what is contained in written text just like any other programming language. It is not necessary to review countless tables to determine which options are set under which conditions. MedState Notation uses simple commands whose functions are inherently recognizable and easy to learn (e.g., ON, OFF, SHOW, ADD, IF, and SET). Placing these commands into logically ordered text gives the user total flexibility over the control of chamb er components, stimuli, and reward mechanisms, as well as data variables and arrays. A well written procedure is a permanent record of the experimental protocol. It can be easily reviewed years later for modification or used as is by other investigators. Many standard procedures have already been written and are described at the end of this section. Four separate applications make up the MED-PC package. Each is designed to handle a specific task as easily and transparently as possible. MedTest verifies hardware function independent of MED-PC. This includes an interface card test, a test for the Programmable Audio Generator (ANL-926), and tests for SmartCtrl interface modules (DIG-716B test shown), standard modules, and SuperPort modules. SOFTWARE : MED-PC IV

136 Trans IV translates and compiles selected MedState Notation procedures into DLL files that may be executed by MED-PC. This application also serves as a text editor with a detailed help index to MedState Notation programming. Error checking code activated during translation clearly points to simple format type errors. Hardware Configuration is used to build a configuration file that tells MED-PC how many boxes are connected, how many inputs and outputs are available to each box, and how are they identified. This utility guides the user step by step through this procedure. It is used to set or update such user controlled parameters as file format, automatic file naming strategy and structure, automatic back up frequency, and data file path. MED-PC IV is the run time or operating system of MED-PC. It lets the user run up to 16 test chambers with up to 1 million data elements per chamber. A single test chamber could have up to 80 inputs and 80 outputs. Interface cabinets for 8 or 16 modules are available. Modules with 8, 12, 16, or 24 inputs/outputs in various combinations are available. A few of the MED-PC IV screens and features are illustrated below. The MED-PC IV Load Wizard is specially designed for first time users. It takes the operator through a series of screens for loading and starting one or more boxes. This can be most helpful when first learning the MED-PC system. This feature may be disabled at any time, and boxes may be loaded from file menu selections, buttons on the tool bar, or customized macros with optional user-defined dialog boxes for the operator. STEP 1 Select a Box STEP 2 Select a Procedure Note: There is no limit to the number of procedures that may be stored in the MPC directory; however, the number displayed in this window can be easily managed with Trans IV. STEP 3 Add Optional IDs, a Comment Line, and Custom File Name, if desired 130

137 STEP 4 Review Choices STEP 5 Enter User Defined Variable Values STEP 6 Repeat Steps 1 5 When box selection is completed, the wizard will proceed to the run time screen with or without issuing a start command. The Run Time Display is, in many ways, similar to earlier versions of Windows MED-PC (WMPC ) and will be easily recognized by seasoned users. The screen is divided into a Status Area, displaying the subject, group, and experiment information, time loaded, and procedure loaded for each box; the Output Area, displaying the status of all outputs; and the Show Area, displaying user-defined information on the experiment. The major improvements to the run time display are that each of these areas may now be individually sized with user selected background and font colors, the output area will now display up to 80 outputs per box, and the show area can now display up to 200 data elements with what you see is what you get labeling from MedState Notation. Run Time Display SOFTWARE : MED-PC IV

138 SOF-731 : MPC2XL DATA TRANSFER UTILITY OS Compatibility: Windows 95/98, NT, 2000, XP and 32 bit Vista For All MED-PC Users INTRODUCING MPC2XL The purpose of this program is to create a fast and easy system for transferring the contents of MED-PC data files to Microsoft Excel spreadsheets, Microsoft Access databases, statistical programs, or virtually any other target. The editor lets you create a profile or template for the layout of transferred data. After a profile is created and saved, the profile can then be used to automatically transfer data to Excel or other targets. The creation of profiles is highly automated, yet very flexible. No programming is required. Any MED-PC data file may be transferred, regardless of the file naming scheme or the internal file format. There are two basic types of profiles that may be created. One is referred to as a row profile, and the other is known as a table profile. Row profiles organize the data from a session into a single spreadsheet row or column, table profiles create multiple rows and columns. CREATING AND EDITING ROW PROFILES Row profiles transfer data to Excel on a row-by-row basis. Every session that is transferred to Excel becomes a row in the spreadsheet. Excel spreadsheets are limited to 256 columns, but the number of rows is practically unlimited. The profile generator which may be easily edited as needed, automatically creates a sample profile. This format is useful for organizing data from many sessions so that summary statistics may be organized for analysis (shown at right). Formulas for summary statistics may be placed directly in the profile so the results are present the instant the data are transferred. CREATING AND EDITING TABLE PROFILES Table profiles may be used in a variety of ways to transfer data in a tabular format to Excel. Table profiles provide a great deal of flexibility, but are not created automatically from sample MED-PC data files in the same fashion as row profiles. There are three basic types of tables that can be created using the table editor: a freestyle table, a table style table, and a record style table. 132

139 FREESTYLE TABLES The simplest table is a Freestyle report that may be created by clicking the Freestyle button which creates a blank table. The right click menu may be used to paste special identifiers into profiles. The are two types of identifiers. One type corresponds directly to data retrieved from MED-PC data files. This includes the box and subject numbers and the year in which the session was started. The second type of identifier begins with an exclamation point and is constructed by MPC2XL from other identifiers. For example,!startdate and!enddate concatenate year, month and day into a single number, expressed YYYYMMDD format. For example, July 3, 1998 would be expressed as , depending upon whether the MSN code used to generate the data file contained the Y2KCOMPLIANT directive. The!CondensedStartTime and!condensed- EndTime functions create a single number reflecting HHMMSS. For example, 10:14:32 would be expressed as Descriptive labels are not automatically entered for identifiers. This allows you to place a descriptive label (or even no label) wherever desired. Figure 2 is an example of a spreadsheet created with the freestyle profile. TABLE STYLE TABLES The table profile style was designed to present trial-oriented data along with session identifying information (shown at right). Clicking the Create Table button creates this type of table. Session identifiers, as well as data, may be placed in the Header Titles and "Header Elements" rows. Header Titles may bear the same name as a data element or they may be different. A key aspect of data tables is the ability to systematically extract data from an array variable without the need to explicitly type in every data element that should appear in the table. This facility is ideal for creating tables displaying the results of trial-oriented sessions. Figure 3 displays data from a delayed non-match to sample protocol. This hypothetical session consists of five trials. For each trial, eight entries were made into array A : the trial number, trial duration, delay value, response tags, counts and latencies. RECORD STYLE TABLES Record tables are designed to transfer trial-oriented data to Excel with adequate descriptive information in each row so that the data in each row stands as an independent record. For example, including subject and date information in each row with trial data allows one to sort or to analyze all of the data for an entire experiment by these elements, perhaps broken down by ranges of dates or by subject subgroups. The key to producing this type of data structure is to place session identifiers, such as Subject, in the first few columns of the table, leaving the Increment and Last Column Element fields blank. The remaining columns contain data elements for each trial. This results in the identifier and data information being present in every row. Note that the transfer labels option should be unchecked when the data is transferred, except for the first time that data are transferred to a given sheet. This will ensure that only data are transferred once a header row has been placed in the spreadsheet. SOFTWARE : DATA TRANSFER UTILITY

140 SOF-722 : SoftCr-PRO CUMULATIVE RECORD GRAPHICAL SOFTWARE OS Compatibility: Windows 2000, XP and 32 bit Vista Our new version of SoftCr, SoftCr Pro, is fully compatible with MED-PC IV Build 51 and higher, (SOF-735) Schedule Manager (SOF-706), and SmartCr (SOF-726). Like the original SoftCr (SOF-721), it can display and/or print partial or complete cumulative records from data files created by the MED-PC, Schedule Manager or SmartCr systems. One significant improvement is cumulative records can be viewed on the same computer that is running MED-PC. SYSTEM HIGHLIGHTS Generates cumulative records in near real time on the same computer that is running MED-PC Can be set up to generate records on networked computers watch an experiment in progress in the lab from the compute in your office. Dynamic, on-screen scaling of the Y-axis and scrolling along the X-axis allow the user to focus on critical time periods of the cumulative record. At any time while reviewing a record, the user may print the screen or the entire record. Easy-to-use menus respond to keyboard entries, function keys, and mouse point-and-click commands. Displays up to 10 event pens that independently track responses and reinforcing events. Event pens may be used to mark a response, the beginning and end of code segments or stimulus durations. The edit parameters function allows the user to customize the display to best represent the features of the experiment. SoftCr-PRO FEATURES: Generate real time cumulative records on the same computer that is running MED-PC The ability to turn on or off trace lines and event pens. This allows the user to focus only on the data that are of the most importance. 134

141 SOF-721 : SoftCr CUMULATIVE RECORD GRAPHICAL SOFTWARE 4.0 OS Compatibility: Windows 98*, 2000 and XP The latest version of SoftCr is fully compatible with MED-PC IV, (SOF-735) Schedule Manager (SOF-706), and SmartCr (SOF-726). Like previous versions it can display and/or print partial or complete cumulative records from IRT data files created by the MED-PC, Schedule Manager or SmartCr systems. One significant improvement is a multi-trace feature that permits up to ten individual traces on the same X-Y axis with up to 10 event lines. SoftCr is compatible with four data formats. It features improved manipulation of data files, an automatic pop-up window for setting graph parameters, on screen menu options, sharper graphics and faster printouts on a wider variety of operating systems. Since the printing of large graphics files can be time consuming, SoftCr includes a userfriendly batch print utility. The total time required to select, display, and print all records is affected by the speed of the processor, access time of the hard drive, and speed and memory of the printer. Dynamic, on-screen scaling of the Y-axis and scrolling along the X-axis allow the user to focus on critical time periods of the cumulative record. At any time while reviewing a record, the user may print the screen or the entire record. Easy-to-use menus respond to keyboard entries, function keys, and mouse point-and-click commands. Displays up to 10 event pens that independently track responses and reinforcing events. Event pens may be used to mark a response, the beginning and end of code segments or stimulus durations. The edit parameters function allows the user to customize the display to best represent the features of the experiment. SOFTWARE : SoftCr PRO & SoftCr CUMULATIVE RECORD GRAPHICAL SOFTWARE

142 VERSION 4.0 NEW FEATURES The ability to turn on or off trace lines and event pens. This allows the user to focus only on the data that are of the most importance. The X and Y Axis can be set to either the standard Axis with Tick Marks or to a Scale that defines a specific time interval. Screen shots can now be saved as either a Windows Meta File (WMF) or a PDF file along with the original Bitmap option. The WMF* and PDF option allows the user to zoom in or out of the document without a loss in resolution. Graphs can now be printed to SoftCr s own PDF printer. This can save on paper and makes the graphs easily portable to other presentation files or web pages. The batch print utility option may also use the SoftCr PDF printer with each record being saved to its own unique file. * Large WMF files may not work with Windows 98. Great for producing cumulative records used as publication-quality figures (CR shown was exported as a WMF from SoftCr and final layout was produced in Adobe Illustrator). 136

143 MEDSTATE NOTATION PROCEDURES Med Associates has always offered MedState Notation code for those users who want to collect data immediately, without first learning this popular text-based language. Several of the more popular procedures resulted in inexpensive, standard catalog items. With the expanded features of MED-PC IV, we can now offer off-the-shelf MedState Notation source code that runs like an advanced custom application. The user will still have the ability to modify and/or expand upon the basic code; however, an operator having absolutely no programming skills may run the procedure and change key control parameters. The combination of MED-PC IV with a ready-to-run procedure produces the first behavioral control system that truly requires no programming-not even table programming, which may at first appear simple, but inevitably becomes more complex than a text based language such as MED-PC IV. SOF-700LA-1 : MedLab 8 Package This set of eight schedules, FR, FI, VR, VI, RR, RI, DISC, and CHAIN, was written for operant chambers with minimum configurations. Each MedState Notation procedure can be modified by the user to meet specific hardware or research requirements. This package is a useful supplement to the sample programs included with MED-PC, with state sets for session timing, response counting, and for creating IRT and event time arrays for a SoftCr cumulative record. SOFTWARE : MEDSTATE NOTATION PROCEDURES MEDLAB 8 PACKAGE

144 SOF-700LA-2 : Operant-Conditioning Lab Package This package consists of five MedState Notation procedures that are well suited for a research or student lab. Dr. Steven Dworkin designed these procedures. The procedures are for the following schedules: Fixed Ratio (FR x) Fixed Interval (FI x) Differential Reinforcement of Zero Responding (DRO) Inter-Response Time Less (IRT < x) Inter-Response Time Greater (IRT > x) The procedures all make use of MED-PC IV s named variables to make running and modifying the schedules very straightforward. For example, the Fixed Interval procedure uses the following named variables: Correct Lever (L=1 R=2) Reward (Pellet=1 Dipper=2 Drug=3) Reward Time (sec) Time Out Following Reward (sec) Session Time (min) Fixed Interval Value Maximum Reinforcers SoftCr Data Array (Yes=1 No=0) The trial data are conveniently stored in an array that prints out in a one row per trial format. Similar data are collected in all the procedures. For example, the data collected in the fixed interval procedure include: Total Responses Correct Response Count Incorrect Response Count % Correct % Incorrect Trial Number Correct Responses Incorrect Responses Pause Time (sec) Run Time (sec) SOFTWARE : MEDSTATE NOTATION PROCEDURES MEDLAB 8 PACKAGES AND OPERANT CONDITIONING LAB PACKAGE 138

145 SOF-700RA-1 : FR Training Procedure Install the FR Training Procedure and the Load Wizard presents a detailed list of session parameters. From this window, the user may select the left or right lever for reward, select an appropriate dispenser and reward time out if desired, determine the session time and ratio value, and turn the optional cumulative record data collection feature on or off. The default settings shown make the left lever correct with pellet reward. The dispenser is activated for 50 ms. Session time runs for 60 minutes with a fixed ratio of 1 and the SoftCr data array is activated. Any of these parameters may be easily changed to accommodate a number of standard operant and drug discrimination procedures. SOFTWARE : MEDSTATE NOTATION PROCEDURES OPERANT CONDITIONING & FR TRAINING

146 SOF-700RA-2 : Progressive Ratio Select the Progressive Ratio procedure and the Load Wizard presents a detailed list of session parameters. From this window, the user may select the left or right lever for reward, select an appropriate device for dispensing the reward and the reward time, set a time out following the reward if desired, set the session time, select between a step or list progressive ratio, set the starting value and step value for a step progressive ratio, set the progressive ratio frequency, and turn the optional cumulative record data collection feature on or off. Any of these parameters may be easily changed to accommodate a number of progressive ratio procedures. 140

147 SOF-700RA-5 : Intra-cranial Self Stimulation (ICSS) Procedures The following procedures have been replicated in MedState Notation code to run on MED-PC IV Behavioral Control Systems. This source code may be used as is, or modified by the user to meet specific research demands. REWARD.mpc is a discrete trial method of ICSS threshold measurement written originally for Dr. Conan Kornetsky, Boston University, School of Medicine. Five trial blocks are presented in descending order until the animal meets an established criteria followed by five trial blocks in ascending order. The default number of columns run in this manner is four. In the REWARD MPC procedure, contingent and non-contingent stimulations are equal. DETECTION.mpc holds the rewarding or response-contingent stimulation constant. Both are described in Kornetsky, Conan and Bain, George, Modern Methods in Pharmacology, Vol. 6, Testing and Evaluation of Drugs of Abuse, Brain-Stimulation Reward: A Model for Drug-Induced Euphoria, pp Custom MedState Notation is also available. For example, a stepwise titration of frequency procedure was written similar to: J.L. Moreau, F. Jenck, J.R. Martin, P. Mortas and W.E. Haefely, European Neuropsychopharmacology, 2, (1992), pp This is an FR1 schedule that holds current constant while frequency steps from 70 Hz to 30 Hz and back again in 10 Hz steps every two minutes. Another example is an autotitration of current procedure that holds frequency constant similar to: Geoffrey K. Mumford, Darryl B. Neill, and Stephen G. Holtzman, Brain Research, 459 (1988), pp This procedure requires two active levers. Starting current is set individually for each animal. One lever delivers stimulation that decreases 3 µa following every fifth reinforcement. The second lever resets the amplitude value back to the original starting current. SOFTWARE : MEDSTATE NOTATION PROCEDURES PROGRESSIVE RATIO & INTRA-CRANIAL SELF STIMULATION

148 SHUTTLE BOX PACKAGES SOF-700RA-7 : Shuttle Source Code Packages The shuttle source code package includes programs for active, passive, and active avoidance FR-2 procedures. ACTIVE The Shuttle Box Active Avoidance procedure is written for systems with eight I/R photobeam sensors, separate left and right light and tone, and either with or without an auto guillotine door. By default, each trial presents both stimuli for five seconds followed by a maximum 25 second aversive stimulation escape interval while the stimuli remain on. The mean ITI interval is 15 seconds and it presents 50 trials. The total session time is set at 60 minutes, however, given the above parameters the test will always end in less than an hour. Select the Shuttle Box Avoidance procedure and the Load Wizard presents a detailed list of session parameters. From this window, the user may set the number of trials to run, select the stimuli to use, set the avoid and escape intervals, enable the CS/UCS overlap and punish ITI crossings flags, and set the maximum session time. A row of data is created for each trial with the trial number, an avoid or escape tag with corresponding latency, left and right chamber activity, crossings, and punished crossings. A summary file includes total values as well as mean avoid and escape latency. PASSIVE The Shuttle Box Passive Avoidance procedures are written for systems with eight I/R photobeam sensors. The training procedure features a 180 second trial, measuring the activity on the light side, latency to the dark side, aversive stimulation delay, and aversive stimulation duration. The test procedure also features a 180 second trial, measuring the activity on the light side and the latency to the dark side. No aversive stimulation is administered during the test procedure. Shuttle Box Active Avoidance FR-2 Shuttle Box Active Avoidance FR-2 program consists of five blocks. By default, the first block is a 5 minute acclimation period, the second block is two FR-1 trials, the third block is a 20 minute observation period, the fourth block is three FR-1 trials, and the fifth block is 25 FR-2 trials, however the duration of each block may be user defined. Setting the duration of a block to zero will cause that block to be skipped, allowing the user to run an FR-2 program without any FR-1 trials or observation periods. By default, each trial presents both stimuli for 5 seconds followed by a maximum 25-second aversive stimulus escape interval while the stimuli remain on. The mean ITI is 15 seconds and the program has a maximum session of time of 60 minutes. The user can also select which stimuli to use, the avoid and escape times, enable the CS/UCS overlap, set the session time, and enable punish ITI crossings. 142

149 All data collected includes trial count, FR value, avoids, avoid latency, escapes, escape latency, left movement, right movement, crossings, and ITI aversive stimuli. Data is collected for each trial on a trial-by-trial basis, and summary data is collected for total FR-1 and FR-2 trials. SOF-700RA-11 : Shuttle Box Step Down Protocols The Shuttle Box Step Down Protocols procedures are written for systems with eight I/R photobeam sensors. The platform should be placed so the subject steps into the right side when stepping down off the platform. In the training procedure, delay to aversive stimulation onset is 0.001" seconds, aversive stimulation duration is 2 seconds, no response time is 180 seconds, and the inter-trial interval is 120 seconds. In the test procedure, no response time is 180 seconds, and the inter-trial interval is 120 seconds. No aversive stimulation is used in the test procedure. The data collected in both procedures are the trial numbers and the response latencies. SOFTWARE : MEDSTATE NOTATION PROCEDURES SHUTTLE BOX PACKAGES SHUTTLE SOURCE CODE & SHUTTLE BOX STEP DOWN PROTOCOLS

150 SOF-700RA-8 : Nine Choice Serial Reaction Time Task In the Nine Choice Serial Reaction Time Task, the subject is required to respond to brief flashes of light presented randomly in one of nine spatial locations. Testing begins with the onset of the house light and the pellet or dipper receptacle light. A head entry issues a free reward presentation and initiates the session timer. Following the reward interval, an ITI is activated for the first trial. Nose poking during the ITI results in a time out and is recorded as a premature response. Stimulus time outs also occur following an incorrect response, or following an error of omission (failure to respond within the limited hold interval). By default this procedure runs for 90 trials or 30 minutes, starting with a fixed ITI interval of 5 seconds and fixed stimulus presentation of 0.5 seconds. Both can be randomized by adding to the LIST statements in the MedState Notation code. The time to respond (limited hold) is 5 seconds and premature responses add a 5 second time out before repeating the ITI. Incorrect responses or errors of omission also add a 5 second time out before starting a new trial. Responses during the time out reset the time-out timer. Twenty elements of data are documented for each trial. Summary data includes correct responses, incorrect responses, omissions, premature responses, perseverant responses, time out responses, total receptacle head entries, percent correct, percent incorrect, percent omission, average latency to correct responses, average latency to incorrect responses, and average latency to reward. 144

151 SOF-700RA-8A : Five Choice Serial Reaction Time Task In the Five Choice Serial Reaction Time Task, the subject is required to respond to brief flashes of light presented randomly in one of five spatial locations. Testing begins with the onset of the house light and the pellet or dipper receptacle light. A head entry issues a free reward presentation and initiates the session timer. Following the reward interval, an ITI is activated for the first trial. Nose poking during the ITI results in a time out and is recorded as a premature response. Stimulus time outs also occur following an incorrect response, or following an error of omission (failure to respond within the limited hold interval). By default this procedure runs for 50 trials or 30 minutes, starting with a fixed ITI interval of 5 seconds and fixed stimulus presentation of 0.5 seconds. Both can be randomized by adding to the LIST statements in the MedState Notation code. The time to respond (limited hold) is 5 seconds and premature responses add a 5 second time out before repeating the ITI. Incorrect responses or errors of omission also add a 5 second time out before starting a new trial. Responses during the time out reset the time-out timer. Sixteen elements of data are documented for each trial. Summary data includes correct responses, incorrect responses, omissions, premature responses, perseverant responses, time out responses, total receptacle head entries, percent correct, percent incorrect, percent omission, average latency to correct responses, average latency to incorrect responses, and average latency to reward. SOFTWARE : MEDSTATE NOTATION PROCEDURES NINE & FIVE CHOICE SERIAL REACTION TIME TASK

152 SOF-700RA-10 : Drug Self Infusion Select the Drug Self Infusion procedure and the Load Wizard presents a detailed list of session parameters. From this window, the user may set the fixed ratio setting, session time, maximum number of infusions, a time out following the infusion if desired, infusion time, and turn the optional cumulative record data collection feature on or off. Any of these parameters may be easily changed to accommodate a number of drug self infusion procedures. The default procedure has the right lever active, although data is collected on both levers. The house light is on throughout the procedure, the stimulus light above the right lever is turned on when the procedure enters the fixed ratio component and is turned off during the time out. Data collected include the number of right and left lever responses during the fixed ratio, infusion, and time out, the time in the fixed ratio, number of infusions, and the number of right lever responses per minute during the fixed ratio. 146

153 SOF-808 : Force Lever The Force Lever Software receives voltage feedback from the lever. The range of this voltage is 0 V when there is no force on the lever, to 10 V when the lever is pressed down completely. This voltage will be referred to as a threshold value. The user may set the low, high and limit threshold values, as well as the maximum time to complete response, minimum and maximum duration above high threshold and whether or not to reward partial responses. The default session length is 10 minutes. SOFTWARE : MEDSTATE NOTATION PROCEDURES DRUG SELF INFUSION & FORCE LEVER

154 SOF-700RA-18 : Variable Schedule This is a Variable Schedule program written for MED-PC IV. Through a series of LIST statements the user is allowed to select between Fixed Ratio (FR), Fixed Interval (FI), Variable Ratio (VR), and Variable Interval (VI) Schedules to run. The LIST statements allow the user to select what the values for each schedule type will be, how long each schedule/trial will run, how long the interval between each schedule/trial is, and which Lever is the correct lever for that trial by use of the stimulus location. The correct lever and the stimulus location must match. For each trial there is a precs and a CS period. The precs and CS period are always the same length. The correct response(s) on the correct lever during either period gives a reward. There is no reward given during the Inter-Trial Interval (ITI) or the pre/post adapt periods. Any responses during the precs period are discarded when the CS period starts. So if the program is running an FR-10 schedule and the animal has four responses when the program switches to the CS period, the four responses are discarded and the animal must start over to meet the FR-10 schedule. The same schedule is run during the precs and CS periods (i.e. A VR-5 is run during the precs and then restarted during the CS period). SOF-700RA-22 : Lick Suppression The Lick Suppression MED-PC Application allows the animal to freely lick from the sipper tube. After a certain number of licks (defined by the variable Fixed Ratio Value) the animal is given an aversive stimulus. The duration of the aversive stimulus is user defined. 148

155 SOF-706 : SCHEDULE MANAGER The included Schedule Manager routines allow researchers to teach students about key concepts in experimental analysis of behavior. By presenting a reinforcement every time a fixed number of responses are made, Fixed Ratio (FR) Schedules demonstrate how response rates will vary when the subject has direct control over the rate of reinforcer presentation. Fixed-Interval (FI) Schedules arrange for delivery of a reinforcer following the first response that occurs after the passage of a fixed-specified time period. This type of schedule allows the experimenter to control the inter-reinforcement interval. Variable-Ratio (VR) and Random-Ratio (RR) Schedules allow the researcher to vary the number of responses required to deliver a reinforcer, either in a pre-defined manner (VR) or using a software random number generator (RR). These schedules are usually associated with the highest rate of subject responses. Variable-Interval (VI) and Random-Interval (RI) Schedules allow the researcher to vary the time period that must elapse before the next response results in delivery of a reinforcer, either in a pre-defined manner (VI) or using a software random number generator (RI). VI and RI schedules are usually associated with low response rates. SOFTWARE : MEDSTATE NOTATION PROCEDURES VARIABLE SCHEDULE, LICK SUPPRESSION & SCHEDULE MANAGER

156 INPUT AND OUTPUT FROM MEDSTATE NOTATION SOF : Graphics Display Routines OS Compatibility: Windows 2000, and XP and 32 Bit Vista The MED-PC Graphics Display Routines program can create up to 32 windows on 32 different monitors. The program can only create one graphics window per monitor. Each graphics window is capable of showing one bitmap or being flooded with one solid color. When a bitmap is displayed it is expanded to fill the entire window so if the picture resolution (size/shape/location) is important, then the bitmap should be the same dimensions as the monitor. Program functions allow the user to control when the graphics window is displayed and what bitmap/color is displayed on the graphics window. This program is useful in cases where you want a specific visual stimulus to be displayed on a computer screen. 150

157 SOF : WAV File Player OS Compatibility: Windows 2000, and XP and 32 Bit Vista The WAV File Player allows for either positive or negative reinforcement using sound through the PC s sound system (sound card). The included program contains one negative reinforcement sound and five positive reinforcement sounds. The positive reinforcement sound to be played is chosen randomly each time the animal gets a reward. The animal receives a reward on a Fixed Ratio schedule. The user may select if the left or right lever is the correct lever. Program default values assign the left lever as the correct lever, a Fixed Ratio value of 1, and a session time of 60 minutes. The user can modify the program so that it plays their own WAV files rather than the ones provided with the program. Furthermore, the program can be modified to use sound as a stimulus or reinforcer in many other ways. For example, the user could set up a protocol to play a WAV file when the animal enters a specific side of a shuttle box. SOFTWARE : INPUT & OUTPUT FROM MEDSTATE NOTATION GRAPHICS DISPLAY ROUTINES & WAV FILE PLAYER

158 SOF : Control of Med Input/Output Modules From Other Languages OS Compatibility: Windows 2000, XP and 32 Bit Vista Control Med Associates Input and Output Devices from a Range of Programming Languages For users who desire the power and flexibility of our interface modules, but do not want to use MED-PC as a programming environment, we are pleased to offer our new software Control of Med Input/Output Modules from Other Languages (SOF-732-3). Our new interface API provides the user with the ability to communicate with the interface using a range of programming languages. Modules and header files provided for use with: Visual Basic 6.0 Delphi C++ Full documentation, including function declarations and programming syntax, is provided. A sample Visual Basic 6.0 project is also included to demonstrate a simple I/O control user interface. 152

159 SOF-710 : Animal Food Intake Monitor OS Compatibility: Windows 2000, XP and 32 Bit Vista Now you can quantitatively measure food intake in rats and mice in chronic studies. Key Features: Software measures food intake using a standard pellet feeder and infrared beam to detect food pellets. Food intake can be displayed graphically in real time in various formats: Number of pellets consumed. Weight of food consumed. Average meal duration. Average time between meals.... and many more Data can be binned according to various criteria such as light/dark periods. Perfect for: Circadian Studies Nutritional Studies Phenotype Characterization General Animal Monitoring SOFTWARE : INPUT & OUTPUT FROM MEDSTATE NOTATION CONTROL OF MED INPUT/ OUTPUT MODULES FROM OTHER LANGUAGES & ANIMAL FOOD INTAKE MONITOR

160 PRODUCTS INDEX NUMERIC product # page(s) product # page(s) product # page(s) product # page(s) ANL ENV-009A 28 ENV-119M-2 48 ENV-203M-45IR 72 ANL-929A-PC 57 ENV-009A-GF 28 ENV ENV-203P 106 ANL ENV-010A 39 ENV-123A-C 98 ENV-205M 99 COM-103A-GP 3 ENV-010B 39 ENV-123A-O 98 ENV-210M 60 DIG-700P2 113 ENV-010C 39 ENV-123AM 98 ENV-215M 43 DIG-703A 118 ENV-010M ENV-124AM 98 ENV-221CL 43, 103 DIG-703B 118 ENV-010MA-GF 37 ENV-125M 99 ENV-221M 50 DIG ENV-010MA-QD 38 ENV-135M 56, 99 ENV-222M 50 DIG-711A 119 ENV-010MB-GF 37 ENV ENV DIG ENV-010MB-QD 37 ENV-200FC 61 ENV-223AM 55 DIG-712F 119 ENV-010MC 36 ENV-200FCW 61 ENV-223HAM 55 DIG-713A 120 ENV-010MD 36 ENV-200FCW-D 61 ENV-224AM 57 DIG ENV-010P-M 36 ENV-200R1AM 60 ENV-224BM 58 DIG-716B 114 ENV-010P-R 36 ENV-200R1M 59 ENV-224CM 58 DIG-716P1 113 ENV-016MD 41 ENV-200R1M-6 59 ENV-225SM 59 DIG-716P2 114 ENV-017M 41 ENV-200R2M 59 ENV DIG-716P3 116 ENV-018MD 40 ENV-200R2M-6 59 ENV-226A 51 DIG-716P3F 116 ENV-018V 40 ENV-200R3AM 65 ENV-226B 51 DIG ENV-020M 41 ENV-200R3BM 65 ENV-227M 43 DIG ENV-022MD 41 ENV-200R3M 65 ENV DIG-722A 121 ENV-022S 41 ENV-200R6 106 ENV DIG ENV-022V 40 ENV-200R ENV-250A 68 DIG ENV-025F28 42 ENV-200R7 60 ENV-250B 68 DIG-726TTL 121 ENV-025FAC 42 ENV-200RL 60 ENV-250C 68 DIG-745ADC 122 ENV-025WM 42 ENV-201A 64 ENV-250RM 69 ENV ENV-025WM-F 42 ENV-202C 63 ENV-250S 68 ENV-005-QD 25, 81 ENV-027-XX 42 ENV-202C6 63 ENV-251-LIM 67 ENV-005A 25 ENV-110M 44 ENV-202M-S 62 ENV-251FM 70 ENV-005A-QD 25, 81 ENV-110RM 44 ENV-202RM-S 63 ENV-251L 69 ENV-005P 98 ENV ENV-202RMA 63 ENV-251M 69 ENV ENV-111C 46 ENV ENV-252-LIM 67 ENV-007-FP 24 ENV-112CM 44 ENV P 73 ENV-252A 66 ENV-007-P3 26 ENV-113AW 49 ENV , 105 ENV-252M 66 ENV-007-VP 24 ENV-113M 49 ENV IR 74, 105 ENV ENV-007A3 26 ENV-114AM 47 ENV ENV-253B 77 ENV-007A3D 26 ENV-114BM 47 ENV , 105 ENV-253C 39 ENV-007CT 24 ENV-114M 46 ENV IR 75, 105 ENV-253SD 76 ENV ENV-115A ENV ENV-254-CB 77 ENV-008-FP 23 ENV-115A ENV IR 72 ENV-256-8S 38 ENV-008-VP 22 ENV-115C 27 ENV ENV-256I 76 ENV-008CT 22 ENV-116M 44 ENV IR 74 ENV-256I-8 76 ENV-008CTC 23 ENV-116RM 45 ENV-203-MINI 75, 106 ENV ENV ENV ENV-203M ENV-275-BP 53 ENV-009-GF 28 ENV-119M-1 48 ENV-203M ENV-275-F

161 PRODUCTS INDEX NUMERIC product # page(s) product # page(s) product # page(s) product # page(s) ENV-275-NPP 52 ENV-323AM 55 ENV-NPW-9L 27 PHM-100A 88 ENV-302HD 64 ENV-323AW 55 ENV-NPW-9M 27 PHM-100VS 89 ENV-302M-S 63 ENV-323HAM 55 MED-007-B1 5 PHM-100VSA 89 ENV-302RL-1 64 ENV-323HAW 55 MED-007-CT-B1 15 PHM-100VSDT 89 ENV-302RL-2 64 ENV-324M 58 MED-007-CT-D1 16 PHM ENV-302RM-S 64 ENV-324W 58 MED-007-D1 6 PHM-102A 90 ENV-302RW-S 64 ENV-325SM 59 MED-007-P1 97 PHM-104A 91 ENV-302W-S 63 ENV-325SW 59 MED-007-PR1 97 PHM ENV-303HDM 62 ENV-335M 56 MED-008-B1 4 PHM ENV-303HDW 62 ENV-335W 56 MED-008-CT-B1 14 PHM ENV-303LP 65 ENV-350CW 69 MED-008-CT-B3 17 PHM ENV-303LPHD 66 ENV-351W 70 MED-008-CT-B4 18 PHM-110-SAI 82 ENV-303M 61 ENV-352AW 66 MED-008-CT-D1 15 PHM-111-EC 95 ENV-303RL 62 ENV-352W 67 MED-008-D1 5 PHM ENV-303W 61 ENV-375-BP 53 MED-307A-B1 7 PHM-115I 83 ENV-307A 29 ENV-375-F 53 MED-307A-CT-B1 19 PHM-115IP 83 ENV-307A-CT 29 ENV-375-NPP 52 MED-307A-CT-D1 20 PHM-119B ENV-307A-FP 30 ENV-406A 37 MED-307A-D1 8 PHM-119B-21-D 82 ENV-307A-GF 30 ENV-406AM 38 MED-307W-B1 8 PHM-119B ENV-307A-QD 81 ENV-410B 78 MED-307W-CT-B1 20 PHM-119B-23-D 82 ENV-307W 31 ENV MED-307W-CT-D1 21 PHM-120A 85 ENV-307W-CT 31 ENV MED-307W-D1 9 PHM-120C 85 ENV-307W-FP 32 ENV MED-600-B1 101 PHM ENV-307W-GF 31 ENV-414S 80 MED-601-B1 100 PHM ENV-307W-QD 81 ENV-414SA 80 MED-601-D1 101 PHM-123C 83 ENV-310M 45 ENV MED-APA-B1M 35 PHM-123D 84 ENV-310W 45 ENV-416S 80 MED-APA-B1R 34 PHM-123P 84 ENV ENV MED-APA-D1M 35 PHM-124B 87 ENV-312-2M 45 ENV-600A 103 MED-APA-D1R 34 PHM-124C 87 ENV-312-2W 45 ENV-600R 103 MED-NP5L-B1 10 PHM-124MA 87 ENV-313M 47 ENV-601A 102 MED-NP5L-D1 11 PHM-124MW 87 ENV-313W 47 ENV-601FP 102 MED-NP5M D1 11 PHM-125B 84 ENV-314M 47 ENV MED-NP5M-B1 11 PHM ENV-314W 47 ENV-610M 104 MED-NP9L-B1 12 PHM ENV-315M 43 ENV MED-NP9L-D1 12, 13 PHM-127A ENV-315W 43 ENV-612M 104 MED-NP9M-B1 13 PHM-127A ENV-316M 48 ENV-621L-GR 104 MED-NP9M-D1 13 PHM ENV-316W 48 ENV-621L-RD 104 MED-OLF-5NPM 54 PHM ENV-321DM 50 ENV-321DW 50 ENV-321M 50 ENV-321W 50 ENV-322M 51 ENV-322W 51 ENV-621L-WH 104 ENV-622M 105 ENV-652AM 107 ENV-652FM 107 ENV-652M 107 ENV , 106 MED-OLF-5NPR 54 MED-SPI MED-SPI MED-SYST-16 3 MED-SYST-8 3 PHM PHM PHM PHM PHM PHM-150B 96 PHM-150B/2 96 INDEX NUMERIC

162 PRODUCTS INDEX NUMERIC product # page(s) product # page(s) product # page(s) product # page(s) PHM SG-216A SG SOF-700RA PHM-152/2 96 SG-216A SG-590A 111 SOF-700RA PHM-155A 96 SG-216C 124 SG SOF-700RA PHM-155B 96 SG-216C1 124 SG SOF-700RA PHM-155C 96 SG-219C SG-6010A 110 SOF-700RA PHM-155D 96 SG-219D 79 SG-6080C 109 SOF-700RA PHM SG-219G SG-6080D 108 SOF-700RA PHM SG SG-6081C 109 SOF-700RA SG SG-230R 125 SG-6081D 108 SOF-700RA-8A 145 SG-210A 123 SG-230RC 126 SG SOF SG-210CB 115, 123 SG SG SOF SG-210CB SG SG SOF SG-210CP , 124 SG SG-6510D 109 SOF SG-210CP-8 115, 124 SG-500T 111 SG-651ODA 109 SOF SG-211F 123 SG SG SOF SG-213F 123 SG-501A 111 SG-716B 115 SOF SG-215D3 122 SG SG-716D 122 SOF SG-215D4 123 SG SG-716D2 122 SOF SG-216A 124 SG SOF-700LA SOF SG-216A SG SOF-700LA SG-216A SG-506A 111 SOF-700RA

163 PRODUCTS INDEX ALPHABETIC product name page(s) product name page(s) AC Fan Option 42 Cables Ad Lib Feeding Food Cup for Rat 61 BNC Output Cables 96 Additional Power Supplies and Accessories 111 DB-15 Control Cables 79 Advanced Syringe Pumps 95 Hand-Held Push Button Cable 125 Analog-to-Digital Interface Package 122 Interface Cables 123 Animal Food Intake Monitor Software Pin Mini-Molex Extension Cables 124 Arm Assembly with Gimbal Ring 82 Power Cables 115, 124 Audio Stimulus 55 Shock Output Cable 79 Audio Generators 56, 57 Universal Cable 115, 123 Auto Guillotine Door 39 Cables and Connection Panels 122 Aversive Stimulation Current Test Package 81 Cage Speakers 57, 58, 59 Aversive Stimulators 78 Cage Tweeter for Rat 58 Back Mounted Receptacle Light for Mouse 64 Ceiling Mount House Light 43 Back-Mount Cannula Connector Pedestal 86 Ceiling Mount Speaker and light 58 Behavior Test Packages 3-21, 100, 101 Center Channel Modular Shuttle Box 36 Behavioral Test Packages Chain Pull Response 46 Basic Classic Modular Mouse Chambers and Accessories Drug Self Administration for Mouse 19, 20 Clear Pigeon Key 99 Drug Self Administration for Rat 14, 15 Clicker Module 56, 99 Five Hole Nose Poke Wall 10, 11 Components for Pigeon, and Small Primate Test Packages 98, 99 Mouse 7, 8 Components for Primate Test Packages Nine Hole Nose Poke Wall 12, 13 Computer-Controlled Constant Current Aversive Stimulation 79 Oral Drug Self Administration for Rat 17, 18 Computers 3 Pigeon or Small Primate 97 Connection Panels 114, 115, 122, 123 Primate 97, 100 Contact Lickometer Controller 67 Primate (Large) 101 Control of Med Input/Output Modules from Other Languages Software 152 Rat 4, 5 Cover Insert for Drug Infusion Tops 23 Shuttle Avoidance Cubicles and Cubicle Accessories Deluxe Entry Ramp for Large Primate 103 Drug Self Administration for Mouse 20, 21 Expanded PVC and Melamine Viewing Window Option 42 Drug Self Administration for Rat 15, 16 Large Primate 103 Five Hole Nose Poke Wall for Mouse 11 MDF for Rat Place Preference 41 Five Hole Nose Poke Wall for Rat 11 Pull-Out Drawer Options 42 Mouse 8, 9 Single MDF Door with Full Viewing Window 42 Nine Hole Nose Poke Wall for Mouse 13 Sound Attenuating 40, 41 Nine Hole Nose Poke Wall for Rat 12 Cumulative Record Graphical Software 134 Shuttle Avoidance Cumulative Record Graphical Software Primate 101 Cup Type Pellet Receptacle for Rat 59 Rat 5, 6 Dacron Mesh Tether 84 Ceiling Mount House Light 103 DC to TTL Adapter 28 V 126 BNC Adapter 96 Deep Extra Tall MDF Sound Attenuating Cubicle 40 BNC Output Cable 96 Delayed Onset Power Strip 111 Bulkhead Ports 53 Deluxe Operant Behavior Test Packages (see Behavioral Test Packages) Cabinets and Chassis DB-15 Control Cables 79 INDEX ALPHABETIC

164 PRODUCTS INDEX ALPHABETIC product name page(s) product name page(s) Dilution Olfactometer 52 Five Hole Nose Poke Wall with Stimulus Lights for Rat 26 Dipper Cups, Set of Five 63 Floors Dipper with Dual Pellet Receptacle for Mouse Chambers 64 Stainless Steel Grid 25, 28, 30-31, 37-38, 98 Dispensers Waste Pans 26 Liquid 64 Foam-Lined Acoustic Cubicle with Viewing Port 41 M&M s 75, 106 Food Intake Monitors for Rat 61 Peanut Dispenser 106 Force Levers 45 Pellet 72-75, 106 Force Lever Software 147 Disposable Plastic Swivel Assembly 83 Force Lickometer 70 Disposable Waste Pan 26 Four Bay Modular Test Chamber 28 Double Rack Mount Enclosure 112 Four Channel I/R Controller 76 Drug Delivery for Rat 82 Four Level Fader Control 51 Drug Delivery line 84 FR Training Procedure Software 139 Drug Delivery Tops 22, 24, 29, 31 Gauge Swivel 87 Drug Self Infusion Software 146 Gerbrands Style Extra Thick Response Lever 44 Dual A/B Scrambler Control 78 Grain Feeder for Pigeons 99 Dual AC Outlet 121 Graphics Display Routines Software 150 Dual Channel Modular Shuttle Box 36 Hand-Held Push Button Cable 125 Dual Contact Lickometer Controller 68 Head Entry Detectors Dual Cup Receptacle with Liquid Pipes for Rat 65 Mouse Liquid Dipper Receptacles 64 Dual Feeder Y Tube 60 Mouse Pellet Receptacles 62 Dual Pellet Receptacles 63 Rat Receptacles 77 Dual Programmable ICSS Stimulators 96 Head Mount Cannula Connector Pedestal 85 Dual Range Constant Current Aversive Stimulation Source 78 High/Low Speed Precision Microliter Syringe Pump 91 Dual Stimulus Display for Mouse Chambers 50 Holding Cage for Saline Infusion 84 Dust cap 86 House Lights 43 Eight Channel I/R Control for Shuttle 39 I/R Controllers 76 Enclosures for Rack Mount Power Supplies 112 ICSS Stimulators and Accessories 96 Entry Ramp for Large Primate Cubicle 103 Illuminated Nose Poke Response 47 Expanded PVC and Melamine Viewing Window Option 42 Individual Infrared Source and Detector 76 External Pellet Cup for Rat 60 Interface Extra Large Dipper Cup 63 Cabinets Extra Large MDF Cubicle 41 Cables 122, 123 Extra Tall Expanded PVC Sound Attenuating Cubicle 40 Connection Package 113 Extra Tall Modular Operant Test Chambers 23, 24 Modules and Components 119, 120, 121 Extra Wide MDF Cubicle 41 Intra-cranial Syringe Pump 94 Fader Control and Cable Package 116 Intra-cranial Self Stimulation (ICSS) Software Procedures 141 Fan Options 42 Input Modules 119 Filler Panel Packages 23, 24, 30, 32, 102 Large Primate Cubicle 103 Five Bay Modular Test Chamber 28 Large Primate Intelligence Modular Cabinet 103 Five Bay Stainless Steel Grid Floor 28 Large Rodent Pecking Key 48 Five Choice Serial Reaction Time Task Software 145 Large Tabletop Cabinet and Power Supplies 109 Five Hole Nose Poke Wall with Olfactory Stimulus 54 Leashes and accessories 85 Five Hole Nose Poke Wall with Stimulus Lights for Mouse

165 PRODUCTS INDEX ALPHABETIC product name page(s) product name page(s) Levers Mini M&M s Dispenser 75, 106 Force 45 Mini-Molex Extension Cable (3-Pin ) 124 Gerbrands 44, 45 Modified Leash Assembly 85 Primate 104 Modular Chamber Exhaust Fans 53 Retractable 44, 45 Modular Chambers 22-24, 27-29, 31 Rolled 44 Modular Guillotine Door for Rat Receptacles 60 Standard Response 44 Modular Mouse Operant Conditioning Chamber 29 Ultra Sensitive 45 Mouse Drug Delivery 87 Lick Suppression Software 148 Mouse Liquid Receptacle with Pipe 65, 66 Lickometers Mouse Volumetric Drinking Tubes 71 Controllers 67, 68 MPC2XL Data Transfer Utility Software 132 Force 70 Multi-Axis Lever Arm for Mouse Chambers 87 Grid Switch 68 Multiple Tone Generator 57 Light Pipe with Photobeam Controllers 69, 70 Multipurpose Sound Generator 57 Lights Nine Choice Serial Reaction Time Task Software 144 Back and Top Mounted for Mouse 64 Nose Poke Port Options 52 Ceiling Mount House 43 Nose Poke Response 46, 47, 48 Dual Stimulus Display for Mouse Chambers 50 Nose Poke Walls 26, 27 House 43 Olfactory Column Saturator 53 Primate Stimulus 104 Olfactory Stimulus Components 52, 53 Receptacle 60, 64 Olfactory Stimulus Package 52 Stimulus 50, 104 Omnidirectional Ceiling Rods 46 Triple Stimulus Display 50, 51 Opaque Cover 39 Triple Stimulus Display Primate 105 Opaque Pecking Key for Mouse Chambers 48 Light Detector 49 Operant Behavior Test Packages (See Behavioral Test Packages) Light Pipe Lickometer with Photobeam Controllers 69, 70 Pedestal Mount Pellet Dispenser for Rat 72, 74 Lindsley Manipulandum 104 Operant-Conditioning Lab Package Software 138 Liquid Ordering Information/Warranty iii Dippers, Dipper Cups 62, 63 Passive Connection Panels 122, 123 Dispensers, Drop Type 64 PCI ADC and Transducer Interface Package 122 Force Lickometer 70 Peanut Dispenser 106 Intake Monitors 67 Pellet Dispensers 72-75, 106 Liquid Dipper for Rat 62 Pellet Receptacles Sippers 66, 67, 107 Cups 59, 60, 61, 63, 65 Volumetric Drinking Tubes 71 Dual Pellet/Dippers 63, 64 Water Bottle and Sipper Tube 69 Dual Feeder Y Tube 60 Low Profile Retractable Response Lever 44 Light 60, 62, 64 M&M s Dispenser 75, 106 Mouse Chambers 61 Manual Guillotine Door 39 Pellet Receptacles and Accessories 59 MDF Cubicle for Rat Place Preference 41 Trough Type Pellet 59 MED-PC IV Software Gram 106, 107 MedLab 8 Package mg 60 MedState Notation Procedures Photobeam Sensors 76 Microprocessor Digital Timer 87 Pigeon Keys 98, 99 INDEX ALPHABETIC

166 PRODUCTS INDEX ALPHABETIC product name page(s) product name page(s) Pivot Floor Shuttle Box 36 Rolled Lever 44 Plastic Swivel Assembly 82 Schedule Manager Software 149 Polysulfone Button and Spring 87 Scramblers Polysulfone Tether 84 Dual A/B Control 78 Power Cables 124 Standalone Adversive 80 Power Supplies 111, 112 Self-Administration Power, Control and Interface Equipment Arm Assembly with Gimbal Ring 82 Primate Cover Insert for Drug Infusion Tops 23 Cubicle/Ramp 103 Drug Delivery 82, 87 Chair Filler Panel Package 102 Drug Self Infusion Software 146 Intelligence Modular Cabinet 103 Head Mount Cannula Connector Pedestal 85 Stimulus Light (Red, White, Green) 104 Leashes and Accessories 85, 86 Programmable Audio Generator 56 Modified Leash Assembly 85 Programmable ICSS Stimulators 96 Multi-Axis Lever Arm for Mouse Chambers 87 Progressive Ratio Software 140 Polysulfone Button and Spring 87 Pull-Out Drawer Options 42 Swivel and Clamps 82, 83, 87 Pumps Tethers 84 Advanced Syringe Pumps 95 Shock Output Cable 79 High/Low Speed Precision Microliter Syringe 91 Shuttle Box Intra-cranial Syringe 94 Auto Guillotine Door 39 Single Speed Safety Syringe 93 Avoidance Test Packages 33, 34, 35 Single Speed Syringe Pumps 88 Chambers 36 Triple Infusion 90 Eight Channel I/R Control for Shuttle 39 Variable Infusion Rate Syringe 92 Grid Floor 37 Variable Speed Syringe 89 Grid Floor Harness 37, 38 Quick Disconnect Harness 25, 37, 38, 81 Hurdle 39 Rack Mount Manual Guillotine Door Volts DC Power Supply 112 Modular Shuttle Boxes 36 Enclosures 112 Opaque Cover 39 Interface Chassis 110 Photobeam Sensors 38 Relay Rack 112 Pivot Floor Shuttle Box 36 Rat Volumetric Drinking Tubes 71 Shuttle Box Avoidance Software Packages 142, 143 Receptacle Light for Rat 60 Shuttle Grid Floor Harness 37 Relay Output Module 121 Shuttle Source Code Packages 142 Relay Rack 112 Shuttle Box Step Down Protocols 143 Response Lever 44 Single Channel I/R Source, Detector, and Control 77 Response Wheels 49 Single Cup Receptacle with Liquid Pipe for Rat 65 Retractable Gerbrands Style Extra Thick Response Lever 45 Single MDF Door with Full Viewing Window 42 Retractable Primate Lever 104 Single Rack Mount Enclosure 112 Retractable Sippers 66, 67, 107 Single Speed Safety Syringe Pump 93 Retractable Ultra Sensitive Levers 45 Single Speed Syringe Pumps 88 Reusable Waste Pan 26 Sipper with Lixit Valve and Solenoid Primate 107 Rodent Nose poke Response Keys 48 Small Modular Primate Test Chair 102 Rodent Pecking Key 48 Small Tabletop Cabinet and Power Supplies

167 PRODUCTS INDEX ALPHABETIC product name page(s) product name page(s) SmartCtrl Packages 113, 114 Test Chambers continued Filler Panel Packages 23, 24, 30, 32 Connection Panel 114, 115 Five Bay Modular Test Chamber 28 Interface Modules 114 Four Bay Modular Test Chamber 28 Power Cables 115 Modular Mouse Operant Conditioning Chamber 29 SoftCr Pro and SoftCr Software 134, 135 Nine Hole Nose Poke 27 Software Small Modular Primate Chair 102 Solid State Grid Floor Scrambler 78 Standard Modular Rat 22 Sonalert Modules 55 Wide Modular Mouse 31 Sound Attenuating Cubicles 40, 41 Tether Clamp 83 Sound Pressure Measurement 57 Tethers 84 Speakers 57, 58, 59 Three Channel Light Control 51 Square Wave Aversive Stimulator 80 Top Mounted Receptacle Light for Mouse 64 Stainless Steel Grid Floor Triple Contact Lickometer Controller 68 Five Bay Grid 28 Triple Cue Nose Poke Response Chambers 47 Mounting Screws 86 Triple Infusion Pumps 90 Mouse 25, 30, 31, 37 Triple Rack Mount Enclosure 112 Pigeon 98 Triple Stimulus Display Rat 25, 37 Primate 105 Small Primate 25 Mouse 51 Waste Pans 26 Rat 50 Standalone USB Interface 118 Trough Type Pellet Receptacle for Rat 59 Standalone Aversive Stimulator/Scrambler 80 TTL to 28 V DC Standalone PCI Interface Packages 117 Adapters 125 Standard Expanded PVC Sound Attenuating Cubicle 40 Powered Adapter 125 Standard Input Module 119 Powered Adapter with Coax Connector 126 Standard MDF Sound Attenuating Cubicle 41 Ultra Sensitive Levers 45 Standard Modular Test Chambers 22 Universal Cables 115 Standard Monkey Lever 104 USB Sound Pressure Level Measurement Package 57 Standard Output Module 120, 121 Variable Infusion Rate Syringe Pump 92 Stimulus Light Fader Control 51 Variable Schedule Software 148 Stimulus Lights 49, 50, 51, 104, 105 Variable Speed Syringe Pumps 89 SuperPort Input Module 119, 120 Volumetric Drinking Tubes for Liquid Intake Monitoring 71 SuperPort Output Module 120, 121 Waste Pans 26 SuperPort Packages 116 Water Bottle and Sipper Tubes 69 Switching Contact Lickometer Controller 68 WAV File Player 151 Swivel, 25 Gauge 87 White Noise Amplifier with Cage Speakers 59 Swivels and Clamps 83 Wide Mouse Modular Syringe Pumps 88, 89, Grid Floor 31 Tabletop Cabinet and Power Supplies Test Chambers 31 Tail Aversive Stimulation Yoke for Small Primates 102 Test Chambers Classic Modular Mouse Chambers 29 Extra Tall Modular Operant Test Chambers 23, 24 INDEX ALPHABETIC

168 ABOUT MED ASSOCIATES INC. Serving Science For Over 35 Years Med Associates Inc. is the leading manufacturer, software developer, and supplier of products for behavioral psychology, pharmacology, neuroscience, and related research and teaching areas. Med Associates Inc. was established in 1970 as a small research and development company. Since its inception, Med Associates Inc. has grown substantially and now manufactures over 400 products. OUR MISSION At Med Associates, we strive to provide our customers with the most economical and practical solutions available to meet their research needs. Our approach integrates all aspects of product research, design, development, and manufacturing and is unmatched in the industry. We highly value our customers input, and work closely with colleagues in academic and industrial research laboratories all over the world. We accommodate individual requests for customized apparatus development whenever possible, which has led to our vast capabilities in manufacturing and product design and development. Over the years we have compiled the largest array of accessories, modules, control systems, and experimental environments available to behavioral scientists from any company. Med Associates is dedicated to teaching, informing, and supporting researchers all over the world in the use of our equipment through our ongoing Short Courses in Neuroscience Series and our on-site installations and training. We value customer feedback and are interested to hear about your experiences. Please contact us at or info@med-associates.com. 162

169 OUR COMPANY Currently Med Associates and the affiliated Zurn and Herrera companies manufacture over 400 products and employ about 100 staff. Our locations include a main manufacturing facility in Georgia, Vermont, the Science Center in St. Albans, Vermont, and representation by several dealers and distributors throughout the world. Our total spatial resources approach 80,000 square feet, with plenty of room to grow. Since its inception, Med Associates has followed a productive growth strategy marked by three key principles: State-of-the-Art Engineering and Design Commitment to Basic Research Manufacturing Excellence Our focus on engineering and design has resulted in the largest array of behavioral test equipment available from any manufacturer. We are continuously pursuing new product development, product enhancements, and ventures into new areas. Basic research is part of the foundation of our product development process. Our St. Albans, Vermont Science Center is home to our in-house test laboratories. We have a vivarium with survival surgical capabilities and several thousand square feet of lab space. In addition, we work closely with researchers in the field to help us design and refine our research equipment. Over the years we have invested heavily into manufacturing equipment, including state-of-the-art automated computercontrolled mills, saws, lathes, routers, electrical circuit board assembly (pick and place), and more. Our staff of manufacturing employees, sales representatives, technicians, engineers, scientists, and executives all work together to design, develop, and produce a large array of products and research tools, and make them available to researchers at economical prices. ABOUT MED ASSOCIATES INC

170 OUR FAMILY Med Associates Inc. is family-owned and operated by the Zurn family of St. Albans, Vermont. The company was founded by Karl Zurn who serves as Chairman of the Board and is involved in product development and electrical engineering design. Karl has Bachelor s and Master s degrees in Electrical Engineering from Villanova University. Karl s three daughters and son-in-law are involved in the operations of Med Associates Inc. and its affiliated Zurn/Herrera Family companies. The youngest daughter, Bridget Zurn, is President of Med Associates Inc. and also the affiliated Mansfield Research and Development. Bridget obtained her Bachelor s and Master s degrees in Computer Science from the University of Vermont, and is currently pursuing The Zurn family. her MBA from the University of Vermont. The eldest daughter, J. Brooks Zurn, obtained her Bachelor s and Master s degrees in Electrical Engineering from the University of Vermont, and is currently a PhD candidate in Electrical Engineering at Virginia Commonwealth University. Mary Zurn Herrera, the middle daughter, received her Bachelor s degree in Psychology from the University of Vermont. She is married to Gerald M. Herrera and they are the parents of Maria Paloma, Isabella Maria, Juliana Marie, Nicholas Matthias, and Dominic Karl Herrera. Gerry Herrera is Vice President of Research and Development at Med Associates, and President of Catamount Research and Development Company, a company started in Bridget Zurn, Karl Zurn and Gerry Herrera at an exhibition conference booth to serve as the main R&D group for the Med Associates Behavioral Product Line. In addition, he is an Adjunct Assistant Professor in the Pharmacology Department at the University of Vermont School of Medicine. Prior to joining Med Associates, Gerry obtained a Doctorate degree in Molecular Physiology and Biophysics from the University of Vermont. Mary Dove and Gerry Herrera and their five children. 164