Curation of Large Scale EHR Data for Use with Biobank Samples
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1 Curation of Large Scale EHR Data for Use with Biobank Samples Global Biobank Week Session 6B: Biobanks and Electronic Health Records Henrik Edgren, CSO
2 Conflicts of interest Employee of MediSapiens Ltd. Visit us at booth 27A. 2
3 Outline Benefits and challenges of EHR data. The challenges of scale. Different types of data and the data curation process. Discrete data and narrative text. 3
4 Benefits of EHR data The data exists and more is recorded continuously. Covers many areas of disease and health. The data covers a long period of time. Collected by healthcare professionals. Particularly useful for population-based biobanks with a more general research purpose. 4
5 Challenges of EHR data The data exists and more is recorded continuously. Covers many areas of disease and health. The data covers a long period of time. Collected by healthcare professionals. Access is often not straightforward. 5
6 The challenges of scale Discrete data, narrative text, laboratory measurements, images etc. So much diverse data that it is almost unusable. More is generated continuously. How do you turn this into clean, standardized and searchable data? 6
7 The data curation process Goals: Structure Query Analyze For all of the data Steps Exploration Cleaning Enrichment Standardization 7
8 Discrete data Goal: all discrete data is encoded in a standardized way. What should these standards be? Some data may already be coded (ad hoc, ICD-9/10, SNOMED-CT), most is not. Ontologies provide existing standards. 8
9 What is an ontology? 9
10 Discrete data Goal: all discrete data is encoded in a standardized way. What should these standards be? Some data may already be coded (e.g. ICD-10, SNOMED-CT), most is not. Ontologies provide existing standards. Manual mapping to them is very time consuming -> automation. Text to map -> search for matching terms in target ontology -> return the best matches along with a score indicating match quality 10
11 Automating ontology mapping 11
12 Discrete data & ontologies Goal: all discrete data is encoded in a standardized way. What should these standards be? Some data may already be coded (e.g. ICD-10, SNOMED-CT), most is not. Ontologies provide existing standards. Manual mapping to them is very time consuming -> automation. Solutions: Data cleaning and enrichment can be automated quite far. Standardization through ontology mapping: Automation Learning 12
13 Narrative text Any free-form text, such as medical statements, pathology reports, etc. A wealth of information not found elsewhere. Nuance and context for discrete data. Varying goals: Make searchable vs. understand Searchable: identify concepts in narrative text -> standardize their representation using ontology terms 13
14 Tagging of narrative text with ontology terms Extract features from words + Char-level characteristics (eg: morphological characteristics, prefixes, suffixes..) Learn how related words are with other words (eg. breast is often followed by cancer) In text, identify relevant entities and classify each as a certain category (eg. breast cancer is a disease) NER: Algorithmic level Word2vec + Convolutional Neural Network (CNN) Bidirectional Long-short term memory (bi-lstm) Conditional Random Fields (CRF) Ontologize entities 14
15 Summing it all up There are great opportunities in using EHR data for biobank samples. Significant challenges remain. Automation, learning and user experience. 15
16 Thank you! Henrik Edgren, CSO MediSapiens Ltd. Mikonkatu 17C Helsinki Finland MediSapiens Inc. One Broadway Cambridge, MA USA (FI) (781) (US) medisapiens.com Copyright 2017 MediSapiens Ltd. All rights reserved.
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