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1 Click to edit Master title style HBP Period 1 Review (Oct 2013 Sep 2014) Human Brain Project Vasilis Vassalos vassalos@aueb.gr

2 Click Human to edit Brain Master Project title style Goal What makes us human? Brain Disease Treatments Computation Technologies Six Platforms Neuroinformatics organizes neuroscience data from the HBP and beyond Brain Simulation internet-accessible collaborative Platform designed for reconstruction and simulation of brain models High Performance Computing developes and provides supercomputing, storage, visualisation and simulation technology that can run on supercomputers. Neuromorphic Computing implements aspects of biological neural networks as analogue or digital copies on electronic circuits. Neurorobotics Experiment with virtual robots connected to simulated brains. Medical Informatics Platform 2

3 Click Medical to edit Informatics Master title Platform style seamless data integration while respecting privacy 3

4 Click to MIP edit Architecture Master title style

5 Click Data to Integration edit Master Challenges title style Web Portal Variable extraction Standardization Federation Layer Query rewriting and Query planning Identify pieces of answers, retrieve them, combine them and maintain privacy/anonymity Mapping Expressivity vs Computational Complexity Correct and efficient distributed execution Local Layer Schema Creation for Data Store Mirrors Schema mapping Mapping Definition: What maps to what, under what conditions Mapping Execution/Data Exchange/Conversion» Expressivity vs Computational Complexity» Efficient execution» Anonymity/privacy Jan 2015 HBP Period 1 Review (Oct 2013 Sep 2014) 5

6 Click Data to Integration edit Master Challenges title style Web Portal Variable extraction Standardization Federation Layer Query rewriting and Query planning Identify pieces of answers, retrieve them, combine them and maintain privacy/anonymity Perform complex mining tasks maintaining privacy/anonymity Local Layer Variable extraction Standardization Schema Creation for Data Store Mirrors Population of Local Data Store Mirrors 6

7 Click to edit Master title style 7

8 Community Click to edit Schema Master Curation title style Module Share Global Mappings Share Public Mappings Endorse (partial) Global/Public Mappings Merge and extend existing schemata Aggregate Mappings from Trusted Users Corporate Presentation 8

9 Online Click to Data edit Integration Master title Module style Rule patients with diagnostics populate the Target diagnostic table 1 st batch of Data patient A has no diagnostics rule not activated for A 2 nd batch of Data diagnostics are received for patient A rule not activated for A Need to re-run for all data Incremental Data Exchange avoid recomputing Corporate Presentation 9

10 Ontology-Based Click edit Master Data Access title Module style Corporate Presentation 10

11 Click Complex to edit Distributed Master Workflows title style Characteristics Complex nontrivial algorithms, e.g., data mining Distributed executed over all relevant hospitals Privacy preservation Moving only aggregates (sufficient statistics) of hospital data Data operator support User defined Functions (UDFs) Iteration Slide 11

12 Dataflow Click to edit Execution Master -title Example style count, Query avg, std L: Σx, Decompose Σx 2, N query into G: N, local avg, and std global parts Partial m-name aggregated Σx Σx 2 N results N, Run avg, global std queries Federation m-name N avg std Partial aggregated results m-name Σx Σx 2 N Local queries Local queries Privacy Wall 1 N Run local Σx,Σx idqueries 2,N Σx,Σx Run local 2,N m-name m-value queries id m-name m-value Slide 12

13 Click to edit Master title style Thank you!