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1 Review Article Drugs 2007; 67 (16): upplementary Material /07/ /$49.95/ Adis Data Information BV. All rights reserved. Multidrug-Resistant treptococcus pneumoniae Infections Current and Future Therapeutic ptions Françoise Van Bambeke, 1 René R. Reinert, 2 Peter C. Appelbaum, 3 Paul M. Tulkens, 1 and Willy E. Peetermans 4 1 Unité de Pharmacologie Cellulaire et Moléculaire, Université Catholique de Louvain, Brussels, Belgium 2 Institute for Medical Microbiology, ational Reference Center for treptococci, University ospital (RWT), Aachen, Germany 3 Department of Pathology, ershey Medical Center, ershey, Pennsylvania, UA 4 Department of Internal Medicine-Infectious Diseases, Katholieke Universiteit Leuven, University ospital Gasthuisberg, Leuven, Belgium upplementary Material This supplementary material contains the figures referred to in the full version of this article, which can be found at

2 Figure 1. Chemical structures of reference cephalosporins and of derivatives in development that are characterised by a high in vitro activity towards. pneumoniae. R 1 R 2 drug -R 1 -R 2 cefuroxime 3 C 2 2 ceftriaxone 3 C cefotaxime 3C 2 2 C 3 cefditoren C 3 2 ceftobiprole 2 cefmatilen P 3 2 ceftaroline C 3 Et

3 2 RWJ

4 Figure 2. Chemical structures of a reference carbapenem and of derivatives in development that are characterised by a high in vitro activity towards. pneumoniae. R drug -R imipenem faropenem C C 3

5 Figure 3. Chemical structures of reference glycopeptides and of derivatives in development that are characterised by a high in vitro activity towards. pneumoniae. R 1 R 2 C 3 3 C R R 3 4 C C 2 C 3 R 5 drug -R 1 -R 2 -R 3 -R 4 -R 5 vancomycin oritavancin C - 2 C 3 telavancin P 3 2 R 2 C R 1 R 3 C 3 R 4 -R 1 -R 2 -R 3 -R 4 teicoplanin -C 3 -C Ac dalbavancin -C - C

6 Figure 4. Chemical structures of a reference ketolide and of derivatives in development that are characterised by a high in vitro activity towards. pneumoniae. 3 C C 3 C 3 3 C C 3 3 C 3 C 2 C 3 C C 3 ( 3 C) 2 C 3 3 C 3 C 2 C 3 C C 3 ( 3 C) 2 C 3 C 3 C 3 telithromycin cethromycin 3 C C 3 3 C C 3 3 C 3 C 2 C 3 C C 3 ( 3 C) 2 C 3 3 C 3 C 2 C 3 C C 3 ( 3 C) 2 C 3 F C 3 C 3 EDP-420 FMA-1485

7 Figure 5. Chemical structures of a reference lincosamide and of a derivative in development that is characterised by a high in vitro activity towards. pneumoniae. R 1 R 2 C 3 drug -R 1 -R 2 clindamycin VIC105555

8 Figure 6. Chemical structures of a reference oxazolidinone and of a derivative in development that is characterised by a high in vitro activity towards. pneumoniae. R drug -R F linezolid 2 ranbezolid

9 Figure 7. Chemical structures of reference tetracyclines and of derivatives in development that are characterised by a high in vitro activity towards. pneumoniae. R 3 R 2 R 1 2 R 4 drug -R 4 -R 3 -R 2 -R 1 tetracycline doxycycline - -C tigecycline - -(C 3) 2 -C 3 PTK (C 3) 2 -C 3

10 Figure 8. Chemical structures of reference quinolones and of derivatives in development that are characterised by a high in vitro activity towards. pneumoniae. R 5 R 6 C R 7 X R 8 R 1 drug X -R 8 -R 1 -R 5 -R 6 -R 7 levofloxacin C - -F C 3 moxifloxacin C --C 3 - -F gemifloxacin - -F 2 garenoxacin C --CF sitafloxacin C - - -F F 2 WCK-771 C - -F C 3 3 C C 3 WCK-1152 C --C 3 - -F 2 3 C C 3 WCK-1153 C --C 3 - -F 2 DX-619 C --C 3 - -F F 2 DK-507k C --C 3 - -F F 2 DC-159a C --C 3 - -F F C 3 2

11 DW-224a - -F 2 PGE C --C 3 - -F olamufloxacin C -C 3-2 -F 2

12 Figure 9. Chemical structures of a reference diaminopyridine and of derivatives in development that are characterised by a high in vitro activity towards. pneumoniae. 2 2 drug -R R trimetoprim iclaprim AR-709

Susceptibility profiles of Nocardia spp. to antimicrobial and antituberculotic

Susceptibility profiles of Nocardia spp. to antimicrobial and antituberculotic agents detected by a microplate Alamar Blue assay Pan Zhao 1, Xiujuan Zhang 2, Pengcheng Du 3, Guilian Li 1, Luxi Li 1, and