Integration of classifications and terminologies in metadata registries based on ISO/IEC 11179
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1 These sheets are only for use in connection with the speech. Integration of classifications and terminologies in metadata registries based on ISO/IEC Sylvie Ngouongo Jürgen Stausberg Ludwig-Maximilian-University of Munich, Germany Institute of Medical Informatics, Biometry and Epidemiology (IBE) Presented by Sylvie Ngouongo
2 Agenda Introduction Objectives Material ISO/IEC V3 Classifications and Terminologies Methods and Results Mapping Import Discussion Conclusion MIE 2011, Sylvie Ngouongo 2
3 Introduction Empirical medical research is based on the collection of observations stored in DBMS; needs services for the maintenance of item collections and improvement of semantic interoperability: Reuse of item`s definitions Quality improvement through harmonization and standardization, Integration and use of controlled vocabularies as value lists for items. MDR-Project in Germany launched in 2009 by the Federal Ministry of Education and Research to set up a national Metadata repository for the support of empirical research. ISO/IEC V3 MIE 2011, Sylvie Ngouongo 3
4 Objectives Appropriateness of ISO/IEC V3 Information technology - Metadata Registries (MDR) part 3 Registry Metamodel and basic attributes for a national MDR in Germany. Possibilities of including well-established classifications and terminologies (controlled vocabularies) using the metamodel of ISO/ IEC V3. MIE 2011, Sylvie Ngouongo 4
5 Material: ISO/IEC V3 Data Description Package ISO/IEC describes the method of standardizing and registering of data elements to make data understandable and sharable. Object_Class person Characteristic sex concept layer * Data_Element_Concept gender * * 1 Conceptual_Domain karyotype <men women> 1 1 representation layer * Data_Element * Value_Domain gender <male female> * 1 <male female> Data Description Package with examples in grey MIE 2011, Sylvie Ngouongo 5
6 Material: ISO/IEC V3 Concept Metamodel Region Concept_System Metamodel Region Classification Metamodel Region MIE 2011, Sylvie Ngouongo 6
7 Material: Classifications and Terminologies ICD-10-GM: International Statistical Classification of Diseases and Related Health Problems 10th Revision German Modifications OPS: German procedure classification The TNM classification of malignant tumors: a well-established standard for the classification of malignant tumors in oncology. the TNM-system classification provides three axes for post-coordination (T: local tumor, N: regional lymph nodes, M: metastasis). MedDRA: Medical Dictionary for Regulatory Activities, the international medical terminology used to classify adverse events associated with the use of biopharmaceuticals and other medical products. SNOMED-CT: Systematized Nomenclature of Medicine-Clinical Terms, a multilingual clinical healthcare terminology, essential for electronic health records. MIE 2011, Sylvie Ngouongo 7
8 Material: Classifications and Terminologies - ClaML Classification Markup Language (ClaML) is attractive as interface standard for the import of classifications (ICD-10-GM, OPS) into the MDR. ClaML: EN 14463:2007, Standard for electronic representation of classification coding schemes. <?xml version="1.0" encoding="utf-8"?> <!DOCTYPE ClaML SYSTEM "claml.dtd"[]> <ClaML version="2.0.0"> <Meta name="toplevelsort" value="i II III IV V VI VII VIII IX X XI XII XIII XIV XV XVI XVII XVIII XIX XX XXI XXII" /> <Meta name="lang" value="en" /> <Meta name="titlelong" value="international Statistical Classification of Diseases and Related Health Problems 10th Revision"/> <?xml <Identifier version="1.0" authority="who" encoding="utf-8"?> uid="srfsfto be added later" /> <!DOCTYPE <ClaML <Meta Title name="toplevelsort version ClaML 2.0.0"> SYSTEM "claml.dtd"[]> < XIII XIV XV XVI XVII XVIII XIX XX ="I XXI II XXII III IV V VI VII VIII IX X XI XII Meta name="lang" value="en" <Meta name="titlelong" B27.0 /> <Identifier of Diseases authorityand Related value="international Health Problems Statistical 10th Revision"/> Classification ="WHO" uid="srfsfto be added later" /> <Title < Class code="b27 < =" name="icd en" version=" 2008" /> " kind=" category"> Small excerpt of ClaML ClaML and its structure s elements 8
9 Methods Mapping Approach and results Import Approach and results MIE 2011, Sylvie Ngouongo
10 Mapping: the approach Mapping of ClaML Elements to elements of ISO/IEC V3 Metamodel. Mapping of vocabularies structures to elements of the ISO/ IEC V3 metamodel. ISO V3 1b Structure Mapping 1c ClAML 1a representation If 1b and 1a, then 1c is possible Structure Mapping 2 ICD-10, OPS MIE 2011, Sylvie Ngouongo 10
11 Mapping : the results Concept_System Metamodel Region ClaML.root; ICD-10-GM; OPS; TNM; MedDRA; SNOMED-CT (Vocabularies) Classification Metamodel Region Classification s semantic ClaML-Classes / Vocabularies-Classes generalization Example of ICD-10 Intestinal infectious Diseases (A00-A09) Hierarchy specialization is_a ClaML-Classes / Cholera MIE 2011, Sylvie Ngouongo Vocabularies-Classes (A00) 11
12 Import: approach and results MIE 2011, Sylvie Ngouongo 12
13 Discussion Representation of classifications and terminologies as sources for value lists of items is quite simple in ISO/IEC V3, however Terminologies (MedDRA, SNOMED-CT) could be easily represented both in the Concept Metamodel Region and the Data Description Package of ISO/IEC V3, Representation of Classifications (ICD-10, OPS, TNM) in the Data Description Package ist not satisfactory yet, Classifications rules (inclusions, exclusions ) and exceptions could not be properly mapped in the Concept Package yet. Full coverage of the item semantic is not reached yet, Implementation on logic level of application needed. Different interpretations and extensions of the ClaML-Standard: DIMDI (ICD-10-GM 2010) vs. WHO (ICD-10-CM 2008). MIE 2011, Sylvie Ngouongo 13
14 Discussion Example of discrepancies between WHO and DIMDI regarding ClaML WHO applies <Modifier> (subclassifications coding) for 4-digit ICD-Classes to their superclasses (3- digit classes) whereas DIMDI applies them to the corresponding 4-digit classes to build the 5-digit subclassifications. M01 (3-digit) à M01.0 (4-digit) à M01.00 (5-digit) <Class code="m01" kind="category" usage="aster"> <SuperClass code="m00-m03" /> <SubClass code="m01.0" /> < code <SubClass code="m01.1" ="M01" kind="category" usage "> <SuperClass code=" /> <SubClass code="m01.0" /> <Class code="m01" kind="category" usage="aster"> <SuperClass code="m00-m03"/> <SubClass code="m01.0"/> <SubClass code="m01.1"/> <SubClass code="m01.2"/> <Class code="m01 < category" usage="aster"> SuperClass <SubClass code="m01.1" /> <SubClass ="M00-M03"/> =" M01.2" /> < ModifiedBy all=" code <Class code="m01.0" kind="category" usage="aster"> <Class code="m01.0" kind="category" usage="aster"> <SuperClass code="m01" /> <Rubric id="d " kind="preferred"> <Class code <Label xml:lang="en" xml:space=" ="M01.0" kind=" category" usage=" < WHO aster"> code <SuperClass code="m01"/> <ModifiedBy all="true" code="s13m00_5"/> <Rubric kind="preferred"> <Class code="m01.0" kind=" <Label xml:lang < category" usage="aster "> <SuperClass </ Class code=" M01 DIMDI 14
15 Conclusion ISO/IEC V3 is powerful and contributes many useful ideas for the definition of a national MDR. An extension of ISO/IEC V3 metamodel to meet the predefined needs of a national MDR might be necessary. A unique interpretation of ClaML by Healthcare organizations (WHO, DIMDI, ) is essential to continue work on the ClaML import interface. MIE 2011, Sylvie Ngouongo 15
16 Acknowledgements The presented work is part of the project MDR - Metadata Repository funded by the German Federal Ministry of Education and Research (BMBF). MIE 2011, Sylvie Ngouongo 16
17 Thanks for your Attention! Take Home Message Support of empirical medical research through Maintenance of item collections: Reuse of item s definitions, Reviews of item collections through harmonization and standardization, Integration and use of controlled vocabularies as value lists for items. ISO is a method of standardizing and registering of data elements to make data understandable and sharable. It is powerful and contributes many useful ideas for the definition of a national MDR. Representation of classifications and terminologies as sources for value lists of items is quite simple in ISO V3. Problems arise when trying to represent classification s rules (inclusions, exclusions ). An extension of ISO V3 metamodel to meet the predefined needs of a national MDR might be necessary. A unique interpretation of the ClaML-Standard by healthcare organizations is required to implement a common ClaML import interface. MIE 2011, Sylvie Ngouongo 17
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