Turning Data Science into a reality with TIBCO Spotfire

Transcription

1 Turning Data Science into a reality with TIBCO Spotfire Eduardo Gonzalez-Couto, Ph.D. Product Manager, PerkinElmer Informatics Basel, 3 rd November 2016

2 Safe Harbor Statement This document shows current intentions regarding product features, behavior, schedules and support; these intentions may change without notice as we respond to customer requirements. Any unreleased products, services or features referenced herein are not currently available and may not be delivered on time or at all. Customers who purchase PerkinElmer informatics applications should make their purchase decisions based upon products, features, and services that are currently available. 2

3 New Informatics for New Data Science The pace of life science data generation and the complexity of the generated data is outperforming existing informatics solutions

4 Introducing PerkinElmer Signals PerkinElmer Signals Cloud-based data store and analytics platform designed for today s and tomorrow s life science needs. Enabling user experience around TIBCO Spotfire supports wide range of data processing workflows and applications. Intelligent Domain-specific entity model and ontologies Machine learning for data normalization and mapping Signals App Store with scientific applications Scalable Big data technology foundation - Spark & HDFS Cloud-scale, elastic SaaS deployment Automated workflows with Automation Services Enabling User friendly scientific applications in TIBCO Spotfire User-driven, self-service access to all relevant data Collaboration within and across the firewall 4

5 PerkinElmer Signals for Translational Break Down The Firewall Between Data And Discovery

6 PerkinElmer s Vision of Translational Medicine Patient Population Stratified Patient Population IHC Quantitative Pathology Multiplex ELISA NGS GEA Fusion CNV Getting the right drug to the right patient at the right time 6

7 From Translational Medicine to Personalized Medicine IHC Quantitative Pathology Precise diagnosis Multiplex ELISA NGS GEA Fusion CNV Targeted Therapy Getting the right drug to the right patient at the right time 7

8 Translational Medicine Workflows Review Secondary Analysis Select Clinical Subject & Samples Secondary Analysis Select Processed Data QA/QC Results PerkinElmer Signals Annotated Raw Data Annotated Processed Data Derived Data Select Secondary Results Data Processing Perform Integrated Analysis Bioinformatician / Data Scientist Focuses on single experiment and starts with an instrument run Raw Data Translational Scientist Starts with a scientific hypothesis and scientific Entities 8

9 PerkinElmer Signals for Translational Visual Analytics and the Cloud - video 9

10 Translational Video

11 PerkinElmer Signals for Screening How Big Data Becomes Breakthrough Data

12 PerkinElmer Signals for Screening Data Import and Aggregation High Content Profiler Spotfire Templates Curve Fitting SAR Real-time Analytics Alerts, Reports, Publish, Collaborate Automated Workflow Signals App Store for Screening Extensible and configurable analytics applications to TIBCO Spotfire. The Signals Apps Store for Screening supports users to create configurable screening data analytics workflows for a wide range of applications. Flexible Configurable and extensible; apps can be combined to protocols; protocols can be saved and shared between users; extension and configuration with custom apps Automated Protocols can be run interactive or fully automated using Automation Services; reporting apps for fully integrated workflows Intelligent Intrinsic domain model awareness enables apps to configure themselves and guide user through input parameters selection 12

13 System Components HCS 3 rd PARTY IMAGE/DATA ANALYSIS SOFTWARE Matlab, ImageJ, CellProfiler etc. HTS SIGNALS for SCREENING Analysis, persistence and management of data generated by the instruments, Columbus, and Spotfire Apps and Protocols COLUMBUS OMERO 5.x Manage image transfer and analysis from instrument to the cloud HPC IMAGE ANALYSIS Columbus leverages compute clusters for scalable image analysis SPOTFIRE APP STORE Interactive front-end for protocol development, analysis, and automation SIGNALS PLATFORM Built to support diverse screening platforms with domain models, archiving, permissions, etc. SEARCH AND ADVANCED SCREENING ANALYTICS Advanced search and cross assay/screen analytics 13 These intentions may change without notice as we respond to customer requirements.

14 PerkinElmer Signals for Screening Agile Visual Analytics - video 14

15 Screening Video

16 High Content Profiler for HCS and HTS Multivariate Statistics Normalization Outlier detection Feature selection Hit selection & stratification Guided Spotfire Workflows Cell and well level analysis Automated, standardized analysis Highly interactive visualization Scientifically validated Image Rendering Hypothesis testing Result validation 16

17 High Content Profiler for HCS and HTS Multivariate Statistics Normalization Outlier detection Feature selection Hit selection & stratification Guided Spotfire Workflows Cell and well level analysis Automated, standardized analysis Highly interactive visualization Scientifically validated Image Rendering Hypothesis testing Result validation 17

18 High Content Profiler for HCS and HTS This summer 18

19 High Content Profiler for HCS and HTS This summer 19

20 High Content Profiler for HCS and HTS This summer 20

21 In-Vivo Pathology Screening PerkinElmer Imaging Informatics Roadmap Profiler Columbus Signals for Screening Signals inform Signals for Imaging Q-Path Spotfire In-Vivo, etc

22 Clinical Application Framework Looking Ahead: Combining Workflow, Holistic Data Provisioning, and Advanced Analytics 22

23 Spotfire in Clinical Development Clinical/Medical Data Review Clinical Operations Health Outcomes & RWE Safety and PV Risk-Based Monitoring 23

24 PerkinElmer Clinical Application Framework One Stop Shop for Clinical Data insights 24

25 New Informatics for New Data Science Covering life science needs 25

26 PerkinElmer and TIBCO Strategic Partnership Bringing Science back into the Spotfire platform Chemistry and Structures Gene Expression 26 Drug Dose Response SAR

27 Thank You Questions?