Cross-frequency coupling. Bernhard Staresina CONIG 09/06/11

Transcription

1 Cross-frequency coupling Bernhard Staresina CONIG 09/06/11

2 Talk Outline I. What is CFC? Definition and functional significance II. How is CFC calculated? PLV-MI, KL-MI III. Example CFC during sleep

3 Terminology

4 Cross Frequency Coupling (CFC) Terminology

5 Terminology Cross Frequency Coupling (CFC) Phase Amplitude Coupling (PAC)

6 Terminology Cross Frequency Coupling (CFC) Phase Amplitude Coupling (PAC) Cross Frequency Phase Amplitude Coupling (CFPAC)

7 Terminology Cross Frequency Coupling (CFC) Phase Amplitude Coupling (PAC) Cross Frequency Phase Amplitude Coupling (CFPAC)

8 I. What

9 I. What

10 Oscillatory interactions of two signals I. What

11 Oscillatory interactions of two signals I. What

12 I. What Definition (Canolty and Knight, 2010)

13 I. What Definition (i) an observed statistical dependence between filtered signals derived from electrical brain activity. (Canolty and Knight, 2010)

14 I. What Definition (i) an observed statistical dependence between filtered signals derived from electrical brain activity. (ii) a transient but mechanistic coupling (mediated by spikes and synaptic activity) between the functionally distinct neuronal subpopulations that give rise to recorded electrical activity. (Canolty and Knight, 2010)

15 I. What low frequencies high frequencies coordination of cortical excitability (global states, sensory input) coordination of local information processing

16 I. What low frequencies high frequencies coordination of cortical excitability (global states, sensory input) coordination of local information processing CFC transfer of information from large-scale brain networks to local processing required for effective computation and synaptic modification

17 I. What Example Effective LTP induction - high frequency bursts, repeated at a ~3-5 Hz inter-burst interval

18 I. What Example Effective LTP induction - high frequency bursts, repeated at a ~3-5 Hz inter-burst interval

19 I. What Example Effective LTP induction - high frequency bursts, repeated at a ~3-5 Hz inter-burst interval

20 Links with behaviour I. What

21 I. What Links with behaviour theta:gamma CFC increases with working memory load in humans (Axmacher et al., 2010)

22 I. What Links with behaviour theta:gamma CFC increases with working memory load in humans (Axmacher et al., 2010) theta:gamma CFC increases with navigation task performance in rodents (Tort et al., 2009)

23 II. How

24 II. How

25 II. How

26 II. How

27 II. How

28 Interlude: different ways of representing phases II. How

29 Interlude: different ways of representing phases II. How

30 Interlude: different ways of representing phases II. How peak (0 deg) trough (180 deg)

31 Interlude: different ways of representing phases II. How peak (0 deg) trough (180 deg) pi/2 pi 0 3pi/2

32 Interlude: different ways of representing phases II. How peak (0 deg) trough (180 deg) pi/2 pi 0 3pi/2

33 Interlude: different ways of representing phases II. How peak (0 deg) trough (180 deg) pi/2 pi 0 3pi/2 pi 0 -pi

34 Interlude: different ways of representing phases II. How peak (0 deg) trough (180 deg) pi/2 pi 0 3pi/2 pi 0 -pi

35 Interlude: different ways of representing phases II. How peak (0 deg) trough (180 deg) pi/2 pi 0 3pi/2 pi 0 -pi

36 Interlude: different ways of representing phases II. How peak (0 deg) trough (180 deg) pi/2 pi 0 3pi/2 pi 0 -pi

37 Phase locking and some of its applications II. How

38 Phase locking and some of its applications II. How

39 Phase locking and some of its applications II. How 1. Alignment of phase values at time t across trials inter-trial phase locking [Phase Locking Index (PLI)]

40 Phase locking and some of its applications II. How 1. Alignment of phase values at time t across trials inter-trial phase locking [Phase Locking Index (PLI)] 2. Alignment of phase difference values between two regions at time t across trials inter-region inter-trial phase locking [Phase Locking Value (PLV)]

41 Phase locking and some of its applications II. How 1. Alignment of phase values at time t across trials inter-trial phase locking [Phase Locking Index (PLI)] 2. Alignment of phase difference values between two regions at time t across trials inter-region inter-trial phase locking [Phase Locking Value (PLV)] 3. Alignment of phase difference values between (i) low frequency phase and (ii) high frequency envelope/power at time t across trials inter-frequency inter-trial phase locking [Cross-Frequency Coupling (CFC)]

42 Calculation of phase locking II. How

43 Calculation of phase locking II. How

44 Calculation of phase locking II. How PLI = 0 PLI =.5 PLI =.75

45 Phase locking and some of its applications II. How 1. Alignment of phase values at time t across trials inter-trial phase locking [Phase Locking Index (PLI)] 2. Alignment of phase difference values between two regions at time t across trials inter-region inter-trial phase locking [Phase Locking Value (PLV)] 3. Alignment of phase difference values between (i) low frequency phase and (ii) high frequency envelope/power at time t across trials inter-frequency inter-trial phase locking [Cross-Frequency Coupling (CFC)]

46 1. Phase Locking Index (inter-trial coupling) II. How

47 1. Phase Locking Index (inter-trial coupling) II. How frequency

48 1. Phase Locking Index (inter-trial coupling) II. How frequency

49 1. Phase Locking Index (inter-trial coupling) II. How frequency

50 2. Phase Locking Factor (inter-region inter-trial coupling) II. How

51 2. Phase Locking Factor (inter-region inter-trial coupling) II. How region A trial 1 region B region A trial 2 region B...

52 2. Phase Locking Factor (inter-region inter-trial coupling) II. How region A trial 1 region B region A trial 2 region B...

53 3. CFCa (inter-frequency inter-trial coupling) II. How

54 3. CFCa (inter-frequency inter-trial coupling) II. How low frequency signal phase-providing

55 3. CFCa (inter-frequency inter-trial coupling) II. How low frequency signal phase-providing high frequency signal amplitude (power)-providing

56 3. CFCa (inter-frequency inter-trial coupling) II. How low frequency signal phase-providing high frequency signal amplitude (power)-providing Envelope of high frequency signal

57 3. CFCa (inter-frequency inter-trial coupling) II. How low frequency signal phase-providing Envelope of high frequency signal

58 CFCb II. Based on Kullback-Leibler Distance Tort et al., 2010 II. How

59 CFCb II. Based on Kullback-Leibler Distance Tort et al., 2010 II. How

60 CFCb II. Based on Kullback-Leibler Distance Tort et al., 2010 II. How

61 CFCb II. Based on Kullback-Leibler Distance Tort et al., 2010 II. How

62 CFCb II. Based on Kullback-Leibler Distance Tort et al., 2010 II. How

63 CFCb II. Based on Kullback-Leibler Distance Tort et al., 2010 II. How

64 CFCb II. Based on Kullback-Leibler Distance Tort et al., 2010 II. How

65 III. Example

66 Background III. Example

67 Background III. Example Memories are initially stored in the hippocampus.

68 Background III. Example Memories are initially stored in the hippocampus. Slow-wave sleep (SWS) facilitates memory consolidation.

69 Background III. Example Memories are initially stored in the hippocampus. Slow-wave sleep (SWS) facilitates memory consolidation. Cross-frequency-coupling (CFC) has been related to synaptic plasticity and memory.

70 Background III. Example Memories are initially stored in the hippocampus. Slow-wave sleep (SWS) facilitates memory consolidation. Cross-frequency-coupling (CFC) has been related to synaptic plasticity and memory. Is there evidence for hippocampal cross-frequency-coupling during SWS in humans?

71 Methods III. Example

72 Methods III. Example ieeg recordings from MTL contralateral to the epileptic focus (n=10)

73 Methods III. Example ieeg recordings from MTL contralateral to the epileptic focus (n=10) classification of sleep stages based on Cz scalp electrode, EOG and EMG

74 Methods III. Example ieeg recordings from MTL contralateral to the epileptic focus (n=10) classification of sleep stages based on Cz scalp electrode, EOG and EMG sleep architecture

75 Methods III. Example ieeg recordings from MTL contralateral to the epileptic focus (n=10) classification of sleep stages based on Cz scalp electrode, EOG and EMG power spectrum sleep:wake

76 Methods III. Example ieeg recordings from MTL contralateral to the epileptic focus (n=10) classification of sleep stages based on Cz scalp electrode, EOG and EMG power spectrum sleep:wake

77 Results III. Example CFC in hippocampus, SWS vs. wake

78 Results III. Example CFC in hippocampus, SWS vs. wake

79 Results III. Example CFC in hippocampus, SWS vs. wake

80 Results III. Example CFC in hippocampus, SWS vs. wake

81 Results III. Example complementary analysis: display of gamma power locked to theta peak

82 Results III. Example complementary analysis: display of gamma power locked to theta peak

83 Results III. Example complementary analysis: display of gamma power locked to theta peak

84 Results III. Example raw data example

85 Results III. Example raw data example

86 Results III. Example raw data example ~200 ms

87 Results III. Example theta:gamma CFC across sleep stages

88 Results III. Example theta:gamma CFC across sleep stages

89 Results III. Example control: phase-scrambled surrogate data

90 Results III. Example control: phase-scrambled surrogate data power spectrum sleep:wake

91 Results III. Example control: phase-scrambled surrogate data power spectrum sleep:wake theta:gamma CFC across sleep stages

92 Summary III. Example

93 Summary III. Example Strong theta:gamma CFC in hippocampus during SWS

94 Summary III. Example Strong theta:gamma CFC in hippocampus during SWS Evidence for effective LTP during SWS?

95 Thank You!