Web Services for Image Management and Analysis in OpenClinica
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1 Web Services for Image Management and Analysis in OpenClinica Thomas M. Deserno, Daniel Haak, Johan Gehlen Department of Medical Informatics, Uniklinik RWTH Aachen, Germany Thomas M. Deserno Dept. of Medical Informatics 1
2 Clinical Trial Center Aachen (CTC-A) Re-established (Nov. 2010) Self standing unit RWTH Aachen University Medical School (Uniklinik) Mission Improvement of study outcome (scientific, economic) Support of investigator initiated trials (IIT) Quality management Methods Process re-structuring & controlling Software (GWT, Dept. of Med. Informatics) Thomas M. Deserno Dept. of Medical Informatics 2
3 Structure Uniklinik RWTH Aachen, Medical School Clinical Trial Center Aachen (CTC-A) Dept. Medical Informatics (IMI) Uniklinik RWTH Aachen, Hospital IT Dept. (UKA) RWTH Aachen University IT Dept. (RKZ) UKA berät beauftragt beauftragt CTC-A IMI RKZ Thomas M. Deserno Dept. of Medical Informatics 3
4 Structure Internet Browser CTC-A Medical Data (Open Clinica) Stufe 5 Pseudonymizer (TMF PID) Studymanagem. (GWT) ecrfs Personal ID Access protocol Study admin IMI Backup (TSM) Backup (TSM) Backup (TSM) Backup (TSM) RKZ Ausbaustufe 4 Ausbaustufe 3 Ausbaustufen 1 & 2 Thomas M. Deserno Dept. of Medical Informatics 4
5 CTC-A Study Management Tool Thomas M. Deserno Dept. of Medical Informatics 5
6 CTC-A Study Management Tool Thomas M. Deserno Dept. of Medical Informatics 6
7 Primary Origins & Interchange CTC-A Data Name of study Study sites Persons, roles, access levels Development of patients (FPI, LPO, History) Function Image processing Data Result images Result measurements OpenClinica Data Current number of patients Images Function Call Data Thomas M. Deserno Dept. of Medical Informatics 7
8 Preferences Maintain OC code GWT Application Server Internet OpenClinica Server Compatibility Updates Full integration Data Function Automation No user interaction ExtGWT Application JAX WS Client Server Java Image Analysis MySQL DBMS SOAP Server JavaScript Excel ecrf OC WS OC Core PostgreSQL DBMS Use standards Communication Data Interchange Data security Data Base FTP File System Client get SFTP put File System Server Data Base FTP Thomas M. Deserno Dept. of Medical Informatics 8
9 OpenClinica Excel ecrf Definition Concept JavaScript enhancement Sends SOAP messages Problem Cross Domain Calls Not allowed to execute client JavaScript code on server Solution PHP proxy server Creates SOAP message Calls OpenClinica web services Thomas M. Deserno Dept. of Medical Informatics 9
10 Implementation JavaScript PHP Proxy Thomas M. Deserno Dept. of Medical Informatics 10
11 Image & Measure Transfer JCraft Java secure channel library (JSch) SFTP connection Data transfer (get) Java code execution Data transfer (put) Web Service OpenClinica Web Server CTC-A Client Well-formed XML file Clinical Data Interchange Standards Consortium Object Data Module (CDISC ODM) Thomas M. Deserno Dept. of Medical Informatics 11
12 Implementation Java code Thomas M. Deserno Dept. of Medical Informatics 12
13 Communication Protocols & Workflow Color scheme Red: OpenClinica Blue: CTC-A Green: Internet Browser-based GUI Example Workflow Conjunctival provocation test (CPT) Image ID Measurements JavaScript JAX-WS Server Java Image Analysis JAX-WS Client OC-WS Server OC Core Metadata Transfer Trigger SOAP (RPC) Trigger SOAP ecrf Entry User OC Core User Query Response Java Image Analysis File System OC Core User Image Upload Store Store SFTP SFTP Image & Result Display File System FTP Server FTP Client File System FTP Client FTP Server Image Transfer Input Image Result Image Thomas M. Deserno Dept. of Medical Informatics 13
14 Result Single-sign-on GWT Application Server ExtGWT Application Internet OpenClinica Server Server OC WS CTC-A study selection metadata transfer Image processing OpenClinica subject selection CRF selection Image upload Image display Processing results JAX WS Client Server Java Image Analysis MySQL Data Base FTP File System Client SOAP get SFTP put PHP Proxy JavaScript Excel ecrf OC-Big File System Server OC Core Postgre SQL Data Base FTP Thomas M. Deserno Dept. of Medical Informatics 14
15 Result 1. Single-sign-on authentification Thomas M. Deserno Dept. of Medical Informatics 15
16 Result 2. CTC-A: study selection Thomas M. Deserno Dept. of Medical Informatics 16
17 Result 3. CTC-A: metadata transfer to OpenClinica Thomas M. Deserno Dept. of Medical Informatics 17
18 Result 3. CTC-A: metadata transfer to OpenClinica Thomas M. Deserno Dept. of Medical Informatics 18
19 Result 3. CTC-A: metadata transfer to OpenClinica Thomas M. Deserno Dept. of Medical Informatics 19
20 Result 3. CTC-A: metadata transfer to OpenClinica Thomas M. Deserno Dept. of Medical Informatics 20
21 Result 4. Functional integration: switching to OpenClinica Thomas M. Deserno Dept. of Medical Informatics 21
22 Result 4. Functional integration: OpenClinica in a new tab Thomas M. Deserno Dept. of Medical Informatics 22
23 Result 5. OpenClinica: subject selection Thomas M. Deserno Dept. of Medical Informatics 23
24 Result 5. OpenClinica: CRF selection Thomas M. Deserno Dept. of Medical Informatics 24
25 Result 5. OpenClinica: image upload Thomas M. Deserno Dept. of Medical Informatics 25
26 Result 5. OpenClinica: image upload Thomas M. Deserno Dept. of Medical Informatics 26
27 Result 5. OpenClinica: image upload Thomas M. Deserno Dept. of Medical Informatics 27
28 Result 6. OpenClinica: image display Thomas M. Deserno Dept. of Medical Informatics 28
29 Result 7. OpenClinica: result images and measurements Thomas M. Deserno Dept. of Medical Informatics 29
30 Summary Workflow Automatic Real-time ready Data Entry Begin Study Selection Study + Users + Roles Meta Data Transfer Context OpenClinica Login ecrf Data Entry Image File Upload Analysis Module Analysis Analysis Results Signal File Save Data Data Entry End Thomas M. Deserno Dept. of Medical Informatics 30
31 Summary Image analysis for controlled clinical trials Java code for image processing OpenClinica for ecrfs Data integration Web services (SOAP) CDISC ODM well-formed XML Functional integration JavaScript PHP proxy Workflow integration Single sign on Thomas M. Deserno Dept. of Medical Informatics 31
32 Future Work Improvements Browser refresh Open / close after automatic ecrf fill Image processing runtime Synchronous vs. asynchronous transfer Extensions RIS / HIS interface (HL7, CDISC-LAB) PACS interface (DICOM) Pseudonymization and randomization services Thomas M. Deserno Dept. of Medical Informatics 32
OpenClinica Extensions: From Nano to Macro Thomas M. Deserno Department of Medical Informatics Uniklinik RWTH Aachen University
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