Demonstration of the CAMARADES-NC3Rs Systematic Review Facility (SyRF) 30 March 2017 Gillian Currie

Transcription

1 Demonstration of the CAMARADES-NC3Rs Systematic Review Facility (SyRF) 30 March 2017 Gillian Currie

2 Outline Previous CAMARADES database SyRF - Systematic Review Facility Educational resources for systematic review and meta-analysis Online platform Flexible for individual projects Demonstration and learn to SyRF

3 CAMARADES Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies Supporting framework for systematic review and meta-analysis of animal studies Look systematically across the modelling of a range of conditions Microsoft Access Data Repository 40 Projects 30 Diseases 25,000 studies from over 400,000 animals

4 Stages of Systematic Review and Meta-analysis Protocol development and registration Systematic search Screen for inclusion.pdf retrieval Meta-data annotation Outcome data extraction Meta-analysis Publication

5 Toolbox for SyrF Protocol development and registration Systematic search Living systematic search Screen for inclusion Machine Learning to aid Screening.pdf retrieval Meta-data annotation Automatic Annotation Outcome data extraction Meta-analysis Data analysis app Publication

6 Go to Website

7 Systematic Review

8 SyRF Traffic

9 Protocol development and registration

10 Systematic review library Protocol development and registration

11 Contact us Protocol development and registration

12 Launch SyRF Protocol development and registration

13 Protocol development and registration

14 Protocol development and registration

15 Protocol development and registration

16 Protocol development and registration

17 Project Details Members Systematic searches Screening details Stages Delete project Protocol development and registration

18 Protocol development and registration

19

20 Protocol development and registration

21 Systematic search

22 Systematic search

23 Systematic search

24 Systematic search

25 Screen for inclusion

26 Screen for inclusion

27 Screening with the help of machine learning For studies with at least 500 hits can use machine learning to aid screening indicate that you want to enable machine learning assisted screening for your project NaCTeM created an API that supports this function Screen for inclusion

28 Meta-data annotation

29 Meta-data annotation

30 Meta-data annotation

31 Meta-data annotation

32 Automatic Annotation

33 True False False True True False True False True False False False False

34 Outcome data extraction

35 Outcome data extraction

36 Meta-analysis

37 Meta-analysis

38 Meta-analysis

39 Meta-analysis Launch Meta-Analysis App

40 Predicted time frame using SyRF Protocol development and registration ~ 1-2 weeks Systematic search ~ 1 week Screen for inclusion ~ 40 weeks.pdf retrieval ~ 80% in 1 day Meta-data annotation Outcome data extraction Meta-analysis Publication ~ 20 weeks ~ 20 weeks ~ 2 weeks ~ 12 weeks ~ 97 weeks 10,000 hit project

41 Predicted time frame using SyRF Protocol development and registration ~ 1-2 weeks ~ 1-2 weeks Systematic search ~ 1 week ~ 1 day Screen for inclusion.pdf retrieval ~ 40 weeks ~ 80% in 1 day ~ 12 weeks ~ 80% in 1 day Meta-data annotation Outcome data extraction Meta-analysis Publication ~ 20 weeks ~ 20 weeks ~ 2 weeks ~ 12 weeks ~ 97 weeks ~ 10 weeks ~ 16 weeks ~ 1 day ~ 12 weeks ~ 52 weeks

42 Protocol development and registration Systematic search Living search Screen for inclusion.pdf retrieval Meta-data annotation Outcome data extraction Meta-analysis Publication Living publication

43 SyRF Architecture

44 Future considerations for SyRF SyRF is a living system and can be adapted as new methods and tools are introduced Scalable Adaptable Future proof Sustainable

45 Tools under development Protocol development and registration Systematic search Duplicate removal tool Search filters for animal studies Screen for inclusion.pdf retrieval PDF retrieval Meta-data annotation Outcome data extraction Meta-analysis Publication Machine assisted data extraction Automatic link to publisher s website

46 Protocol development and registration Systematic search Screen for inclusion Living systematic search Duplicate removal tool Search filters for animal studies Machine Learning to aid Screening.pdf retrieval PDF retrieval Meta-data annotation Outcome data extraction Meta-analysis Automatic Annotation Machine assisted data extraction Data analysis app Publication Automatic link to publisher s website

47 Thank you CAMARADES group Protocol development and registration Emily Sena Malcolm Macleod Gillian Currie Sarah McCann Jing Liao Christopher Sena Paula Grill Kaitlyn Hair Qianying Wang Zsanett Bahor (PhD) Alexandra Bannach-Brown (PhD) Systematic search Screen for inclusion.pdf retrieval Meta-data annotation Outcome data extraction Meta-analysis Publication