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21 .*,'783(+*,+',*(&A*+2#227)+,%3)#%,&,.6&,2#&)-6."+-2"**24 F _"#("#)#&)-6*)&-#T3*'7)#(*/**2 &--#)%#,')#27.#'("#)+'B*,]52#A#-*38#,(*),*(;+--1#/7)("#)+,A#'(+%&(#2 16("# >#&),+,%J&)-6 51*7(\#&,7(5--#)%6<>J5\?'(7264H,("+'()&+-."+-2)#,&)#)&,2*8+:#2+,*,#*/(;*2+#('Xb,#"&-/*/ ("#[QU+,.-72#2."+-2)#,/*--*;&3#&,7(0.*,(&+,+,%2+#(9;"#)#&'("#*("#)"&-/*/("#'#."+-2)#,&A*+2 3#&,7(0.*,(&+,+,% /**2 7,(+- ("#6 1#.*8# (")## 6#&)' *-24 5/(#) G7&,(+/6+,% ]5 2#A#-*38#,( +, #&." %)*73+(.&,2#(#)8+,#2;"#("#)#&)-62+#(&)6.*,'783(+*,*/3#&,7(&--#)%#,'*)&A*+2&,.#*/3#&,7(.*,'783(+*,27)+,%#&)-6."+-2"**2+,/-7#,.#'("#)+'B*/]52#A#-*38#,(4 F9FE Q4F]H>5==MHI@a5HbIXH@\5HMJNJ\HNJM@5>L5MMHJM]aIOHb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h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k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b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

22 87(&(+*,'*/456#&,2\54H,("+''(726("#6+,.-72#2'#A#,(60*,#3&(+#,(';+("3#&,7(&--#)%6<\5?/)*8 H)#-&,29 J,%-&,29 &,2 "# I#("#)-&,2'9 &,2 CUUU.*,()*-'9 ;"+." ;#)#,*( '#,'+(+:#2 (* 3#&,7(4 L*(" %)*73';#)#'.)##,#2/*)EEfE2#-Q&,2MSUCl87(&(+*,'*/4654*+3,)&4(&"#'#87(&(+*,'&..*7,(/*) &33)*T+8&(#-6[[h*/("##45687(&(+*,'+,("#H)+'"3*37-&(+*,4])*8%#,*(63+,%&,2'(&(+'(+.&-&,&-6'+'.&,1#.*,.-72#2("&(456,7--87(&(+*,'+,.)#&'#2("#)+'B*,\52#A#-*38#,(;+("&,bM*/S4FmWShOH ne4f0cu4em\nftcu 0[ 4 Q[ M#3-+.&(+*,*/("+''(726;&'2*,#&8*,%("#O&,&2+&,3*37-&(+*,4H,("+''(726 FWU +,2+A+27&-' '7//#)+,% /)*8 \5 &,2 fwc O&,&2+&,.*,()*-'9 ;"+." "&2 &, 7,B,*;, \5 '(&(7'9 ;#)# +,.-72#24 L*(" %)*73' ;#)# '.)##,#2 /*) /*7) (&(+*,'X EEfE2#-Q9 MSUCl9 KFEQDl9 &,2 MEQQDl4 *+3,)&5(&"#'#87(&(+*,'&..*7,(/*)&33)*T+8&(#-6WSh*/45687(&(+*,'+,("#H)+'"3*37-&(+*,4"+' )#3-+.&(+*, '(726 &-'* 2#8*,'()&(#2 ("&( -*''0*/0/7,.(+*, */ /+-&%%)+, +,.)#&'#2 ("# )+'B (* 2#A#-*3 \5 <ibmjnc4wmwshohnc4q0e4[m\ns4qtcu 0S?4 Q[ O*))#.(+,% /*) 5N ;&',#.#''&)69 1#.&7'# 5N +('#-/ +' &-'* & )+'B /&.(*) /*) \5 2#A#-*38#,(4 5/(#) ("+'.*))#.(+*,9 -*''0*/0/7,.(+*, 87(&(+*,' */ 456# ;#)# '(+-- )+'B /&.(*)' /*) \5 <ibmjnf4fm WSh OHnC4D0f4Fm \n4uuuf? Q[.,54&'7 *A +'3&6'#&-/.1;"-#',-?'3.,."3.":,4'.&3.36'?,",&'8(),*/5AAIA9&0C(*92D#"<5(2&(*(03/&9(',*6?,&82,-&(*62,8-/4 with peanut allergy :(10&(9(-&9.2,'12,?*)*&+,%-# and 1000 non peanut-sensitized controls Genotypes and statistical tests Patients (n) Controls (n) No FLG mutations detected (homozygous wild-type) One wild-type and 1 FLG mutant allele (heterozygous) Two FLG loss-of-function mutations 2 0 (homozygous or compound heterozygous) Total Proportion of individuals carrying FLG loss-of-function mutations (%) Fisher exact test P OR (95% CI) 5.3 ( ).,54&') *A +'3&6'#&-/.1;"-#',-?'3.,."3.":,4'.&3.36''.,82",&'8(),*/5AAIA9&0C52D#"<5/BACH<5(*9 2ACCH<5(2&(*(03/&9(',*6?,+(*(9)(*62,8-/4 :(10&(9(-&9.2,'12,?*)*&+,%-' Genotypes and statistical tests Patients (n) Controls (n) No FLG mutations detected (homozygous wild-type) One wild-type and 1 FLG mutant allele (heterozygous) Two FLG loss-of-function mutations 9 4 (homozygous or compound heterozygous) Total Proportion of individuals carrying FLG loss-of-function mutations (%) Fisher exact test P OR (95% CI) 1.9 ( ) 5-("*7%"("+''(726&''78#2("&(&87(&(+*,+,456+'&)+'B/&.(*)/*)]52#A#-*38#,(9&,*("#)'(726 '"*;#2("&(("#)#-&(+*,'"+31#(;##,45687(&(+*,&,2'#,'+(+:&(+*,(*/**2&--#)%#,';&'&1'#,(+,CfS +,2+A+27&-' '7//#)+,% /)*8 5N4 [C "#)#/*)#9 '(+-- 8*)# '(72+#' &)#,##2#2 (* +,A#'(+%&(# ("# 3*''+1-# &''*.+&(+*,1#(;##,456&,2]52#A#-*38#,(4 AA

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f.,54&'( *E +'4"3.'/'3/0&'//?',44&%#&-3'.2,.':,-'5&'"-2,4&?6' More commonly reported Wheat flour Seafood (crustaceans more than bony fish) Soy Peanut Hen's egg Milk Less commonly reported Asparagus Carrots Tea leaves Bell peppers Garlic Green beans Seeds White potato Tomato Rice Carmine dye H, ("+'."&3(#) ("# )#'3+)&(*)6 1&))+#) ;+-- 1# 2+'.7''#24 5/(#) 2#'.)+1+,% '*8#.*83*,#,(' */ ("# )#'3+)&(*)61&))+#)9'*8##A+2#,.#;+--1#%+A#,9;"+.".*,/+)8'("&(("#+,"&-&(+*,*//**2&--#)%#,'8&6 )#'7-(+,'#,'+(+:&(+*,4H(+'-+B#-6("&('#,'+(+:&(+*,(*+,"&-#2/**2&--#)%#,'*..7)';"#,("#)#'3+)&(*)6 1&))+#)+'.*83)*8+'#24L#.&7'#("#3)*(*.&2"#)+,0C%#,#&//#.('("#)#'3+)&(*)61&))+#)9+(+'3-&7'+1-# ("&(("#3)*(*.&2"#)+,0C%#,#3-&6'&)*-#+,'#,'+(+:&(+*,(*/**2&--#)%#,'4 QW H,("#-&'('#.(+*,*/("+'."&3(#) ("# 3*''+1-# &''*.+&(+*, 1#(;##, 3)*(*.&2"#)+,0C &,2 '#,'+(+:&(+*, (* /**2 &--#)%#,' ;+-- 1# 2#'.)+1#24 S4CMJK\HM5bM`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

24 ( " %*2#/&/6#)'&(7'++#+( /3(%(+2"#+'/+*("#%&#-0 "#87.7'-&6#)3)*A+2#'("#/+)'(3"6'+*-*%+.&-2#/#,'#&%&+,'(+,"&-#2&--#)%#,'&,28+.)**)%&,+'8'4 >+B#("#+,(#'(+,&-#3+("#-+789("#)#'3+)&(*)6#3+("#-+78.*,(&+,'&33)*T+8&(#-6[fUU%*1-#(.#--'#&." 'G7&)# #(#)4 "#'# %*1-#(.#--'9 (*%#("#) ;+(" *("#) 87.*7'.#--'9.*,(&+, %)&,7-#' /+--#2 ;+(" 87.7'4_"#,("#'#.#--''#.)#(#("#87.7'0.*,(&+,+,%%)&,7-#'9&CUo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h4 SU9SC b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bIb]]bbN5>>JM=JIK@5`MJKa>HIKJIKHHc5Hb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bbO5NRJMHICXH@\5HMJNMJK\HM5bM`L5MMHJM]aIOHb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pC0\)*(*.&2"#)+,/&8+-69;"+."+'& 8#81#) */ ("# O&2"#)+, '73#)/&8+-64 S[ "# #T()&.#--7-&) 2*8&+, */ pc0\)*(*.&2"#)+,'.*,'+'(' */.&2"#)+,'9;"#)#&'("#+,()&.#--7-&)&)#&*/("+'/&8+-6.*,'+'('*/O@C9O@E9&,2O@F)#%+*,'4 QW N#A#-*38#,(*/*)%&,'+'*,#*/("#8&+,/7,.(+*,'*/\)*(*.&2"#)+,0C45,*("#)+83*)(&,(/7,.(+*,*/ "#%&'8 *8 +'&<;%&33"/-';,..&%-'/';:?276' -+9%")/-2&9,')*(*03&<-2&//&9(%&(-)+(0/)9&,.%&2&/-)2(,23&-)%&0)8'(*91&?&&*(9;(+&* +&00/4'&<-2&//),*,.-+9%")/7)/8(0)/&9?)%%&8/&,.(*)1,9)&/(6()*/-+9%"-2,&)*/4' :.)682&(9(-&9.2,'>,--&0'(*)*&+,%- AD

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qQ+,)#'3+)&(*)6#3+("#-+&-.#--'4"+' )#'7-('+,&.*83)*8+'#21&))+#)/7,.(+*,*/("#)#'3+)&(*)6()&.(4@&61#2*;,)#%7-&(+*,*/+,(#%)+,qQ -#&2'(*'#,'+(+:&(+*,(*/**2&--#)%#,'4 SD AE

27 7"#-(10((2% ]**2&--#)%6+'&,+,.)#&'+,%3)*1-#8+,;#'(#),+:#2.*7,()+#'45-("*7%"("##T&.(3)#A&-#,.#*/]5+' 7,B,*;,9 ("# O#,(#)' /*) N+'#&'# O*,()*- &,2 \)#A#,(+*, '"*;#2 &, +,.)#&'# +, 3)#A&-#,.# */ Cfh 1#(;##,CWWD&,2EUUD+,("#a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b("#) 3&(+#,(' 2#A#-*3 ]5 ;+("*7( 3)#A+*7' /**2 &--#)%#,.*,'783(+*,4 "+' +,2+.&(#' ("&( '#,'+(+:&(+*,(*/**2&--#)%#,'+'&-'*3*''+1-#A+&*("#))*7(#'("&,("#*)&-)*7(#4"#.7(&,#*7')*7(# &,2 ("# )#'3+)&(*)6 )*7(# &)# 3*''+1-# )*7(#' */ '#,'+(+:&(+*,4 K#,'+(+:&(+*, A+& ("# )#'3+)&(*)6 &,2.7(&,#*7' )*7(# 8&6 1# &."+#A#2 16 1&))+#) 2#/#.(' +, )#'3#.(+A#-6 ("# )#'3+)&(*)6 ()&.( &,2 ("# #3+2#)8+'4K#A#)&-/**2&--#)%#,'.&,#,(#)("#"78&,1*26A+&("#)#'3+)&(*)6&,2e*).7(&,#*7')*7(#9 )#'7-(+,%+,&--#)%+.'#,'+(+:&(+*,4"#'#/**2&--#)%#,'&)##,78#)&(#2+,*+3,)&.4 W.,54&'* 8 +'4"3.'/'//?',44&%#&-3'.2,.'3&'.2&'%&3;"%,./%1',-?G/%' :.,-&/3'%/.&'/'3&-3"."@,."/-6' :(10&(9(-&9.2,'(/&2,)*&+,%- Allergen Lipid transfer protein Sunflower seed Sesame seed Poppy seed Pine nut Almond Peanut Lupine Soybean Other legumes Garlic Dill Kiwi Cereals Buckwheat Fish and seafood Egg Milk Pork Meat Anisakis Possible sensitization route transdermal, airborne airborne airborne airborne transdermal, airborne transdermal transdermal a, airborne a airborne airborne transdermal, airborne transdermal airborne unknown airborne transdermal, airborne airborne, transdermal airborne airborne airborne transdermal, airborne a Allergy upon first exposure has been reported but sensitization route is unknown. AH

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31 "#2+//#)#,(3#&,7(#T()&.(';#)#-*&2#2*,KNK0\5=J%#-'<'##533#,2+THHm3)*(*.*-CXrKNK0\5=Js?4 5/(#) )7,,+,% ("# KNK0\5=J9 &--#)%#, 3)*(#+,' ;#)# ()&,'/#))#2 *, & \dn] 8#81)&,# <'## 533#,2+T HHm 3)*(*.*- EX r)&,'/#) (* \dn] 8#81)&,#s?4 5/(#) ("+' ()&,'/#)9 ;#'(#), 1-*( 2#(#.(+*, ;&' 3#)/*)8#2 <'##533#,2+THH93)*(*.*-FXr_#'(#),1-*(2#(#.(+*,s?4]*)("#;#'(#),1-*(2#(#.(+*,91-**23-&'8&*/& 3&(+#,(;+("\5;&'7'#2&'&/+)'(&,(+1*264u0H%J-&1#-#2;+("RM\;&'7'#2&''#.*,2&,(+1*264 (( +2-&2( "#%&' 7C+H &3.&%-'54/.3 6 ' / &7&2(0-&(*8(00&26&*/+(*1&,1/&27&9(.&2?&/&2*10,9&&+),* 4 'K' (2>&2 L -K- &-/)* L /K/ (0)7( L #5 "D5 B#5 CD K ) *+81(),*)'&,.-&-/)*)* /&+,*9/ L "5 A5 D5 "#5 "D5 B#5 CD5 E#5 J# K ) *+81(),*)'&,.-&-/)*)*')*8&/ 4 B"