Ludwig Fahrmeir Gerhard Tute. Statistical odelling Based on Generalized Linear Model. íecond Edition. . Springer

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1 Ludwig Fahrmeir Gerhard Tute Statistical odelling Based on Generalized Linear Model íecond Edition. Springer

2 Preface to the Second Edition Preface to the First Edition List of Examples List of Figures List of Tables v vii xvii xxi xxv 1. Introduction Outline and Examples Remarks on Notation Notes and Further Reading Modelling and Analysis of Cross-Sectional Data: A Review of Univariate Generalized Linear Models Univariate Generalized Linear Models Data 16 Coding of Covariates 16 Grouped and Ungrouped Data Definition of Univariate Generalized Linear Models Models for Continuous Responses 22 Normal Distribución 22 Gamma Distribution 23 Inverse Gaussian Distribution Models for Binary and Binomial Responses 24 Linear Probability Model 25 Probit Model 26 Logit Model 26 Complementar;- Log-Log Model 26 Complementar y Log-Model 26 Binary Models as Threshold Models of Latent Linear Models 29 Parameter Interpretaron 29 Overdispersion Models for Count Data 36 Log-linear Poisson Model 36

3 x Linear Poisson Model Likelihood Infcrence Máximum Likelihood Estimation 38 Log-líkelihood, Score Function and Information Matrix 39 Numérica! Computation of the MLE by Iterative Methods 41 Uniqueness and Existence of MLEs* 43 Asymptotic Properties 44 Discussion of Regularity Assumptions* 46 Additional Scale or Overdispersion Parameter Hypothesis Testing and Goodness-of-Fit Statistics Goodness-of-Fit Statistics Some Extensions Quasi-likelihood Models 55 Basic Models 55 Variance Functions with Unknown Parameters 58 Nonconstant Dispersión Parameter Bayesian Models Nonlinear and N'onexponential Family Regression Models* Notes and Further Reading Models for Multicategorical Responses: Multivariate Extensions of Generalized Linear Models Multicategorical Response Models Multinomial Distribution Data The Multivariate Model Multivariate Generalized Linear Models Models for Nominal Responses The Principie of Máximum Random Utility Modelling of Explanatory Variables: Choice of Design Matrix Models for Ordinal Responses Cuinulative Modeís: The Threshold Approach 83 Cumulan ve Logistic Model or Proportional Odds Model 83 Grouped Cox Model or Proportional Hazards Model. 86 Extreme Maximal-value Distribution Model Extended Versions of Cumulative Models Link Functions and Design Matrices for Cumulative Models Sequential Models 92 Generalized Sequential Models 95 Link Functions of Sequential Models 98

4 Contente xi Strict Stochastic Ordering* Two-Step Models 100 Link Function and Design Matrix for Two-Step Models Alternative Approaches Statisticaí Inference Máximum Likelihood Estimation 105 Numerical Computation Testing and Goodness-of-Fit 107 Testing of Linear Hypotheses 107 Goodness-of-Fit Statistics Power-Divergence Family* 109 Asymptotic Properties under Classical "'Fixed Cells" Assumptions 111 Sparseness and "Increasing-Cells11 Asymptotics Muí ti vánate Models for Correlated Responses Conditionai Models 114 Asymmetric Models 114 Sytnmetric Models Marginal Models 119 Marginal Models for Correlated Univaríate Responses 120 The Generalized Estimating Approach for Statisticaí Inference 123 Marginal Models for Correlated Categórica! Responses 129 Likelihood-based Inference for Marginal Models Notes and Further Reading 136 Bayesian Inference Selecting and Checking Models Variable Seíection Selection Criteria Selection Procedures 142 All-Subsets Selection 142 Stepwise Backward and Forward Selection Diagnostics Diagnostic Tools for the Classical Linear Model Generalized Hat Matrix Residuals and Goodness-of-Fit Statistics Case Deletion General Tests for Misspecification* Estimation under Model Misspecification Hausman-type Tests 165 Hausman Tests 165 Information Matrix Test 166

5 xii Tests for Xonnested Hypotheses 167 Tests Based on Artificial Nesting 168 Generalized Wald and Scorc Tests Xotes and Flirther Reading 170 Bayesian Model Determination 170 Robust Estímales 172 Model Tests Against Smooth Aíternatives Serni- and Nonparametric Approaches to Regression Analysis Snioothing Techniques for Continuóos Responses Regression Spiines and Other Basis Functions 174 Regression Spiines 176 Other Basts Functions 178 Regularizatiori Smoothing Spiines Local Estimators 183 Simple Xeighborhood Smoothers 183 Local Regression 184 Bias-Variance Trade-off 187 Relation to Other Smoothers Selcction of Smoothing Parameters Smoothing for Non-Gaussian Data Basis Function Approach 193 Fisher Scoring for Penalized Likelihood* Penalization and Spline Smoothing 195 Fisher Scoring for Generalized Spline Smoothing* Choice of Smoothing Pararneter Localizing Generalized Linear Models 198 Local Fitting by Weighted Scoring Modelling with Múltiple Covariates Modelling Approaches 207 Generalized Additive Models 207 Partially Linear Models 208 Varyirig-Coefficient Models 208 Projection Pursuit Regression 209 Basis Function Approach Estimation Concepts 213 Backfitting Algoríthm for Generalized Additive Models 213 Backfitting with Spline Functions 217 Choice of Smoothing Parameter 220 Partial Linear Models Semiparametric Bayesian Inference for Generalized Regression 221

6 xiii Gaussian Responses 221 Smoothness Priors Approaches 221 Basis Function Approaches 227 Modets with Múltiple Covariates Non-Gaussian Responses 231 Latent Variable Models for Categorical Responses Notes and Further Reading Fixed Parameter Models for Time Series and Longitudinal Data Time Series Conditional Models 242 Generalized Autoregressive Models 242 Quasi-Likelihood Models and Generalized Autoregression Moving Average Models Statistical Inference for Conditional Models Marginal Models 255 Estimation of Marginal Models Longitudinal Data Conditional Models 261 Generalized Autoregressive Models. Quasi-Likelihood Models 261 Statistical Inference 262 Transition Models 264 Subject-specific Approaches and Conditional Likelihood Marginal Models 267 Statistical ínference Generalized Additive Models for Longitudinal Data Notes and Further Reading Random Effects Models Linear Random Effects Models for Normal Data Two-stage Random Effects Models 285 Random Intercepts 286 Random Slopes 287 Multilevel Models Statistical Inference 289 Known Variance-Covariance Components 289 Unknown Variarice-Covariance Components 289 Derivation of the EM algorithrn* Random Effects in Generalized Linear Models 292 Generalized Linear Models with Random Effects Examples Estimation Based on Posterior Modes 298

7 xiv Known Variance-Covariance Components Unknown Variance-Covariance Components Algorithmic Details* 300 Fisher Scoring for Given Variance-Covariance Components 300 EM Type Algorithm Estimation by Integration Techniques Máximum Likeíihood Estimation of Fixed Parameters 303 Direct Maximization Using Fitting Techniques for GLMs 305 Nonparametric Máximum Likeíihood for Finite Mixtures Posterior Mean Estimation of Random Effects Indirect Maximization Based on the EM Algorithm* Algorithmic Details for Posterior Mean Estimation* Examples Bayesian Mixed Models 321 Bayesian Generalized Mixed Models 321 Generalized Additive Mixed Models Marginal Estimation Approach to Random Effects Models Notes and Further Reading State Space and Hidden Markov Models Linear State Space Models and the Raiman Filter Linear State Space Models Statistical Inference 337 Linear Kalman Filtering and Smoothing 338 Kalman Filtering and Smoothing as Posterior Mode Estimation* 340 Unknown Hyperparameters 342 EM Algorithm for Estimating Hyperparameters* Non-Normal and Nonlinear State Space Models Dynamic Generalized Linear Models 345 Categorical Time Series Nonlinear and Nonexponential Family Models* Non-Normal Filtering and Smoothing Posterior Mode Estimation 351 Generalized Extended Kalman Filter and Smoother*. 352 Gauss-Newton and Fisher-Scoring Filtering and Smoothing* 354 Estimation of Hyperparameters* 356 Some Applications Markov Chain Monte Cario and Integration-based Approaches 361 MCMC Inference 362

8 n I i IV xv Integration-bascd Approaches Longitudinal Data State Space Modelling of Longitudinal Data Inference For Dynamic Generalized Linear Mixed Models Spatial and Spatio-temporal Data Notes and Further Reading Survival Models Models for Continuous Time Basic Models 385 Exponential Distribution 386 Weibull Distribution 387 Piecewise Exponential Model Parametric Regression Modeis 388 Location-Scale Models for log T 388 Proportional Hazards Models 389 Linear Transformation Models and Binary Regression Models Censoñng 391 Randorn Censoring 391 Type I Censoring Estimation 393 Exponentiaí Model 394 Weibull Model 394 Piecewise Exponentiaí Model Models for Discrete Time Life Table Estimates Parametric Regression Models 400 The Grouped Proportional Hazards Model 400 A Generalized Versión: The Model of Aranda-Ordaz. 402 The Logistic Model 403 Sequentiai Model and Parameterization of the Baseline Hazard Máximum Likelihood Estimation Time-varying Covariates 408 Interna! Covariates* 411 Máximum Likelihood Estimation* Discrete Models for Múltiple Modes of Failure Basic Models Máximum Likelihood Estimation Smoothing in Discrete Survival Analysis Smoothing Life Table Estimates Smoothing with Covariates Dvnamic Discrete-Time Survival Models 423

9 xvi Posterior Mode Snioothing 423 Fully Bayesian Inference via MCMC Ri'inarks and Further Reading 429 A 433 A.l Exponential Families and Generalized Linear Models 433 A.2 Basic Ideas for Asymptotics 437 A.3 EM Algorithm 442 A.4 Numerical Integration 443 A.5 Monte Cario Methods 449 B. Software for Fitting Generalized Linear Models and Extensions 455 Bibliographv 467 Author Index 505 Subject Index 512

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