3 piece system. Treat necks. 75 degrees of angulation* mm. 17 mm. Overlapping stents provide multiple sealing points for every apex

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2 3 piece system with multiple options for patient customization. Broad range of sizes in the standard offerings Overlapping stents provide multiple sealing points for every apex Multiple treatment options for customization Treat necks as short as mm or up to 75 degrees of angulation* mm 17 mm 80 0 mm * of angulation requires a minimum neck length of mm

3 To the aorta Suprarenal and infrarenal barbs for ensuring stent-graft fixation Superior fixation to the aorta and within stent modules Within stent modules TREOVANCE is designed to be a highly conformable and adaptable The unique Lock-stent, with rounded barbs, secures attachment of the main body avoiding modular disconnection mm mm mm 14 mm mm ** mm **180 mm length leg extension only available in 8, and 12mm leg diameters

4 Proximal Clasp Distal Leg Clasp Navitel Delivery System offers an accurate deployment Proximal clasp and distal leg clasp The Navitel Delivery System features a proximal clasp assembly to allow for both cranial and caudal adjustment before the bare stent is released. The distal leg clasp permits late repositioning via control of the ipsilateral leg. Flexible tip and sheath feature hydrophilic coating for easier navigation Navitel Delivery System offers a controlled and easy access management Detachable sheath provides less access manipulation as well as continuous vascular access for percutaneous procedures.

5 AT RAUMATIC INT RODUCER SHEATH Low Profile Main Body: Leg: UÊÓäÊÌ ÊÓnÊ Ê võàv>ìi\ê18 Fr (OD) UÊÊÊnÊÌ Ê {Ê Ê i}\ê (OD) UÊÎäÊÌ ÊÎÈÊ Ê võàv>ìi\ê19 Fr (OD) UÊ ÇÊÌ ÊÓ{Ê Ê i}\ê (OD) Main Grip TÕrn Knob Release Grip,i i>ãiê V iì>v >L iê- i>ì VÌ ÛiÊ}>à iìêãi> à L>V Ê vêã i>ì Ê>ÃÊà i>ì ÃÊ`iÌ>V i`êvà Ê > Ê}À «

6 Bright ideas for aortic endovascular solutions RELAY Thoracic CE Mark 2005 Bolton Medical Custom Made Program 2006 FDA Phase I Trial Completion 250 mm length lowest number of stent-graft per patient within TEVAR RELAY NBS Thoracic CE Mark RELAY NBS PLUS Thoracic CE Mark Approval FDA Phase II Trial Completion 20 RELAY PLUS Thoracic CE Mark Approval 3000 Patients treated with the 2009 Brand 2000 Patients treated with the Brand Halfway point in the U.S. Phase II clinical trial TREOVANCE Abdominal Advandce Study completion 2011 First Human RELAY Branched Thoracic Stent- Graft Case 5000 patients treated with the RELAY Thoracic Stent- Graft Brand 2012 TREOVANCE Abdominal CE Mark Submission Branched project development

7 In TEVAR... RELY on RELAY Flexible and conformable stent-graft Wide range of sizes: Off-the-shelf and Custom Made Proximal clasping in all stent-grafts for precise deployment Unique delivery system for improved navigability RELAY PLUS, RELAY NBS PLUS and TREOVANCE are certified by SGS (0) according to Council Directive 93/42/EEC as amended 2007/47/EC US Only - RELAY PLUS: Caution: Federal Law (US) restricts this device to sale by or on the order of a physician. RELAY NBS and RELAY NBS PLUS: not available for sale in the United States. Treovance: CAUTION - Investigational Device. Limited by United States law to investigational use Manufacturer: Bolton Medical España, S.L.U. C\ Newton 18-24, Sant Esteve Sesrovires, Barcelona, Spain U.S. Headquarters. Bolton Medical Inc. 799 International Parkway, Sunrise, FL 33325,

8 Bifurcated Main Body Selection Chart Aortic Inner Proximal Lowest Renal Diameter Landing Zone to Aortic (proximal neck MINIMUM Bifurcation angle <_60 ) Length (neck MINIMUM angle <_60 ) Length Proximal Diameter Contralateral Length Profile Description TREOVANCE Catalog Reference Fr 20 mm Bifurcate - 80 mm 28-B S Fr 20 mm Bifurcate - 0 mm 28-B1-20-0S Fr 20 mm Bifurcate - mm 28-B1-20-S Fr 22 mm Bifurcate - 80 mm 28-B S Fr 22 mm Bifurcate - 0 mm 28-B1-22-0S Fr 22 mm Bifurcate - mm 28-B1-22-S Fr 24 mm Bifurcate - 80 mm 28-B S Fr 24 mm Bifurcate - 0 mm 28-B1-24-0S Fr 24 mm Bifurcate - mm 28-B1-24-S Fr 26 mm Bifurcate - 80 mm 28-B S Fr 26 mm Bifurcate - 0 mm 28-B1-26-0S Fr 26 mm Bifurcate - mm 28-B1-26-S Fr 28 mm Bifurcate - 80 mm 28-B S Fr 28 mm Bifurcate - 0 mm 28-B1-28-0S Fr 28 mm Bifurcate - mm 28-B1-28-S Fr 30 mm Bifurcate - 80 mm 28-B S Fr 30 mm Bifurcate - 0 mm 28-B1-30-0S Fr 30 mm Bifurcate - mm 28-B1-30-S Fr 33 mm Bifurcate - 80 mm 28-B S Fr 33 mm Bifurcate - 0 mm 28-B1-33-0S Fr 33 mm Bifurcate - mm 28-B1-33-S Fr 36 mm Bifurcate - 80 mm 28-B S Fr 36 mm Bifurcate - 0 mm 28-B1-36-0S Fr 36 mm Bifurcate - mm 28-B1-36-S Notes: For Proximal Neck angle 61-75, choose the next larger device required Proximal Landing zone length of mm. For Proximal Neck angle 61-75, the maximum treatable aortic diameter is 30 mm. Proximal Cuff Selection Chart Proximal Aortic Inner Landing zone Proximal Diameter Covered TREOVANCE MINIMUM and Distal Profile Description (proximal neck Length Catalog Reference Length (neck Diameter Angle <60 ) angle <_60 ) Note: Cuff extensions available on each 20 proximal diameter 40 in the following 18 Fr labeled lengths: 40, 2055 mm and Cuff mm. 28-C S Fr 20 mm Cuff - 55 mm 28-C S Fr 20 mm Cuff - 70 mm 28-C S Fr 22 mm Cuff - 40 mm 28-C S Fr 22 mm Cuff - 55 mm 28-C S Fr 22 mm Cuff - 70 mm 28-C S Fr 24 mm Cuff - 40 mm 28-C S Fr 24 mm Cuff - 55 mm 28-C S Fr 24 mm Cuff - 70 mm 28-C S Fr 26 mm Cuff - 40 mm 28-C S Fr 26 mm Cuff - 55 mm 28-C S Fr 26 mm Cuff - 70 mm 28-C S Fr 28 mm Cuff - 40 mm 28-C S Fr 28 mm Cuff - 55 mm 28-C S Fr 28 mm Cuff - 70 mm 28-C S Fr 30 mm Cuff - 40 mm 28-C S Fr 30 mm Cuff - 55 mm 28-C S Fr 30 mm Cuff - 70 mm 28-C S Fr 33 mm Cuff - 40 mm 28-C S Fr 33 mm Cuff - 55 mm 28-C S Fr 33 mm Cuff - 70 mm 28-C S Fr 36 mm Cuff - 40 mm 28-C S Fr 36 mm Cuff - 55 mm 28-C S Fr 36 mm Cuff - 70 mm 28-C S Notes: For Proximal Neck angle 61-75, choose the next larger device required Proximal Landing zone length of mm. For Proximal Neck angle 61-75, the maximum treatable aortic diameter is 30 mm. Limb Extension Selection Chart Treovance is a product manufactured by Bolton Medical Spain and sold in Italy by Bolton Medical Italia Iliac Landing Limb Extension Iliac Inner Covered TREOVANCE Zone MINIMUM Distal Profile Description Diameter Length Catalog Reference Length Diameter 8 80 /8 mm Leg Extension - 80 mm 28-L S 8 0 /8 mm Leg Extension - 0 mm 28-L1-08-0S /8 mm Leg Extension - mm /8 mm Leg Extension - mm 28-L1-08-S 28-L1-08-S /8 mm Leg Extension mm 28-L S /8 mm Leg Extension mm 28-L S 80 / mm Leg Extension - 80 mm 28-L1--080S 0 / mm Leg Extension - 0 mm 28-L1--0S 9 / mm Leg Extension - mm / mm Leg Extension - mm 28-L1--S 28-L1--S 160 / mm Leg Extension mm 28-L1--160S 180 / mm Leg Extension mm 28-L1--180S /12 mm Leg Extension - 80 mm 28-L S 12 0 /12 mm Leg Extension - 0 mm 28-L1-12-0S /12 mm Leg Extension - mm /12 mm Leg Extension - mm 28-L1-12-S 28-L1-12-S /12 mm Leg Extension mm 28-L S /12 mm Leg Extension mm 28-L S /14 mm Leg Extension - 80 mm 28-L S 14 0 /14 mm Leg Extension - 0 mm 28-L1-14-0S /14 mm Leg Extension - mm 28-L1-14-S 14 /14 mm Leg Extension - mm 28-L1-14-S /14 mm Leg Extension mm 28-L S 17 0 /17 mm Leg Extension - 0 mm 28-L1-17-0S /17 mm Leg Extension - mm /17 mm Leg Extension - mm 28-L1-17-S 28-L1-17-S /17 mm Leg Extension mm 28-L S 20 0 /20 mm Leg Extension - 0 mm 28-L1-20-0S /20 mm Leg Extension - mm /20 mm Leg Extension - mm 28-L1-20-S 28-L1-20-S /20 mm Leg Extension mm 28-L S 24 0 /24 mm Leg Extension - 0 mm 28-L1-24-0S /24 mm Leg Extension - mm /24 mm Leg Extension - mm 28-L1-24-S 28-L1-24-S /24 mm Leg Extension mm 28-L S Straight Extension mm Straight Extension - 80 mm 28-S S 9 80 mm Straight Extension - 80 mm 28-S1--080S mm Straight Extension - 80 mm 28-S S Bolton Medical Srl (società con sistema di gestione qualità certificato ISO 9001:2008) Viale Monza Milano Tel: Fax: customerservice@boltonmedical.com - infoitalia@boltonmedical.com Reperibilità 24/ All measures are in mm unless differently specified 28-MK0123 IT 2013_01_TRE