Introduction. Biomedical Image Analysis. Contents. Prof. Dr. Philippe Cattin. MIAC, University of Basel. Feb 22nd, of

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1 Introduction Prof. Dr. Philippe Cattin MIAC, University of Basel Contents Abstract 1 Varia About Me About these Slides 2 My Research 2.1 Segmentation Segmentation of Facial Soft Tissues Segmentation of Spinal-Cord Segmentation of Spinal-Cord (2) 2.2 Organ Motion 4D MRI Mathematical Motion Model Principle/Motivation for MRgHIFU Motion Compensation Result Prediction from 2D Ultrasound MR and Ultrasound Fusion Prediction Results 2.3 Registration Smooth Deformation Model Artificial Example Example Registration with our Liver Images Example with our Liver Images Lung Motion 2.4 Augmented Reality and Navigation ARALPAN: Intra-op AR System Tablet-based Image-guided Therapy Inertia-based Navigation 2.5 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone SEM Piezoosteotome Cut Bone Laser Cut Bone Contents of :30 2 of :30

2 Abstract (2) Varia A short overview of the Medical Imaging Analysis projects that my group conducts. About Me (4) My Name: Philippe C. Cattin Apprenticeship at BBC/ABB Baden (Physics Laboratory Technician) HTL Brugg-Windisch (Computer Science) ETH Zurich (Computer Science) Ph.D. at the Institute of Robotics, ETH Zurich "Biometric Authentication System Using Human Gait" Post-Doc at the Computer Vision Lab, ETH Zurich Head of the Medical Image Analysis Group, ETH Zurich Assoc. Professor at the Medical Faculty of the University Basel Name of the group "Medical Image Analysis Center (MIAC)" 3 of :30 4 of :30

3 About these Slides Generated with hotspot/kilauea [ All hotspot presentations are generated from an XML source file A table of contents as well as all outline slides are generated automatically Also usefull for online presentations Varia (5) My Research Segmentation Allows to easily include formulas such as Hotspot/Kilauea is not usefull if you prefer a GUI Segmentation of Facial Soft Tissues Incorporation of statistical shape knowledge into the graph-cut segmentation process. (8) Masseter muscle Challenging task due to the high density artefacts 5 of :30 6 of :30

4 Segmentation Segmentation Segmentation of Spinal-Cord (9) Segmentation of Spinal-Cord (2) (10) Segmentation for sub-voxel atrophy measurement (red) background, (green) foreground, (yellow) automatic segmentation (red) background, (green) foreground, (yellow) automatic segmentation fine segmentation Precision of of the area that corresponds to in the radius 7 of :30 8 of :30

5 Organ Motion Mathematical Motion Model Organ Motion (13) 4D MRI (12) Voxelsize, Frequency 4-Dimensional statistical liver motion model Maximum Intensity Projection of the right liver lobe 4D Lung reconstruction, 24 sagittal slices, 11 stacks 9 of :30 10 of :30

6 Organ Motion Organ Motion Principle/Motivation for MRgHIFU (14) Motion Compensation Result (15) Advantages No radiation or chemotherapy No bleeding No surgery Faster recovery Minimal side effects HIFU Ablation Respiratory Motion Prediction error with the atlas based approach Principle of HIFU 11 of :30 12 of :30

7 Organ Motion Organ Motion Prediction from 2D Ultrasound (16) MR and Ultrasound Fusion (17) Given A static 3D exhalation CT image 2D/3D Ultrasound image of the liver Output Prediction of the liver/lung position 13 of :30 14 of :30

8 Prediction Results Organ Motion (18) Registration Smooth Deformation Model (20) 15 of :30 16 of :30

9 Registration Registration Artificial Example (21) Example Registration with our Liver Images (22) Variational approach that simultaneously segments and registers. Reference image Floating image Motion field Reference image Floating image Motion segmentation (continuous cuts) Motion field 17 of :30 18 of :30

10 Registration Registration Example with our Liver Images (23) Lung Motion (24) Motion segmentation and motion field 19 of :30 20 of :30

11 Augmented Reality and Navigation Tablet-based Image-guided Therapy Augmented Reality and Navigation (27) ARALPAN: Intra-op AR System (26) 21 of :30 22 of :30

12 Inertia-based Navigation Augmented Reality and Navigation (28) Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome (30) 23 of :30 24 of :30

13 Computer-Assisted Robot-guided Laser Osteotome Computer-Assisted Robot-guided Laser Osteotome SEM of Natural Bone (31) SEM Piezoosteotome Cut Bone (32) 25 of :30 26 of :30

14 Computer-Assisted Robot-guided Laser Osteotome Laser Cut Bone (33) 27 of :30

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