Institute of Psychiatry A Centre of Excellence. 7, D. L. Khan Road, Kolkata

Transcription

1 Page 1 of 57 Institute of Psychiatry A Centre of Excellence 7, D. L. Khan Road, Kolkata Specifications for State of the Art, Top of the Line, 3T MR PET

2 Page 2 of 57 System Configuration Index 1. Magnet, Gantry size 2. Patient handling system and patient table 3. Shim system 4. Gradient system 5. Radio frequency system 6. RF coils 7. Host computer and Array processor 8. Operators Console 9. Additional Console / work station, Image storage 10. Date acquisition System, Image Reconstruction, Real-time reconstruction, Software 11. Parallel acquisition, 12. Imaging specification, Factors affecting image quality,image display,image Quality, Image Recording Device, 13. Pulse sequences and Acquisition protocols 14. Paediatric Protocol 14. Multi nuclear in vivo spectroscopy 15. Post processing and evaluation software 16. Multi format camera 17. Steriotaxy 18. Networking & Image Transfer, Image Archiving, Image evaluation tools 19. Miscellaneous, Patient communication system, Patient Registration 20. Anesthesia equipment requirement, Cardiac rhythm monitor cum Defibrillator 21. Patient Accessories 22. Accessories 23. Pet Specifications 24. Accessories 25. Site Preparation 26. Background of company 27. Power Supply 28. Environmental and Power Requirement 29. Important Notice 30. Annexure

3 Page 3 of 57 Specifications for a New State of the Art, Top of the line, integrated whole body 3 T MR-PET System with latest generation gradient system and detector system Competitive bids (Technical and price separately) are invited for installation of a state of the art, top of the line fully DICOM-3 compatible true whole body stable 3 Tesla MRI-PET system with high homogeneity and latest high performance gradients having digital radio frequency system with optimized matching multi channel coils. Must be capable of large volume and high resolution imaging in conventional, ultra fast mode including echo planer imaging (EPI) with state of the art features, fully functional and integrated with whole body PET system with simultaneous acquisition. Broad specifications, essential configuration and capabilities of the proposed system are given below. The quotations may be submitted for the latest technology available at the time of quotation. All quotations must be submitted in the format given below. Specifications quoted are essential requirement of this equipment while terms & conditions are mentioned separately. System must be DICOM-3/HL7 standard compliant. The system should be cost effective, reliable and provide excellent performance with technical features for clinical imaging and with high patient through put besides advanced biomedical research. All the specifications quoted should be supported by the authentic data sheet. When the standard vendor data sheet disagrees with the bid response, clarification should accompany in the form of letter/certificate from appropriate authority in the absence of which vendor data sheet will prevail for the purpose of evaluation and decision of the technical evaluation committee shall be final and binding on the supplier. Any item not covered under standard set should be quoted separately. In case the company has other technical features will be part of the specifications and must be offered. Please make separate bids for the technical and price components. Cost of items/features wherever asked should be quoted in the price bid only, failure would automatically disqualify the bidder. Price of each item must be quoted separately. Total price of the system as per tender specifications must be quoted categorically. Please respond to each specification in the same format and order as mentioned in the document, and specify the verification document from the data sheet against each column. All compliance to the Tender should be in the form of Original Data sheet or Original Certificate from the manufacturer. Items under Work in Progress will be considered only for research agreement. Please respond to each point in detail and do not mention yes or no only. Additional relevant technical features suitable for our requirement will be given due preference. Wherever required, additional information should be provided as a separate document with reference to the specific section being addressed. Also note that if new developments occur and an upgraded system becomes available between the notification of this tender and the time of finalization of the bid, then the newer upgraded version must be supplied. To implement the research protocol along with essential requirement will be provided by the vendor(software, hardware, and training) All commercially available software for clinical use, and also research protocols should be supplied with the equipment at the time of installation. In addition, all future, free comprehensive software upgrade guarantee must be provided The detailed specification that follows shall be understood to be minimum requirement. Offer should comprise delivery, installation, official release and safety acceptance until hand over the system including the accessories necessary for operation.

4 Page 4 of 57 SPECIFICATIONS MAGNET - Actively shielded extremely homogeneous, lightweight super conducting magnet with operational field strength of 3.0 Tesla and A external interference shielding suitable for high resolution imaging and multinuclear spectroscopy. 1 Element in magnet coil & type of shielding of coil Please specify suitable for high resolution 2 3 Operational Magnetic field strength and Operational Frequency of the system With shielded Magnet Distance of the 0.5mT line from isocentre a. X - axis meter (inch) b. Y -axis meter (inch) c. Z - axis meter (inch) imaging Please specify. Does 5G line fall within the confines of the magnet room? 4 Size of sweet spot Please specify 5 Temporal stability Specify in ppm/hr 6 Operating frequency of your system Should be at least 60 cm well lit and ventilated after 7. Dimensions of Bore/Gantry Size positioning of gradient coil, body coil, Shim and RF antenna. Bore opening should be flared at both end. Mention the dimension of flare portion 7a. A. Bore Diameter B. Total bore length C. Bore opening D. Dimension of flare portion LCD Display panel Physiological signals - like ECG / VCG, respiratory signals etc.,

5 Page 5 of 57 8 and table position should be displayed in the console. Display of identification of connected coil, table position and also remote selection of coil element must also be possible In tune of tons with 9 Magnet weight - 100% topped up liquid helium, tank and gradient coils 10 Helium tank capacity in liters Please specify 11 Helium Refill Interval In days- Should be maximum Helium boil off rate in stand by and operational modes and effect of high gradient on 12 Please specify boils off 13 Helium level monitoring equipment in the magnet and facility for appropriate quick shut down of the magnet in the event of emergency. 14 Emergency helium release button should be provided at least in two places [inside MR examination room and console room] 15 Repairable cold head or replaceable cold head 16 Type of shielding - Active /passive Please specify Is magnet shielded against external interference? (eg. Moving ferromagnetic objects 17 Please specify (eg. lifts), transformers Is this shielding against external interference active during a scan? Specify active shimming and passive shimming. Should have provision for automatic in vivo dynamic shimming to improve homogeneity of magnetic field and stability The magnet power supply for ramping up the magnet included or not Shielding of External Interference. System should include features that prevent static and dynamic environmental interference from the ferrous objects in the vicinity while the acquisition is going on

6 Page 6 of 57 Smaller fringe field preferred. Please specify 5 Gauss and 10 Gauss Line in X,Y,Z 21 axis of your system 22 Off centre FOV Shimming feasibility cm DSV ± 40 cm DSV ± Specify homogeneity of system after shimming (shim turned off and on) using volume 30 cm DSV ± RMS multipoint plot. Details on number of plane plots used for measurement as well 20 cm DSV ± as number of measurement point per plane should be clearly specified. The space 10 cm DSV ± should be minimum (small ppm the better). Homogeneity should be measured in at Eg: 40cm DSV = least 20 planes and 20 point in each plane inside a spherical volume in ppm. 0.5ppm 24 Maximum FOV with uniform fat sat 25 Long-term stability of the magnetic field ppm/hour 26 Noise level inside the gantry and examination room should be minimum as possible 27 Physiological signal display on Gantry Please specify Specify the limit in ppm/hr. Field instability not be exceed 0.1% ppm Long-term stability of the magnetic field ppm/hour Specify db level. Any special technique used to reduce noise level and its effect on SNR should be mentioned 28 Internal light for patient alignment (specify source) 29 B 1 Built - in 2 way Intercom facility to communicate with patient is required Patient handling system / Patient Table Panel at the front of the magnet for controlling table movement (including home, isocentre, in and out movement),. start/stop/pause scan, ventilation and lighting Computer controlled patient table movement in vertical and horizontal direction.

7 Page 7 of Specify the type of patient table: whether conventional removable trolley type or fixed type/detachable top If fixed type what facility is incorporated for shifting the patients on MR table Separate patient transport system, non-magnetic stretcher for separate patient 4 transport. 5 Lowest table height Positional accuracy of the patient table should be specified. Better accuracy and reproducibility in advanced application such as CE MRA is 6 required. Peripheral MRA with stepping table movement. 7 Accuracy of repositioning Please specify 8 Scannable range and accuracy Specify. 9 Digital display of table position on panel on front of magnet 10 Availability of table control from console (e g. for peripheral MRA) 11 To start, stop and pause a scan at the magnet control panel specify 12 Longitudinal table seed Please specify Patient load - patient load ability should be at least 150kg 13 Please specify Integrated patient physiological signal monitoring. (ECG, respiration and pulse). Gating hardware and software for ECG, Pulse, respiration etc to be provided on front of magnet with alarm Does physiological measurement unit travel with the patient table? Availability of additional display of physiological data in the examination room. 17 One button iso-center positioning 18 Home positioning (out) just by push button 19 Gating hardware provided or not for external interface 20 Immediate table release and manual table move from gantry in case of emergency 21 All parts of the table should be protected from liquid spill

8 Page 8 of Provide detail on Patient immobilization devices. e.g. Security straps and cushions/ railings etc 23 Fresh air ventilation 24 Intercom system from consol to magnet room 25 Diffuse interior light with long lasting light source 26 Duplicate controls and indicator All patient essential accessories and comfort aid to be listed. Cushions, mattresses, and 27 other patient comfort accessories to be provided. Details can be worked out. 28 Close circuit TV and CCD video camera for patient monitoring. 29 Hand held patient alarm system 30 Music entertainment system for patient (integrated, inclusive of CD/DVD player and radio and disc interface Patient music head set must be magnet compatible inside the 31 magnet bore and should be able to fit in the ears with head coil in place 32a. a. MR compatible syringe/infusion pump, MR compatible IV stand, MR compatible oxygen cylinder (2) along with a MR compatible anesthesia machine with a vaporizer and ventilator of standard make. (this is repeated in accessories) for adult and pediatric applications, please specify the make and Model b. Patient monitoring device with Pulse oxymeter), O2 with adult and pediatric monitor, NIBP, Et CO2 32b. sampling line, MR compatible Laryngoscope for adults and children etc probe, please specify the make and model C 1 SHIM System High performance and highly stable shim system with global and localized manual & auto shimming for high homogeneity magnetic field for imaging and spectroscopy. 2 Type of shim a Active b Passive (Iron etc) Whether iron bars used for shimming get heated

9 Page 9 of 57 during imaging and interferes with magnetic homogeneity and deteriorates the image c a+b 3 Number of independent active shim channels Please specify 4 Number of installed shim coils used for active shimming. Please specify 5 Is it possible to automatically improve the field homogeneity according to the individual patient (at the touch of a button)? 6 Extended shim system a. Is an extended shim system available for precise additional fine-tuning of homogeneity for non-linear high order terms once the 6a patient is positioned inside the system? 6b. b. Provide patient specific advanced high order shim for on line correction Auto or manual. D. Gradient System 1 The gradient system should be the latest generation to deliver maximum performance in terms of short TR, TE, and Echo Spacing in EPI and short TE capability in DWI.. High order of stability, linearity and minimum acoustic noise is required Gradient Fidelity (as defined in terms of peak instantaneous time integral of error between input and output over 100 EPI waveforms) Actively shielded gradient system in X, Y, Z and other planes. Capable of performing single shot EPI and multi shot EPI including conventional and fluoroscopic imaging in all planes; and multi nuclear spectroscopy. Maximum gradient field strength (40mT/m) in XYZ planes in homogenous volume or above in accordance with FDA approved data. Effective gradient field strength (diagonal in X,Y, Z direction) Please specify Specify

10 Page 10 of Max slew rate for each of x-, y- and z-axes 200T/m/s 7. Max slew rate for combined x-, y- and z-axes 300T/m/s 8 Duty cycle at maximum and minimum strength at full peak -100% X gradient rise time from 0 to maximum Amplitude Minimum rise time with a slew rate of at least 200T/m/s with maximum gradient field Y gradient rise time T/m/s, independent of each axis from 0 to maximum Amplitude Z gradient time from 0 to maximum amplitude Specify Gradient rise time profile with increment of 0.5mT/m to maximum Specify minimum gradient slew rate of system with amplitude and rise time in non resonant mode. Type of the gradient resonant or nonresonant. from 0 to maximum Amplitude 12 Please comment on Level of eddy current compensation in % and drift 13 Gradient linearity in % of image volume 14 The system should have efficient and adequate provision for eddy current compensation Type of Cooling Details of effective cooling system for gradient coil and 15 heat dissipation and 16 maintenance of its temperature..: Accessories provided to reduce acoustic noise in fast and EPI mode in the magnet Liquid cooled for better duty cycle performance. Gradient amplifier should be liquid cooled. 17 Type of gradient system for EPI Power supply for gradient coil system 18

11 Page 11 of Is the same gradient power supply being used for EPI and conventional imaging? Specify type of gradient strength wave forms possible at maximum gradient strength and minimum rise time specified above for your system. Different type of waveform generated by gradient system of your equipment. 21 Smallest field of view in 2D and 3D EPI specify Largest field of view with guaranteed homogeneity 22 of +/-1ppm or lower 23 Maximum Field of view at the maximum gradient strength specify Please confirm that max FOV quoted above is available on 24 all three axes - x-y-z (This is critical aspect and the peak gradient quoted should be available in imaging mode across all the 3 axes.). 25 Shortest TE in 3D gradient Echo at 256 X 256 matrix 26 Is there a provision of ultra-short TE imaging? Please elaborate if yes 27 Minimum Slice thickness in 2D least will be preferred Specify 28 Minimum Slice thickness in 3D - least will be preferred Specify Minimum TR, TE and slice thickness in EPI including other imaging modes and. 29 minimum volume localization in spectroscopy. Confirm the availability of following Measurement Matrix X 128 to 1024 X 1024 in 2D & 3D eg , 256 2, 512 2, Higher gradient performance if available at time of supply must be offered, clearly indicating the clinical application along with other details such as minimum TE, TR, slice thickness, slice per second etc. 32 Future up-gradation of gradient performance in term of amplitude and rise time should be possible at site.

12 Page 12 of Mechanism / safety measures to avoid peripheral nerve stimulation by high gradient stimulation. Specify E. RF System 1 Digital solid state, broad band RF System. Capable of EPI and multinuclear [Proton 31P, 19F etc] spectroscopy. Digital transmitter and receiver capable of precise frequency and phase control of RF pulses with the smallest incremental frequency range of 1KW. Minimum 32 channels or more with 1MHz receiver band with each channel. Higher channel will be Preferred 2 RF transmitter power to be adequate for high resolution imaging with acceptable power deposition (SAR check) in conventional and EPI mode in term of KW 18kw or more either as single or combination of amplifiers. It should be possible to monitor RF power deposition in the real time mode. Is the RF transmission by optical cable? 3. Specify transmitter frequency range (eg MHz) 4 RF synthesizer resolution in Hz [ Hz/step ] 5 Range receiver band width - Receiver Minimum 1 MHz (not sampling bandwidth) 6. Is RF spoiling possible? Provide technical details 7. Is gradient spoiling possible? Provide technical details 8 Bandwidth of each additional receiver channel 9. Have all channels the same band width? specify 10. Phase resolution degree / step or better 11 System should have necessary hardware to support quadrature phased array and flexi coils.

13 Page 13 of 57 Broad Band RF receiver with at least 32 channels or higher Is there any system in transmitter as well as receiver side. Receiver Bandwidth for superior RF inbuilt performance (=/> 1 MHz each channel). Receiver to support 12 or more elements of indicator to parallel acquisition coils, 12 compatible with parallel imaging techniques with Scan time detect reduction factors of at channel least upto 4 or more in 2D & 3D sequences. failure. Sampling rate of analog digital converter (ADC) 13 Do all ADCs have the same sampling rate? 14 No. of receiver channel for phase array coils system 15 Band width of each receiving channel 16 Receiver signal resolution 32 bit or higher 17 Receiver signal dynamic upto 24 bit 18 Extended radio frequency (RF system) Is tuning of RF coil necessary (auto tuning)? An extended RF system with a higher number of simultaneously usable receiving channels Maximum number of simultaneously receiving element. Single, dual or multiple. System should support linear polarized and CP Coils. CP coils should be quoted for 22 all application possible An extended RF system with a higher number of receiving channel should be available and be offered as standard. Please specify maximum number of coils simultaneously connected

14 Page 14 of What are the nuclei that can be studied with the hardware provided for spectroscopy? 1H, 31P All (10 86 MHz) Multi Nuclei System should have necessary hardware to perform 1H, 31P, 19F spectroscopy. For If Optional each coil please specify the type of coil ie. transmit and receive or receive only and Cost to be FOV values. Optionally quote the 31P and 19F hardware and software specified Specify the coils for C, F and Na, Spectroscopy Heart and Liver P31 spectroscopy If Optional 25 coils and quote the price optionally Cost to be specified Double resonant RF channel for spectroscopy provided or not, to enable proton If Optional decoupled studies Cost to be 26 specified Linear Quadrature 28 System should include RF room shielding and include RF door screen to minimize radio frequency (RF) interference to a minimum level. 29 Noise (in db) of the preamplifier F. Radiofrequency coil:

15 Page 15 of 57 RF coils in addition to main body coil (Transmit / Receive or receive coils) auto tune, array or no tune coils. Coil / RF design should support compatibility to coils manufactured by other manufacturers. All array coils should be compatible with parallel imaging technique/s. (In all cases specify whether transmit- receive, receive only, and the number of elements and channels). All coils should be preferably no tune coils. The pulse sequences must be variable and controllable from the operator console Applications Please confirm that the system can adapt to coils developed and manufactured by other manufacturers also (Third party items). Please specify the measures taken to prevent dielectric artifacts? Please specify the number of channels and elements available for each coil. Please mention the true acceleration factor for each of the array coils. Multi channel array coils for high-speed parallel acquisition Technique Ergonomically designed patient friendly fatigue free head coil Head, Body (chest, abdomen, Pelvis), Heart, Head multi channel, Wrist, Cervical spine, Thoracic spine (T), Lumbar spine, Whole spine, Extremities and joints, Shoulder, Breast Complete package of flexible and rigid quadrature coils with specification including pediatric coils. Is it possible for phased array coils to receive signal from multiple surface coils simultaneously without switching or splitting hardware/software? Possibility of simultaneous use of a surface coil and quad coil?

16 Page 16 of Multi channel array coils for High Speed parallel acquisition Technique - mention the coils and other elements Imaging from multiple coils simultaneous acquisitions from 2or more array coils with simultaneous elements activation from different coils should be there. Remote coil selection (head neck spine) - in conjunction with above, confirm if facility to select the coil elements from the main console should be there. Hardware required for imaging two general purpose flexible coils (flexi coil inter phase). Body coil must be actively decoupled during surface coil imaging 8 Following coils must be provided - 9 Description of offered coils - under following head No. of channel in brain (head coil, head and neck), 9a a. Type of coil - Number of channels and name of coil abdomen, spine, cardiac imaging coil and in other coils 9b b. Application 9c c. Number of coil elements 9d d. Flexible or rigid 10 Integrated body array coil / resonator - circular polarized / quadrature channel or higher Head array Coil with RF mirror and optical mirror for maximum sensitivity and homogeneity. Specify the internal diameter of head coil. Coil should be EPI compatible Head coil must be compatible with stereotactic frame available in the institute. Specify, the type and speed and technique applied with the coils. Coils sensitivity technique for reducing the acquisition time by factor of four or m zyxore. Specify your channels and elements in coil and technique available withthe coil.

17 Page 17 of At least (higher will be preferred) channel Neurovascular imaging coil. Should be a standard coil or the combination of coil elements preferably quadrature to cover entire neck from the aortic arch up to and including the circle of Willis At least channel Coil for Head -Neck - Spine to be 13 quoted as standard 14 Eye/Ear coil 15 At least channel C-T-L Spine Coil to be quoted as standard. Coil for C,T and L Spine - should be phase array / quadrature (CP) 16 Body array coil (at least channel) for thorax, abdominal, pelvic application, peripheral angios. Should be `array' and quadrature (CP) 17 Flexible coil small - CP or Quadrature for extremity or joint Neck coil should be array and quadrature Flexible coil large CP or quadrature for abdomen, extremity Bilateral carotid surface coil for simultaneous high resolutions imaging of carotid plaques Phased array TMJ coil [ CP or Quadrature] 21 Phased array shoulder coil 22 Peripheral Angio Coil -Peripheral angio coil or equivalent coil with CP/quadrature and array technology should be quoted for Performing renal to ankle angio coverage 23 Cardiac coil dedicated cardiac for high speed and high resolution imaging. Please specify the elements Higher will be preferred Dual tuned coils for head and heart/liver for doing imaging and 1H/31P spectroscopy 24 to be quoted optionally Head coil for 23Na imaging to be quoted optionally Phased array shoulder coil for high resolution imaging Higher will be preferred

18 Page 18 of Flexi coil for research purpose (General purpose 3" and 5" coils) Channel Breast Coil 16 Channel Knee Coil 29 G 1 2 Coil tuning, impedance matching, RF power parameter and preamp gain adjustment must be fully computer automated and optimized for each patient. All coils should have built in pre-amplification be ensure high SNR Host computer and array processor Efficient, fast, powerful and latest computer system with color 24 or more LCD /LED monitor to visualize MR and PET data in parallel and fused forms and with sufficient memory and computational speed (1024x1024 matrix image display, dual core 3GHz processor or equivalent, 324Gb RAM, 400Gb RAID HDD or larger (latest available at time of supply) to match the single shot echo planar imaging [EPI], interactive angiogram, multiplaner, three dimensional [3D] reconstruction, surface rendering and dynamic imaging, vascular imaging/angiography, functional imaging, DTI, cardiac evaluation (calculation of ejection factor etc) fluoroscopic imaging and adequate storage for the images and adequate storage for the images and other applications. Necessary image processor (>4GB RAM or more ) with sufficiently large memory for ultra fast image reconstruction capable of performing real time image reconstruction in 50ms or less for the above application mode and dedicated hardware for data conditioning and digital filtering. Quote highest order computer available with you Host computer should possess these minimum requirements: CD-R & DVD-R writer, TCP/IP port, postprocessing software installed. Computer should possess these minimum requirements: Quad core 3GHz processor (64-bit) or equivalent, 16Gb RAM, 400 Gb RAID HDD 3 Word length-must be 64 bit- 128 bit or higher Quote reconstruction 4 Reconstruction speed Speed, Number of images per second with matrix

19 Page 19 of Main Memory (RAM) Expandable, Image RAM capacity, 4-8 GB or more Mention Hard disc Hard disc capacity for 256 X 256 matrix size images or more capacity in GB or TB. Higher will be prefered Two DVD/CD Read/write drive for writing of images, spectra and raw data along with the necessary software for reading the images and Give configuration spectra on CD-ROM Provision for archival of k-space data and raw (unprocessed) images. DICOM-3 interface to hook DICOM laser camera (dry view) capable of storing, printing 1024 X 1024 matrix images in various formats (1-20) without loss of digital resolution must be made available. One special port [serial / parallel] with necessary interface for inter - linking the machine with a PC of Windows XP/window 7/UNIX/LINIX loaded Operating System and TCP/IP communication protocol for transfer of data [image; spectra (raw & processed) and text] over Internet. Necessary image format including header and footer information of stored imaging and spectroscopy data are to be provided with necessary hardware and software to access the raw data. Access to advanced source code for generating new sequences is to be provided with necessary and adequate literature and hardware support including cross compiler or any other relevant software for pulse programming. A list of sequences (imaging and spectroscopy) which can be opened, read and modified by trained persons working on sequence programming (Research collaboration) 1 Terabyte or more? under research agreement For research purpose

20 Page 20 of Necessary operating system software / compilers for C, C++, FORTRAN and database package such as INTEGRESS or ORACLE, mathlab etc. is part of pakage 15 Upgradeability of the Host CPU - company must upgrade the host CPU hardware at end of every three year or As and when Host CPU is upgraded in the similar system after a new release by the firm with out an extra cost. 16 Type and number of reconstruction processor H Acquisition of next sequence must be possible while the image for last sequence is being reconstructed. One additional consoles apart from main consol and one work station (Details in separate section) Operator's Console - Provide detailed specification including resolution, workstation based and operating platform Simultaneous scan, reconstruction and image display capabilities. New scans to be initializable while reconstruction of previous scans is ongoing. Second Console/Workstation for fmri scanning and postprocessing should possess these minimum requirements: 18 LCD monitor, 1280x1024 screen resolution, 2.66GHz processor or equivalent, 4Gb RAM, 250Gbor higher HDD, CD-R & DVD-R writer, TCP/IP port, fmri stimulation and postprocessing software installed, synchronized with scanner.

21 Page 21 of 57 a. Online display b. The possibility of automatically displaying images immediately after reconstruction should be available c. Simultaneous use of the main console for other task d. Can next scan be started before the reconstruction of the previous scan has been ended (parallel scan and reconstruction) e. How many data sets can be reconstructed simultaneously (Actual scan not yet finished plus number of previous scans still being reconstructed) f. Monitor size at least 18" TFT flat/colour monitor magnetically shielded. Display matrix X 1024 (1 K) or more Specify resolution 1. Does operator's console contains the following. a. Emergency scan abort capability b. Manual Override c. Audio system for communication d. Integrated respiratory, pulse and cardiac wave form display e. Ergonomically designed operator chair f. Provision for entering pulse programme and pulse generator g. Does the system provide the following - a. Room oxygen level indicator b. Gas transfer fitting and accessories c. Acute voltage regulator with UPS (specify capacity, with backup time 30 minutes) d. Details of gradient cooling Amplifier Gradient coils e. Monitor for viewing f. recorder with interface for online / real time connected to the operator s console for work station g. Pediatric leads for ECG, Pulse gaiting and respiratory gaiting h. AVI movie maker and CD i. Workstation should be provided with a workstation table and two ergonomically designed operator chair

22 Page 22 of 57 I. Additional Remote Evaluation Workstations With Colour Display Two separate multi modality work Stations capable of calculation, post processing etc including MIP, MPR and spectral analysis, perfusion, PET Images, PET-MRI fusion, DTI, fmri,rt2*, Cardiac analysis software, EPI functional imaging and filming. These work stations should be able to receive DICOM images from CT, DSA lab etc. Printing must be possible from all these workstations. Should be identical in performance as main measurement console and having same user interface (controllable from the keyboard and mouse facility) with evaluation capabilities like MIP, MPR, surface reconstruction and spectral analysis etc. This provides the clinician with the ability to independently manipulate and analyze images separate from the operator's console. It must be completely independent to allow totally unconstrained operation. Have its own `CPU and array processor. Necessary interface for data transfer, along with recording must be provided: Two Workstation for MRI,fMRI/PET scanning and postprocessing should possess these minimum requirements: 18 LCD monitor, 1280x1024 screen resolution, 2.66GHz processor or equivalent, 4Gb RAM, 250Gb HDD, CD-R & DVD-R writer, TCP/IP port, fmri stimulation and postprocessing software installed, synchronized with scanner. Specify the following for work station Type of CPU, Word length Main Memory (RAM), Hard disc storage capacity of 1 TB or higher and DVD writer to be included, Type of array processor Raw data memory, Word length of array processor, Array processor memory (RAM) standard, Array processor memory (RAM) expandable

23 Page 23 of a. The image format must conform to ACR-NEMA format standard b.. Provide details of image format and header information for imaging and spectroscopy data c. The main console and work station should operate on the same platform preferably with the immediate image transfer (Automatic Data transfer capabilities). d. Image documentation should be possible from the main console as well as the workstations e. Additional post-processing software on the workstations display facility must be provided. Provide details of software on main and additional console Display of cardiac cine images in movie mode with rapid AVI (Automatic Virtual Imaging) creation. Provide details of the cardiac package on additional console Calculation of ventricular area and volume, stroke volume, ejection fraction and relative ejection fraction. Calculation of myocardial thickness, mass and signal intensity for multiple myocardial segments Time volume diagram generation, filling rates and myocardial wall motion. Graphic display of output calculation of flow and velocity parameter with colour coded display of velocity parameters. Complete comprehensive cardiac post processing software should be provided with regular upgrades in future Processor memory (RAM) Colour monitor at least 18" LCD / TFT / Flat colour monitor - provide detail specify make & resolution (1024 X 1024 dot resolution or better) Processing of 2D/3D CSI (Chemical Shift Imaging) with paramagnetic metabolic mapping Post processing of BOLD data sets for colour overlay of functional and anatomical data should be real time. Should have capability to calculate colour display of real MTT, real 5. CBV, real CBF. Analysis of vessel disease with the possibility of detection of vessel segments and to quantity changes in vessel size. 3D VTR software for visualization of complex anatomy. Complete 3D reformation package (MR and CT) Provide required Interface for existing equipment (CT, MRI, Ultrasound, DSA). in the department. Enclosed detailed configuration of network.

24 Page 24 of 57 Following hardware and software options should be made available with the workstation - 3D Spin Echo sequences - EPI The system should perform functional MRI for surgical planning The system performed cerebral blood volume imaging for surgical and therapy monitoring System should perform diffusion weighted EPI for diagnosis of stroke 10 Connection with PACS must be provided with all supporting software J. Quality Control a. MR Quality control phantoms should be provided, (Provide multi-modality phantom) for MRI-MRS-PET studies. ACR phantom and other required tools for daily, weekly, monthly, yearly analysis should be provided b. PET quality control phantoms for daily, weekly, monthly, yearly analysis should be provided K SOFTWARE PACKAGES on WORKSTATION Compatible with data from high resolution MRI Units, CT, PET CT All the software and other imaing packages modalities available on the main 1 console should also be available on both workstation also Required Interface for existing equipment (CT, MRI, Ultrasound, DSA) in the department. Detailed configuration of network is available from the computer division. 2

25 Page 25 of 57 L 1 2 DATA acquisition List details of sequences All Coils should be capable of running all sequences including that can be performed Diffusion imaging for and Proton spectroscopy each RF coil with / without PET System should be capable of 2D & 3D acquisitions in conventional, fast, ultra fast spin echo and gradient echo modes so that real time online images can be observed. 2D multi slice imaging should be possible in all planes (axial - sagittal - coronal. Oblique & double oblique) 3 4 Matrix X 128, 256 X 256, 512 X 512, 1024 X 1024 and rectangular matrix selectable in steps of 1. Half Fourier or other technique to reduce scan acquisition time while maintaining adequate SNR. Specify pulse sequences and techniques where 1024 x 1024 matrix can be employed Indicate feasibility of performing moving table MRI/PET experiments. Feasibility of CT like whole body scanogram with continuous table movement 3D volume, multiple continuous slabs, multiple inter leaved and multiple overlapping slabs. 7 Slice thickness in 2D & partition in 3D to be freely selectable. 8 Dynamic acquisition (Serial imaging with capability to initiate scan sequence) either from the magnet panel or from the console. Dynamic acquisition: number of repeat scans with delay time either identical time 9 interval or selectable. 10 Auto slice positioning from the localizer imaging

26 Page 26 of Maximum off center positioning anterior - posterior and lateral direction should be selectable. Gating physiological signal like ECG, pulse, respiratory, external signal triggering (interface for triggering input pulse from external source) Simultaneous acquisition, processing and display of image data in multi slice mode. Selection of VOI's from oblique slices should be possible while doing spectroscopy. Artifact reduction / imaging enhancement / imaging filtering / image subtraction / addition / multiplication / division techniques 16 Graphic presentations must be available 17 Flow - 1st and 2nd order flow artifact compensation Presentation slabs - a number of re-locatable saturation bands be able to be placed either inside or outside the region of interest. Fat saturation techniques, frequency selective RF pulses to suppress fat signals in the measured image FOV. Magnetization transfer saturation: Off resonance RF pulses to suppress signals from stationary tissue in FOV phase contrast capability in 2D & 3D mode. Please provide details of 21 Method for efficient SAR management hardware and software methods 22 Image intensity correction 23 Breath hold acquisition Free breathing acquisition (2D, 3D) for thoracic and abdominal 24 imaging 25 Imaging a. EPI mode b. Data acquisition in all three standard planes (axial, sagittal, coronal) and oblique and double oblique planes. c. Higher matrix acquisition capabilities in single shot EPI acquisition time. TR, TE and slice thickness should be clearly mentioned and supported by data sheet references.

27 Page 27 of 57 M Parallel Acquisition - System should have parallel acquisition capabilities complying the following requirements a. Compatible for all 2D as well as 3D sequences b. Should be. combinable with all orientations (Transverse, sagittal, coronal, oblique and double oblique) c. Should support up to factor 4 or higher for reduction in scan time for all applications as compared to normal acquisition. d. Should be combinable with all imaging applications (Neuro, Cardiac, Body, musculoskeletal, angio including CE angio.) e. Dedicated coil for reducing imaging acquisition time should be supplied (Fully compatible with parallel acquisition technique N Imaging Specifications 1 a. Minimum TE in Gradient Echo Please specify b. 2D c. 3D 2 a. Minimum TR in Gradient Echo Please specify b. 2D c. 3D 3 Minimum slice thickness 2D for all sequences. Should not be greater than 0.2 mm 4 Minimum slice thickness 3D for all sequences. Should be less than 0.1mm 5 Minimum FOV for all sequences (2D & 3D) :?1 cm or better 40 cm above (Maximum 6 Maximum FOV for all sequences (2D and 3D) gradient amplitude should be possible over this FOV) 7 Prospective motion detection and correction 1D - 2D 8 Is an acquisition technique with prospective motion correction available 9 Prospective motion detection correction - 3D motion correction available? If yes, does it include a correction in all 3 linear direction and especially all three rotational directions? Is it suited for functional MRI with increased sensitivity and specificity?

28 Page 28 of 57 Isn t possible to simultaneously acquire several slice packages with different 10. angulations (multi slice, multi angle) Prospective motion detection correction 3D motion correction available? If yes, doesn t include a correction in all 3 linear direction and especially all three rotational directions? Is it possible to perform scans with arbitrarily sorted K - space filling (elliptical sequential, arbitrary assignment etc) If yes, isn t suited for functional MRI with increased sensitivity and specificity 13. Is it possible to perform scan with segmented K - space? Is it possible to perform scans with shared echo technique? 14. (reduced scan time by a factor of two for different applications) Availability of pre saturation techniques (spatial resolution) Maximum number of pre saturation areas Graphical positioning of the pre saturation area Double oblique pre saturation areas Is it possible to perform all fat and water saturation techniques including in phase and out phase imaging with a single sequence? 17. Use of magnetization transfer contrast technique (MTC) for all sequences possible? Please list the sequences where it is not possible Ensure the availability of Frequency selective fat saturation Frequency selective water excitation B-factor (Diffusion studies) Specify X 1024 acquisition must be available X 1024 reconstruction must be available Minimum echo spacing EPI at 128 X

29 Page 29 of Rectangular FOV Specify size 24. Half Fourier Imaging Provide detail Rectangular matrix size, rectangular FOV 25. Maximum ETL, 128 or better in full Fourier transformation Please give the details 3D sequences, Please list the 3D sequences type with submillimeter isotropic 26. resolution ECG Trigger including one set of patient lead wires, Two fiber optic peripheral gating 27. probe - one adult and one pediatric Physiological synchronization Displaying and triggering of ECG, pulse, - respiration and external 28. triggering sources on main console. To perform a scan with an external trigger - sourceeg. Pulse generator for functional imaging. 29. Display the ECG on magnet 30. Advanced trigger detection 31. Arrhythmia minimization 32. Peripheral trigger 33. Pulse / Respiratory trigger O BASIC Pulse Sequences & Application Parameter PULSE SEQUENCES System should be capable of selecting TR and TE as per requirement in majority of the pulse sequences 1 a. Spine Echo (SE) - Multi slice single echo, multi slice multi echo (8 echo or more) with minimum TR & TE. SE with symmetrical and asymmetrical echo intervals. Inversion Recovery (IR) including short TI - modified IRSE, 2 FLAIR, DIR (Double Inversion Recovery) 3 MT with SE and FLAIR 4 STIR (Short Tan Inversion Recovery)

30 Page 30 of SPIR b. Gradient Echo - Gradient Echo with; transverse gradient / RF spoiling and transverse gradient re-phasing eg. GRASS etc. 3D gradient echo with shortest TR & TE, free choice of flip angle selection while 6. maintaining SNR. 7 1 Dynamic study for Pre & post contrast scans time intensity studies (Wash in and wash out) and Kinematics c. Fast Sequences i. FSE - Fast spine echo in 2D & 3D mode. Tl, T2 and PD contrast capable of acquiring maximum. of slices with a given TR and minimum TE, Echo train should be at least 256 or more in fast sine echo mode. 2 ii. Ultra short fast spin echo Half Fourier acquisition capabilities should be available with/without diffusion 3 gradient and in combination with fast spine echo. 4 iii. Fast spine echo with inversion recovery., iv. Fast gradient spine echo IR multi slice, multi echo mode with minimum turbo factor. Sequences should incorporate RF focusing to acquire ultra 5 fast gradient spin echo. 6 Fast gradient echo sequences should incorporate RF spoiling & other techniques to acquire image in ultra fast 2D & 3D modes 7 Fat & water suppressed imaging sequences. Ultra - Fast sequences 1 a. EPI (Echo Planar Imaging) Single shot and multi shot optimized sequences for TI, T2 and PD imaging. Perfusion, regular diffusion values (3 directions) EPI - FLAIR, EPI -IR, EPI- FLAIR diffusion Tensor, EPI - MT - FLAIR. Tensor diffusion for diffusion studies, suitable artifact / fat suppression techniques to be incorporated in the sequence to have optimum image quality. There should be capability of calculating ADC map (Isotropic and anisotropy from regular diffusion and tensor data.) It should be possible to perform arterial spin labeling (ASL) of the brain and cardiac perfusion study; and the corresponding software to give various perfusion maps with quantification possibility. Specify the number of shots for EPI in 64x64, 128x128 and 256x256 matrices.

31 Page 31 of 57 2 b. If any of the. items are not available as clinical tool at present and available as research tool may be provided under research agreement. c. Is it possible to prescribe oblique planes in DTI? If so pl provide the processing software for the same. Single shot selectable with all coils including phased array coils for very fast imaging of trauma patients. Please specify whether it is possible to perform DTI of the liver in vivo? Please specify 3 Optimized sequence package for special applications a. MR angio - Comprehensive angio software package with and with out use of contrast for the whole body. b. 2D TOF, 3D TOF, TOF overlapping sequence c. 2D / 3D phase contrast with and without gating and magnetization transfer saturation d. Black Blood angiography for cerebral, pulmonary abdominal and peripheral vessels. e. For peripheral angio moving table angiography must be provided so that complete limb can be examined in single go f. Bolus tracking software package must be provided. g. Sequences for breath hold angiography with contrast enhancement should be offered h. Time resolved MRA with high temporal resolution and high spatial resolution. 4 Advanced MR cardiac examination package for evaluation of heart in long and short axis with white as well as black blood cardiac imaging. Morphology, wall motion, perfusion imaging, cardiac tagging technique, real time interactive imaging free breathing cardiac MR examination. Myocardial viability, myocardial perfusion. Software package for full automated analysis should be available. Velocity quantification, quantification of aortic and pulmonary flow should be available. Please describe full details with specifications on temporal resolution Package for coronary artery imaging including sequences for motion compensation, prospective and retrospective gating should be available. Contrast enhanced and without contrast enhanced sequences for coronary angiography must be available..

32 Page 32 of 57 SEQUENCES FOR ADVANCED APPLICATIONS 1 a. Sequence package for diffusion study in organ like brain, Kidney, muscle, heart, liver etc. Perfusion study in organ system like Kidney, Brain, Muscle, Heart etc evaluation package for calculating CBV, CBF, MTT, Perfusion MAP etc. (Should be possible on main Console in real time) b. Flow quantification in vessel & CSF, hepatobliary system c. Optimized breath hold sequences for abdominal studies including angiograms. State sequences offered with acquisition time. 2 a. Integrated complete hardware, and software tools for presentation, data collection and analysis solution for fmri assessment b. Dual computer with software for experimental control, patient management and functional analysis high end computer (Latest Generation at time of supply) with CD/DVD drive for experiment presentation loaded with E-prime SW80 GB Hard Disk with at least 2MB video RAM Brain Voyager package or equivalent functionality Master control interface between computer and peripheral devices Large LCD patient display with Head Coil mount in magnet room, patient head phones, patient microphone and 5*2 keypad response unit LCD display should have unrestricted FOV (non-goggle based system must be quoted).lcd display fixed on top of Head Coil RF detector and console enabled TTL triggered for pulse synchronization Fibre Optic cable between Magnet and console. Paradigm generator should have pre-set of paradigms for experiment generation and user programmable paradigm generation should be possible as well CD/DVD for patient entertainment 3.OT compatible and FDA cleared. c. Sequence package for functional mapping of brain with paradigms for motor tasks,perceptual tasks,attention tasks,memory tasks and cognitive tasks with digital sound editor,graphics editor, generalised tasks editor etc.utilities and sutable software for its evaluation. Please give details of post processing software. SPM [Statistical Parameter Mapping] package for evaluation of functional MR images]

33 Page 33 of Internal Ear Imaging-Details of sequences available MR cholangiography, MR pancreatiogram; MR urography, specialized sequences and processing to perform MRCP. Give details of sequences available. MR ventriculography & Cisternography Flow quantification package for CSF with dynamic CSF flow imaging at aqua duct and spinal canal. Dynamic MR Elastography-If not available as clinical, may be supplied under research agreement Please give details of post processing software. 7 Pulmonary 2D/3D MRA sequences 8 Navigator technique for collection of functional imaging data 9 Artifact reducing software for eg. reducing CSF flow artifacts in FLAIR 2D/3D imaging. 10 Any other new or relevant sequences may be quoted P Multinuclear in vivo spectroscopy a. System should have capability to perform proton in vivo to perform multinuclear, spectroscopy. State 1 decoupled spectroscopy minimum TE & TR for spectroscopy sequences [1H, 31P, 19F] 3 Water suppression Spectroscopic mapping Please provide details of broadband proton decoupling for optimal water suppression Facilities for second channel for double resonance technique