Photonics / Imaging / Display
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1 Photonics / Imaging / Display Presenters: Prof. Chak-Yin Tang (PolyU) / Dr. Kevin Tsia (HKU) Other Members: Prof. Chi Hou Chan (CityU) Dr. Kenneth Kin-Yip Wong (HKU) Prof. Edmund Lam (HKU) Prof. Yongping Zheng (PolyU) Theme-based Research Scheme - Research Grants Council Town Hall Meeting June 19, 2015
2 Healthcare Imaging Fundamental sciences Societal aspects From images to understandings
3 Diagnostic imaging Current status Global market size: $32.3B in 2014 to $49B in China: A rapidly expanding market Every $385 spent on imaging decreased a patient s hospital stay by one day (saving ~$3000 per patient) Molly Beinfeld et. al., Radiology, June Frost & Sullivan 2013 So far, we have some images, and some understandings
4 Grand challenge: From better images to better understandings molecule Cell tissue...but, image information is extremely heterogeneous: Multiscale: molecules, cells, tissues, organisms Multidimensional: 3D + time (dynamics) Complex & quantitative: molecular, structural, functional Regenerative medicine Neuroscience Cancer diagnostics
5 Redefine imaging: What is missing? Imaging platforms Image analytics Image visualization Speed Video-rate live-cell imaging Olympus: Microscopy resource center Information content Clinical ultrasound Nature (2015) Ease of Understanding Ultrafast optical imaging Nature 458, 1145 (2009)
6 Redefine imaging: What is missing? Speed Image visualization Functional ultrasound + photoacoustic imaging Nature Medicine 18, 1297 (2013) Information content Digital pathology Nature Photonics 7, 739 (2013) Ease of Understanding Whole brain phenotypes Nature 497, 332 (2013)
7 Photonics Imaging: A New Paradigm Length (m) Time (s) NIR tomography New imaging platforms: Optical Go coherence multimodal tomography (OCT) Computational imaging: High spatial Confocal resolution microscopy + large-scale Super-resolution microscopy New imaging platforms: High spatiotemporal resolution Computational imaging: Single-pixel imaging Complex and Big Image Data Analytics
8 New Era of Biomedical Ultrasound Imaging Moving machine to patient to provide anatomical to molecular imaging Nano-particle Anatomical Imaging Molecular Imaging Functional Imaging Micro-bubble Moving ultrasound machine to patient instead of moving patient to machine - Clinical needs and feasibility clearly demonstrated, BUT - Resolution and functionality to be improved with breakthrough developments - Breakthroughs needed in ultrasound transducer techniques and 3D image formation - Functional imaging, e.g. elasticity imaging, high resolution Doppler flow - More effective use of images via big data analysis and cloud computing
9 Display of Volumetric Images in 3D Media Nanoparticle Doped Polymeric 3D Display in Freeform Shape Quantum Dots Size Dependent Emission 3D Volumetric Image Challenge Excite quantum dots with focused laser to create lighting voxel with colors, resolution, and frame rate to be comparable to 2-D display. 3D Blood Flow Visualization (whole heart 4D flow MRI ) Scattering Voxel Laser Beam with Focal Point Modulation in z-axis Heart Image MEMS Scanning Micro-mirror for Steering in x- and y- axes 1ORpeB6j0gc
10 Examples of Existing Strengths in Hong Kong Plankton ecology Material sciences Fundamental sciences Ultrafast OCT 3D image visualization Autonomous vehicles Optogenetic functional MRI THz spectroscopy & imaging Biometric Security and Recognition Computational imaging and analytics Ultrahigh-throughput single-cell imaging Label-free nonlinear optical microscopy Imaging for neural recording/stimulation Molecular/functional ultrasound imaging... Biometric Security Societal aspects
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