Mission; Foster adoption of
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1 Version 10
2 ission; Foster adoption of pragmatic and cost effective standards for accurate and reproducible longitudinal quantitation of biologic parameters with clinical relevance and known sigma
3 ilestone horizon/pet-ct RSNA 10 and on RSNA 08 RSNA 09 Calibration Phantoms Characterization Lo, i rads Interoperability of Results Encoding RoI Definition* Quantitation Computation Documentation of terms Image Quality etrics Dynamic Range lesion size** Value,, L Feasibility,, L edium Priority,, L Quick its N/A *Adoption, but Define by 2008 Chair,, L Clunie TBN **Ideal Phantom Current phantom by 2008
4 Quick its RSNA 08 (next deliverable) Clunie; Quantitation Computation Gagnon; Software version tracking Kinahan; Digital Reference Objects Images aguire; Covariates rationale* (Normalization) Turkington; RoI Definition (Adoption) Frank; Editorial in follow-up to aguire needs * in some cases just enabling data capture & reporting
5 Next Steps Chairs convene working groups Letter to editor in follow-up to aguire needs article Develop matrices Identify commonalities within QIBA (eg RoI) Identify adjacent players, stakeholders Deliver goods Report out during RSNA 08 Reprioritize remaining deliverables, eg 3D and iterative reconstruction has created a quagmire!
6 Umbrella vs. Niche AACR EORTC NCIA* UPICT CDISC SN NIST FDA NCI ASCO QIBA AI SI ACRIN IRATS AAP PhRA NEA ITA Contingencies Communications *Data Test Bed
7 onitoring Rx Benefit = Individualized edicine Convergence of Biomarkers and Diagnostics /o Commercial Dx Individuals - thresholds Categorical, staging Workflow/# studies Binary choice of Rx Biomarkers become Dx Populations means Continuous, quantitative Automation/bias Longitudinal Rx effect Quantifying the effects of drugs in development may beg access to biomarkers as diagnostics
8 Topic F V Chair Calibration Phantoms Build and use 2009 Step 1 Use Existing Phantoms Image Quality etrics Step 2 Characterization appropos of low, high radiation Scanner QC Patient/Image/Visit?Repeat Scan (Near term, Current practice) Enhanced PET Object Adoption L >2011 inimum easurable Lesion 2009 Dynamic Range Current Phantom, Ideal Phantom Longitudinal Quantitation Qualitative New Lesion Threshold ROI Definition 2008 (define) Turkington + vct Draw boundary (adopt)
9 Topic F V Chair Data Extraction 1) 2008 Analysis (in ROI) 2) ) Factors in Decision 2) Recommended Choice Digital Ref Object Software Phantom Reference Data Set Version Tracking 2008 Gagnon-vendors Image? Quantification 2008 Kinahan-SN Raw Data To Reconstruction (Black Box)
10 Topic F V Chair Software Phantom Reference Data Set Image? Data? Covariates/Normalizations Serum Glucose LB 1) Factors in rationale 1) 2) 1) ) acguiresend requests and will compile list 2) Build normalization into products Quantitation Computation 2008 Clunie Document Terms Inputs QC >2011 Interoperability 2009 Results Encoding
11 Topic F V Chair Artifact Contrast L L Prostheses L L Define Factors in Low vs. Dose (RADS) 2008 Define factors and rationale L Recommendations Combination Scanning RECIST & PET
12 Version 10
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