The new version of the GATE simulation platform
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1 The new version of the GATE simulation platform Thibault Frisson Université de Lyon Léon Bérard anti-cancer center, CREATIS, CNRS On behalf of the OpenGATE Collaboration
2 Outline GATE overview Main features Examples
3 Outline GATE overview Main features Examples
4 GATE structure Simulation platform for medical applications User scripts C++ coding needed Application classes Framework Geant4 PET/SPECT/CT /Radiotherapy developments GATE Geant4
5 User script example: geometry # BLOCK /gate/module/daughters/name block /gate/module/daughters/insert box # C R Y S T A L /gate/block/daughters/name crystal /gate/block/daughters/insert box /gate/crystal/placement/settranslation cm /gate/crystal/geometry/setxlength 3.0 cm /gate/crystal/geometry/setylength 3.0 mm /gate/crystal/geometry/setzlength 3.8 mm /gate/crystal/setmaterial NaI /gate/crystal/vis/setvisible 1 A block detector # R E P E A T C R Y S T A L /gate/crystal/repeaters/insert cubicarray /gate/crystal/cubicarray/setrepeatnumberx 2 /gate/crystal/cubicarray/setrepeatnumbery 8 /gate/crystal/cubicarray/setrepeatnumberz 8 /gate/crystal/cubicarray/setrepeatvector mm
6 User script example: geometry A scanner module # R E P E A T BLOCK /gate/block/repeaters/insert cubicarray /gate/block/cubicarray/setrepeatnumberx 1 /gate/block/cubicarray/setrepeatnumbery 8 /gate/block/cubicarray/setrepeatnumberz 12 /gate/block/cubicarray/setrepeatvector cm
7 User script example: geometry A complete tomograph # R E P E A T MODULE /gate/module/repeaters/insert ring /gate/module/ring/setrepeatnumber 8
8 User script example: physics /gate/physics/addprocess IonInelastic /gate/physics/processes/ioninelastic/setmodel G4BinaryLightIonReaction (All) /gate/physics/processes/ioninelastic/setmodel G4LEAlphaInelastic alpha /gate/physics/processes/ioninelastic/g4binarylightionreaction/setemin 80 MeV alpha /gate/physics/processes/ioninelastic/g4binarylightionreaction/setemax 20 GeV alpha /gate/physics/processes/ioninelastic/g4lealphainelastic/setemin 0 MeV alpha /gate/physics/processes/ioninelastic/g4lealphainelastic/setemax 80 MeV alpha /gate/physics/processes/ioninelastic/setdataset G4IonsShenCrossSection
9 The OpenGATE Collaboration 21 institutes (Bulgaria, Chile, France, Germany, Greece, Holland, Korea, USA) development and validation of the GATE software First public release: public versions (Open source) ~1500 users User support (mailing list training courses documentation) GATE community GATE: a simulation toolkit for PET and SPECT, Physics in Medicine and Biology, "Citations Prize" award (most citations in the preceding five years)
10 The OpenGATE Collaboration Complementary to G4 Application oriented validated PET/SPECT dozens of publications CT scan Radiotherapy/ Hadrontherapy
11 Outline GATE overview Main features Examples
12 Geometry Standard G4 volumes Voxelized images - new navigator (phantoms/patients) Movement Ionization potential Example of systems already modeled: Siemens - ECAT EXACT HR+ GE - Advance Elekta - Precise micropet FOCUS 220 Philips - Allegro Courtesy of the OpenGATE collaboration
13 Time Time dependent phenomena: system movements SPECT, PET or CT detector (rotation/translation) multi-leaf collimator patient / phantom source decay kinetics
14 Physics Processes: EM processes (Standard, Low energy, Penelope) Hadronic processes (flexible selection of models and cross sections) /gate/physics/addprocess IonInelastic alpha Optimization: Production cuts per region /gate/physics/electron/setcutinregion myvolume 0.1 mm Step limiter /gate/physics/setmaxstepsizeinregion patient 0.1 mm User limits EM options /gate/physics/processes/electronionisation/setstepfunction mm Variance reduction Splitting/Russian roulette (parametrizable with filters) /gate/physics/processes/bremsstrahlung/setsplitting Fictitious cross section /gate/physics/addprocess Fictitious
15 Output Output file format: ROOT, ASCII, LMF, image (interfile, ECAT, Raw sinogram.) Actors + Filters (based on G4 scorers and G4Filters): allow to get any information anywhere in the simulation or to modify simulation behavior 3D dose scorer Simulation statistic Track killer.. PET/SPECT detector response and electronic treatments (front end, coincidences, blurring, dead time ) Courtesy of the OpenGATE collaboration
16 Source Standard G4 GPS Voxelized image Phase space Courtesy of the OpenGATE collaboration
17 Outline GATE overview Main features Examples
18 Oncology: Simulation of a whole body PET scan - Start acqui. : 264 MBq - 7 bed positions - 7 per bed position 2006: 13 h. & 7000 CPUs Including attenuation Speed-up factor ~ 10 Tumor volume 22 ml 2009: 48 h. & 200 CPUs Courtesy of CEA
![simulation Simulation result [ 18 F]FDG scan](/docs-images/85/91399555/images/19-1.jpg "simulation - micropet FOCUS 220 system -")
19 Molecular and pre-clinical imaging CT scan: attenuation Full numerical phantom GATE simulation Simulation result [ 18 F]FDG scan simulation - micropet FOCUS 220 system - Injected dose: 200 µci - Start acquisition: 45 min. after injection - Acquisition time: 15 [ Jan et al ]
20 CT imaging 4D MOBY phantom Simulation: 24h & 10 CPU PIXSCAN-XPAD3 (developed in CPPM, Marseille) X-ray beam 17 kev Courtesy of imxgam group (CPPM) [ A. Bonissent et al - to be published in proceedings of ITBS09 ]
21 Precise - Elekta Radiotherapy [ L. Grevillot et al Submitted ]
22 Hadron-PET Monitoring of the deposited dose using PET imaging for a 12 C treatment feasibility test Fragmentation: 12 C 15 O ß + emitting radionuclide 11 C 1 beam C 3 beams C Complete breathing cycle from 4D CT Hounsfield number Classical PET system 20 min post-irradiation acquisition
23 Hadron-PET 12 C deposited dose 13 Gy 0
24 Hadron-PET Map of 11 C with E kin = 0
25 Hadron-PET 11 C PET imaging
26 Hadron-PET Deposited dose Deposited dose 11 C PET imaging 11 C PET imaging 15 O PET imaging 15 O PET imaging Bq/cc Work in progress..
27 Conclusion Simulation platform for medical applications Application oriented Complementary to G4 PET/SPECT CT scan Radiotherapy / Hadrontherapy Validated and commonly used In development GATE version 6.0 December 2009
28 Futur Next step: Optical imaging GPU Major questions: CAD Hadronic physics validation
29 Contacts Irène BUVAT, collaboration spokesperson Sébastien JAN, collaboration technical coordinator - sebastien.jan@cea.fr Nicolas KARAKATSANIS, GATE efficiency optimisation working group coordinator knicolas@mail.ntua.gr Dimitris VISVIKIS, dosimetry application working group coordinator visvikis@univ-brest.fr GATE Workshop MIC NSS IEEE 2009, Orlando 29 october 2009
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