University of Bath Seminar - Biology

Transcription

1 CambridgeSoft Solutions University of Bath Seminar - Biology

2 ChemBioOffice Ultra ChemBioDraw ChemBio3D Ultra ChemBioFinder/ Ultra ChemBioViz Ultra E-Notebook Ultra Inventory Ultra BioAssay Ultra ChemDraw and CombiChem for Excel Struct = Name Chem NMR ChemScript Pro Mnova Lite STATISTICA Base ChemDraw and Chem3D Active X Pro Plugins & Controls ChemINDEX (Index, RXN, NCI & AIDS) 1-year subscription to ChemACX and Drugs: Synonyms and Properties GAMESS

3 ChemBioOffice Site Subscriptions Unlimited usage within institution Desktop or Workgroup (for individual or shared environments) All departments have access to required software Software updates and administrator support included Software can be used on any machine (lab, laptop, home) Individual online software downloads = less administration Site licenses reduce support load Multi-year site licenses reduce long-term cost

4 BIOLOGY NOTEBOOK BioAssay BioDraw Biology Notebook ChemBioOffice Overview

5 E-notebook Ultra Desktop - Biology Notebook; Free-form interface with Searchability -

6 Biology Notebook Configuration - Free-form interface with enhanced searchability - Seamless integration with Microsoft Office 2007 Ability to add as many sections as needed Free-form drawing section

7 E-notebook Office 2007 Compatibility - Work seamlessly with Office

8 Adding Sections to the E-notebook - Images, documents, pdfs and more - Types of sections available Example of an image in the notebook

9 E-notebook new Searching Functions - Better searching - Enhanced layout of Search sections Better Reaction and Text Search functionalities Full text structure search

10 E-notebook new Searching Functions - Better searching - When typing a word to search, the contents and the names of collections and documents are searched and the results displayed Search all MS Office text Here is an example of a simple text query where we search for the word offline Here are the results from that search Here we have clicked on one of the results of the search and find the word offline in a word document

11 E-notebook Offline Functionality - Work at home, on the plane; anywhere off the network - Work Offline Functionality

12 Audit Trail and Security - Maintain 21CFR Part 11 Compliance - Location of audit trail

13 Rendering of experiment into one, nicely formatted document E-notebook E-signatures - Maintain 21CFR Part 11 Compliance -

14 BIODRAW BioAssay BioDraw Biology Notebook ChemBioOffice Overview

15 BioDraw - BioDraw Samples-

16 BioDraw - Monthly Downloads - cambridgesoft com/articles/def ault.aspx?articleid=677&l=en

17 BIOASSAY BioAssay BioDraw Biology Notebook ChemBioOffice Overview

18 What is BioAssay? Import and storage of assay data Automated dhandling of assay workflows Graphical outputs and heat maps Mathematical manipulation and analysis of assay information

19 What is BioAssay - Example Customer Workflow Experimental Set-Up Import manually into Excel Analyze Data using 3rd party plug-in Use custom built macro to link plate ID Calculations and curve fit

20 What is BioAssay - BioAssay Workflow Experimental Set-Up Import manually into Excel Analyze Data using 3rd party plug-in Use custom built macro to link plate ID Calculations and curve fit

21 Making BioAssay Work - Data sources Plate Setup Data Defines what type of plate you are working with. (Ex: 96-well, 384- well) Well Setup Data Defines what substance is in each well of the plate. (Ex: Empty, compound, negative control, positive control) Protocol Setup Data Defines what actions and calculations you want to take place upon import of data Raw Data Can be virtually anything and can be in plate block format, columnar data or a custom format that you can define

22 Making BioAssay work - % Inhibition Experiment -Workflow- Accept data from plate reader Prompt for Find positive Graph % Calculate % plate ID, and negative Inhibition inhibition notebook #, control wells against against raw scientist and calculate Compound data in wells name average ID

23 Making BioAssay work Raw Data -Plate Block Format-

24 Making BioAssay work plate and well setup Plate Setup 96-well plate Well setup 8 Positive Controls 8 Negative Controls 80 test compounds

25 What is a protocol? A hierarchical representation of your experiment workflow

26 Data Hierarchical Representation -Here is your ipod- Genre Atit Artist Album Song Crying Aerosmith Big Ones Janies s Got a Gun Rock Rolling Stones Nine Lives Exile on Main St. Out of Out Heads Falling off Satisfaction Cry to me

27 Data Hierarchical Representation -Initial Screen Experiment- Plate Well B05 Plate 1229 B06 H12

28 Data Hierarchical Representation -IC50 Experiment- Plate Compound Concentration Well Compound X 1mg/L B05 B06 Plate 1 0.1mg/L H12 Compound Y 0.01mg/L 0.001mg/L E01 E02

29 BioAssay Individual User -New Features - Excel Analysis Export data from BioAssay into Excel Automatically launch a specified excel macro or add-in to be run to process the data Import the manipulated data back into BioAssay using a pre-defined file import template Analysis Results Excel Results File

30 BioAssay Shared Environment - Embedded in the Notebook -