Dimitrios Mitsouras, Ph.D.

Transcription

1 Dimitrios Mitsouras, Ph.D. Harvard Medical School Brigham And Women s Hospital Dept. of Radiology 75 Francis St Intent/Status Potentially seeking R&D/consulting position in scientific computing/medical imaging; no geographical restriction. Citizen of Greece, current H-1B status until 10/2007. Education Massachusetts Institute of Technology Cambridge, MA 6/2000-8/2004: Ph.D., Electrical Engineering and Computer Science. Dissertation: A Numerical Approach: Broadband Technologies for Efficient Magnetic Resonance Imaging. 9/1998-5/2000: M.Sc., Electrical Engineering and Computer Science, GPA: 5.0/5.0. Thesis: Near Real-Time 2D Non-Fourier Basis MRI. 9/1994-5/1998: B.Sc., Computer Science, GPA: 3.95/4.0. Thesis: A Numerical Approach: Simulations and Statistics for Studying Large Scale Structure Formation in the Universe. Positions Held Harvard Medical School 10/ Present: Instructor in Radiology Brigham & Women s Hospital 10/ Present: Research Associate; Lead Research Scientist, Cardiovascular Imaging Section. Honors Student stipend recipient, International Society for Magnetic Resonance in Medicine Best 1998 Thesis award (one of 4), Sc.B. received with honors in Computer Science, and, Magna cum Laude (highest awarded by institution) NASA Rhode Island regional Space Grant (one of 4 recipients) Royce Fellowship (one of 25 recipients). Teaching Massachusetts Institute of Technology Cambridge, MA 1999: Teaching Assistant, Introduction to Algorithms, Profs. Leiserson & Rivest. 1998: Teaching Assistant, Laboratory in Software Engineering, Prof. Liskov. Providence,RI 1996: Teaching Assistant, Introduction to Software Engineering and C++, Prof. Reiss. Systems C++, C, Java, Pascal (procedural & OO), Perl, MIPS assembly, Scheme, GE EPIC, Matlab DCE/RPC, X window, Motif, OpenGL, VRML 1.0 (OpenInventor) Research MIT, Brigham & Women s Hospital Cambridge, MA : Near optimal, near real-time dynamic adaptive Magnetic Resonance Imaging using non-fourier encoding. Applied compression ideas to MR signal acquisition by directly inducing signal compression via RF excitation, thus generating a signal carrying compressed information about the sample. Developed novel MR sequences capable of applying the RF encoding paradigm

2 based on fast imaging sequences (e.g., Spiral, Echo-Planar, FSE) and the methods required for image reconstruction. Developed the theory of RF encoding in the presence of parallel RF receiver coil arrays, in a manner that both further increases achievable signal compression and reduces RF excitation time. Developed the theory of FOLDing RF excitations, using the signal space concurrently with the time axis for signal compression via RF encoding. Developed a Scanner Real-Time hardware & software pipeline, largely replacing most aspects of the imaging pipeline of a commercial MR imager. System provided adaptive control of signal encoding, compression, and subsequent decoding and reconstruction of MR images. End product is capable of continuous adaptive MR imaging at an order of magnitude faster than current technologies. Brigham & Women s Hospital Summers 2003 & 2004: Designed and implemented novel 3D Inner Volume MRI techniques, for use on clinical MR scanners. Careful control of magnetization evolution enabled the combination of seemingly incompatible technologies (spin selection, and, echo trains formed by non-selective refocusing RF excitations). This led to ultra-high isotropic resolution imaging over small (e.g., 5cm cubic) volumes of interest, in clinically viable imaging times. Since imaging can be targeted to only the region/pathology of interest without restrictions, imaging time is reduced compared to present state of the art methods. Extensions are leading to clinically viable T 2 quantitation., Royce Fellowship, NASA Space Grant 5/1996-5/1999: Designed and implemented simulations of large scale structure formation in the universe. Developed asymptotically faster algorithms to compute statistical measures of structure, such as the Minkowski functionals, thus enabling differentiation between structure formation models over the large numbers of galaxies measured by present studies. Results helped design the observation strategy for the UBC/Laval 2.7m Liquid Mirror Telescope. Fall 1997: Developed and programmed a distributed WWW dynamic caching layer for Java applets, fully transparent to client/server implementations. Servers transparently doubled as intermediate caches arranged in a tree structure as reflected by physical topology. Execution proceeded with only a portion of the address space of the root server, while un-cached objects where fetched on-demand upon access. 9/1996-5/1997: Developed a novel auto-classifying mixture modeler for satellite multi-spectral images which was used to infer surface topology. A novel application of computational geometry methods allowed accurate extraction of the end-member spectra (i.e., constituents), such as the shade component. Accurate 3D topology was inferred from the latter via shape from shading algorithms and software was developed for 3D fly-through visualization. Spring 1996: Developed the RPC++ compiler which, given an extended IDL specification, produced C++ stubs that enabled distributing objects. The compiler provided object pointers including polymorphism as well as exception handling across networked systems. Fall 1996: Designed and implemented a fully functional multi-threaded, multi-process, micro-kernel OS in C++, with user level file system, name server and terminal manager, based on Sun s Spring OS. Publication List Books 1. Mitsouras D., A Numerical Approach: Simulations and Statistics for Studying Large Scale Structure Formation in the Universe,, Wayland Press, 103p., Journal Papers 1. Mitsouras D., Mulkern R.V., Owens C.D., Conte M.S., Ersoy H., Luu T.M., Whitmore A.G., Creager M.A., Rybicki F.J., High Resolution Peripheral Vein Bypass Graft Wall Studies Using High Sampling Efficiency Inner Volume 3D FSE, Magnetic Resonance in Medicine, ;in press, 2007.

3 2. Mitsouras D., Mulkern R.V., Afacan O., Brooks D.H., Rybicki F.J., Basis Function Cross- Correlations for Robust k-space Sample Density Compensation, with Application to the Design of RF Excitations, Magnetic Resonance in Medicine, 57; , Mitsouras D., Zientara G.P., Edelman A., Rybicki F.J., Enhancing the Acquisition Efficiency of Fast Magnetic Resonance Imaging via Broadband Encoding of the Signal Content, Magnetic Resonance Imaging, 24; , Kyriakos W., Hoge W.S., Mitsouras D., Generalised Encoding Through the Use of Selective Excitation in Accelerated Parallel MRI, NMR in Biomedicine, 19; , Mitsouras D., Mulkern R.V., Rybicki F.J., Strategies for Inner Volume 3D Fast Spin Echo Magnetic Resonance Imaging using non-selective Refocusing Radio Frequency Pulses, Medical Physics, 33; , Mitsouras D., Hoge W.S., Rybicki F.J., Kyriakos W., Edelman A., Zientara G.P., Non-Fourier Encoded MRI Using Multiple Receiver Coils, Magnetic Resonance in Medicine, 52; , Trac H., Mitsouras D., Hickson P., Brandenberger R., Topology of the Las Campanas Redshift Survey, Monthly Notices of the Royal Astronomical Society, 330; , (astro-ph/ ) 8. Mitsouras D., Brandenberger R.H., Hickson P., Topological Statistics and the LMT Galaxy Redshift Project, Monthly Notices of the Royal Astronomical Society, 305;19-27, (astroph/ ) Conference Papers 1. Afacan O, Mitsouras D, Brooks DH, Mulkern RV, Rybicki FJ. Comparing MR Imaging Properties of Spirals Using the Singular Spectrum of the Analytical Fourier Basis Cross-Correlation Matrix, in Proc. IEEE International Symposium on Biomedical Imaging (ISBI); 2007 Metro Washington, DC, 4; , 4/ Hoge W.S., Mitsouras D., Rybicki F.J., Mulkern R.V., Westin C.-F., Registration of multidimensional image data via sub-pixel resolution phase correlation, in Proc. IEEE International Conference on Image Processing (ICIP-03), Barcelona, Spain, II; , 9/ Mitsouras D., Near Real-Time 2D Dynamic Adaptive MRI Using Near-Optimal Spatial Encoding, in Proc. ISMRM Workshop on Minimum MR Data-Acquisition Methods, Florida, USA, 71-75, 10/2001. Proceedings 1. Mitsouras D, Mulkern RV, Afacan O, Brooks DH, Rybicki FJ, k-space Sample Density Compensation via Basis Function Cross-Correlations, with Application to the Design of 2D RF Excitations, in Proc. 15 th ISMRM, Berlin, Germany, p.1701, 5/ Mitsouras D, Mulkern RV, Owens CD, Conte MS, Creager MA, Ersoy H, Luu TM, Rybicki FJ, Ultra-High Resolution Vessel Imaging at 1.5T: Peripheral Vein Bypass Graft Wall Imaging via Non-Selective Refocusing Inner Volume 3D Fast Spin Echo, in Proc. 15 th ISMRM, Berlin, Germany, p.2472, 5/ Roebuck JR, Mitsouras D, Haker SJ, Rybicki FJ, Tempany CM, Mulkern RV, Carr-Purcell- Meiboom-Gill (CPMG) Imaging of Prostate Cancer; Trading Time for Information: High Quality T2 Images and Quantitative T2 Values for Cancer Discrimination, in Proc. 15 th ISMRM, Berlin, Germany, p.3675, 5/ Mitsouras D., Mulkern R.V., Rybicki F.J., Single slab-selective 3D CPMG multi-echo sequence with short inter-echo spacing for short-component T2 quantitation, in Proc. 14 th ISMRM, Seattle, Washington, p.3026, 5/ Mitsouras D., Madore B., Rybicki F.J., Panych L.P., Edelman A., Zientara G.P., Accelerated MR Imaging via FOLDing the non-fourier Encoded Dimensions, in Proc. 12 th ISMRM, Kyoto, Japan, p.2092, 5/2004.

4 6. Mitsouras D., Rybicki F.J., Edelman A., Zientara G.P., Ultra High Spatio-Temporal Resolution 3D Dynamic MRI via Adaptive non-fourier Encoding: Experimental Results, in Proc. 12 th ISMRM, Kyoto, Japan, p.2667, 5/ Mitsouras D., Mulkern R.V., Edelman A., Zientara G.P., Rybicki F.J., 3D Ultra-Fast Spin Echo Inner Volume MRI: Neuroimaging Applications, in Proc. 12 th ISMRM, Kyoto, Japan, p.2105, 5/ Kyriakos W.E., Mitsouras D., Rybicki F.J., Mulkern R.V., Accelerated Cardiac Selective Excitation (CASE) imaging in parallel using SPACE RIP, in Proc. 20 th ESMRMB, Rotterdam, Netherlands, p.479, 9/ Mitsouras D., Hoge W.S., Edelman A. & Zientara G.P., MR Imaging via Non-Fourier Encoding and Multiple Receiver Coils, in Proc. 11 th ISMRM, Toronto, Canada, p.16, 5/ Mitsouras D., Mulkern R.V., Panych L.P., Edelman A., Zientara G.P. & Rybicki F.J., Strategies for Inner Volume 3D Fast Spin Echo MRI, in Proc. 11 th ISMRM, Toronto, Canada, p.968, 5/ Mitsouras D., Panych L.P., Edelman A. & Zientara G.P., Spiral Echo-Planar Trajectories for 3D Non-Fourier Encoded MRI, in Proc. 11 th ISMRM, Toronto, Canada, p.991, 5/ Mitsouras D., Edelman A., Panych L.P., Jolesz F.A. & Zientara G.P., 3D Non-Fourier Dynamic Adaptive MRI via Near-Optimal Spatial Encoding: Towards Real-Time Imaging, in Proc. 10 th ISMRM, Honolulu, Hawaii, p.2379, 5/ Mitsouras D., Panych L.P., Edelman A., Jolesz F.A. & Zientara G.P., Fast Multiple-Excitation Multiple-Echo Spin-Echo Pulse Sequence for Non-Fourier Spatial Encoding, in Proc. 9 th Meeting ISMRM, Glasgow, Scotland, p.1808, 4/ Mitsouras D., Edelman A., Panych L.P., Jolesz F.A. & Zientara G.P., Sub-Second Continuous 2D Non-Fourier Dynamic Adaptive MRI Using Near-Optimal Spatial Encoding, in Proc. 9 th ISMRM, Glasgow, Scotland, p.1779, 4/ Mitsouras D., Edelman A., Panych L.P., Jolesz F.A. & Zientara G.P., Echo Planar Pulse Sequence for 3D Dynamic Adaptive MRI, in Proc. 9 th ISMRM, Glasgow, Scotland, p.1807, 4/ Mitsouras D., Edelman A., Panych L.P., Jolesz F.A. & Zientara G.P., Super-Resolved MRI by Back-Projection, in Proc. 9 th ISMRM, Glasgow, Scotland, p.764, 4/ Zientara G.P., Masurkar A.V., Mitsouras D., Panych L.P. & Jolesz F.A., Non-Orthogonal Non-Fourier Spatial Encoding for Dynamic MRI, in Proc. 9 th ISMRM, Glasgow, Scotland, p.782, 4/ Mitsouras D., Masurkar A.V., Zhao L., Panych L.P., Edelman A., Jolesz F.A & Zientara G.P., Implementation of Hybrid Basis Non-Fourier Spatial Encoding for Dynamic Adaptive MRI, In Proc. 8 th ISMRM, Boulder, Colorado, p.1431, 4/2000. Abstracts 1. Mitsouras D., Mulkern R.V., Owens C., Conte M., Creager M., Rybicki F.J., Application of high-resolution inner-volume 3D black-blood T 1 - and T 2 -weighted fast spin echo imaging to peripheral vein bypass graft imaging, in Proc. 92 nd Meeting of the Radiological Society of North America, Chicago, Illinois, 11/ Mitsouras D., Mulkern R.V., Edelman A., Zientara G.P., Rybicki F.J., Neuroimaging Applications of Two Reduced Field-of-View 3D Fast Spin Echo Magnetic Resonance Imaging Methods with Ultrashort, Non-selective, Hard-pulse Refocusing Radiofrequency Pulses, in Proc. 90 th Meeting of the Radiological Society of North America, Chicago, Illinois, p.452, 11/2004.

5 3. Owens C.D., Wake N., Schanzer A., Ifantides C., Rybicki F.J., Whitmore A.G., Mitsouras D., Gerhard-Herman M.D., Belkin M., Creager M.A., Conte M.S., Early Remodeling of Lower Extremity Vein Grafts: Modulation of Hemodynamic Adaptation by Systemic Inflammation, Research Initiatives In Vascular Disease Conference, Washington, D.C., Other References Fluent in Greek, reading & writing French. Upon request: Prof. Alan Edelman, MIT Dept. of Applied Mathematics, and, Computer Science and Artificial Intelligence Laboratory; Dr. Frank J. Rybicki, Harvard Medical School & Brigham and Women s Hospital Dept. of Radiology; Prof. Robert Mulkern, HMS & Children s Hospital Dept. of Radiology; Prof. Gary Zientara, HMS & BWH Dept. of Radiology; Prof. Robert Brandenberger, Dept. of Physics.