Save Money. Kromasil Columns packed by Phenomenex

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1 Replace your Kromasil and Save Money Kromasil Columns packed by Phenomenex OPTION 1 Direct 2 Replacement Chrom-Clone Guaranteed* direct replacement to Kromasil Significant cost savings OPTION Performance Upgrade Kinetex Guaranteed* performance improvement to Kromasil Far higher efficiency Increased sensitivity Greater productivity Phenomenex List Price 5 C18 1Å 25 x 4.6 mm Phenomenex List Price 5 C18 1Å 25 x 4.6 mm Phenomenex List Price 5 C18 1Å 25 x 4.6 mm C8 also available * See guarantees inside

2 Chrom-Clone Chrom-Clone Why Chrom-Clone? Guaranteed Replacement to Kromasil Based Columns Kromasil Significant Cost Savings Manufactured by Phenomenex for Reproducibility Long Column Lifetime Get the Same Chrom-Clone Reproducibility Anywhere in the World Chrom-Clone columns are packed and manufactured only by Phenomenex, thereby reducing the chance of column-to-column variation. You will receive columns of consistent quality and reproducibility, and will benefit from Phenomenex s excellent customer support and technical service. Material Comparison Chrom-Clone. Kromasil 5, Spherical Particle Size 3.5, Spherical and Shape 5, Spherical Pore Size 1 Å C8, C18 1 Å Surface Area 37 m 2 /g C8, C18 34 m 2 /g Carbon Load 13% C8 12% 18 % C18 19 % If KromaClone analytical columns do not provide the equivalent separation as compared to an AkzoNobel or Phenomenex packed Kromasil column of the same particle size, phase and dimensions, return the product with comparative data within 45 days for a FULL REFUND. 216 Phenomenex, Inc. All rights reserved.

3 Kinetex Core-Shell Technology Why Kinetex? Kinetex Guaranteed Performance Improvement to Kromasil Based Columns Improved Results Better Productivity Easy Transferability Better Performance than Fully Porous Particles Replace your Kromasil column with a Kinetex Core-Shell HPLC column to see considerable improvements in your chromatographic performance. Gain higher efficiency, improved sensitivity, and resolution. By switching, experience decreased run times and reduced solvent usage helping you save more money. Kromasil Solid Core Porous Shell Fully Porous Kinetex Core-Shell Average Efficiency Gain with Kinetex* 5 VS 5 9 % Higher 3 VS % Higher If you are not completely satisfied with Kinetex core-shell columns, return the product with comparative data within 45 days for a FULL REFUND. * May not be representative of all applications. Phenomenex l WEB:

4 Swap Out Kromasil Based Columns and Save Significantly with Chrom-Clone Chrom-Clone is guaranteed to provide equivalent separation as compared to your existing Kromasil column packed by Akzo- Nobel or Phenomenex, at a fraction of the price. Kromasil Chrom-Clone v Kromasil 5 C18 1 Å 15 x 4.6 mm 3 Aromatic Acids Chrom-Clone 5 C18 1 Å 15 x 4.6 mm min Kromasil 5 C18 1 Å 15 x 4.6 mm min Kromasil 5 C18 1 Å 15 x 4.6 mm App ID App ID App ID 2299 Steroids Basic Drugs min Chrom-Clone 5 C18 1 Å 15 x 4.6 mm min Chrom-Clone 5 C18 1 Å 15 x 4.6 mm App ID App ID 2317 App ID min min Comparative separations may not be representative of all applications. Phenomenex l WEB:

5 Upgrade to Superior Core-Shell Performance Without changing column specifications, Kinetex core-shell columns will dramatically improve original Kromasil methods. Get dramatic increases in sensitivity, resolution, and efficiency for your compounds and methods. s Kinetex Aromatic Acids Kinetex 5 C18 1 Å 15 x 4.6 mm Steroids Kinetex 5 C18 1 Å 15 x 4.6 mm min Basic Drugs Kinetex 5 C18 1 Å 15 x 4.6 mm App ID min App ID App ID *Same backpressure, 41% faster analysis *More than 9% increase in sensitivity *143% efficiency increase, sharper peak shape Conditions for all columns: Columns: Kinetex 5 C18 Chrom-Clone 5 C18 Kromasil 5 C18 Dimensions: 15 x 4.6 mm Mobile Phase: A:.1 % H 3 PO 4 in Water B: Acetonitrile with.1 % H 3 PO 4 (5:5) Flow Rate: 1. ml/min Detection: 254 nm Sample: 1. Benzoic acid 2. o-toluic acid 3. Naproxen Conditions for all columns: Columns: Kinetex 5 C18 Chrom-Clone 5 C18 Kromasil 5 C18 Dimensions: 15 x 4.6 mm Mobile Phase: A:.1 % H 3 PO 4 in Water B: Acetonitrile C: Methanol (54:35:11) Flow Rate: 1. ml/min Detection: 254 nm Sample: 1. Hydrocortisone 2. Corticosterone a-Hydroxyprogesterone 4. Cortisone acetate Ketoprogesterone Conditions for all columns: Columns: Kinetex 5 C18 Chrom-Clone 5 C18 Kromasil 5 C18 Dimensions: 15 x 4.6 mm Mobile Phase: A: 2 mm Potassium Phosphate (ph 7.) B: Methanol (6:4) Flow Rate:.8 ml/min Detection: 254 nm Sample: 1. Uracil 2. Procainamide 3. N-Acetylprocainamide min *Comparative separations may not be representative of all applications. Phenomenex l WEB:

6 Your Current Column KromaClone DIRECT REPLACEMENT TO Kromasil SecurityGuard Cartridges (mm) Phases 125 x x x x 3.* /1pk Kromasil 5 C18 5 C18 E-4741-D F-4741-E G-4741-E AJ-4287 Your Current Column SecurityGuard Cartridges (mm) Phases 15 x x x 3.* /1pk Kromasil 5 C8 5 C8 F-474-E G-474-E AJ-429 * SecurityGuard Analytical Cartridges require universal holder Part No.: KJ-4282 Your Current Column Kinetex PERFORMANCE IMPROVEMENT TO Kromasil SecurityGuard ULTRA Cartridges Phases 1 x x x 4.6 3pk Kromasil 3.5 C C18 D-4462-E F-4462-E AJ-8768 Kromasil 5 C18 5 C18 D-461-E F-461-E G-461-E AJ-8768 Your Current Column SecurityGuard ULTRA Cartridges Phases 15 x x 4.6 3pk Kromasil 5 C8 5 C8 F-461-E G-461-E AJ-877 SecurityGuard ULTRA Cartridges require holder, Part No.: AJ-9 Easily improve methods with allowable changes Terms and Conditions Subject to Phenomenex Standard Terms & Conditions, which may be viewed at Trademarks Chrom-Clone, SecurityGuard, and MidBore are trademarks and Kinetex is a registered trademark of Phenomenex. Kromasil is a registered trademark of AkzoNobel Pulp and Performance Chemicals AB. Disclaimer Phenomenex is not affiliated with AkzoNobel. Comparative separations may not be representative of all applications. SecurityGuard is patented by Phenomenex. U.S. Patent No. 6,162,362 CAUTION: this patent only applies to the analytical-sized guard cartridge holder, and does not apply to SemiPrep, PREP or ULTRA holders, or to any cartridges. 216 Phenomenex, Inc. All rights reserved. Phenomenex products are available worldwide. For the distributor in your country, contact Phenomenex USA, International Department at international@phenomenex.com Australia t: +61 () f: +61 () au Finland t: +358 () f: nordic Luxembourg t: +31 () f: +31 () nl Spain t: f: esp Austria t: +43 () f: +43 () anfrage@phenomenex.com France t: +33 () f: +33 () france Mexico t: f: tecnicomx@phenomenex.com Sweden t: +46 () f: nordic BR _W Belgium t: +32 () (French) t: +32 () (Dutch) f: +31 () be Canada t: +1 (8) f: +1 (31) China t: +86 () f: +86 () china Denmark t: f: nordic Germany t: +49 () f: +49 () anfrage@phenomenex.com India t: +91 () f: +91 () india Ireland t: +353 () f: eire Italy t: f: italia The Netherlands t: +31 () f: +31 () nl New Zealand t: +64 () f: +64 () nz Norway t: f: nordic Puerto Rico t: +1 (8) 541-HPLC f: +1 (31) United Kingdom t: +44 () f: +44 () uk USA t: +1 (31) f: +1 (31) All other countries Corporate Office USA t: +1 (31) f: +1 (31)