Group Sta/s/cs with BESA and BrainWave

Transcription

1 24/04/12 Group Sta/s/cs with BESA and Graciela Tesan, PhD CCD From raw data to p- values 1

2 MEG and EEG data preprocessing and analysis BESA Sta/s/cs: analyses of EEG ac/vity and MEG distributed sources : analysis of event related beamformer It s a long way to the top if you want to do group sta/s/cs BESA Research & Sta/s/cs License required for each module (Research, MRI, Sta/s/cs) Good for visual inspec/on of data Mul/ple dipole fiung Distributed source analysis Frequency analysis and beamforming Group sta/s/cs: with and without structural MRI Free but requires Matlab Newest version improved for visual inspec/on of group data Event related beamformer and TFR Analysis Group sta/s/cs withstructural MRI only hxp://cheynelab.utoronto.ca 2

3 It s a long way to the top if you want to do group sta/s/cs BESA Research & Sta/s/cs Data collec/on Data preprocessing Coregistra/on Expor/ng/Modifying auxiliary files Event file crea/on Impor/ng Data to BESA Merge files Paradigm crea/on Averaging Data visualiza/on and analysis MRI coregistra/on (op/onal) Data visualiza/on: Distributed Source analysis? Mul/ple dipole Models? Beamforming? Electrode clustering? Subject Analysis: *.dat/*.swf/*._r/*.avr Group Analysis Data collec/on Data preprocessing Coregistra/on Expor/ng auxiliary files Event file crea/on Impor/ng Data to Merge files DS crea/on Data visualiza/on and analysis Data visualiza/on: Event Related Beamforming/ TFR MRI crea/on/coregistra/on using CTF so`ware (dicom to ni`y to mri) Subject Analysis : ERB/TFR Group Analysis It s a long way to the top if you want to do group sta/s/cs BESA Research& Sta/s/cs Data collec/on Data preprocessing Coregistra/on Expor/ng/Modifying auxiliary files Event file crea/on Impor/ng Data to BESA Merge files à batch processing Paradigm crea/on Averaging à batch processing Data visualiza/on and analysis MRI coregistra/on (op/onal) Data visualiza/on: Distributed Source analysis? Mul/ple dipole Models? Beamforming? Electrode clustering? Subject Analysis: à batch processing Group Analysis Data collec/on Data preprocessing Coregistra/on Expor/ng auxiliary files Event file crea/on Impor/ng Data to Merge files (if needed) DS crea/on Data visualiza/on and analysis Data visualiza/on: Event Related Beamforming/ TFR MRI crea/on/coregistra/on using CTF so`ware (dicom to ni`y to mri) Subject Analysis à batch processing Group Analysis 3

4 Hypotheses Children and adults generate an M170 in response to faces Which areas are ac/vated? What s the latency of the response across groups? Sta/s/cs in BESA Iden/fy clusters (sensors/electrodes/sources) across /me, frequency or space Preliminary t- tests (parametric) Non- parametric permuta/on tests + data clustering Does the ini/al cluster of sensors/electrodes/voxels survive permuta/on? 4

5 Group Analysis: Processing Faces Face processing in children and adults 22 child par/cipants (MEG/EEG recording) 9 adult par/cipants (MEG/EEG recording) Eyetracker to present next trial upon fixa/on 5 condi/ons: Faces/Scrambled Faces/Cars/Scrambled Cars/Aliens and Monsters About 20 minutes long (80 trials/condi/on, fewer for condi/on 5), making it ideal to work with 3-5 year olds EEG data in BESA Sta/s/cs 5

6 EEG data in BESA Sta/s/cs EEG data in BESA Sta/s/cs 6

7 EEG data in BESA Sta/s/cs EEG data in BESA Sta/s/cs 7

8 EEG data in BESA Sta/s/cs MEG data in BESA Sta/s/cs: Distributed Source Analysis 8

9 MEG data in BESA Sta/s/cs: Distributed Source Analysis MEG data in BESA Sta/s/cs: Distributed Source Analysis 9

10 Beamformer Analysis Event related beamformer SAM analysis Virtual sensor TFR Group Sta/s/cs: a non- parametric permuta/on test 10

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