Publisher & Contact Information

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1 EDITORIAL DESCRIPTION: Interventional Oncology 360 offers original articles, news, blogs, and multimedia to support all professionals in interventional oncology, including interventional radiologists, oncologists, nurse practitioners, physician assistants, nurses, and radiologic technologists. Reflecting the broad spectrum of specialties involved, Interventional Oncology 360 will also address referring physician groups in surgery, medical oncology, and radiation therapy. Publisher & Contact Information Jeff Martin Vice President/Group Publisher (800) , ext Carson McGarrity Associate Publisher (215) Stephanie Starman Associate National Sales Accounts Manager (800) , ext Jeff Benson National Account Manager (484) Lam Wang Advertising Sales Associate (800) , ext Interventional Oncology 360 is on:, LLC an HMP Communications Holdings Company tinyurl.com/io360facebook 70 E. Swedesford Road Suite 100 Malvern, PA tinyurl.com/io360linkedin twitter.com/interventonc360

2 General Information EDITORIAL DESCRIPTION: (Mission Statement) Interventional Oncology 360 is a web-based publication that seeks to inform readers on the latest advancements in interventional oncologic treatments. It provides an educational resource to increase knowledge and enable multidisciplinary collaboration in this rapidly growing field. Interventional Oncology 360 is designed for all professionals in the interventional oncology field, including interventional radiologists, oncologists, nurse practitioners, physician assistants, nurses, and radiologic technicians. Reflecting the broad spectrum of specialties involved, Interventional Oncology 360 will also address this practice as it relates to referring physician groups in surgery, medical oncology, and radiation therapy. Articles undergo peer review by members of the advisory editorial board and the clinical editor, Govindarajan Narayanan, MD. The site features original contributions, clinical reviews, case studies, late-breaking clinical trial results, product information, facility profiles, multimedia, editorial commentary, blogs, and interviews with key opinion leaders. Interventional Oncology 360 is available in web, mobile, and tablet application versions. ESTABLISHED 2013 ADVERTISING ACCEPTANCE & COPY All advertising is subject to the publisher s approval. SERVICES TO ADVERTISERS Online advertising, reprints, enduring materials, ad testing, meeting planning, marketing, web archive programs, list rental, classified and recruitment advertising. PROMOTION AT MAJOR MEETINGS: The Symposium on Clinical Interventional Oncology (CIO) at ISET (February 4-5, 2017, Hollywood, Florida) The Society for Interventional Radiology Annual Scientific Meeting (March 4-11, 2017, Washington, D.C.) WCIO (June 8-11, 2017, Boston, Massachusetts) Synergy Miami: A Multidisciplinary Approach to Interventional Oncology (November 8-11, 2017, Miami, Florida) ISSUANCE Online-exclusive publication Interventional Oncology 360 has a presence on major social media outlets.

3 Skyscraper Leaderboard (Banner 1) Banner2 FOLD Banner 3 Banner 4 Block 1 Tile 1 Tile 2 Block 2 Block 3 Tile 3 File size not to exceed 100k. For video and other rich media ads, please see the technical specifications on page 6. All sizes shown as width x height. Skyscraper 160x600 $5,500 Every Page Leaderboard (Banner 1) 728x90 $3,500 Every Page Banner 2 (above fold) 578x60 $3,000 Every Page Banner 3 (below fold) 578x60 $2,000 Every Page Banner 4 (below fold) 578x60 $1,500 Every Page Tile 1 (above fold) 300x100 $3,500 Every Page Tile 2 300x100 $2,500 Every Page Tile 3 (above fold) 300x100 $2,000 Every Page Block 1 (above fold) 300x250 $4,000 Every Page Block 2 300x250 $2,500 Every Page Block 3 300x250 $2,000 Every Page Corner-page peels Rate Notes $6,500 Home Page Additional charges for rich media ad units: expandables, floaters, etc. Rate $1,000

4 E-Newsletters Leaderboard Size in pixels Rate Leaderboard 728x90 $3,000 Banner 2 (above fold) 300x100 $2,500 Banner 3 (below fold) 300x100 $2,500 Banner 4 728x90 $2,000 Banner 2 Banner 3 Banner 4 E-Blast Publication Size in pixels Rate IO360 $750 per 1,000 Per Distribution

5 Classifieds Reprints/EPrints: Please contact Lam Wang, Advertising Sales Associate at: or (800) , ext Classified/Recruitment: Please contact Lam Wang, Advertising Sales Associate at: or (800) , ext Internet opportunities: Runs: 30 days *all prices are net Online Rate: Includes service fee, contact link, and text hyperlink. Must be limited to 200 words. 30 days text only $ days PDF $600 Banner Advertising: Main Page $3,000 Classified Page $1,000 Tile Advertising: Main Page $2,000 Classified Page $800 *Please note: HMP Communications.com services require at least five (5) business days lead time to schedule your online advertising. Files must arrive in electronic form and be web-ready or in PDF format. E-News: Classifieds available. Contact representative for details. E-Blast: State by State $0.95

6 Technical Specifications Creative Unit Name (WxH in pixels) Maximum Expanded (WxH in pixels) Max File Load Size Max Additional File Load Size for OBA Self- Reg Compliance (Note 1) Subsequent Max Polite File Load Size Subsequent Max User- Initiated File Load Size Subsequent Max User- Initiated Additional Streaming File Size Max Video & Animation Frame rate Rich Media Ad Guidance In- Banner Video (file- loaded) 300x250 Expansion 40 KB 5 KB 100 KB 2.2 MB for N/A 24 fps 15- sec 30- sec Must be user- 728x90 not allowed video file load In- Banner Video (streaming) for these 100 KB N/A Unlimited for units Maximum Animation Length (i.e. Flash ) Max Video Length Audio Initiation initiated Hot Spot Expandable/ Retractable 300x250 to 600x KB 5 KB 100 KB 2.2 MB for 160x600 to 600x600 files 728x90 to 728x315 Unlimited for 24 fps 15- sec 30- sec 1/4 size of original ad (collapsed size). Only initiated Pop Ups 300x x480 Expansion not allowed for these units 40 KB 5 KB 100 KB 2.2 MB for files Unlimited for 24 fps 15- sec 30- sec Floating Variable Expansion not allowed 80 KB 5 KB 160 KB 2.2 MB for files Unlimited for 24 fps 15- sec 30- sec Between- the- Page (aka "Interstitial") Variable Expansion not allowed 80 KB 5 KB 160 KB 2.2 MB for files Unlimited for 24 fps 10- sec (ad displays for only 10 sec and disappears if no interaction) 30- sec only if user interacts within first 10 sec of display (otherwise ad disappears) Abbreviations: px = pixel sec = seconds Z- index Range Max Percentage of CPU Usage (Note 3) Minimum Required Controls 0-4,999 30% Controls = Play, Pause, Mute (volume control to zero (0) output may 5,000-1,999,999 (for entire ad unit) 30% Control = Close X on expanded panel and "Expand" on collapsed panel 16pt (21px) Retract Feature = Either Click to close/expand or Enable Mouse- Off Retraction Video must include: Play, Pause, Mute (volume control to zero (0) output may N/A Pop- ups display in their own browser window, so pop- up ad content has its own z- index 30% "Close" control provided by browser window. Video must include: Play, Pause, Mute (volume control to zero (0) output may 2,000,000-2,999,999 30% Control = Close X 16pt (11px) Video must include: Play, Pause, Mute (volume control to zero (0) output may N/A Unless the ad covers content on the target page, then use range for overlays: 6,000, % "Close" control provided by browser window if ad displays in its own browser window. If overlaid on target page, include "Close X" button. 16pt (21px) Video must include: Play, Pause, Mute (volume control to zero (0) output may Labeling Requirements, Font Size, etc. In the browser bar, all Pop Ups labeled with: Name of Network/Advertis er, Publisher, Browser Type [in this order] (ex.: "Advertising.com - CBS Market Watch - Microsoft Internet Explorer") Label = "Advertisement" 16pt (21px) Label = "Advertisement" 16pt (21px) Submission Lead- Time Implementation Notes & Best Practices Expansion must be user- initiated (note 2). image file the same dimensions of the original (collapsed) ad dimensions. Duration of display: 10- sec max if no user interaction; up to 30- sec when user is engaged with ad within first 10 sec.

7 Technical Specifications Creative Unit Name (WxH in pixels) Maximum Expanded (WxH in pixels) Max File Load Size Max Additional File Load Size for OBA Self- Reg Compliance (Note 1) Subsequent Max Polite File Load Size Medium Rectangle 300x250 Expansion not allowed for this unit 40 KB 5 KB Wide Skyscraper 160x600 Expansion not allowed for this unit 40 KB 5 KB Leaderboard 728x90 Expansion not allowed for this unit 40 KB 5 KB Abbreviations: px = pixel sec = seconds Specifications Unit Type (WxH in Pixels) Pop- Up 300x250 Pop- Up Large 550x480 Subsequent Max User- Initiated File Load Size Subsequent Max User- Initiated Additional Streaming File Size Universal Ad Package (UAP) Max Video & Animation Frame rate Maximum Animation Length (i.e. Flash ) Max Video Length Audio Initiation Hot Spot Z- index Range Max Percentage of CPU Usage (Note 3) Minimum Required Controls Labeling Requirements, Font Size, etc. Submission Lead- Time Implementation Notes & Best Practices for 24 fps 15- sec Video not allowed for see "In- Banner Video" & Rich Media units below un- mute); default state hotspot for at least 1- sec. 0-4,999 20% N/A Min 3 business for 24 fps 15- sec Video not allowed for see "In- Banner Video" & Rich Media units below un- mute); default state hotspot for at least 1- sec. 0-4, N/A Min 3 business for 24 fps 15- sec Video not allowed for see "In- Banner Video" & Rich Media units below un- mute); default state hotspot for at least 1- sec. 0-4, N/A Min 3 business Pop- Up Guidelines Maximum File Load Size Audio/Video Initiated Close Box 40 KB ly 100 KB Subsequent Polite File Load 2.2 MB for User- Initiated File Load Unlimited User- Initiated User- Initiated Controlled by browser

8 Technical Specifications HTML5 Best Practices Notes (Best practices are provided in more detail in IAB s HTML5 for Digital Advertising guide for Ad designers & Creative Technologists) Improve Display HTML5 ads are like mini-web pages. You can improve the initial display by following a few guidelines: Provide inline css and use HTML to deliver initial display resources as much as possible. Limit initial dependencies on any render-blocking.js or.css. Load interactive elements as a deferred or secondary subload, but keep them efficient using techniques such as caching. Defer heavy file weights until user initiates interaction. Use techniques such as byte serving to download partial content and to optimize for autoplay video. Avoid any unnecessary downloads. Improve time-to-visual and complete download In order to provide the fastest time to a visual experience: Combine all supporting files (e.g. JavaScript toolkits, libraries, HTML, and CSS) whenever possible. Use well-distributed, cached libraries to provide supporting files instead of providing them with the ad. Check device bandwidth, and tailor supporting files and other elements to the environment and experience. Image Assets Consolidate images wherever possible. Use sprite sheets for multiple display assets and animation. Cache all reusable objects. Video Assets Defer heavy payload until user interaction. Use techniques such as byte serving to download partial content and to optimize for autoplay video. Avoid unnecessary downloads. Caching: Use CDN-hosted files and caching of static objects as much as possible. Video Notes: HTML5 streaming video, but it can simulate a streaming experience using adaptive bitrate streaming technologies such as HLS and MPEG-DASH. Use MPEG-4 (MP4) file formats for H.264-encoded video for a more seamless delivery across devices. The H.264 codec should use a Baseline profile to allow for more diverse execution in systems that range from a cellular connection on a mobile screen to a high-speed cable connection on an HTTP-connect TV screen. For audio, AAC is more widely supported (PCM audio is unsupported in Flash players). At a minimum, the MP4/H.264 file format should be provided, but alternate files using formats such as WebM and VP8 may also be submitted. Use the web-optimized setting when encoding the MP4 file, which sets the MOOV (movie) atom at the of the file. Formatting files for adaptive bitrate streaming enables a smoother viewer experience. Adaptive bitrate streaming uses short fragments (2-3 seconds) of the video at different quality leveles and stores them in a playlist file such as M3U8. During playback, the player detects bandwidth at the of each fragment and plays the fragment at the quality level best suited to the bandwidth and player environment. Common protocols for adaptive bitrate streaming include HTTP Live Streaming (HLS) in the U.S. and MPEG-DASH in the EU. Assets and Resources Delivery Ad servers should strive to maintain a persistent connection to avoid duplicate downloads for each asset. Package assets to allow for maintaining a persistent connection. All assets and files should be delivered using Gzip and use relative paths. Use minification and/or compression where applicable to minimize the file load size.

9 Technical Specifications HTML Best Practices Maximum width of pixels. Design for simplicity using grid-based layers while avoiding complicated elements that require HTML floats or positions. Avoid the use of background images and gradients. Use basic cross-platform fonts such as Arial and Times New Roman. Don t neglect the mobile user. Code all HTML structure using tables and nested tables for more complicated layouts. Use element attributes such as valign, cellpadding, and width. Keep CSS simple and avoid using compound style declarations, shorthand code (#000 rather than #000000), complex selectors (descendant and child selectors), and css layout properties such as position and clear. Make sure all CSS is inline before sending. Use absolute links for images. Use GIF images rather than Javascript and Flash as they are largely unsupported. Make responsive if the design allows for it but keep in mind that not all clients support media queries. Do not use background images as they are not supported across all clients. Do not use JavaScript, Submission Forms, Layers, or Rich Media (i.e. Flash movies, animation). These cause deliverability issues which can affect the responses, hinder our deliverability for future s, and do not render correctly in many ISPs. The more images/graphics there are, the more time it takes for a recipient to download. Potential customers will be lost if they have to wait for images to download in order to read or act on the message. The higher the ratio of image-to-text area in an HTML, the higher the SPAM score. We recommend no more than 1/3 of the design area be images or graphics, and the rest should be formatted text Use fonts that are universal on the Internet such as Arial, Verdana, Tahoma, or Times New Roman. Any other fonts will resort to a default font if the recipient doesn t have it installed on their computer. Minimize the number of fonts, sizes, and colors used in the design for easy flow and professional look. When possible, avoid using white (#FFFFFF) text. Spammers sometimes use white text on white backgrounds to prevent visibility of some text, so spam filters may flag usage of white text. Use ALT tags in the HTML code for each image used in the HTML design. Headers and navigation menus work well, especially those featuring a brand or logo. Minimize graphics and images to logos, photos of products, or situational photos that support the message visually. Don t rely on graphics and images for the main content of the message. Keep the length of the short, concise, and about one page maximum in length. Newsletters may be longer, but the further details of a message should be left on a hyperlinked web page. Use bullet points to identify key points in the message. Clearly identify what the call to action is that you want the recipient to make to act on your offer. Buttons work.